Cited by 247Ubiquitin and proteasome pathwaysGenetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy

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The proteasome in brain aging

Keller, J·2002·Ageing Research Reviews

DOI 10.1016/s1568-1637(01)00006-x

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Abstract

The proteasome is a large intracellular protease, present in all cells of the central nervous system (CNS), that is responsible for the majority of intracellular protein degradation. In particular, the proteasome is responsible for the degradation of most oxidized, aggregated, and misfolded proteins. The importance of proteasome activity to neuronal homeostasis is highlighted by previous studies demonstrating that proteasome inhibition alone is sufficient to induce neuron death in vitro. Recent studies indicate that alterations in proteasome activity may occur during, and possibly contribute to, the aging process. These data raise the possibility that alterations in the proteasome proteolytic pathway may contribute to the elevations in protein oxidation, protein aggregation, and neurodegeneration evident in the aging CNS. The focus of this review is to describe what is currently known about the proteasome in the CNS, describe established age-related alterations in proteasome biology, and to discuss how such alterations in proteasome biology may ultimately contribute to the aging of the CNS.

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Authors: Keller, J.
Affiliations: University of Kentucky (US)
Corresponding author: Keller, J
ORCID: Keller, J
Venue: Ageing Research Reviews
Publisher: Elsevier BV
Published: 2002-04
Volume: 1
Issue: 2
Pages: 279-293
ISSN: 1568-1637 (ISSN-L)
DOI: 10.1016/s1568-1637(01)00006-x
OpenAlex: W1983882750
Cited by: 247
References: 82
Citations by year: 2023: 4 · 2022: 6 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 7 · 2017: 10 · 2016: 6 · 2015: 5 · 2014: 13 · 2013: 8 · 2012: 15
FWCI: 8.00
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Ageing Research Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (R01AG018437, AG18437)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: proteasome, brain aging, protein degradation, protein oxidation, protein aggregation, protein misfolding, neurodegeneration, neuronal homeostasis, proteasome inhibition, central nervous system
MeSH terms: Aging, Brain, Cysteine Endopeptidases, Humans, Multienzyme Complexes, Oxidative Stress, Proteasome Endopeptidase Complex

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