The effect of an electronic monitoring device with audiovisual reminder function on adherence to inhaled corticosteroids and school attendance in children with asthma: a randomised controlled trial
Abstract
Background Suboptimum adherence to preventive asthma treatment is associated with substantial morbidity and mortality, yet adherence often remains poor. We aimed to investigate whether use of an inhaler with audiovisual reminders leads to improved adherence and asthma outcomes in school-aged children who presented to the emergency department with an asthma exacerbation.Methods We did a randomised controlled trial in patients aged 6-15 years who attended the regional emergency department in Auckland, New Zealand with an asthma exacerbation and were on regular inhaled corticosteroids. Using a simple, unrestricted block randomisation with block sizes of 200, we randomly assigned patients to receive an electronic monitoring device for use with their preventer inhaler with the audiovisual reminder functions either enabled to support adherence to inhaled corticosteroids (intervention group) or disabled (control group). Participants were followed up every 2 months for 6 months. The primary outcomes were adherence to preventive inhaled corticosteroids and number of days absent from school for any reason. Asthma control was assessed as a secondary outcome. All analyses were done in the intention-to-treat population. This trial is registered with the Australian New Zealand Clinical Trials Registry, number ACTRN12613001353785.Findings The study took place between May 10, 2010, and Feb 26, 2012. We randomly assigned 220 patients, 110 to the intervention group and 110 to the control group. Median percentage adherence was 84% (10th percentile 54%, 90th percentile 96%) in the intervention group, compared with 30% (8%, 68%) in the control group (p<0·0001). The proportion of days absent from school for any reason was 1·9% (10th percentile 0·0%, 90th percentile 7·9%) in the intervention group and 1·7% (0·0%, 8·6%) in the control group. The change in asthma morbidity score from baseline to 6 months was significantly greater in the intervention group than in the control group (p=0·008), with a reduction of 2·0 points from a mean baseline score of 9·3 (SD 2·2) to 7·3 (2·1) in the intervention group, compared with a reduction of 1·2 points from a baseline of 9·2 (2·5) to 8·0 (2·2) in the control group.Interpretation Use of an electronic monitoring device with an audiovisual reminder led to significant improvements in adherence to inhaled corticosteroids in school-aged children with asthma. This intervention could be beneficial for the improvement of asthma control in patients for whom poor asthma control is related to poor adherence.Funding Health Research Council of New Zealand and Cure Kids.
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Despite interventions and treatments aimed at addressing modifiable factors and comorbidities, some children with difficult asthma and Asthma plus may not improve because of continued poor adherence with medications or ongoing high exposure to allergens, in which case they should be considered as having refractory difficult asthma or refractory Asthma plus.
“However, despite interventions and treatments aimed at addressing modifiable factors and comorbidities, some children with DA and Asthma plus may not improve [e.g., because of the continued poor adherence with medications (50, 68), or ongoing high exposure to allergens (69–71)], in which case they should be considered as having refractory DA or refractory Asthma plus (46, 72).”
From Epidemiology of Asthma in Children and Adults (2019) · cites this paper as [68]
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Epidemiology of Asthma in Children and Adults
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“, because of the continued poor adherence with medications (50, 68), or ongoing high exposure to allergens (69–71)], in which case they should be considered as having refractory DA or refractory Asthma plus (46, 72).”
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“Furthermore, the New Zealand trial found that the children in the intervention group suffered significantly less exacerbations and their lung function improved (25).”
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“The Use of an electronic monitoring device with an audiovisual reminder led to significant improvements in adherence to ICS in a group of school-aged children with asthma who attended an emergency department in Auckland, New Zealand [229].”
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“Indeed, several recent studies have provided evidence supporting the patient benefits of such digital interventions, particularly in children and adolescents [10-14].”
Systematic Review of Digital Interventions for Pediatric Asthma Management
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“(35, 38, 42, 44) Adherence Effectiveness Improvements in adherence were documented in thirteen (87%) of the fifteen studies.(31-38, 40-42, 44, 45) Specifically, ten studies (67%) demonstrated that adherence was significantly better in the intervention group compared to the control group at post intervention.”
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New and future strategies to improve asthma control in children
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“EMDs provide accurate, objective, and detailed information on day-to-day patient adherencewithout significantly disrupting a patient’s natural medication-taking behavior.(25) The SmartTouch (formerly SmartTrack; Adherium, Auckland, New Zealand) and Propeller (Propellor Health, Madison, Wis) sensors are 2 of the more a…”
BackgroundMethodResultInfluentialThe Digital Asthma Patient: The History and Future of Inhaler Based Health Monitoring Devices
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“(117)”
Pulmonary inhalation for disease treatment: Basic research and clinical translations
Wang, B., Wang, L., Yang, Q., Zhang, Y., Qinglai, T., Yang, X., Xiao, Z., Lei, L., & Li, S. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.100966 · Cited by 98 · see citing works
Simoni, A. D., Horne, R., Fleming, L., Bush, A., & Griffiths, C. (2017) · BMJ Open · doi:10.1136/bmjopen-2016-015245 · Cited by 91 · see citing works
A Systematic Evaluation of Asthma Management Apps Examining Behavior Change Techniques
Ramsey, R. R., Caromody, J. K., Voorhees, S. E., Warning, A., Cushing, C. C., Guilbert, T. W., Hommel, K. A., & Fedele, D. A. (2019) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2019.03.041 · Cited by 87 · see citing works
“This technique has been incorporated and tested in self-management interventions for patients with asthma and the use of medication reminders has been shown to improve adherence.(23,24) One implicit advantage of using mobile apps to support self-management is that apps can provide real-time intervention by prompting u…”
MethodDigital Inhalers for Asthma or Chronic Obstructive Pulmonary Disease: A Scientific Perspective
Chan, A. H. Y., Pleasants, R. A., Dhand, R., Tilley, S. L., Schworer, S. A., Costello, R. W., & Merchant, R. K. (2021) · Pulmonary Therapy · doi:10.1007/s41030-021-00167-4 · Cited by 84 · see citing works
Severe asthma in children—a review of definitions, epidemiology, and treatment options in 2019
Ahmed, H., & Turner, S. (2019) · Pediatric Pulmonology · doi:10.1002/ppul.24317 · Cited by 83 · see citing works
“There is a sound evidence base that electronic logging of ICS treatment leads to improved asthma outcomes, and such meters may become more commonly used in clinical practice.(57,58) Directly observed inhaler treatment using video conference technology may also be useful in some situations.”
BackgroundApplication of Machine Learning Algorithms for Asthma Management with mHealth: A Clinical Review
Tsang, K. C. H., Pinnock, H., Wilson, A. M., & Shah, S. A. (2022) · Journal of Asthma and Allergy · doi:10.2147/jaa.s285742 · Cited by 83 · see citing works
Vasbinder, E. C., Goossens, L. M. A., Mölken, M. R., de Winter, B. C. M., van Dijk, L., Vulto, A. G., Blankman, E. I. M., Dahhan, N., Schie, M. T. M. V., Versteegh, F. G. A., et al. (2016) · European Respiratory Journal · doi:10.1183/13993003.01698-2015 · Cited by 80 · see citing works
Mobile Health and Inhaler-Based Monitoring Devices for Asthma Management
Himes, B. E., Leszinsky, L., Walsh, R. N., Hepner, H., & Wu, A. C. (2019) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2019.08.034 · Cited by 80 · see citing works
Lavorini, F., Janson, C., Braido, F., Stratelis, G., & Løkke, A. (2019) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753466619884532 · Cited by 76 · see citing works
Digital health interventions in children with asthma
Ferrante, G., Licari, A., Marseglia, G. L., & Grutta, S. L. (2020) · Clinical & Experimental Allergy · doi:10.1111/cea.13793 · Cited by 76 · see citing works
S2k-Leitlinie zur fachärztlichen Diagnostik und Therapie von Asthma 2023
Lommatzsch, M., Criée, C.-P., de Jong, C. C. M., Gappa, M., Geßner, C., Gerstlauer, M., Hämäläinen, N., Haidl, P., Hamelmann, E. H., Horak, F., et al. (2023) · Pneumologie · doi:10.1055/a-2070-2135 · Cited by 81 · see citing works
O'Dwyer, S., Greene, G., MacHale, E., Cushen, B., Sulaiman, I., Boland, F., Bosnic-Anticevich, S. Z., Mokoka, M., Reilly, R. B., Taylor, T. E., et al. (2019) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2019.09.008 · Cited by 71 · see citing works
Barrett, M., Combs, V., Su, J. G., Henderson, K., Tuffli, M., & Collaborative, T. A. L. (2018) · Health Affairs · doi:10.1377/hlthaff.2017.1315 · Cited by 71 · see citing works
Smartphone-based vs paper-based asthma action plans for adolescents
Perry, T. T., Marshall, A., Berlinski, A., Rettiganti, M. R., Brown, R. H., Randle, S. M., Luo, C., & Bian, J. (2017) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2016.11.028 · Cited by 67 · see citing works
Effect of a mobile health, sensor-driven asthma management platform on asthma control
Barrett, M., Humblet, O., Marcus, J. E., Henderson, K., Smith, T., Eid, N. S., Sublett, J. W., Renda, A. M., Nesbitt, L., Sickle, D. V., et al. (2017) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2017.08.002 · Cited by 67 · see citing works
Pearce, C. J., & Fleming, L. (2018) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2018.1532290 · Cited by 66 · see citing works
Calthorpe, R. J., Smith, S., Gathercole, K., & Smyth, A. R. (2020) · Thorax · doi:10.1136/thoraxjnl-2019-213233 · Cited by 61 · see citing works
Moore, A. C., Preece, A., Sharma, R. K., Heaney, L. G., Costello, R. W., Wise, R. A., Ludwig-Sengpiel, A., Mosnaim, G. S., Rees, J., Tomlinson, R. D., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.03103-2020 · Cited by 63 · see citing works
New Concepts and Technological Resources in Patient Education and Asthma Self-Management
Poowuttikul, P., & Seth, D. (2020) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-020-08782-w · Cited by 61 · see citing works
“The investigators also evaluated the SmartTrack device; however, this trial involved children and adolescents with persistent asthma [77], not in adults as seen in the first trail.”
MethodResultLjungberg, H., Carleborg, A., Gerber, H., Öfverström, C., Wolodarski, J., Menshi, F., Engdahl, M., Eduards, M., & Nordlund, B. (2019) · European Respiratory Journal · doi:10.1183/13993003.00983-2019 · Cited by 61 · see citing works
“Studies using an electronic monitoring device with an audio-visual reminder showed significant improvements in adherence to inhaled corticosteroids in school-aged children [16] and in”
MethodRemote Monitoring of Patient- and Family-Generated Health Data in Pediatrics
Foster, C. C., Schinasi, D. A., Kan, K., Macy, M. L., Wheeler, D. S., & Curfman, A. (2022) · PEDIATRICS · doi:10.1542/peds.2021-054137 · Cited by 63 · see citing works
Asthma and Allergy Mobile Apps in 2018
Kagen, S., & Garland, A. (2019) · Current Allergy and Asthma Reports · doi:10.1007/s11882-019-0840-z · Cited by 58 · see citing works
Digital Health Intervention for Asthma: Patient-Reported Value and Usability
Merchant, R. K., Inamdar, R., Henderson, K., Barrett, M., Su, J. G., Riley, J., Sickle, D. V., & Stempel, D. A. (2018) · JMIR mhealth and uhealth · doi:10.2196/mhealth.7362 · Cited by 57 · see citing works
“A limited but growing body of literature demonstrates the effectiveness of digital interventions in improving clinical outcomes, including asthma control, adherence, and symptom-free days [9-24].”
BackgroundChinese Guideline on allergen immunotherapy for allergic rhinitis
Bao, Y., Chen, J., Cheng, L., Guo, Y., Hong, S., Kong, W., Lai, H., Li, H., Li, H., Li, J., et al. (2017) · Journal of Thoracic Disease · doi:10.21037/jtd.2017.10.112 · Cited by 56 · see citing works
Bringing asthma care into the twenty-first century
Larsson, K., Kankaanranta, H., Janson, C., Lehtimäki, L. A., Ställberg, B., Løkke, A., Høines, K. J., Roslind, K., & Ulrik, C. S. (2020) · npj Primary Care Respiratory Medicine · doi:10.1038/s41533-020-0182-2 · Cited by 56 · see citing works
Porsbjerg, C. M., Ulrik, C. S., Skjold, T., Backer, V., Lærum, B. N., Lehman, S., Janson, C., Sandström, T., Bjermer, L. H., Dahlén, B., et al. (2018) · European Clinical Respiratory Journal · doi:10.1080/20018525.2018.1440868 · Cited by 54 · see citing works
“patients with non-intentional adherence due to forgetfulness may need a more feasible regimen such as oncedaily dosing [100], and inhaler reminders [101,102].”
BackgroundReal-life inhaler adherence and technique: Time to get smarter!
Chrystyn, H., Audibert, R., Keller, M., Quaglia, B., Vecellio, L., & Roche, N. (2019) · Respiratory Medicine · doi:10.1016/j.rmed.2019.09.008 · Cited by 56 · see citing works
Asthma Management in the Era of Smart-Medicine: Devices, Gadgets, Apps and Telemedicine
Katwa, U., & Rivera, E. (2018) · The Indian Journal of Pediatrics · doi:10.1007/s12098-018-2611-6 · Cited by 52 · see citing works
“Despite these improvements, there was no difference between the two groups regarding missed school days, lung function or emergency department visits [11].”
BackgroundInterventions on Adherence to Treatment in Children With Severe Asthma: A Systematic Review
Boutopoulou, B., Koumpagioti, D., Matziou, V. N., Priftis, K. Ν., & Douros, K. (2018) · Frontiers in Pediatrics · doi:10.3389/fped.2018.00232 · Cited by 53 · see citing works
“There is a relatively lack of studies focusing on severe asthma, but the above findings are in agreement with the results of studies dealing with all kinds of asthma in children (24, 59).”
BackgroundResultA review of the use and effectiveness of digital health technologies in patients with asthma
Unni, E., Gabriel, S., & Ariely, R. (2018) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2018.10.016 · Cited by 52 · see citing works
A Practical Approach to Severe Asthma in Children
Barsky, E. E., Giancola, L. M., Baxi, S. N., & Gaffin, J. M. (2017) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201708-637fr · Cited by 50 · see citing works
Kenyon, C. C., Gruschow, S. M., Quarshie, W. O., Griffis, H. M., Leach, M., Zorc, J. J., Bryant-Stephens, T. C., Miller, V. A., & Feudtner, C. (2018) · Journal of Asthma · doi:10.1080/02770903.2018.1424195 · Cited by 50 · see citing works
“The first study recruited late adolescents and adults on daily inhaled steroids from general practice providers and specifically excluded patients who had an exacerbation in the preceding month (19) and the second recruited children aged 6–15 four weeks after presenting to an ED with asthma symptoms (20).”
Background100 Years of Drug Delivery to the Lungs
Lavorini, F., Buttini, F., & Usmani, O. S. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_335 · Cited by 50 · see citing works
Delivery Technologies for Orally Inhaled Products: an Update
Moon, C., Smyth, H. D. C., Watts, A. B., & Williams, R. O. (2019) · AAPS PharmSciTech · doi:10.1208/s12249-019-1314-2 · Cited by 49 · see citing works
Digital Inhalers and Remote Patient Monitoring for Asthma
Mosnaim, G. S., Greiwe, J. C., Jariwala, S. P., Pleasants, R. A., & Merchant, R. K. (2022) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2022.06.026 · Cited by 49 · see citing works
Chan, A. H. Y., Foot, H., Pearce, C. J., Horne, R., Foster, J. M., & Harrison, J. (2022) · PLOS ONE · doi:10.1371/journal.pone.0265715 · Cited by 47 · see citing works
Self-citationTrajectory Analyses of Adherence Patterns in a Real-Life Moderate to Severe Asthma Population
van Boven, J. F. M., Koponen, M., Lalic, S., George, J., Bell, J. S., Hew, M. J., & Ilomäki, J. (2019) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2019.12.002 · Cited by 47 · see citing works
Novel electronic adherence monitoring devices in children with asthma: a mixed-methods study
Makhecha, S., Chan, A. H. Y., Pearce, C. J., Jamalzadeh, A., & Fleming, L. (2020) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2020-000589 · Cited by 46 · see citing works
Dierick, B. J. H., Achterbosch, M., Eikholt, A. A., Been-Buck, S., Klemmeier, T., van de Hei, S. J., Hagedoorn, P., Kerstjens, H. A. M., Kocks, J. W. H., & van Boven, J. F. M. (2023) · Respiratory Medicine · doi:10.1016/j.rmed.2023.107376 · Cited by 44 · see citing works
van de Hei, S. J., Stoker, N., Blok, B. M. J. F.-D., Poot, C. C., Meijer, E., Postma, M. J., Chavannes, N. H., Kocks, J. W. H., & van Boven, J. F. M. (2023) · npj Primary Care Respiratory Medicine · doi:10.1038/s41533-023-00343-w · Cited by 46 · see citing works
Factors associated with medication adherence in school-aged children with asthma
Chan, A. H. Y., Stewart, A. W., Foster, J. M., Mitchell, E. A., Camargo, C. A., & Harrison, J. (2016) · ERJ Open Research · doi:10.1183/23120541.00087-2015 · Cited by 43 · see citing works
Long-Term Cost-Effectiveness of Digital Inhaler Adherence Technologies in Difficult-to-Treat Asthma
van de Hei, S. J., Kim, C., Honkoop, P., Sont, J. K., Schermer, T. R., MacHale, E., Costello, R. W., Kocks, J. W. H., Postma, M. J., & van Boven, J. F. M. (2023) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2023.06.051 · Cited by 42 · see citing works
Howard, S., Lang, A. R., Sharples, S., & Shaw, D. E. (2016) · Applied Ergonomics · doi:10.1016/j.apergo.2016.06.018 · Cited by 41 · see citing works
Novel methods for device and adherence monitoring in asthma
Bonini, M., & Usmani, O. S. (2017) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000439 · Cited by 41 · see citing works
Identifying Critical Errors: Addressing Inhaler Technique in the Context of Asthma Management
Bosnic-Anticevich, S. Z., Cvetkovski, B., Azzi, E., Srour, P., Tan, R. H., & Kritikos, V. S. (2018) · Pulmonary Therapy · doi:10.1007/s41030-018-0051-0 · Cited by 41 · see citing works
Gregoriano, C., Dieterle, T., Breitenstein, A.-L., Dürr, S., Baum, A., Giezendanner, S., Maier, S., Leuppi-Taegtmeyer, A. B., Arnet, I., Hersberger, K. E., et al. (2019) · Respiratory Research · doi:10.1186/s12931-019-1219-3 · Cited by 41 · see citing works
Foster, J. M., Reddel, H. K., Usherwood, T. P., Sawyer, S. M., & Smith, L. D. (2017) · Respiratory Medicine · doi:10.1016/j.rmed.2017.05.013 · Cited by 41 · see citing works
Systematic Assessment of Difficult-to-Treat Asthma: Principles and Perspectives
Hew, M. J., Menzies-Gow, A. N., Hull, J. H., Fleming, L., Porsbjerg, C. M., Brinke, A. T., Allen, D. J., Gore, R. B., & Tay, T. R. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.02.036 · Cited by 40 · see citing works
The Effect of Connected “Smart” Inhalers on Medication Adherence
Zabczyk, C., & Blakey, J. (2021) · Frontiers in Medical Technology · doi:10.3389/fmedt.2021.657321 · Cited by 39 · see citing works
Costello, R. W., Foster, J. M., Grigg, J., Eakin, M. N., Canonica, G. W., Yunus, F., & Ryan, D. P. (2016) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2016.04.002 · Cited by 39 · see citing works
What is New in the Management of Childhood Asthma?
Gupta, A. K., Bhat, G., & Pianosi, P. T. (2018) · The Indian Journal of Pediatrics · doi:10.1007/s12098-018-2705-1 · Cited by 39 · see citing works
Dhruve, H., & Jackson, D. J. (2022) · European Respiratory Review · doi:10.1183/16000617.0271-2021 · Cited by 41 · see citing works
Chan, A. H. Y., Stewart, A. W., Harrison, J., Black, P., Mitchell, E. A., & Foster, J. M. (2017) · Expert Review of Medical Devices · doi:10.1080/17434440.2017.1322505 · Cited by 38 · see citing works
Arcoleo, K. J., McGovern, C. M., Kaur, K., Halterman, J. S., Mammen, J. R., Crean, H. F., Rastogi, D., & Feldman, J. M. (2019) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201807-462oc · Cited by 36 · see citing works
Harrington, C. B., Langhans, E., Shelef, D. Q., Savitz, M., Whitmore, C., & Teach, S. J. (2017) · Journal of Asthma · doi:10.1080/02770903.2017.1323915 · Cited by 35 · see citing works
“Use of electronicmonitoring devices would have potentially improved our measurements of adherence [23].”
BackgroundZijp, T. R., Touw, D. J., & van Boven, J. F. M. (2020) · Patient Preference and Adherence · doi:10.2147/ppa.s240443 · Cited by 35 · see citing works
Sumino, K., Locke, E. R., Magzamen, S. L., Gylys-Colwell, I., Humblet, O., Nguyen, H. Q., Thomas, R. M., & Fan, V. S. (2017) · Journal of Aerosol Medicine and Pulmonary Drug Delivery · doi:10.1089/jamp.2017.1383 · Cited by 34 · see citing works
“The SmartTouch inhaler sensor improved the adherence to inhaled steroids in adults and adolescents with asthma,((4,13)) and more recently, the use of the reminder function of the inhaler sensor was shown to improve adherence and reduce asthma morbidity in children who visited the ED for asthma exacerbations.((5)) Anot…”
eHealth Technologies for Monitoring Pediatric Asthma at Home: Scoping Review
van der Kamp, M. R., Hengeveld, V., Brusse-Keizer, M. G. J., Thio, B., & Tabak, M. (2023) · Journal of Medical Internet Research · doi:10.2196/45896 · Cited by 34 · see citing works
“Some studies used automatic reminders (text message feedback [206], audiovisual reminders in the device [204], and app-based reminders [207]), whereas other studies had nurses [205,208] or pharmacists [78,200,209] providing feedback.”
Pleasants, R. A., Chan, A. H. Y., Mosnaim, G. S., Costello, R. W., Dhand, R., Schworer, S. A., Merchant, R. K., & Tilley, S. L. (2022) · Respiratory Medicine · doi:10.1016/j.rmed.2022.107038 · Cited by 33 · see citing works
Lee, J. R., Leo, S., Liao, S., Ng, W. R., Tay, T. Y. N., Wang, Y., Ang, W. H. D., & Lau, Y. (2021) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2021.104037 · Cited by 33 · see citing works
Electronic inhaler monitoring and healthcare utilization in chronic obstructive pulmonary disease
Alshabani, K., Attaway, A. H., Smith, M. J., Majumdar, U., Rice, R., Han, X., Wang, X., & Hatipoglu, U. S. (2019) · Journal of Telemedicine and Telecare · doi:10.1177/1357633x19850404 · Cited by 31 · see citing works
Current technological advancement in asthma care
Hakizimana, A., Devani, P., & Gaillard, E. A. (2024) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2024.2380067 · Cited by 29 · see citing works
“Similarly, Chan et al. [106] reported that the use of an electronic monitoring device with an in-built audio-visual reminder, significantly improved adherence in school-aged children with asthma.”
Howard, S., Lang, A. R., Sharples, S., & Shaw, D. E. (2016) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2016-000159 · Cited by 29 · see citing works
Ramsey, R. R., Holbein, C. E., Powers, S. W., Hershey, A. D., Kabbouche, M. A., O’Brien, H. L., Kacperski, J. E., Shepard, J., & Hommel, K. A. (2018) · Cephalalgia · doi:10.1177/0333102418756864 · Cited by 29 · see citing works
Teufel, R. J., Patel, S. K., Shuler, A. B., Andrews, A. L., Nichols, M. G., Ebeling, M. D., Dawley, E. H., Mueller, M., Ruggiero, K. J., & Treiber, F. A. (2018) · JMIR Pediatrics and Parenting · doi:10.2196/pediatrics.9796 · Cited by 29 · see citing works
“Adherence to the controller medication (inhaled corticosteroids) regimen was calculated daily in 12-hour increments (12:00 am to 11:59 am and 12:00 pm to 11:59 pm) as the number of doses prescribed compared with the number taken over 12 hours to avoid the impact of medication overdosing and dumping [26,27].”
Greene, G., & Costello, R. W. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1628017 · Cited by 29 · see citing works
“The term smart inhaler covers a range of technology from simple tracking devices which record when an inhaler was used [4–6], to those which remind patients to take their inhaler [7,8], offer feedback on technique and timing, or record the interaction of environment and individual that prompts inhaler use.”
BackgroundOptimizing Patient Management and Adherence for Children Receiving Growth Hormone
Acerini, C. L., Wac, K., Bang, P., & Lehwalder, D. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00313 · Cited by 28 · see citing works
“For asthma management in children, an inhaler with audiovisual reminders and electronic monitoring increased corticosteroid adherence to 84% compared with 30% in a control group, and was associated with improved asthma morbidity score (26).”
BackgroundIntegrated Adherence Monitoring for Inhaler Medications
Hew, M. J., & Reddel, H. K. (2019) · JAMA · doi:10.1001/jama.2019.1289 · Cited by 28 · see citing works
Technology Interventions for Nonadherence: New Approaches to an Old Problem
Bender, B. G. (2017) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2017.10.029 · Cited by 27 · see citing works
Dierick, B. J. H., Achterbosch, M., Been-Buck, S., Klemmeier, T., van de Hei, S. J., Hagedoorn, P., Kerstjens, H. A. M., Kocks, J. W. H., & van Boven, J. F. M. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-059929 · Cited by 27 · see citing works
Sonney, J., Duffy, M., Hoogerheyde, L. X., Langhauser, E., & Teska, D. (2018) · Journal of Pediatric Health Care · doi:10.1016/j.pedhc.2018.07.008 · Cited by 27 · see citing works
Electronic Adherence Monitoring in a High-Utilizing Pediatric Asthma Cohort: A Feasibility Study
Kenyon, C. C., Chang, J. C. H., Wynter, S.-A., Fowler, J., Long, J., & Bryant-Stephens, T. C. (2016) · JMIR Research Protocols · doi:10.2196/resprot.5362 · Cited by 26 · see citing works
Adherence to treatment in allergic respiratory diseases
Baiardini, I., Novakova, S. M., Mihaicuta, S. D., Oğuzülgen, İ. K., & Canonica, G. W. (2018) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2019.1554438 · Cited by 26 · see citing works
“Randomized controlled trials have shown that EMD with an audiovisual reminder led to significant improvements in adherence to ICS in school-aged children with asthma [90].”
BackgroundBittner, B., Chiesi, C. S., Kharawala, S., Kaur, G., & Schmidt, J. (2019) · Medical Devices Evidence and Research · doi:10.2147/mder.s198943 · Cited by 25 · see citing works
“In a randomized study of 220 children aged 6–15 years with asthma exacerbation treated with ICS, audiovisual reminder functions (AVRFs) on the SmartInhalerTM device used with a preventer inhaler was either enabled (intervention group) or disabled (control group).(48) The follow-up period was 6 months, and adherence wa…”
MethodTailored medication adherence incentives for high-risk children with asthma: a pilot study
Kenyon, C. C., Sundar, K. G., Gruschow, S. M., Quarshie, W. O., Feudtner, C., Bryant-Stephens, T. C., & Miller, V. A. (2019) · Journal of Asthma · doi:10.1080/02770903.2019.1648503 · Cited by 24 · see citing works
Chen, J., Xu, J., Zhao, L., Zhang, J., Yin, Y., & Zhang, F. (2020) · Allergy Asthma and Clinical Immunology · doi:10.1186/s13223-020-00466-6 · Cited by 25 · see citing works
Transitioning Asthma Care From Adolescents to Adults
Nanzer, A. M., Lawton, A., d’Ancona, G., & Gupta, A. K. (2021) · CHEST Journal · doi:10.1016/j.chest.2021.05.019 · Cited by 25 · see citing works
- Authors
- Chan, A. H. Y., Stewart, A. W., Harrison, J., Camargo, C. A., Black, P. N., & Mitchell, E. A.
- Affiliations
- University of Auckland (NZ)
- Harvard University (US)
- Corresponding author
- Chan, Amy H Y
- Venue
- The Lancet Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 3
- Issue
- 3
- Pages
- 210-219
- ISSN
- 2213-2600 (ISSN-L)
- OpenAlex
- W2164117859
- Cited by
- 265
- References
- 60
- Citations by year
- 2026: 19 · 2025: 21 · 2024: 25 · 2023: 21 · 2022: 21 · 2021: 22 · 2020: 25 · 2019: 37 · 2018: 27 · 2017: 22 · 2016: 18 · 2015: 6
- FWCI
- 28.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet Respiratory Medicine (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- ResearchSpace (University of Auckland) (submittedVersion)
- Topics
- Health Sciences › Medicine › Family Practice › Medication Adherence and Compliance
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Health Professions › General Health Professions › Mobile Health and mHealth Applications
- Keywords
- medication adherence, inhaled corticosteroids, asthma, electronic monitoring devices, school attendance, asthma exacerbations, emergency department, children, asthma control, inhaler devices
- MeSH terms
- Absenteeism, Administration, Inhalation, Adolescent, Adrenal Cortex Hormones, Asthma, Child, Equipment Design, Humans, New Zealand, Schools, Treatment Outcome, Reminder Systems, Monitoring, Ambulatory, Anti-Asthmatic Agents, Medication Adherence
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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