Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study
Open accessAbstract
Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with high mortality, uncertain cause, and few treatment options. Studies have identified a significant genetic risk associated with the development of IPF; however, mechanisms by which genetic risk factors promote IPF remain unclear. We aimed to identify genetic variants associated with IPF susceptibility and provide mechanistic insight using gene and protein expression analyses. Methods We used a two-stage approach: a genome-wide association study in patients with IPF of European ancestry recruited from nine different centres in the UK and controls selected from UK Biobank (stage 1) matched for age, sex, and smoking status; and a follow-up of associated genetic variants in independent datasets of patients with IPF and controls from two independent US samples from the Chicago consortium and the Colorado consortium (stage 2). We investigated the effect of novel signals on gene expression in large transcriptomic and genomic data resources, and examined expression using lung tissue samples from patients with IPF and controls. Findings 602 patients with IPF and 3366 controls were selected for stage 1. For stage 2, 2158 patients with IPF and 5195 controls were selected. We identified a novel genome-wide significant signal of association with IPF susceptibility near A-kinase anchoring protein 13 ( AKAP13 ; rs62025270, odds ratio [OR] 1·27 [95% CI 1·18–1·37], p=1·32 × 10 −9 ) and confirmed previously reported signals, including in mucin 5B ( MUC5B ; rs35705950, OR 2·89 [2·56–3·26], p=1·12 × 10 −66 ) and desmoplakin ( DSP ; rs2076295, OR 1·44 [1·35–1·54], p=7·81 × 10 −28 ). For rs62025270, the allele A associated with increased susceptibility to IPF was also associated with increased expression of AKAP13 mRNA in lung tissue from patients who had lung resection procedures (n=1111). We showed that AKAP13 is expressed in the alveolar epithelium and lymphoid follicles from patients with IPF, and AKAP13 mRNA expression was 1·42-times higher in lung tissue from patients with IPF (n=46) than that in lung tissue from controls (n=51). Interpretation AKAP13 is a Rho guanine nucleotide exchange factor regulating activation of RhoA, which is known to be involved in profibrotic signalling pathways. The identification of AKAP13 as a susceptibility gene for IPF increases the prospect of successfully targeting RhoA pathway inhibitors in patients with IPF. Funding UK Medical Research Council, National Heart, Lung, and Blood Institute of the US National Institutes of Health, Agencia Canaria de Investigación, Innovación y Sociedad de la Información, Spain, UK National Institute for Health Research, and the British Lung Foundation.
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Raghu, G., Collard, H. R., Egan, J. J., Martinez, F. J., Behr, J., Brown, K. K., Colby, T. V., Cordier, J.-F., Flaherty, K. R., Lasky, J. A., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2009-040gl · Cited by 7,186 · see citing works
Efficacy and Safety of Nintedanib in Idiopathic Pulmonary Fibrosis
Richeldi, L., du Bois, R. M., Raghu, G., Azuma, A., Brown, K. K., Costabel, U., Cottin, V., Flaherty, K. R., Hansell, D. M., Inoue, Y., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1402584 · Cited by 4,654 · see citing works
(2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.2.ats01 · Cited by 4,196 · see citing works
A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis.
King, T. E., Bradford, W. Z., Castro-Bernardini, S., Fagan, E. A., Glaspole, I., Glassberg, M. K., Gorina, E., Hopkins, P. M., Kardatzke, D., Lancaster, L., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1402582 · Cited by 3,975 · see citing works
A reference panel of 64,976 haplotypes for genotype imputation
the Haplotype Reference Consortium (2016) · Nature Genetics · doi:10.1038/ng.3643 · Cited by 2,836 · see citing works
A new multipoint method for genome-wide association studies by imputation of genotypes
Marchini, J., Howie, B., Myers, S., McVean, G., & Donnelly, P. (2007) · Nature Genetics · doi:10.1038/ng2088 · Cited by 2,609 · see citing works
Raghu, G., Rochwerg, B., Zhang, Y., Garcia, C. A. C., Azuma, A., Behr, J., Brozek, J. L., Collard, H. R., Cunningham, W., Homma, S., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201506-1063st · Cited by 1,916 · see citing works
Clinical course and prediction of survival in idiopathic pulmonary fibrosis
Ley, B., Collard, H. R., & King, T. E. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201006-0894ci · Cited by 1,765 · see citing works
The support of human genetic evidence for approved drug indications
Nelson, M. R., Tipney, H., Painter, J. L., Shen, J., Nicoletti, P., Shen, Y., Floratos, A., Sham, P. C., Li, M. J., Wang, J., et al. (2015) · Nature Genetics · doi:10.1038/ng.3314 · Cited by 1,666 · see citing works
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis
Fingerlin, T. E., Murphy, E., Zhang, W., Peljto, A. L., Brown, K. K., Steele, M. P., Loyd, J. E., Cosgrove, G. P., Lynch, D., Groshong, S., et al. (2013) · Nature Genetics · doi:10.1038/ng.2609 · Cited by 809 · see citing works
Self-citationThomas, A. Q., Lane, K., Phillips, J., Prince, M., Markin, C., Speer, M., Schwartz, D. A., Gaddipati, R., Marney, A., Johnson, J., et al. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200112-123oc · Cited by 641 · see citing works
Self-citationNoth, I., Zhang, Y., Ma, S., Flores, C., Barber, M., Huang, Y., Broderick, S. M., Wade, M. S., Hysi, P. G., Scuirba, J., et al. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70045-6 · Cited by 605 · see citing works
Self-citationThe rising incidence of idiopathic pulmonary fibrosis in the UK
Navaratnam, V. V., Fleming, K. M., West, J., Smith, C. J. P., Jenkins, G. R., Fogarty, A., & Hubbard, R. (2011) · Thorax · doi:10.1136/thx.2010.148031 · Cited by 484 · see citing works
Self-citationStuart, B. D., Choi, J., Zaidi, S., Xing, C., Holohan, B., Chen, R., Choi, M., Dharwadkar, P., Torres, F., Girod, C. E., et al. (2015) · Nature Genetics · doi:10.1038/ng.3278 · Cited by 469 · see citing works
Peljto, A. L., Zhang, Y., Fingerlin, T. E., Ma, S., Garcia, J. G. N., Richards, T. J., Silveira, L. J., Lindell, K. O., Steele, M. P., Loyd, J. E., et al. (2013) · JAMA · doi:10.1001/jama.2013.5827 · Cited by 453 · see citing works
Self-citationWilborn, J., Crofford, L. J., Burdick, M. D., Kunkel, S. L., Strieter, R. M., & Peters-Golden, M. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117866 · Cited by 390 · see citing works
Wain, L. V., Shrine, N. R. G., Miller, S., Jackson, V. E., Ntalla, I., Artigas, M. S., Billington, C. K., Kheirallah, A. K., Allen, R. J., Cook, J. P., et al. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00283-0 · Cited by 384 · see citing works
Self-citationJenkins, G. R. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27183 · Cited by 314 · see citing works
Stuart, B. D., Lee, J. S., Kozlitina, J., Noth, I., Devine, M. S., Glazer, C. S., Torres, F., Kaza, V., Girod, C. E., Jones, K. D., et al. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70124-9 · Cited by 310 · see citing works
Self-citationLung eQTLs to Help Reveal the Molecular Underpinnings of Asthma
Hao, K., Bossé, Y., Nickle, D. C., Paré, P. D., Postma, D. S., Laviolette, M., Sandford, A. J., Hackett, T., Daley, D., Hogg, J. C., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003029 · Cited by 302 · see citing works
Self-citationvan Moorsel, C. H. M., van Oosterhout, M. F. M., Barlo, N. P., de Jong, P. A., van der Vis, J. J., Ruven, H. J. T., van Es, H. W., van den Bosch, J. M. M., & Grutters, J. C. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200906-0953oc · Cited by 294 · see citing works
DePianto, D. J., Chandriani, S. J., Abbas, A. R., Jia, G., N'Diaye, E. N., Caplazi, P., Kauder, S. E., Biswas, S., Karnik, S. K., Ha, C., et al. (2014) · Thorax · doi:10.1136/thoraxjnl-2013-204596 · Cited by 289 · see citing works
The pathogenesis of idiopathic pulmonary fibrosis
Coward, W. R., Saini, G., & Jenkins, G. R. (2010) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465810379801 · Cited by 271 · see citing works
Self-citationYang, I. V., Coldren, C. D., Leach, S. M., Seibold, M. A., Murphy, E., Lin, J., Rosen, R. Z., Neidermyer, A. J., McKean, D. F., Groshong, S. D., et al. (2013) · Thorax · doi:10.1136/thoraxjnl-2012-202943 · Cited by 244 · see citing works
Self-citationKeerthisingam, C. B., Jenkins, G. R., Harrison, N. K., Hernández-Rodríguez, N. A., Booth, H., Laurent, G. J., Hart, S. L., Foster, M. L., & McAnulty, R. J. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64092-8 · Cited by 241 · see citing works
Self-citationMushiroda, T., Wattanapokayakit, S., Takahashi, A., Nukiwa, T., Kudoh, S., Ogura, T., Taniguchi, H., Kubo, M., Kamatani, N., & Nakamura, Y. (2008) · Journal of Medical Genetics · doi:10.1136/jmg.2008.057356 · Cited by 239 · see citing works
Knipe, R. S., Tager, A. M., & Liao, J. K. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009381 · Cited by 233 · see citing works
AKAP-Lbc Anchors Protein Kinase A and Nucleates Gα12-selective Rho-mediated Stress Fiber Formation
Diviani, D., Soderling, J. A., & Scott, J. D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106629200 · Cited by 230 · see citing works
Xu, M. Y., Porte, J., Knox, A. J., Weinreb, P. H., Maher, T. M., Violette, S. M., McAnulty, R. J., Sheppard, D., & Jenkins, G. R. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080160 · Cited by 212 · see citing works
Self-citationExploration of a potent PI3 kinase/mTOR inhibitor as a novel anti-fibrotic agent in IPF
Mercer, P. F., Woodcock, H. V., Eley, J. D., Platé, M., Sulikowski, M. G., Durrenberger, P. F., Franklin, L., Nanthakumar, C. B., Man, Y., Genovese, F., et al. (2016) · Thorax · doi:10.1136/thoraxjnl-2015-207429 · Cited by 206 · see citing works
Self-citationC-X-C Motif Chemokine 13 (CXCL13) is a Prognostic Biomarker of Idiopathic Pulmonary Fibrosis
Vuga, L. J., Tedrow, J. R., Pandit, K. V., Tan, J., Kass, D. J., Xue, J., Chandra, D., Leader, J. K., Gibson, K. F., Kaminski, N., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201309-1592oc · Cited by 197 · see citing works
Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use
Taylor, C. P., Traynelis, S. F., Siffert, J. O., Pope, L. E., & Matsumoto, R. R. (2016) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2016.04.010 · Cited by 188 · see citing works
Marchal-Sommé, J., Uzunhan, Y., Marchand-Adam, S., Valeyre, D., Soumelis, V., Crestani, B., & Soler, P. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.10.5735 · Cited by 179 · see citing works
Plasma B Lymphocyte Stimulator and B Cell Differentiation in Idiopathic Pulmonary Fibrosis Patients
Xue, J., Kass, D. J., Bon, J. M., Vuga, L. J., Tan, J., Csizmadia, E., Otterbein, L. E., Soejima, M., Levesque, M. C., Gibson, K. F., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203476 · Cited by 161 · see citing works
Optimal designs for two‐stage genome‐wide association studies
Skol, A. D., Scott, L. J., Abecasis, G. R., & Boehnke, M. (2007) · Genetic Epidemiology · doi:10.1002/gepi.20240 · Cited by 129 · see citing works
Dendritic Cells Accumulate in Human Fibrotic Interstitial Lung Disease
Marchal-Sommé, J., Uzunhan, Y., Marchand-Adam, S., Kambouchner, M., Valeyre, D., Crestani, B., & Soler, P. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200609-1347oc · Cited by 123 · see citing works
Pi, M., Spurney, R. F., Tu, Q., Hinson, T. K., & Quarles, L. D. (2002) · Endocrinology · doi:10.1210/en.2002-220240 · Cited by 120 · see citing works
Coward, W. R., Feghali‐Bostwick, C. A., Jenkins, G. R., Knox, A. J., & Pang, L. (2014) · The FASEB Journal · doi:10.1096/fj.13-241760 · Cited by 118 · see citing works
REVIEW ARTICLE. MICROSATELLITES AND PCR GENOMIC ANALYSIS
Koreth, J., O’Leary, J. J., & McGee, J. O. (1996) · The Journal of Pathology · doi:10.1002/(sici)1096-9896(199603)178:3 · Cited by 104 · see citing works
A Rho Exchange Factor Mediates Thrombin and Gα12-induced Cytoskeletal Responses
Majumdar, M., Seasholtz, T. M., Buckmaster, C., Toksoz, D., & Brown, J. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.38.26815 · Cited by 102 · see citing works
Fingerlin, T. E., Zhang, W. E., Yang, I. V., Ainsworth, H. C., Russell, P. H., Blumhagen, R. Z., Schwarz, M. I., Brown, K. M., Steele, M. P., Loyd, J. E., et al. (2016) · BMC Genetics · doi:10.1186/s12863-016-0377-2 · Cited by 98 · see citing works
Self-citationBrx Mediates the Response of Lymphocytes to Osmotic Stress Through the Activation of NFAT5
Kino, T., Takatori, H., Manoli, I., Wang, Y., Tiulpakov, A. N., Blackman, M. R., Su, Y. A., Chrousos, G. P., DeCherney, A. H., & Segars, J. H. (2009) · Science Signaling · doi:10.1126/scisignal.2000081 · Cited by 95 · see citing works
Pulmonary fibrosis in the era of stratified medicine
Mathai, S. K., Newton, C. A., Schwartz, D. A., & Garcia, C. K. (2016) · Thorax · doi:10.1136/thoraxjnl-2016-209172 · Cited by 77 · see citing works
Self-citationEpigenetic regulation of cyclooxygenase-2 by methylation of c8orf4 in pulmonary fibrosis
Evans, I., Barnes, J. L., Garner, I., Pearce, D. R., Maher, T. M., Shiwen, X., Renzoni, E. A., Wells, A. U., Denton, C. P., Laurent, G. J., et al. (2016) · Clinical Science · doi:10.1042/cs20150697 · Cited by 74 · see citing works
Self-citationCampbell, D. A., Poulter, L. W., Janossy, G., & du Bois, R. M. (1985) · Thorax · doi:10.1136/thx.40.6.405 · Cited by 72 · see citing works
The Rho Guanine Nucleotide Exchange Factor AKAP13 (BRX) Is Essential for Cardiac Development in Mice
Mayers, C. M., Wadell, J., McLean, K., Venere, M., Malik, M., Shibata, T., Driggers, P. H., Kino, T., Guo, X. C., Koide, H., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.106856 · Cited by 68 · see citing works
Refining Susceptibility Loci of Chronic Obstructive Pulmonary Disease with Lung eqtls
Lamontagne, M., Couture, C., Postma, D. S., Timens, W., Sin, D. D., Paré, P. D., Hogg, J. C., Nickle, D. C., Laviolette, M., & Bossé, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070220 · Cited by 61 · see citing works
Self-citationGSTCD and INTS12 Regulation and Expression in the Human Lung
Obeidat, M., Miller, S., Probert, K., Billington, C. K., Henry, A. P., Hodge, E., Nelson, C. P., Stewart, C. E., Swan, C., Wain, L. V., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074630 · Cited by 44 · see citing works
Self-citationActivated Gαq family members induce Rho GTPase activation and Rho‐dependent actin filament assembly
Dutt, P., Kjøller, L., Giel, M., Hall, A., & Toksoz, D. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03625-6 · Cited by 44 · see citing works
Association Between the MUC5B Promoter Polymorphism rs35705950 and Idiopathic Pulmonary Fibrosis
Zhu, Q., Zhang, X., Zhang, S., Tang, S., Min, H.-Y., Yi, L., Xu, B., & Song, Y. (2015) · Medicine · doi:10.1097/md.0000000000001901 · Cited by 42 · see citing works
Kino, T., Souvatzoglou, E., Charmandari, E., Ichijo, T., Driggers, P. H., Mayers, C. M., Alatsatianos, A., Manoli, I., Westphal, H., Chrousos, G. P., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m509339200 · Cited by 42 · see citing works
A-kinase anchoring protein-Lbc promotes pro-fibrotic signaling in cardiac fibroblasts
Cavin, S., Maric, D., & Diviani, D. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.11.008 · Cited by 36 · see citing works
del Vescovo, C. D., Cotecchia, S., & Diviani, D. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00887-12 · Cited by 33 · see citing works
Bear, M. D., Li, M., Liu, Y., Giel–Moloney, M., Fanburg, B. L., & Toksoz, D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.062513 · Cited by 20 · see citing works
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Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline
Raghu, G., Remy-Jardin, M., Myers, J. L., Richeldi, L., Ryerson, C. J., Lederer, D. J., Behr, J., Cottin, V., Danoff, S. K., Morell, F., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201807-1255st · Cited by 4,103 · see citing works
Lederer, D. J., & Martinez, F. J. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1705751 · Cited by 2,056 · see citing works
Fibrosis: from mechanisms to medicines
Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works
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Moss, B. J., Ryter, S. W., & Rosas, I. O. (2021) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-042320-030240 · Cited by 852 · see citing works
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Distler, J. H. W., Györfi, A., Ramanujam, M., Whitfield, M. L., Königshoff, M., & Lafyatis, R. (2019) · Nature Reviews Rheumatology · doi:10.1038/s41584-019-0322-7 · Cited by 645 · see citing works
Idiopathic pulmonary fibrosis: Disease mechanisms and drug development
Spagnolo, P., Kropski, J. A., Jones, M. G., Lee, J. S., Rossi, G., Karampitsakos, Τ., Maher, T. M., Tzouvelekis, A., & Ryerson, C. J. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107798 · Cited by 638 · see citing works
Self-citationHatabu, H., Hunninghake, G. M., Richeldi, L., Brown, K. M., Wells, A. U., Rémy‐Jardin, M., Verschakelen, J., Nicholson, A. G., Beasley, M. B., Christiani, D. C., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30168-5 · Cited by 600 · see citing works
Emerging therapeutic opportunities for integrin inhibitors
Slack, R. J., Macdonald, S. J. F., Roper, J. A., Jenkins, G. R., & Hatley, R. J. D. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00284-4 · Cited by 557 · see citing works
Idiopathic Pulmonary Fibrosis: An Update on Pathogenesis
Mei, Q., Liu, Z., Zuo, H., Yang, Z., & Qu, J. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.797292 · Cited by 360 · see citing works
Idiopathic pulmonary fibrosis: state of the art for 2023
Podolanczuk, A. J., Thomson, C. C., Remy-Jardin, M., Richeldi, L., Martinez, F. J., Kolb, M., & Raghu, G. (2023) · European Respiratory Journal · doi:10.1183/13993003.00957-2022 · Cited by 359 · see citing works
Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis
Allen, R. J., Guillen-Guio, B., Oldham, J. M., Ma, S.-F., Dressen, A., Paynton, M. L., Kraven, L. M., Obeidat, M., Li, X., Ng, M., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201905-1017oc · Cited by 329 · see citing works
Self-citationOxidative Stress in Pulmonary Fibrosis
Otoupalova, E., Smith, S., Cheng, G., & Thannickal, V. J. (2020) · Comprehensive physiology · doi:10.1002/cphy.c190017 · Cited by 310 · see citing works
Pulmonary fibrosis: from pathogenesis to clinical decision-making
Koudstaal, T., Funke-Chambour, M., Kreuter, M., Molyneaux, P. L., & Wijsenbeek, M. S. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.08.010 · Cited by 259 · see citing works
Self-citationTherapeutic targets in lung tissue remodelling and fibrosis
Liu, G., Philp, A. M., Corte, T. J., Travis, M. A., Schilter, H. C., Hansbro, N. G., Burns, C. J., Eapen, M. S., Sohal, S. S., Burgess, J. K., et al. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107839 · Cited by 251 · see citing works
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Martin, P. B., Pardo-Pastor, C., Jenkins, G. R., & Rosenblatt, J. (2024) · Science · doi:10.1126/science.adp2974 · Cited by 259 · see citing works
The leading role of epithelial cells in the pathogenesis of idiopathic pulmonary fibrosis
Selman, M., & Pardo, A. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109482 · Cited by 236 · see citing works
COVID-19 and pulmonary fibrosis: a potential role for lung epithelial cells and fibroblasts
John, A. E., Joseph, C., Jenkins, G., & Tatler, A. L. (2021) · Immunological Reviews · doi:10.1111/imr.12977 · Cited by 219 · see citing works
Self-citationTime for a change: is idiopathic pulmonary fibrosis still idiopathic and only fibrotic?
Wolters, P. J., Blackwell, T. S., Eickelberg, O., Loyd, J. E., Kaminski, N., Jenkins, G., Maher, T. M., Molina-Molina, M., Noble, P. W., Raghu, G., et al. (2018) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30007-9 · Cited by 196 · see citing works
Self-citationPsaila, B., Wang, G., Rodriguez-Meira, A., Li, R., Heuston, E. F., Murphy, L., Yee, D., Hitchcock, I. S., Sousos, N., O’Sullivan, J., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.04.008 · Cited by 185 · see citing works
Inui, N., Sakai, S., & Kitagawa, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22116107 · Cited by 169 · see citing works
Sex and Gender Differences in Lung Disease
Silveyra, P., Fuentes, N., & Bauza, D. E. R. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-68748-9_14 · Cited by 152 · see citing works
Jäger, B., Schupp, J. C., Plappert, L., Terwolbeck, O., Artysh, N., Kayser, G., Engelhard, P., Adams, T. S., Zweigerdt, R., Kempf, H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-33193-0 · Cited by 142 · see citing works
Idiopathic Pulmonary Fibrosis: Epidemiology, Natural History, Phenotypes
Sauleda, J., Núñez, B., Sala, E., & Soriano, J. B. (2018) · Medical Sciences · doi:10.3390/medsci6040110 · Cited by 137 · see citing works
Air pollutants, genetic susceptibility and risk of incident idiopathic pulmonary fibrosis
Cui, F., Sun, Y., Xie, J., Li, D., Wu, M., Song, L., Hu, Y., & Tian, Y. (2022) · European Respiratory Journal · doi:10.1183/13993003.00777-2022 · Cited by 139 · see citing works
Progress in Understanding and Treating Idiopathic Pulmonary Fibrosis
Kropski, J. A., & Blackwell, T. S. (2019) · Annual Review of Medicine · doi:10.1146/annurev-med-041317-102715 · Cited by 123 · see citing works
Idiopathic pulmonary fibrosis: Molecular mechanisms and potential treatment approaches
Glass, D. S., Grossfeld, D. J., Renna, H. A., Agarwala, P., Spiegler, P. A., Kasselman, L. J., Glass, A. D., DeLeon, J. R., & Reiss, A. B. (2020) · Respiratory Investigation · doi:10.1016/j.resinv.2020.04.002 · Cited by 124 · see citing works
Tobacco Smoking and Risk for Pulmonary Fibrosis
Bellou, V., Belbasis, L., & Εvangelou, Ε. (2021) · CHEST Journal · doi:10.1016/j.chest.2021.04.035 · Cited by 119 · see citing works
Pardo, A., & Selman, M. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0373ps · Cited by 120 · see citing works
Adjustment for index event bias in genome-wide association studies of subsequent events.
Dudbridge, F., Allen, R. J., Sheehan, N. A., Schmidt, A. F., Lee, J. C., Jenkins, R. G., Wain, L. V., Hingorani, A. D., & Patel, R. S. (2019) · Nature Communications · doi:10.1038/s41467-019-09381-w · Cited by 115 · see citing works
Self-citationOverlap of Genetic Risk between Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis
Hobbs, B. D., Putman, R. K., Araki, T., Nishino, M., Guðmundsson, G., Gudnason, V. G., Eiríksdóttir, G., Zilhäo, N. R., Dupuis, J., Xu, H., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201903-0511oc · Cited by 118 · see citing works
Self-citationPulmonary fibrosis: pathogenesis and therapeutic strategies
Wang, J., Li, K., Hao, D., Li, X., Zhu, Y., Yu, H., & Chen, H. (2024) · MedComm · doi:10.1002/mco2.744 · Cited by 119 · see citing works
Moore, C. M., Blumhagen, R. Z., Yang, I. V., Walts, A. D., Powers, J., Walker, T., Bishop, M. M., Russell, P. H., Vestal, B. E., Cardwell, J., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201810-1891oc · Cited by 111 · see citing works
Self-citationMesenchymal stem cells in fibrotic diseases—the two sides of the same coin
Qin, L., Liu, N., Bao, C.-L.-M., Yang, D.-Z., Ma, G.-X., Yi, W.-H., Xiao, G.-Z., & Cao, H.-L. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00952-0 · Cited by 114 · see citing works
Althobiani, M. A., Russell, A., Jacob, J., Ranjan, Y., Folarin, A., Hurst, J. R., & Porter, J. C. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1296890 · Cited by 119 · see citing works
The interplay of DAMPs, TLR4, and proinflammatory cytokines in pulmonary fibrosis
Bolourani, S., Brenner, M., & Wang, P. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02113-y · Cited by 109 · see citing works
Fibrosis: cross-organ biology and pathways to development of innovative drugs
Rieder, F., Nagy, L. E., Maher, T. M., Distler, J. H. W., Kramann, R., Hinz, B., & Prunotto, M. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01158-9 · Cited by 117 · see citing works
Self-citationIdiopathic pulmonary fibrosis.
Koudstaal, T., & Wijsenbeek, M. S. (2023) · La Presse Médicale · doi:10.1016/j.lpm.2023.104166 · Cited by 105 · see citing works
Beyond epithelial damage: vascular and endothelial contributions to idiopathic pulmonary fibrosis
May, J. M., Mitchell, J. A., & Jenkins, G. R. (2023) · Journal of Clinical Investigation · doi:10.1172/jci172058 · Cited by 100 · see citing works
Molecular Mechanisms and Cellular Contribution from Lung Fibrosis to Lung Cancer Development
Samarelli, A. V., Masciale, V., Aramini, B., Coló, G. P., Tonelli, R., Marchioni, A., Bruzzi, G., Gozzi, F., Andrisani, D., Castaniere, I., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212179 · Cited by 92 · see citing works
The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis
Saito, A., Horie, M., Micke, P., & Nagase, T. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113611 · Cited by 91 · see citing works
Moore, C. M., Jacobson, S. A., & Fingerlin, T. E. (2019) · Human Heredity · doi:10.1159/000508558 · Cited by 84 · see citing works
Self-citationEmerging role of immune cells as drivers of pulmonary fibrosis
Mutsaers, S. E., Miles, T., Prêle, C. M., & Hoyne, G. F. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108562 · Cited by 86 · see citing works
Abramson, M. J., Murambadoro, T., Alif, S. M., Benke, G., Dharmage, S. C., Glaspole, I., Hopkins, P. M.-A., Hoy, R. F., Klebe, S., Moodley, Y. P., et al. (2020) · Thorax · doi:10.1136/thoraxjnl-2019-214478 · Cited by 81 · see citing works
Kam, M. L. W., Nguyen, T. T. T., & Ngeow, J. Y. Y. (2021) · npj Genomic Medicine · doi:10.1038/s41525-021-00198-5 · Cited by 84 · see citing works
Idiopathic Pulmonary Fibrosis Is Associated with Common Genetic Variants and Limited Rare Variants
Peljto, A. L., Blumhagen, R. Z., Walts, A. D., Cardwell, J., Powers, J., Corte, T. J., Dickinson, J. L., Glaspole, I., Moodley, Y. P., Vašáková, M., et al. (2023) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202207-1331oc · Cited by 81 · see citing works
Self-citationPost-intubation subglottic stenosis: aetiology at the cellular and molecular level
Dorris, E., Russell, J., & Murphy, M. (2021) · European Respiratory Review · doi:10.1183/16000617.0218-2020 · Cited by 85 · see citing works
Emerging drug delivery strategies for idiopathic pulmonary fibrosis treatment
Ghumman, M., Dhamecha, D. L., Gonsalves, A., Fortier, L., Sorkhdini, P., Zhou, Y., & Menon, J. U. (2021) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2021.03.017 · Cited by 79 · see citing works
Mesenchymal Stem Cells for the Treatment of Idiopathic Pulmonary Fibrosis
Tzouvelekis, A., Toonkel, R. L., Karampitsakos, Τ., Medapalli, K., Ninou, I., Aidinis, V., Bouros, D. E., & Glassberg, M. K. (2018) · Frontiers in Medicine · doi:10.3389/fmed.2018.00142 · Cited by 78 · see citing works
Bowman, W. S., Echt, G., & Oldham, J. M. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.680997 · Cited by 76 · see citing works
Self-citationMa, H., Wu, X., Li, Y., & Xia, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.963054 · Cited by 78 · see citing works
Invernizzi, R., Barnett, J. L., Rawal, B., Nair, A., Ghai, P., Kingston, S., Chua, F., Wu, Z., Wells, A. U., Renzoni, E., et al. (2020) · European Respiratory Journal · doi:10.1183/13993003.01519-2019 · Cited by 72 · see citing works
Self-citationAdegunsoye, A., Kropski, J. A., Behr, J., Blackwell, T. S., Corte, T. J., Cottin, V., Glanville, A. R., Glassberg, M. K., Griese, M., Hunninghake, G. M., et al. (2024) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202401-0238so · Cited by 76 · see citing works
Self-citationIntegrating Genomics Into Management of Fibrotic Interstitial Lung Disease
Adegunsoye, A., Vij, R., & Noth, I. (2019) · CHEST Journal · doi:10.1016/j.chest.2018.12.011 · Cited by 71 · see citing works
Self-citationMatson, S. M., Lee, J. S., & Eickelberg, O. (2020) · European Respiratory Journal · doi:10.1183/13993003.02533-2020 · Cited by 68 · see citing works
Emerging Roles of Airway Epithelial Cells in Idiopathic Pulmonary Fibrosis
Chakraborty, A., Mastalerz, M., Ansari, M., Schiller, H. B., & Staab-Weijnitz, C. A. (2022) · Cells · doi:10.3390/cells11061050 · Cited by 68 · see citing works
Allen, R. J., Oldham, J. M., Jenkins, D. A., Leavy, O. C., Guillén‐Guío, B., Melbourne, C., Ma, S., Jou, J., Kim, J. S., CleanUP-IPF Investigators of the Pulmonary Trials Cooperative, et al. (2022) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(22)00251-x · Cited by 70 · see citing works
Self-citationEnvironmental Causes of Idiopathic Pulmonary Fibrosis
Gandhi, S. A., Tonelli, R., Murray, M., Samarelli, A. V., & Spagnolo, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216481 · Cited by 68 · see citing works
Reynolds, C., Fabiola Del Greco, M., Allen, R. J., Flores, C., Jenkins, G. R., Maher, T. M., Molyneaux, P. L., Noth, I., Oldham, J. M., Wain, L. V., et al. (2023) · European Respiratory Journal · doi:10.1183/13993003.01585-2022 · Cited by 67 · see citing works
Self-citationThe genetics of interstitial lung diseases
Borie, R., Guen, P. L., Ghanem, M., Taillé, C., Dupin, C., Dieudé, P., Kannengiesser, C., & Crestani, B. (2019) · European Respiratory Review · doi:10.1183/16000617.0053-2019 · Cited by 75 · see citing works
Oxidative Stress in Pulmonary Fibrosis
Otoupalova, E., Smith, S., Cheng, G., & Thannickal, V. J. (2020) · Comprehensive physiology · doi:10.1002/j.2040-4603.2020.tb00120.x · Cited by 65 · see citing works
Cutting, C. C., Bowman, W. S., Đao, N. H., Pugashetti, J. V., Garcia, C. K., Oldham, J. M., & Newton, C. A. (2021) · CHEST Journal · doi:10.1016/j.chest.2021.01.026 · Cited by 64 · see citing works
Self-citationPartanen, J., Häppölä, P., Zhou, W., Lehistö, A., Ainola, M., Sutinen, E., Allen, R. J., Stockwell, A., Leavy, O. C., Oldham, J. M., et al. (2022) · Cell Genomics · doi:10.1016/j.xgen.2022.100181 · Cited by 61 · see citing works
Self-citationIdiopathic pulmonary fibrosis and diabetes mellitus: a meta-analysis and systematic review
Bai, L., Li, Z., Pan, T., Wang, W., Wang, D., Turner, C., Zhou, X., & He, H. (2021) · Respiratory Research · doi:10.1186/s12931-021-01760-6 · Cited by 55 · see citing works
Fibrosis: Lessons from OMICS analyses of the human lung
Yu, G., Ibarra, G. H., & Kaminski, N. (2018) · Matrix Biology · doi:10.1016/j.matbio.2018.03.014 · Cited by 52 · see citing works
What have we learned from basic science studies on idiopathic pulmonary fibrosis?
Yanagihara, T., Sato, S., Upagupta, C., & Kolb, M. R. J. (2019) · European Respiratory Review · doi:10.1183/16000617.0029-2019 · Cited by 54 · see citing works
Palomäki, A., Palotie, A. V., Koskela, J. T., Eklund, K. K., Pirinen, M., Ripatti, S., Laitinen, T., & Mars, N. (2021) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2021-220698 · Cited by 52 · see citing works
Lee, J. S., La, J. L., Aziz, S., Dobrinskikh, E., Brownell, R., Jones, K. D., Achtar‐Zadeh, N., Green, G., Elicker, B. M., Golden, J. A., et al. (2021) · Histopathology · doi:10.1111/his.14334 · Cited by 52 · see citing works
Self-citationReversing Mechanoinductive DSP Expression by CRISPR/dCas9–mediated Epigenome Editing
Qu, J. T., Zhu, L., Zhou, Z., Chen, P., Liu, S., Locy, M. L., Thannickal, V. J., & Zhou, Y. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201711-2242oc · Cited by 50 · see citing works
Extracellular Matrix Stiffness in Lung Health and Disease
Guo, T., He, C., Venado, A. E., & Zhou, Y. (2022) · Comprehensive physiology · doi:10.1002/cphy.c210032 · Cited by 100 · see citing works
Hao, Y. T., Bates, S., Mou, H., Yun, J. H., Pham, B., Liu, J., Qiu, W., Guo, F., Morrow, J. D., Hersh, C. P., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201910-1958oc · Cited by 49 · see citing works
Extracellular Matrix Stiffness in Lung Health and Disease
Guo, T., He, C., Venado, A. E., & Zhou, Y. (2022) · Comprehensive physiology · doi:10.1002/j.2040-4603.2022.tb00222.x · Cited by 48 · see citing works
Borie, R., Cardwell, J., Konigsberg, I. R., Moore, C. M., Zhang, W. E., Sasse, S. K., Gally, F., Dobrinskikh, E., Walts, A. D., Powers, J., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202110-2308oc · Cited by 45 · see citing works
Self-citationTrethewey, S. P., & Walters, G. I. (2018) · Medicina · doi:10.3390/medicina54060108 · Cited by 45 · see citing works
KLF4 regulates TERT expression in alveolar epithelial cells in pulmonary fibrosis
Wang, H., Xu, H., Lyu, W., Xu, Q., Fan, S., Chen, H., Wang, D., Chen, J., & Dai, J. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04886-7 · Cited by 46 · see citing works
Transcriptome analysis of IPF fibroblastic foci identifies key pathways involved in fibrogenesis
Guillotin, D., Taylor, A. R., Platé, M., Mercer, P. F., Edwards, L. M., Haggart, R. D., Miele, G., McAnulty, R. J., Maher, T. M., Hynds, R. E., et al. (2020) · Thorax · doi:10.1136/thoraxjnl-2020-214902 · Cited by 43 · see citing works
Self-citationVagapova, E. R., Lebedev, T. D., & Prassolov, V. (2021) · Scientific Reports · doi:10.1038/s41598-021-90701-w · Cited by 42 · see citing works
Incidence and Progression of Fibrotic Lung Disease in an At-Risk Cohort
Steele, M. P., Peljto, A. L., Mathai, S. K., Humphries, S. M., Bang, T. J., Oh, A. S., Teague, S. D., Cicchetti, G., Sigakis, C. J. G., Kropski, J. A., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202206-1075oc · Cited by 42 · see citing works
Self-citationPCSK6 and Survival in Idiopathic Pulmonary Fibrosis
Oldham, J. M., Allen, R. J., Lorenzo-Salazar, J. M., Molyneaux, P. L., Ma, S., Joseph, C., Kim, J. S., Guillén‐Guío, B., Hernández-Beeftink, T., Kropski, J. A., et al. (2023) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202205-0845oc · Cited by 42 · see citing works
Self-citationToll-Interacting Protein in Pulmonary Diseases. Abiding by the Goldilocks Principle
Li, X., Goobie, G. C., Gregory, A. D., Kass, D. J., & Zhang, Y. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0470tr · Cited by 40 · see citing works
Lung Microenvironments and Disease Progression in Fibrotic Hypersensitivity Pneumonitis
Sadeleer, L. J. D., McDonough, J. E., Schupp, J. C., Yan, X., Vanstapel, A., Herck, A. V., Everaerts, S., Geudens, V., Sacreas, A., Goos, T., et al. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202103-0569oc · Cited by 40 · see citing works
Zhang, Y., Zhao, M., Guo, P., Wang, Y., Liu, L., Zhao, J., Gao, L., Yuan, Z., Xue, F., & Zhao, J. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103669 · Cited by 40 · see citing works
Trade-offs in aging lung diseases
van Moorsel, C. H. M. (2018) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000476 · Cited by 39 · see citing works
Urinary exosomes derived circRNAs as biomarkers for chronic renal fibrosis
Cao, Y., Shi, Y., Yang, Y., Wu, Z., Peng, N., Xiao, J., Dou, F., Xu, J., Pei, W., Fu, C., et al. (2022) · Annals of Medicine · doi:10.1080/07853890.2022.2098374 · Cited by 38 · see citing works
Genomics and the Acute Respiratory Distress Syndrome: Current and Future Directions
Hernández-Beeftink, T., Guillén‐Guío, B., Villar, J., & Flores, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20164004 · Cited by 37 · see citing works
Self-citationLeavy, O. C., Ma, S., Molyneaux, P. L., Maher, T. M., Oldham, J. M., Flores, C., Noth, I., Jenkins, G. R., Dudbridge, F., Wain, L. V., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202008-3211le · Cited by 38 · see citing works
Self-citationExisting and emerging biomarkers for disease progression in idiopathic pulmonary fibrosis
Inchingolo, R., Varone, F., Sgalla, G., & Richeldi, L. (2018) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2019.1553620 · Cited by 37 · see citing works
Mattoo, H., & Pillai, S. S. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-03874-y · Cited by 36 · see citing works
Transcriptomic and Epigenetic Profiling of Fibroblasts in Idiopathic Pulmonary Fibrosis
Hanmandlu, A., Zhu, L., Mertens, T. C. J., Collum, S., Bi, W., Xiong, F., Wang, R., Amirthalingam, R. T., Ren, D., Han, L., et al. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0437oc · Cited by 37 · see citing works
Progressive lung fibrosis: reprogramming a genetically vulnerable bronchoalveolar epithelium
Bridges, J. P., Vladar, E. K., Kurche, J. S., Krivoi, A., Stancil, I. T., Dobrinskikh, E., Hu, Y., Sasse, S. K., Lee, J. S., Blumhagen, R. Z., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci183836 · Cited by 40 · see citing works
Self-citationWang, L., Liu, H., He, Q., Gan, C., Li, Y., Zhang, Q., Yao, Y., He, F., Ye, T., & Yin, W. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115663 · Cited by 35 · see citing works
Crișan-Dabija, R. A., Pavel, C.-A., Popa, I. V., Țăruș, A., & Burlacu, A. (2020) · Journal of Proteome Research · doi:10.1021/acs.jproteome.0c00387 · Cited by 35 · see citing works
Clinical implications of telomere dysfunction in lung fibrosis
Molina‐Molina, M., & Borie, R. (2018) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000506 · Cited by 36 · see citing works
Genomics of Human Fibrotic Diseases: Disordered Wound Healing Response
Stone, R. C., Chen, V., Burgess, J. L., Pannu, S., & Tomic‐Canic, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228590 · Cited by 35 · see citing works
Idiopathic pulmonary fibrosis and the role of genetics in the era of precision medicine
Alonso-González, A., Tosco-Herrera, E., Molina‐Molina, M., & Flores, C. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1152211 · Cited by 33 · see citing works
Self-citationDissecting the Role of Mesenchymal Stem Cells in Idiopathic Pulmonary Fibrosis: Cause or Solution
Samarelli, A. V., Tonelli, R., Heijink, I. H., Medina, A. M., Marchioni, A., Bruzzi, G., Castaniere, I., Andrisani, D., Gozzi, F., Manicardi, L., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.692551 · Cited by 34 · see citing works
Antifibrotic effects of sodium-glucose cotransporter-2 inhibitors: A comprehensive review
Shakour, N., Karami, S., Iranshahi, M., Butler, A. E., & Sahebkar, A. (2023) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2023.102934 · Cited by 32 · see citing works
Federal clinical guidelines on diagnosis and treatment of idiopathic pulmonary fibrosis
Avdeev, S. N., Айсанов, З. Р., Belevskiy, А. S., Ilkovich, M. M., Коган, Е. А., Мержоева, З. М., Petrov, D., Samsonova, M. V., Terpigorev, S. A., Трушенко, Н. В., et al. (2022) · PULMONOLOGIYA · doi:10.18093/0869-0189-2022-32-3-473-495 · Cited by 31 · see citing works
Mendoza-Álvarez, A., Guillén‐Guío, B., Baez‐Ortega, A., Hernandez-Perez, C., Lakhwani-Lakhwani, S., Maeso, M.-D.-C., Lorenzo-Salazar, J. M., Morales, M., & Flores, C. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00439 · Cited by 30 · see citing works
Self-citationNovel idiopathic pulmonary fibrosis susceptibility variants revealed by deep sequencing
Lorenzo-Salazar, J. M., Ma, S., Jou, J., Hou, P., Guillén‐Guío, B., Allen, R. J., Jenkins, G. R., Wain, L. V., Oldham, J. M., Noth, I., et al. (2019) · ERJ Open Research · doi:10.1183/23120541.00071-2019 · Cited by 31 · see citing works
Self-citationRuwisch, J., Sehlmeyer, K., Roldán, N., García‐Álvarez, B., Pérez‐Gil, J., Weaver, T. E., Ochs, M., Knudsen, L., & López-Rodríguez, E. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2019-0358oc · Cited by 30 · see citing works
- Authors
- Allen, R. J., Porte, J., Braybrooke, R., Flores, C., Fingerlin, T. E., Oldham, J. M., Guillen-Guio, B., Ma, S.-F., Okamoto, T., John, A. E., Obeidat, M., Yang, I. V., Henry, A., Hubbard, R. B., Navaratnam, V., Saini, G., Thompson, N., Booth, H. L., Hart, S. P., Hill, M. R., Hirani, N., Maher, T. M., McAnulty, R. J., Millar, A. B., Molyneaux, P. L., Parfrey, H., Rassl, D. M., Whyte, M. K. B., Fahy, W. A., Marshall, R. P., Oballa, E., Bossé, Y., Nickle, D. C., Sin, D. D., Timens, W., Shrine, N., Sayers, I., Hall, I. P., Noth, I., Schwartz, D. A., Tobin, M. D., Wain, L. V., & Jenkins, R. G.
- Affiliations
- University of Leicester (GB)
- University of Nottingham (GB)
- Universidad de La Laguna (ES)
- National Jewish Health (US)
- University of California, Davis (US)
- University of Chicago (US)
- University of Colorado Denver (US)
- University of British Columbia (CA)
- University College Hospital (GB)
- Hull York Medical School (GB)
- University of Oxford (GB)
- Centre for Inflammation Research (GB)
- National Institute for Health and Care Research (GB)
- University College London (GB)
- University of Bristol (GB)
- Royal Papworth Hospital (GB)
- GlaxoSmithKline (United Kingdom) (GB)
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- University Medical Center Groningen (NL)
- Corresponding author
- Wain, Louise V
- ORCID
- Allen, Richard J
- Porte, Joanne
- Braybrooke, Rebecca
- Flores, Carlos
- Fingerlin, Tasha E
- Oldham, Justin M
- Ma, Shwu-Fan
- Okamoto, Tsukasa
- John, Alison E
- Obeidat, Ma'en
- Yang, Ivana V
- Henry, Amanda
- Hubbard, Richard B
- Navaratnam, Vidya
- Saini, Gauri
- Hart, Simon P
- Hirani, Nik
- Maher, Toby M
- McAnulty, Robin J
- Molyneaux, Philip L
- Parfrey, Helen
- Rassl, Doris M
- Whyte, Moira K B
- Fahy, William A
- Marshall, Richard P
- Bossé, Yohan
- Nickle, David C
- Sin, Don D
- Timens, Wim
- Shrine, Nick
- Sayers, Ian
- Hall, Ian P
- Noth, Imre
- Schwartz, David A
- Tobin, Martin D
- Wain, Louise V
- Venue
- The Lancet Respiratory Medicine
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 5
- Issue
- 11
- Pages
- 869-880
- ISSN
- 2213-2600 (ISSN-L)
- PMC
- PMC5666208
- OpenAlex
- W2767079004
- Cited by
- 297
- References
- 54
- Citations by year
- 2026: 21 · 2025: 28 · 2024: 24 · 2023: 39 · 2022: 42 · 2021: 40 · 2020: 45 · 2019: 30 · 2018: 25 · 2017: 2
- FWCI
- 23.07
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- The Lancet Respiratory Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, cc-by)
- Nottingham ePrints (University of Nottingham) (submittedVersion, cc-by)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Leicester Research Archive (University of Leicester) (submittedVersion, cc-by)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, cc-by)
- Bristol Research (University of Bristol) (submittedVersion, cc-by)
- Spiral (Imperial College London) (submittedVersion, other-oa)
- Funders
- National Heart, Lung, and Blood Institute (P01 HL092870, R01 HL097163)
- National Institute for Health and Care Research
- Medical Research Council Canada (MC_PC_12010)
- Agencia Canaria de Investigación, Innovación y Sociedad de la Información (CS-2013–13–017, TESIS2015010057)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Keywords
- idiopathic pulmonary fibrosis, genetic susceptibility, AKAP13, MUC5B, DSP, genetic variants, lung gene expression, alveolar epithelium, lymphoid follicles, lung resection, European ancestry, transcriptomics, proteomics, lung proteome
- MeSH terms
- Tertiary Lymphoid Structures, Aged, Europe, Female, Humans, Male, Middle Aged, Proto-Oncogene Proteins, RNA, Messenger, Genetic Variation, Signal Transduction, Minor Histocompatibility Antigens, Case-Control Studies, Genetic Predisposition to Disease, rhoA GTP-Binding Protein, White People, A Kinase Anchor Proteins, Idiopathic Pulmonary Fibrosis, Genome-Wide Association Study, Alveolar Epithelial Cells, Rho Guanine Nucleotide Exchange Factors
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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