Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis
Open accessPublished version of a preprint
Abstract
Rationale: Idiopathic pulmonary fibrosis (IPF) is a complex lung disease characterized by scarring of the lung that is believed to result from an atypical response to injury of the epithelium. Genome-wide association studies have reported signals of association implicating multiple pathways including host defense, telomere maintenance, signaling, and cell–cell adhesion. Objectives: To improve our understanding of factors that increase IPF susceptibility by identifying previously unreported genetic associations. Methods: We conducted genome-wide analyses across three independent studies and meta-analyzed these results to generate the largest genome-wide association study of IPF to date (2,668 IPF cases and 8,591 controls). We performed replication in two independent studies (1,456 IPF cases and 11,874 controls) and functional analyses (including statistical fine-mapping, investigations into gene expression, and testing for enrichment of IPF susceptibility signals in regulatory regions) to determine putatively causal genes. Polygenic risk scores were used to assess the collective effect of variants not reported as associated with IPF. Measurements and Main Results: We identified and replicated three new genome-wide significant (P < 5 × 10−8) signals of association with IPF susceptibility (associated with altered gene expression of KIF15, MAD1L1, and DEPTOR) and confirmed associations at 11 previously reported loci. Polygenic risk score analyses showed that the combined effect of many thousands of as yet unreported IPF susceptibility variants contribute to IPF susceptibility. Conclusions: The observation that decreased DEPTOR expression associates with increased susceptibility to IPF supports recent studies demonstrating the importance of mTOR signaling in lung fibrosis. New signals of association implicating KIF15 and MAD1L1 suggest a possible role of mitotic spindle-assembly genes in IPF susceptibility.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A genetic locus associated with DEPTOR is associated with increased risk of developing IPF.
“More recently, a genetic locus associated with DEPTOR , a gene involved in several cellular functions including negative regulation of mTOR (mechanistic target of rapamycin), has also been associated with increased risk of developing IPF (Allen et al., 2020).”
From Pulmonary fibrosis: Emerging diagnostic and therapeutic strategies (2023) · cites this paper as Allen et al., 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Sudlow, C., Gallacher, J., Allen, N., Beral, V., Burton, P., Danesh, J., Downey, P., Elliott, P., Green, J., Landray, M., et al. (2015) · PLOS Medicine · doi:10.1371/journal.pmed.1001779 · Cited by 12,728 · see citing works
The Ensembl Variant Effect Predictor
McLaren, W., Gil, L., Hunt, S. E., Riat, H. S., Ritchie, G. R. S., Thormann, A., Flicek, P., & Cunningham, F. (2016) · Genome Biology · doi:10.1186/s13059-016-0974-4 · Cited by 8,099 · see citing works
Raghu, G., Collard, H. R., Egan, J. J., Martinez, F. J., Behr, J., Brown, K. K., Colby, T. V., Cordier, J.-F., Flaherty, K. R., Lasky, J. A., et al. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.2009-040gl · Cited by 7,186 · see citing works
Giambartolomei, C., Vukcevic, D., Schadt, E. E., Franke, L., Hingorani, A. D., Wallace, C., & Plagnol, V. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004383 · Cited by 4,261 · see citing works
(2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.2.ats01 · Cited by 4,196 · see citing works
Diagnosis of Idiopathic Pulmonary Fibrosis. An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline
Raghu, G., Remy-Jardin, M., Myers, J. L., Richeldi, L., Ryerson, C. J., Lederer, D. J., Behr, J., Cottin, V., Danoff, S. K., Morell, F., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201807-1255st · Cited by 4,103 · see citing works
Self-citationGenetic effects on gene expression across human tissues
GTEx Consortium (2017) · Nature · doi:10.1038/nature24277 · Cited by 4,036 · see citing works
Self-citationRobust relationship inference in genome-wide association studies
Manichaikul, A., Mychaleckyj, J. C., Rich, S. S., Daly, K., Sale, M., & Chen, W.-M. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq559 · Cited by 3,541 · see citing works
Self-citationA reference panel of 64,976 haplotypes for genotype imputation
the Haplotype Reference Consortium (2016) · Nature Genetics · doi:10.1038/ng.3643 · Cited by 2,836 · see citing works
A new multipoint method for genome-wide association studies by imputation of genotypes
Marchini, J., Howie, B., Myers, S., McVean, G., & Donnelly, P. (2007) · Nature Genetics · doi:10.1038/ng2088 · Cited by 2,609 · see citing works
Predicting effects of noncoding variants with deep learning–based sequence model
Zhou, J., & Troyanskaya, O. G. (2015) · Nature Methods · doi:10.1038/nmeth.3547 · Cited by 2,338 · see citing works
Ward, L. D., & Kellis, M. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr917 · Cited by 2,229 · see citing works
Lederer, D. J., & Martinez, F. J. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1705751 · Cited by 2,056 · see citing works
Self-citationRaghu, G., Rochwerg, B., Zhang, Y., Garcia, C. A. C., Azuma, A., Behr, J., Brozek, J. L., Collard, H. R., Cunningham, W., Homma, S., et al. (2015) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201506-1063st · Cited by 1,916 · see citing works
Self-citationClinical course and prediction of survival in idiopathic pulmonary fibrosis
Ley, B., Collard, H. R., & King, T. E. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201006-0894ci · Cited by 1,765 · see citing works
The support of human genetic evidence for approved drug indications
Nelson, M. R., Tipney, H., Painter, J. L., Shen, J., Nicoletti, P., Shen, Y., Floratos, A., Sham, P. C., Li, M. J., Wang, J., et al. (2015) · Nature Genetics · doi:10.1038/ng.3314 · Cited by 1,666 · see citing works
PRSice: Polygenic Risk Score software
Euesden, J., Lewis, C. M., & O’Reilly, P. F. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu848 · Cited by 1,149 · see citing works
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis
Fingerlin, T. E., Murphy, E., Zhang, W., Peljto, A. L., Brown, K. K., Steele, M. P., Loyd, J. E., Cosgrove, G. P., Lynch, D., Groshong, S., et al. (2013) · Nature Genetics · doi:10.1038/ng.2609 · Cited by 809 · see citing works
Self-citationShort telomeres are a risk factor for idiopathic pulmonary fibrosis
Alder, J. K., Chen, J. J.-L., Lancaster, L., Danoff, S., Su, S.-C., Cogan, J. D., Vulto, I., Xie, M., Qi, X., Tuder, R. M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804280105 · Cited by 805 · see citing works
Noth, I., Zhang, Y., Ma, S., Flores, C., Barber, M., Huang, Y., Broderick, S. M., Wade, M. S., Hysi, P. G., Scuirba, J., et al. (2013) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(13)70045-6 · Cited by 605 · see citing works
Self-citationXu, Y. J., Mizuno, T., Sridharan, A., Du, Y., Guo, M., Tang, J., Wikenheiser‐Brokamp, K. A., Perl, A. T., Funari, V. A., Gokey, J. J., et al. (2016) · JCI Insight · doi:10.1172/jci.insight.90558 · Cited by 571 · see citing works
Shrine, N. R. G., Guyatt, A. L., Erzurumluoglu, A. M., Jackson, V. E., Hobbs, B. D., Melbourne, C., Batini, C., Fawcett, K. A., Song, K. S., Sakornsakolpat, P., et al. (2019) · Nature Genetics · doi:10.1038/s41588-018-0321-7 · Cited by 539 · see citing works
Self-citationA Bayesian Measure of the Probability of False Discovery in Genetic Epidemiology Studies
Wakefield, J. (2007) · The American Journal of Human Genetics · doi:10.1086/519024 · Cited by 486 · see citing works
Stuart, B. D., Choi, J., Zaidi, S., Xing, C., Holohan, B., Chen, R., Choi, M., Dharwadkar, P., Torres, F., Girod, C. E., et al. (2015) · Nature Genetics · doi:10.1038/ng.3278 · Cited by 469 · see citing works
MUC5B Promoter Polymorphism and Interstitial Lung Abnormalities
Hunninghake, G. M., Hatabu, H., Okajima, Y., Gao, W. D., Dupuis, J., Latourelle, J. C., Nishino, M., Araki, T., Zazueta, O. E., Kurugol, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1216076 · Cited by 457 · see citing works
Self-citationCOPDGene Investigators, Hobbs, B. D., ECLIPSE Investigators, LifeLines Investigators, International COPD Genetics Network Investigators, UK BiLEVE Investigators, de Jong, K., Lamontagne, M., Bossé, Y., Shrine, N. R. G., et al. (2017) · Nature Genetics · doi:10.1038/ng.3752 · Cited by 399 · see citing works
Self-citationSakornsakolpat, P., Prokopenko, D., Lamontagne, M., Reeve, N. F., Guyatt, A. L., Jackson, V. E., Shrine, N. R. G., Qiao, D., Bartz, T. M., Kim, D. K., et al. (2019) · Nature Genetics · doi:10.1038/s41588-018-0342-2 · Cited by 370 · see citing works
Self-citationStuart, B. D., Lee, J. S., Kozlitina, J., Noth, I., Devine, M. S., Glazer, C. S., Torres, F., Kaza, V., Girod, C. E., Jones, K. D., et al. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70124-9 · Cited by 310 · see citing works
Self-citationLung eQTLs to Help Reveal the Molecular Underpinnings of Asthma
Hao, K., Bossé, Y., Nickle, D. C., Paré, P. D., Postma, D. S., Laviolette, M., Sandford, A. J., Hackett, T., Daley, D., Hogg, J. C., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003029 · Cited by 308 · see citing works
Self-citationAllen, R. J., Porte, J., Braybrooke, R., Flores, C., Fingerlin, T. E., Oldham, J. M., Guillen-Guio, B., Ma, S.-F., Okamoto, T., John, A. E., et al. (2017) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(17)30387-9 · Cited by 297 · see citing works
Self-citationKif15 Cooperates with Eg5 to Promote Bipolar Spindle Assembly
Tanenbaum, M. E., Macůrek, L., Janssen, A., Geers, E. F., Álvarez‐Fernández, M., & Medema, R. H. (2009) · Current Biology · doi:10.1016/j.cub.2009.08.027 · Cited by 280 · see citing works
The pathogenesis of idiopathic pulmonary fibrosis
Coward, W. R., Saini, G., & Jenkins, G. R. (2010) · Therapeutic Advances in Respiratory Disease · doi:10.1177/1753465810379801 · Cited by 271 · see citing works
Self-citationMushiroda, T., Wattanapokayakit, S., Takahashi, A., Nukiwa, T., Kudoh, S., Ogura, T., Taniguchi, H., Kubo, M., Kamatani, N., & Nakamura, Y. (2008) · Journal of Medical Genetics · doi:10.1136/jmg.2008.057356 · Cited by 239 · see citing works
An Exome Sequencing Study to Assess the Role of Rare Genetic Variation in Pulmonary Fibrosis
Petrovski, S., Todd, J. L., Durheim, M. T., Wang, Q., Chien, J. W., Kelly, F. L., Frankel, C. W., Mebane, C. M., Ren, Z., Bridgers, J., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201610-2088oc · Cited by 235 · see citing works
The mTORC1/4E-BP1 axis represents a critical signaling node during fibrogenesis
Woodcock, H. V., Eley, J. D., Guillotin, D., Platé, M., Nanthakumar, C. B., Martufi, M., Peace, S., Joberty, G., Poeckel, D., Good, R. B., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-07858-8 · Cited by 224 · see citing works
Self-citationDressen, A., Abbas, A. R., Cabanski, C. R., Reeder, J., Ramalingam, T. R., Neighbors, M., Bhangale, T., Brauer, M. J., Hunkapiller, J., Reeder, J., et al. (2018) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30135-8 · Cited by 193 · see citing works
Self-citationThe pathogenesis of COPD and IPF: Distinct horns of the same devil?
Chilosi, M., Poletti, V. E., & Rossi, A. (2012) · Respiratory Research · doi:10.1186/1465-9921-13-3 · Cited by 183 · see citing works
Kang, J. U., Koo, S. H., Kwon, K. C., Park, J. W., & Kim, J. (2008) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2007.12.004 · Cited by 180 · see citing works
Heterozygous RTEL1 mutations are associated with familial pulmonary fibrosis
Kannengiesser, C., Borie, R., Ménard, C., Réocreux, M., Nitschké, P., Gazal, S., Mal, H., Taillé, C., Cadranel, J. L., Nunès, H., et al. (2015) · European Respiratory Journal · doi:10.1183/09031936.00040115 · Cited by 162 · see citing works
Conditional eQTL analysis reveals allelic heterogeneity of gene expression
Jansen, R., Hottenga, J.-J., Nivard, M. G., Abdellaoui, A., Laport, B., de Geus, E. J., Wright, F. A., Penninx, B. W. J. H., & Boomsma, D. I. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx043 · Cited by 141 · see citing works
Overlap of Genetic Risk between Interstitial Lung Abnormalities and Idiopathic Pulmonary Fibrosis
Hobbs, B. D., Putman, R. K., Araki, T., Nishino, M., Guðmundsson, G., Gudnason, V. G., Eiríksdóttir, G., Zilhäo, N. R., Dupuis, J., Xu, H., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201903-0511oc · Cited by 115 · see citing works
Self-citationMoore, C. M., Blumhagen, R. Z., Yang, I. V., Walts, A. D., Powers, J., Walker, T., Bishop, M. M., Russell, P. H., Vestal, B. E., Cardwell, J., et al. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201810-1891oc · Cited by 111 · see citing works
Self-citationFingerlin, T. E., Zhang, W. E., Yang, I. V., Ainsworth, H. C., Russell, P. H., Blumhagen, R. Z., Schwarz, M. I., Brown, K. M., Steele, M. P., Loyd, J. E., et al. (2016) · BMC Genetics · doi:10.1186/s12863-016-0377-2 · Cited by 98 · see citing works
Self-citationA reference panel of 64,976 haplotypes for genotype imputationPreprint
McCarthy, S., Das, S., Kretzschmar, W. W., Delaneau, O., Wood, A. R., Teumer, A., Kang, H. M., Fuchsberger, C., Danecek, P., Sharp, K., et al. (2015) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/035170 · Cited by 89 · see citing works
SNPsea: an algorithm to identify cell types, tissues and pathways affected by risk loci
Slowikowski, K., Hu, X., & Raychaudhuri, S. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu326 · Cited by 81 · see citing works
Coghlan, M. A., Shifren, A., Huang, H. J., Russell, T. D., Mitra, R. D., Zhang, Q., Wegner, D., Cole, F. S., & Hamvas, A. (2014) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2014-000057 · Cited by 79 · see citing works
TheMUC5Bpromoter polymorphism is associated with specific interstitial lung abnormality subtypes
Putman, R. K., Guðmundsson, G., Araki, T., Nishino, M., Sigurdsson, S. O., Gudmundsson, E. F., Eiríksdóttir, G., Aspelund, T., Ross, J. C., Estépar, R. S. J., et al. (2017) · European Respiratory Journal · doi:10.1183/13993003.00537-2017 · Cited by 79 · see citing works
Self-citationPancreatic Cancer Patient Survival Correlates with DNA Methylation of Pancreas Development Genes
Thompson, M. J., Rubbi, L., Dawson, D. W., Donahue, T. R., & Pellegrini, M. A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0128814 · Cited by 70 · see citing works
Refining Susceptibility Loci of Chronic Obstructive Pulmonary Disease with Lung eqtls
Lamontagne, M., Couture, C., Postma, D. S., Timens, W., Sin, D. D., Paré, P. D., Hogg, J. C., Nickle, D. C., Laviolette, M., & Bossé, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070220 · Cited by 61 · see citing works
Self-citationCoe, B. P., Lee, E. H. L., Chi, B., Girard, L., Minna, J. D., Gazdar, A. F., Lam, S. C., MacAulay, C. E., & Lam, W. L. (2005) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20260 · Cited by 58 · see citing works
Interstitial Lung Abnormalities Are Associated with Acute Respiratory Distress Syndrome
Putman, R. K., Hunninghake, G. M., Dieffenbach, P. B., Barragan-Bradford, D., Serhan, K., Adams, U., Hatabu, H., Nishino, M., Padera, R. F., Fredenburgh, L. E., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201604-0818le · Cited by 56 · see citing works
Self-citationThe proinflammatory role of HECTD2 in innate immunity and experimental lung injury
Coon, T. A., McKelvey, A. C., Lear, T., Rajbhandari, S., Dunn, S. R., Connelly, W., Zhao, J. Y., Han, S., Liu, Y., Weathington, N. M., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aab3881 · Cited by 49 · see citing works
Self-citationA role for telomere length and chromosomal damage in idiopathic pulmonary fibrosis
McDonough, J. E., Martens, D. S., Tanabe, N., Ahangari, F., Verleden, S. E., Maes, K., Verleden, G. M., Kaminski, N., Hogg, J. C., Nawrot, T. S., et al. (2018) · Respiratory Research · doi:10.1186/s12931-018-0838-4 · Cited by 49 · see citing works
Self-citationGSTCD and INTS12 Regulation and Expression in the Human Lung
Obeidat, M., Miller, S., Probert, K., Billington, C. K., Henry, A. P., Hodge, E., Nelson, C. P., Stewart, C. E., Swan, C., Wain, L. V., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074630 · Cited by 44 · see citing works
Self-citationAssociation Between the MUC5B Promoter Polymorphism rs35705950 and Idiopathic Pulmonary Fibrosis
Zhu, Q., Zhang, X., Zhang, S., Tang, S., Min, H.-Y., Yi, L., Xu, B., & Song, Y. (2015) · Medicine · doi:10.1097/md.0000000000001901 · Cited by 42 · see citing works
Das, F., Bera, A., Ghosh‐Choudhury, N., Abboud, H. E., Kasinath, B. S., & Choudhury, G. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109608 · Cited by 36 · see citing works
Targeted resequencing reveals genetic risks in patients with sporadic idiopathic pulmonary fibrosis
Deng, Y., Li, Z., Liu, J., Wang, Z., Cao, Y., Mou, Y., Fu, B., Mo, B., Wei, J., Cheng, Z., et al. (2018) · Human Mutation · doi:10.1002/humu.23566 · Cited by 31 · see citing works
GARFIELD - GWAS Analysis of Regulatory or Functional Information Enrichment with LD correctionPreprint
Iotchkova, V., Ritchie, G. R. S., Geihs, M., Morganella, S., Min, J. L., Walter, K., Timpson, N. J., Dunham, I., Birney, E., & Soranzo, N. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/085738 · Cited by 28 · see citing works
FORGE: A tool to discover cell specific enrichments of GWAS associated SNPs in regulatory regions
Dunham, I., Kulesha, E., Iotchkova, V., Morganella, S., & Birney, E. (2015) · F1000Research · doi:10.12688/f1000research.6032.1 · Cited by 24 · see citing works
Telomeres revisited:RTEL1variants in pulmonary fibrosis
Kropski, J. A., & Loyd, J. E. (2015) · European Respiratory Journal · doi:10.1183/13993003.00710-2015 · Cited by 15 · see citing works
The 2018 Annual Meeting of the International Genetic Epidemiology Society
Veil, R., Granell, R., Laprise, C., James, A., Freidin, M. B., Khusnutdinova, E. K., von Mutius, E., Probst-Hensch, N. M., Leynaert, B., & Bouzigon, E. (2018) · Genetic Epidemiology · doi:10.1002/gepi.22163 · Cited by 2 · see citing works
Flagged first, then by citations
1 of the 62 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [18]Allen RJ Guillen-Guio B Oldham JM Ma SF Dressen A Paynton ML et al Genome-wide association study of susceptibility to idiopathic pulmonary fibrosis [preprint] bioRxiv; 2019 [accessed 2019 May 14]. Available from: https://www.biorxiv.org/content/10.1101/636761v1 PMC7047454 31710517 · DOI
Cited by
Sorted by citations
Pulmonary fibrosis and COVID-19: the potential role for antifibrotic therapy
George, P. M., Wells, A. U., & Jenkins, R. G. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30225-3 · Cited by 1,085 · see citing works
An integrated cell atlas of the lung in health and disease
Sikkema, L., Ramírez-Suástegui, C., Strobl, D. C., Gillett, T. E., Zappia, L., Madissoon, E., Markov, N. S., Zaragosi, L., Ji, Y., Ansari, M., et al. (2023) · Nature Medicine · doi:10.1038/s41591-023-02327-2 · Cited by 856 · see citing works
Self-citationPathogenic Mechanisms Underlying Idiopathic Pulmonary Fibrosis
Moss, B. J., Ryter, S. W., & Rosas, I. O. (2021) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-042320-030240 · Cited by 838 · see citing works
Wijsenbeek, M. S., Suzuki, A., & Maher, T. M. (2022) · The Lancet · doi:10.1016/s0140-6736(22)01052-2 · Cited by 556 · see citing works
Self-citationTargeting PI3K/AKT signaling for treatment of idiopathic pulmonary fibrosis
Wang, J., Hu, K., Cai, X., Yang, B., He, Q., Wang, J., & Weng, Q. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.07.023 · Cited by 463 · see citing works
Maher, T. M. (2024) · JAMA · doi:10.1001/jama.2024.3669 · Cited by 415 · see citing works
Self-citationTGF ‐β as a driver of fibrosis: physiological roles and therapeutic opportunities
Budi, E. H., Schaub, J. R., Decaris, M. L., Turner, S., & Derynck, R. (2021) · The Journal of Pathology · doi:10.1002/path.5680 · Cited by 300 · see citing works
Roles of Macrophage Polarization and Macrophage-Derived miRNAs in Pulmonary Fibrosis
Kishore, A., & Petřek, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.678457 · Cited by 270 · see citing works
Pulmonary fibrosis: from pathogenesis to clinical decision-making
Koudstaal, T., Funke-Chambour, M., Kreuter, M., Molyneaux, P. L., & Wijsenbeek, M. S. (2023) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2023.08.010 · Cited by 259 · see citing works
Self-citationGenetic mechanisms of critical illness in Covid-19Preprint
Pairo‐Castineira, E., Clohisey, S., Klarić, L., Bretherick, A. D., Rawlik, K., Parkinson, N., Pasko, D., Walker, S., Richmond, A., Fourman, M. H., et al. (2020) · medRxiv · doi:10.1101/2020.09.24.20200048 · Cited by 237 · see citing works
Duckworth, A., Gibbons, M., Allen, R. J., Almond, H., Beaumont, R. N., Wood, A. R., Lunnon, K., Lindsay, M. A., Wain, L. V., Tyrrell, J., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30364-7 · Cited by 228 · see citing works
Self-citationHost genetic factors determining COVID-19 susceptibility and severity
Velavan, T. P., Pallerla, S. R., Rüter, J., Augustin, Y. S., Kremsner, P. G., Krishna, S., & Meyer, C. G. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103629 · Cited by 213 · see citing works
COVID-19 and pulmonary fibrosis: a potential role for lung epithelial cells and fibroblasts
John, A. E., Joseph, C., Jenkins, G., & Tatler, A. L. (2021) · Immunological Reviews · doi:10.1111/imr.12977 · Cited by 219 · see citing works
Bhattacharya, M., & Ramachandran, P. (2023) · Nature Immunology · doi:10.1038/s41590-023-01551-9 · Cited by 148 · see citing works
Precision medicine advances in idiopathic pulmonary fibrosis
Karampitsakos, Τ., Juan-Guardela, B. M., Τzouvelekis, Α., & Herazo‐Maya, J. D. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104766 · Cited by 147 · see citing works
From ARDS to pulmonary fibrosis: the next phase of the COVID-19 pandemic?
Michalski, J. E., Kurche, J. S., & Schwartz, D. A. (2021) · Translational research · doi:10.1016/j.trsl.2021.09.001 · Cited by 134 · see citing works
Self-citationCho, M. H., Hobbs, B. D., & Silverman, E. K. (2022) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00510-5 · Cited by 133 · see citing works
Self-citationThe Roles of Immune Cells in the Pathogenesis of Fibrosis
Huang, E., Peng, N., Xiao, F., Hu, D., Wang, X., & Lu, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155203 · Cited by 130 · see citing works
Air pollutants, genetic susceptibility and risk of incident idiopathic pulmonary fibrosis
Cui, F., Sun, Y., Xie, J., Li, D., Wu, M., Song, L., Hu, Y., & Tian, Y. (2022) · European Respiratory Journal · doi:10.1183/13993003.00777-2022 · Cited by 130 · see citing works
European Respiratory Society statement on familial pulmonary fibrosis
Borie, R., Kannengiesser, C., Antoniou, K. M., Bonella, F., Crestani, B., Fabre, A., Froidure, A., Galvin, L., Griese, M., Grutters, J. C., et al. (2022) · European Respiratory Journal · doi:10.1183/13993003.01383-2022 · Cited by 130 · see citing works
Self-citationAllen, R. J., Stockwell, A., Oldham, J. M., Guillén‐Guío, B., Schwartz, D. A., Maher, T. M., Flores, C., Noth, I., Yaspan, B. L., Jenkins, G. R., et al. (2022) · Thorax · doi:10.1136/thoraxjnl-2021-218577 · Cited by 126 · see citing works
Self-citationValenzi, E., Tabib, T., Papazoglou, A., Sembrat, J., Bittar, H. E. T., Rojas, M. M., & Lafyatis, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.595811 · Cited by 123 · see citing works
Cellular Senescence: Pathogenic Mechanisms in Lung Fibrosis
Parimon, T., Hohmann, M. S., & Yao, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126214 · Cited by 120 · see citing works
A second update on mapping the human genetic architecture of COVID-19
Initiative, T. C.-1. H. G., Leadership, Kanai, M., Andrews, S. J., Cordioli, M., Stevens, C. R., Neale, B. M., Daly, M. J., Ganna, A., Writing group, et al. (2023) · Nature · doi:10.1038/s41586-023-06355-3 · Cited by 121 · see citing works
Pardo, A., & Selman, M. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0373ps · Cited by 117 · see citing works
Mayr, C. H., Simon, L. M., Leuschner, G., Ansari, M., Gote-Schniering, J., Geyer, P. E., Angelidis, I., Strunz, M., Singh, P., Kneidinger, N., et al. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.202012871 · Cited by 105 · see citing works
Cell-type-specific and disease-associated expression quantitative trait loci in the human lung
Natri, H. M., Azodi, C. B. D., Peter, L. M., Taylor, C. J., Chugh, S., Kendle, R., Chung, M.-I., Flaherty, D. K., Matlock, B. K., Calvi, C. L., et al. (2024) · Nature Genetics · doi:10.1038/s41588-024-01702-0 · Cited by 117 · see citing works
Idiopathic pulmonary fibrosis.
Koudstaal, T., & Wijsenbeek, M. S. (2023) · La Presse Médicale · doi:10.1016/j.lpm.2023.104166 · Cited by 105 · see citing works
Shared genetic etiology between idiopathic pulmonary fibrosis and COVID-19 severity
Fadista, J., Kraven, L. M., Karjalainen, J. M., Andrews, S. J., Geller, F., Initiative, T. C.-1. H. G., Baillie, J. K., Wain, L. V., Jenkins, G. R., & Feenstra, B. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103277 · Cited by 90 · see citing works
Self-citationMolecular Mechanisms and Cellular Contribution from Lung Fibrosis to Lung Cancer Development
Samarelli, A. V., Masciale, V., Aramini, B., Coló, G. P., Tonelli, R., Marchioni, A., Bruzzi, G., Gozzi, F., Andrisani, D., Castaniere, I., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212179 · Cited by 92 · see citing works
Wang, L., Balmat, T. J., Antonia, A. L., Constantine, F. J., Henao, R., Burke, T. W., Ingham, A., McClain, M. T., Tsalik, E. L., Ko, E. R., et al. (2021) · Genome Medicine · doi:10.1186/s13073-021-00904-z · Cited by 86 · see citing works
Idiopathic Pulmonary Fibrosis Is Associated with Common Genetic Variants and Limited Rare Variants
Peljto, A. L., Blumhagen, R. Z., Walts, A. D., Cardwell, J., Powers, J., Corte, T. J., Dickinson, J. L., Glaspole, I., Moodley, Y. P., Vašáková, M., et al. (2023) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202207-1331oc · Cited by 81 · see citing works
Self-citationSrc family kinases and pulmonary fibrosis: A review
Li, H., Zhao, C., Tian, Y., Lü, J., Zhang, G., Liang, S., Chen, D., Liu, X., Kuang, W., & Zhu, M. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110183 · Cited by 78 · see citing works
Bowman, W. S., Echt, G., & Oldham, J. M. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.680997 · Cited by 76 · see citing works
Self-citationAdegunsoye, A., Kropski, J. A., Behr, J., Blackwell, T. S., Corte, T. J., Cottin, V., Glanville, A. R., Glassberg, M. K., Griese, M., Hunninghake, G. M., et al. (2024) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202401-0238so · Cited by 75 · see citing works
Self-citationAllen, R. J., Oldham, J. M., Jenkins, D. A., Leavy, O. C., Guillén‐Guío, B., Melbourne, C., Ma, S., Jou, J., Kim, J. S., CleanUP-IPF Investigators of the Pulmonary Trials Cooperative, et al. (2022) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(22)00251-x · Cited by 68 · see citing works
Self-citationEnvironmental Causes of Idiopathic Pulmonary Fibrosis
Gandhi, S. A., Tonelli, R., Murray, M., Samarelli, A. V., & Spagnolo, P. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216481 · Cited by 68 · see citing works
Cellular Senescence in Idiopathic Pulmonary Fibrosis
Kellogg, D. L., Kellogg, D. L., Musi, N., & Nambiar, A. M. (2021) · Current Molecular Biology Reports · doi:10.1007/s40610-021-00145-4 · Cited by 67 · see citing works
A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities
Moll, M. R., Peljto, A. L., Kim, J. S., Xu, H., Debban, C. L., Chen, X., Menon, A. A., Putman, R. K., Ghosh, A., Saferali, A., et al. (2023) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202212-2257oc · Cited by 63 · see citing works
Self-citationCutting, C. C., Bowman, W. S., Đao, N. H., Pugashetti, J. V., Garcia, C. K., Oldham, J. M., & Newton, C. A. (2021) · CHEST Journal · doi:10.1016/j.chest.2021.01.026 · Cited by 64 · see citing works
Self-citationPartanen, J., Häppölä, P., Zhou, W., Lehistö, A., Ainola, M., Sutinen, E., Allen, R. J., Stockwell, A., Leavy, O. C., Oldham, J. M., et al. (2022) · Cell Genomics · doi:10.1016/j.xgen.2022.100181 · Cited by 61 · see citing works
Self-citationRare and Common Variants in KIF15 Contribute to Genetic Risk of Idiopathic Pulmonary Fibrosis
Zhang, D., Povysil, G., Kobeissy, P. H., Li, Q., Wang, B., Amelotte, M., Jaouadi, H., Newton, C. A., Maher, T. M., Molyneaux, P. L., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202110-2439oc · Cited by 56 · see citing works
Self-citationPulmonary fibrosis: Emerging diagnostic and therapeutic strategies
Selvarajah, B., Platé, M., & Chambers, R. C. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2023.101227 · Cited by 57 · see citing works
DPP9 deficiency: An inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling
Harapas, C. R., Robinson, K. S., Lay, K., Wong, J., Traspas, R. M., Nabavizadeh, N., Raas‐Rothschild, A., Boisson, B., Drutman, S. B., Laohamonthonkul, P., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abi4611 · Cited by 57 · see citing works
Genetic Risk Factors for Idiopathic Pulmonary Fibrosis: Insights into Immunopathogenesis
Michalski, J. E., & Schwartz, D. A. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s280958 · Cited by 55 · see citing works
Self-citationIdentification of a missense variant in SPDL1 associated with idiopathic pulmonary fibrosis
Dhindsa, R. S., Mattsson, J., Nag, A., Wang, Q., Wain, L. V., Allen, R. J., Wigmore, E. M., Ibáñez, K., Vitsios, D., Deevi, S. V. V., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-01910-y · Cited by 56 · see citing works
Self-citationMolyneaux, P. L., Fahy, W. A., Byrne, A. J., Braybrooke, R., Saunders, P. T., Toshner, R., Albers, G. J., Chua, F., Renzoni, E. A., Wells, A. U., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202107-1769oc · Cited by 52 · see citing works
Self-citationThe Proteomic Profile of Interstitial Lung Abnormalities
Axelsson, G. T., Guðmundsson, G., Pratte, K., Aspelund, T., Putman, R. K., Sanders, J. L., Gudmundsson, E. F., Hatabu, H., Guðmundsdóttir, V., Guðjónsson, A., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202110-2296oc · Cited by 52 · see citing works
Self-citationGenetics of chronic respiratory disease
Sayers, I., John, C., Chen, J., & Hall, I. P. (2024) · Nature Reviews Genetics · doi:10.1038/s41576-024-00695-0 · Cited by 52 · see citing works
Self-citationTargeting Growth Factor and Cytokine Pathways to Treat Idiopathic Pulmonary Fibrosis
Ma, H., Liu, S., Li, S., & Xia, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.918771 · Cited by 51 · see citing works
Update in Interstitial Lung Disease 2020
Podolanczuk, A. J., Wong, A. W., Saito, S., Lasky, J. A., Ryerson, C. J., & Eickelberg, O. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202103-0559up · Cited by 52 · see citing works
Molecular Signatures of Idiopathic Pulmonary Fibrosis
Konigsberg, I. R., Borie, R., Walts, A. D., Cardwell, J., Rojas, M., Metzger, F., Hauck, S. M., Fingerlin, T. E., Yang, I. V., & Schwartz, D. A. (2021) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0546oc · Cited by 50 · see citing works
Self-citationHao, Y. T., Bates, S., Mou, H., Yun, J. H., Pham, B., Liu, J., Qiu, W., Guo, F., Morrow, J. D., Hersh, C. P., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201910-1958oc · Cited by 49 · see citing works
Self-citationA Causal Atlas on Comorbidities in Idiopathic Pulmonary Fibrosis
Zhu, J., Zhou, D., Wang, J., Yang, Y., Chen, D., He, F., & Li, Y. (2023) · CHEST Journal · doi:10.1016/j.chest.2023.02.038 · Cited by 47 · see citing works
Borie, R., Cardwell, J., Konigsberg, I. R., Moore, C. M., Zhang, W. E., Sasse, S. K., Gally, F., Dobrinskikh, E., Walts, A. D., Powers, J., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202110-2308oc · Cited by 45 · see citing works
Self-citationCellular and Molecular Mechanisms in Idiopathic Pulmonary Fibrosis
Zhang, Y., & Wang, J. (2023) · Advances in respiratory medicine · doi:10.3390/arm91010005 · Cited by 44 · see citing works
Self-citationZhang, Y., Gu, L., Xia, Q., Tian, L., Jia, Q., & Cao, M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00415 · Cited by 45 · see citing works
Self-citationLung histopathological findings in COVID-19 disease – a systematic review
Pannone, G., Caponio, V. C. A., Stefano, I. S. D., Ramunno, M. A., Meccariello, M., Agostinone, A., Pedicillo, M. C., Troiano, G., Zhurakivska, K., Cassano, T., et al. (2021) · Infectious Agents and Cancer · doi:10.1186/s13027-021-00369-0 · Cited by 43 · see citing works
McErlean, P. K., Bell, C. G., Hewitt, R. J., Busharat, Z., Ogger, P. P., Ghai, P., Albers, G. J., Calamita, E., Kingston, S., Molyneaux, P. L., et al. (2021) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202101-0004oc · Cited by 42 · see citing works
Self-citationIncidence and Progression of Fibrotic Lung Disease in an At-Risk Cohort
Steele, M. P., Peljto, A. L., Mathai, S. K., Humphries, S. M., Bang, T. J., Oh, A. S., Teague, S. D., Cicchetti, G., Sigakis, C. J. G., Kropski, J. A., et al. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202206-1075oc · Cited by 42 · see citing works
Self-citationPCSK6 and Survival in Idiopathic Pulmonary Fibrosis
Oldham, J. M., Allen, R. J., Lorenzo-Salazar, J. M., Molyneaux, P. L., Ma, S., Joseph, C., Kim, J. S., Guillén‐Guío, B., Hernández-Beeftink, T., Kropski, J. A., et al. (2023) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202205-0845oc · Cited by 42 · see citing works
Self-citationXu, F., Tanabe, N., Vasilescu, D. M., McDonough, J. E., Coxson, H. O., Ikezoe, K., Kinose, D., Ng, K. W., Verleden, S. E., Wuyts, W. A., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103325 · Cited by 41 · see citing works
Toll-Interacting Protein in Pulmonary Diseases. Abiding by the Goldilocks Principle
Li, X., Goobie, G. C., Gregory, A. D., Kass, D. J., & Zhang, Y. (2020) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2020-0470tr · Cited by 40 · see citing works
Self-citationZhang, Y., Zhao, M., Guo, P., Wang, Y., Liu, L., Zhao, J., Gao, L., Yuan, Z., Xue, F., & Zhao, J. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103669 · Cited by 40 · see citing works
Self-citationGenome-wide association studies of COVID-19: Connecting the dots
Ferreira, L. C., Gomes, C. E. M., Rodrigues-Neto, J. F., & Jerônimo, S. M. B. (2022) · Infection Genetics and Evolution · doi:10.1016/j.meegid.2022.105379 · Cited by 40 · see citing works
Li, X., Goobie, G. C., & Zhang, Y. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01999-4 · Cited by 39 · see citing works
Self-citationZhang, K., Li, A., Zhou, J., Zhang, C., & Chen, M. (2023) · Respiratory Research · doi:10.1186/s12931-022-02309-x · Cited by 38 · see citing works
Mohammed, O. A., Abdel‐Reheim, M. A., Saleh, L. A., Alamri, M. M. S., Alfaifi, J. A., Adam, M. I. E., Farrag, A. A. M., AlQahtani, A. A. J., BinAfif, W. F., Hashish, A. A., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16081123 · Cited by 38 · see citing works
Leavy, O. C., Ma, S., Molyneaux, P. L., Maher, T. M., Oldham, J. M., Flores, C., Noth, I., Jenkins, G. R., Dudbridge, F., Wain, L. V., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202008-3211le · Cited by 38 · see citing works
Self-citationAlternative splicing in lung influences COVID-19 severity and respiratory diseases
Nakanishi, T., Willett, J., Farjoun, Y., Allen, R. J., Guillén‐Guío, B., Adra, D., Zhou, S., & Richards, J. B. (2023) · Nature Communications · doi:10.1038/s41467-023-41912-4 · Cited by 34 · see citing works
Self-citationQian, W., Cai, X., & Qian, Q. (2020) · Aging · doi:10.18632/aging.102882 · Cited by 36 · see citing works
Jönsson, E., Ljung, L., Norrman, E., Freyhult, E., Ärlestig, L., Dahlqvist, J., & Rantapää‐Dahlqvist, S. (2021) · Lara D. Veeken · doi:10.1093/rheumatology/keab441 · Cited by 36 · see citing works
Cloning a profibrotic stem cell variant in idiopathic pulmonary fibrosis
Wang, S., Rao, W. H., Hoffman, A., Lin, J. M., Li, J., Lin, T., Liew, A.-A., Vincent, M., Mertens, T. C. J., Karmouty‐Quintana, H., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abp9528 · Cited by 35 · see citing works
Self-citationProgressive lung fibrosis: reprogramming a genetically vulnerable bronchoalveolar epithelium
Bridges, J. P., Vladar, E. K., Kurche, J. S., Krivoi, A., Stancil, I. T., Dobrinskikh, E., Hu, Y., Sasse, S. K., Lee, J. S., Blumhagen, R. Z., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci183836 · Cited by 37 · see citing works
Self-citationLung regeneration: diverse cell types and the therapeutic potential
Chen, Y., Li, Z., Ji, G., Wang, S., Mo, C., & Ding, B. (2024) · MedComm · doi:10.1002/mco2.494 · Cited by 35 · see citing works
Beghé, B., Cerri, S., Fabbri, L. M., & Marchioni, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179292 · Cited by 33 · see citing works
Idiopathic pulmonary fibrosis and the role of genetics in the era of precision medicine
Alonso-González, A., Tosco-Herrera, E., Molina‐Molina, M., & Flores, C. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1152211 · Cited by 33 · see citing works
Self-citationCommon idiopathic pulmonary fibrosis risk variants are associated with hypersensitivity pneumonitis
Furusawa, H., Peljto, A. L., Walts, A. D., Cardwell, J., Molyneaux, P. L., Lee, J. S., Pérez, E. R. F., Wolters, P. J., Yang, I. V., & Schwartz, D. A. (2022) · Thorax · doi:10.1136/thoraxjnl-2021-217693 · Cited by 33 · see citing works
Self-citationIncidence of interstitial lung abnormalities: the MESA Lung Study
McGroder, C. F., Hansen, S. L., Stukovsky, K. H., Zhang, D., Nath, H. P., Salvatore, M. M., Sonavane, S. K., Terry, N. L. J., Stowell, J. T., D’Souza, B. M., et al. (2023) · European Respiratory Journal · doi:10.1183/13993003.01950-2022 · Cited by 32 · see citing works
Self-citationDissecting the Role of Mesenchymal Stem Cells in Idiopathic Pulmonary Fibrosis: Cause or Solution
Samarelli, A. V., Tonelli, R., Heijink, I. H., Medina, A. M., Marchioni, A., Bruzzi, G., Castaniere, I., Andrisani, D., Gozzi, F., Manicardi, L., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.692551 · Cited by 32 · see citing works
The role of interleukin-33 in organ fibrosis
Carmine, S. D., Scott, M. M., McLean, M. H., & McSorley, H. J. (2022) · Discovery Immunology · doi:10.1093/discim/kyac006 · Cited by 30 · see citing works
Pulmonary Sequelae of COVID-19: Focus on Interstitial Lung Disease
Johnston, J., Dorrian, D., Linden, D. A., Stanel, S. C., Rivera‐Ortega, P., & Chaudhuri, N. (2023) · Cells · doi:10.3390/cells12182238 · Cited by 30 · see citing works
The Dawn of Precision Medicine in Fibrotic Interstitial Lung Disease
Karampitsakos, Τ., Tourki, B., & Herazo‐Maya, J. D. (2024) · CHEST Journal · doi:10.1016/j.chest.2024.10.042 · Cited by 31 · see citing works
C-MYC induces idiopathic pulmonary fibrosis via modulation of miR-9-5p-mediated TBPL1
Qin, H., Tang, Y., Mao, Y., Zhou, X., Xu, T., Liu, W., & Su, X. (2022) · Cellular Signalling · doi:10.1016/j.cellsig.2022.110274 · Cited by 30 · see citing works
Interstitial lung abnormalities are associated with decreased mean telomere length
Putman, R. K., Axelsson, G. T., Ash, S. Y., Sanders, J. L., Menon, A. A., Araki, T., Nishino, M., Yanagawa, M., Gudmundsson, E. F., Qiao, D., et al. (2022) · European Respiratory Journal · doi:10.1183/13993003.01814-2021 · Cited by 28 · see citing works
Self-citationVerma, A., Tsao, N. L., Thomann, L. O., Ho, Y.-L. A., Iyengar, S. K., Luoh, S., Carr, R. M., Crawford, D. C., Efird, J. T., Huffman, J. E., et al. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010113 · Cited by 28 · see citing works
Rackow, A. R., Nagel, D. J., McCarthy, C., Judge, J., Lacy, S. H., Freeberg, M. A. T., Thatcher, T. H., Kottmann, R. M., & Sime, P. J. (2020) · European Respiratory Journal · doi:10.1183/13993003.00075-2020 · Cited by 28 · see citing works
Ghosh, A., Hobbs, B. D., Yun, J. H., Saferali, A., Moll, M. R., Xu, Z., Chase, R., Morrow, J. D., Ziniti, J. P., Sciurba, F. C., et al. (2022) · Respiratory Research · doi:10.1186/s12931-022-02013-w · Cited by 27 · see citing works
Self-citationWang, Q., Xie, Z., Wu, Q., Jin, Z., Yang, C., & Feng, J. (2021) · Chinese Medical Journal · doi:10.1097/cm9.0000000000001288 · Cited by 26 · see citing works
Lifestyle, Genetic Susceptibility, and the Risk of Idiopathic Pulmonary Fibrosis
Ma, Y., Cui, F., Li, D., Wang, J., Tang, L., Xie, J., Hu, Y., & Tian, Y. (2023) · CHEST Journal · doi:10.1016/j.chest.2023.04.008 · Cited by 26 · see citing works
Mapping brain endophenotypes associated with idiopathic pulmonary fibrosis genetic risk
Mohammadi‐Nejad, A., Allen, R. J., Kraven, L. M., Leavy, O. C., Jenkins, G. R., Wain, L. V., Auer, D. P., & Sotiropoulos, S. N. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104356 · Cited by 25 · see citing works
Self-citationDemystifying pulmonary fibrosis
Jenkins, G. R. (2020) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00365.2020 · Cited by 23 · see citing works
Cell type-specific and disease-associated eQTL in the human lungPreprint
Natri, H. M., Azodi, C. B. D., Peter, L. M., Taylor, C. J., Chugh, S., Kendle, R., Chung, M.-I., Flaherty, D. K., Matlock, B. K., Calvi, C. L., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.17.533161 · Cited by 24 · see citing works
Multi-omics and multi-stages integration identified a novel variant associated with silicosis risk
Jin, C., Tao, X., Zhang, W., Xu, H., Wu, Y., Chen, Q., Li, S., Ning, A., Wang, W., Wu, Q., et al. (2024) · Archives of Toxicology · doi:10.1007/s00204-024-03795-2 · Cited by 23 · see citing works
Self-citationDistinguishing constitutional from acquired bone marrow failure in the hematology clinic
Groarke, E. M., Young, N. S., & Calvo, K. R. (2021) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2021.101275 · Cited by 23 · see citing works
Zhou, Y., Zhang, Y., Zhao, R., Cheng, Z., Tang, M., Qiu, A., Yang, D., Lu, Y., Lian, Y., Zhuang, X., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.796932 · Cited by 23 · see citing works
Self-citationRiesmeijer, S. A., Kamali, Z., Ng, M., Drichel, D., Piersma, B., Becker, K., Layton, T. B., Nanchahal, J., Nothnagel, M., Vaez, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44451-0 · Cited by 21 · see citing works
Self-citationAdvances in idiopathic pulmonary fibrosis diagnosis and treatment
Liu, H., Shen, J., & He, C. (2025) · Chinese Medical Journal - Pulmonary and Critical Care Medicine · doi:10.1016/j.pccm.2025.02.001 · Cited by 21 · see citing works
Familial Interstitial Lung Disease
Kropski, J. A. (2020) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0040-1708054 · Cited by 22 · see citing works
Diagnostic Classification of Interstitial Lung Disease in Clinical Practice
Adegunsoye, A., & Ryerson, C. J. (2021) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2021.03.002 · Cited by 21 · see citing works
Self-citation
- Authors
- Allen, R. J., Guillen-Guio, B., Oldham, J. M., Ma, S.-F., Dressen, A., Paynton, M. L., Kraven, L. M., Obeidat, M., Li, X., Ng, M., Braybrooke, R., Molina-Molina, M., Hobbs, B. D., Putman, R. K., Sakornsakolpat, P., Booth, H. L., Fahy, W. A., Hart, S. P., Hill, M. R., Hirani, N., Hubbard, R. B., McAnulty, R. J., Millar, A. B., Navaratnam, V., Oballa, E., Parfrey, H., Saini, G., Whyte, M. K. B., Zhang, Y., Kaminski, N., Adegunsoye, A., Strek, M. E., Neighbors, M., Sheng, X. R., Gudmundsson, G., Gudnason, V., Hatabu, H., Lederer, D. J., Manichaikul, A., Newell, J. D., O’Connor, G. T., Ortega, V. E., Xu, H., Fingerlin, T. E., Bossé, Y., Hao, K., Joubert, P., Nickle, D. C., Sin, D. D., Timens, W., Furniss, D., Morris, A. P., Zondervan, K. T., Hall, I. P., Sayers, I., Tobin, M. D., Maher, T. M., Cho, M. H., Hunninghake, G. M., Schwartz, D. A., Yaspan, B. L., Molyneaux, P. L., Flores, C., Noth, I., Jenkins, R. G., & Wain, L. V.
- Affiliations
- University of Leicester (GB)
- Unidad de Investigacion, Hospital Universitario Ntra. Sra. de Candelaria and
- University of California, Davis (US)
- Division of Pulmonary and Critical Care Medicine
- Genentech (US)
- University of British Columbia (CA)
- Nuffield Orthopaedic Centre (GB)
- National Institute for Health and Care Research (GB)
- Servei de Pneumologia, Laboratori de Pneumologia Experimental, Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Barcelona, Spain
- Channing Division of Network Medicine
- Siriraj Hospital (TH)
- University College London Hospitals NHS Foundation Trust (GB)
- GlaxoSmithKline (United Kingdom) (GB)
- Castle Hill Hospital (GB)
- Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health
- Centre for Inflammation Research (GB)
- University College London (GB)
- University of Bristol (GB)
- Division of Epidemiology and Public Health and
- Royal Papworth Hospital (GB)
- Nottingham University Hospitals NHS Trust (GB)
- University of Pittsburgh (US)
- Yale University (US)
- University of Chicago (US)
- Department of Respiratory Medicine, Landspital University Hospital, Reykjavik, Iceland
- University of Iceland (IS)
- Brigham and Women's Hospital (US)
- Columbia University (US)
- University of Virginia (US)
- University of Iowa (US)
- Boston University (US)
- Wake Forest University Health Sciences (US)
- National Jewish Health (US)
- Institut universitaire de cardiologie et de pneumologie de Québec (CA)
- Icahn School of Medicine at Mount Sinai (US)
- Merck & Co., Inc., Rahway, NJ, USA (United States) (US)
- University Medical Center Groningen (NL)
- Centre for Human Genetics (GB)
- University of Nottingham (GB)
- Universidad de La Laguna (ES)
- National Institute for Health Research, Nottingham Biomedical Research Centre and
- Corresponding author
- Wain, Louise V.
- ORCID
- Allen, Richard J.
- Oldham, Justin M.
- Ma, Shwu-Fan
- Dressen, Amy
- Paynton, Megan L.
- Kraven, Luke M.
- Obeidat, Ma'en
- Li, Xuan
- Ng, Michael
- Braybrooke, Rebecca
- Hobbs, Brian D.
- Putman, Rachel K.
- Sakornsakolpat, Phuwanat
- Fahy, William A.
- Hart, Simon P.
- Hirani, Nik
- Hubbard, Richard B.
- McAnulty, Robin J.
- Navaratnam, Vidyia
- Parfrey, Helen
- Saini, Gauri
- Whyte, Moira K. B.
- Zhang, Yingze
- Kaminski, Naftali
- Adegunsoye, Ayodeji
- Strek, Mary E.
- Neighbors, Margaret
- Gudnason, Vilmundur
- Hatabu, Hiroto
- Lederer, David J.
- Manichaikul, Ani
- Newell, John D.
- O’Connor, George T.
- Ortega, Victor E.
- Xu, Hanfei
- Fingerlin, Tasha E.
- Bossé, Yohan
- Hao, Ke
- Joubert, Philippe
- Nickle, David C.
- Sin, Don D.
- Timens, Wim
- Furniss, Dominic
- Morris, Andrew P.
- Zondervan, Krina T.
- Hall, Ian P.
- Sayers, Ian
- Tobin, Martin D.
- Maher, Toby M.
- Cho, Michael H.
- Hunninghake, Gary M.
- Schwartz, David A.
- Yaspan, Brian L.
- Molyneaux, Philip L.
- Flores, Carlos
- Noth, Imre
- Wain, Louise V.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2020-03-01
- Volume
- 201
- Issue
- 5
- Pages
- 564-574
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- PMC
- PMC7047454
- OpenAlex
- W2983449145
- Cited by
- 329
- References
- 62
- Citations by year
- 2026: 37 · 2025: 49 · 2024: 37 · 2023: 67 · 2022: 53 · 2021: 54 · 2020: 28 · 2019: 3
- FWCI
- 26.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- American Journal of Respiratory and Critical Care Medicine (publishedVersion, cc-by)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, other-oa)
- Edinburgh Research Explorer (University of Edinburgh) (acceptedVersion, other-oa)
- Repository@Hull (Worktribe) (University of Hull) (submittedVersion, cc-by)
- Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Opin vísindi (Opin vísindi) (submittedVersion, cc-by)
- Research Explorer (The University of Manchester) (submittedVersion, cc-by-nc-nd)
- Spiral (Imperial College London) (submittedVersion, other-oa)
- Hirsla (Landspítali University Hospital) (submittedVersion, other-oa)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion, other-oa)
- Funders
- U.S. Department of Veterans Affairs (CDA13-017)
- Wellcome Trust (WT202849/Z/16/Z, 95161, /Z/11/Z, WT202849, 097152, 097152/Z/11/Z)
- Broad Institute
- Ministerio de Ciencia, Innovación y Universidades (RTC-2017-6471-1, OA17/008, RTC-2017, PT17/0019)
- Instituto Tecnológico y de Energías Renovables (OA17/008, RTC-2017-6471-1)
- Michael Smith Health Research BC
- National Institute for Health and Care Research (RP-2017-08-ST2-014, NF-SI-0617-10096, CS-2013-13-017)
- British Lung Foundation (C17-3, WT202849/Z/16/Z)
- Asthma and Lung UK (RP-2017-08-ST2-014, AUK-PG-2013-188)
- University of Leicester
- European Commission (2013-2016, PT17/0019)
- Agencia Canaria de Investigación, Innovación y Sociedad de la Información (OA17/008, TESIS2015010057)
- National Institutes of Health (n01hc95164-17-0-1, UL1TR001420, n01hc95165-34-0-1, n01hc95161-24-0-1, n01hc095169-003, N01-HC- 95166, 2013-2016, n01hc95166-21-0-1, N01-HC9-5168, R01130974, n01hc95162-31-0-1, n01hc95168-27-0-1, n01hc95160-18-0-1, n01hc095167-000, N01-HC- 95159, UL1TR001079, n01hc95163-22-0-1, PT17/0019, HHSN263201500003I, n02hl64278-6-0-0, HHSN268201500003I, n01hc95159-40-0-1, UL1TR000040, UL1-TR-, N01‐HC‐95161, N01- HC-95163, N01- HC-95165, N01‐HC‐95160, N01 HC95164, N01-HC-95167, N02-HL-64278, N01-HC95162, N01‐HC‐95169, HL136928, DK-063491, UL1TR001863, UL1TR001881)
- Medical Research Council (MC_PC_12010, G1000861, MR/N005953/1)
- Instituto de Salud Carlos III (2013-2016, PT17/0019)
- European Regional Development Fund (RTC-2017-6471-1, PT17/0019, of the PE I+D+i 2013-2016, RTC-2017, PE I+D+i 2013-2016, OA17/008, PT17/0019, 000040, 2013-2016)
- Agencia Estatal de Investigación (RTC-2017-6471-1)
- NIHR Leicester Biomedical Research Centre
- NIHR Nottingham Biomedical Research Centre
- National Heart, Lung, and Blood Institute (DK-063491, R01HL130796, N01 HC-95159, N01-HC-95160, R01HL097163, N01-HC095169, RTC-2017-6471-1, WT202849/Z/16/Z, N01 HC-95168, N01-HC-095165, R01HL113264, HL131565, N01 HC95167, K23HL138190, (N01-HC-95163, N01 HC095163, N01 HC-95161, N01 HC95165, N01HC95164, HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95167, N01-HC-95168, N01-HC-95169, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, R01HL137927, R01HL103676, N02 HL064278, CS-2013-13-017, UG3HL151865, N01-HC-95167, N01-HC-95168, UL1-TR-, N01-HC-095159, N01-HC, N01 HC095168, N02- HL-64278, N01-HC-095162, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95161, N01-HC-95162, N01-HC-95163, HC-95168, N01-HC-095161, HL136928, R01HL111024, HHSN268201500003C, HHSN26820150 0003I, R01HL149836, HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01, N01 HC095167, C17-3, K08HL136928, K08HL140087, N01-HC-095160, R01HL137234, N01 HC095166, HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01 HC095164, UL1-TR-000040, UL1-TR-001079, UL1-TR-001420, N01‐HC‐95166, R33HL120770, P01HL092870, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, RP-2017-08-ST2-014, N01-HC-95159, N01-HC-95160, N01 HC-95162, R01HL131565, HC95159, UH3HL151865, R01HL130974, T32HL007085, R01HL135142, HL64278, N01 HC95169)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK063491)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
- Keywords
- idiopathic pulmonary fibrosis, genetic susceptibility, genome-wide association study, KIF15, MAD1L1, DEPTOR, mTOR signaling, mitotic spindle assembly, polygenic risk score, gene expression, regulatory elements, pulmonary fibrosis
- MeSH terms
- Aged, Female, Humans, Male, Middle Aged, Spindle Apparatus, Signal Transduction, Gene Expression, Case-Control Studies, Kinesins, Risk Assessment, Cell Cycle Proteins, Genetic Predisposition to Disease, Intracellular Signaling Peptides and Proteins, Idiopathic Pulmonary Fibrosis, Genome-Wide Association Study, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
