Ipilimumab-induced autoimmune adrenalitis

Min, Le; Ibrahim, Nageatte

doi:10.1016/s2213-8587(13)70031-7

Cited by 112Adrenal Hormones and DisordersCancer Immunotherapy and BiomarkersPituitary Gland Disorders and Treatments

Ipilimumab-induced autoimmune adrenalitis

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Min, Le, Ibrahim, Nageatte·2013·The Lancet Diabetes & Endocrinology

DOI 10.1016/s2213-8587(13)70031-7PMC PMC4106239

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Adrenal insufficiency occurs in about 1% of immune checkpoint inhibitor users and more frequently in those receiving combination regimens such as anti-CTLA4 plus anti-PD1/PD-L1 agents, where it occurs in 4% to 8%.
“The occurrence of AI in ICI users has been reported in about 1% of cases and more frequently in individuals receiving combination regimens like anti-CTLA4 plus anti-PD1/PD-L1 agents (4%-8%) (25, 28, 29).”
From The Changing Face of Drug-induced Adrenal Insufficiency in the Food and Drug Administration Adverse Event Reporting System (2022) · cites this paper as [28]

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“Min L, Ibrahim N. Ipilimumab-induced autoimmune adrenalitis.”
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“…them, such as the ipilimumab-associated colitis (Kim et al., 2013a), hepatitis (Kim et al., 2013b), alveolitis (Rao and Grumett, 2016), adrenalitis (Min and Ibrahim, 2013) and hypophisitis (Albarel et al., 2015) are evident on imaging and should always be well documented and reported during the…”
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Authors: Min, L., & Ibrahim, N.
Affiliations: Brigham and Women's Hospital (US)
Dana-Farber Cancer Institute (US)
ORCID: Min, Le
Ibrahim, Nageatte
Venue: The Lancet Diabetes & Endocrinology
Publisher: Elsevier BV
Published: 2013-11
Volume: 1
Issue: 3
Pages: e15
ISSN: 2213-8587 (ISSN-L)
DOI: 10.1016/s2213-8587(13)70031-7
PMC: PMC4106239
OpenAlex: W2032060513
Cited by: 112
References: 0
Citations by year: 2026: 2 · 2025: 5 · 2024: 5 · 2023: 9 · 2022: 10 · 2021: 15 · 2020: 19 · 2019: 16 · 2018: 10 · 2017: 8 · 2016: 7 · 2015: 4 · 2014: 1 · 2013: 1
FWCI: 3.42
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: The Lancet Diabetes & Endocrinology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007529)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (K08HD070957)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords: ipilimumab, autoimmune adrenalitis, Addison's disease, secondary adrenal insufficiency, CTLA-4 blockade, melanoma, hypophysitis, aldosterone, hydrocortisone replacement
MeSH terms: Ipilimumab, Adrenal Gland Diseases, Adrenal Insufficiency, Antibodies, Monoclonal, Autoimmune Diseases, Female, Humans, Inflammation, Melanoma, Middle Aged, Tomography, X-Ray Computed

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