Cancer immunotherapy—immune checkpoint blockade and associated endocrinopathies.

Byun, David J.; Wolchok, Jedd D.; Rosenberg, Lynne M.; Girotra, Monica

doi:10.1038/nrendo.2016.205

Cited by 685Cancer Immunotherapy and BiomarkersAdrenal Hormones and DisordersPituitary Gland Disorders and Treatments

Cancer immunotherapy—immune checkpoint blockade and associated endocrinopathies.

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Byun, David J., Wolchok, Jedd D., Rosenberg, Lynne M., Girotra, Monica·2017·Nature Reviews Endocrinology

DOI 10.1038/nrendo.2016.205PMC PMC5629093

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Abstract

Advances in cancer therapy in the past few years include the development of medications that modulate immune checkpoint proteins. Cytotoxic T-lymphocyte antigen 4 (CTLA4) and programmed cell death protein 1 (PD1) are two co-inhibitory receptors that are expressed on activated T cells against which therapeutic blocking antibodies have reached routine clinical use. Immune checkpoint blockade can induce inflammatory adverse effects, termed immune-related adverse events (IRAEs), which resemble autoimmune disease. In this Review, we describe the current data regarding immune-related endocrinopathies, including hypophysitis, thyroid dysfunction and diabetes mellitus. We discuss the clinical management of these endocrinopathies within the context of our current understanding of the mechanisms of IRAEs.

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Thyroid tissue B cells are activated, leading to the secretion of antithyroid antibodies such as antithyroid peroxidase and antithyroglobulin antibodies, which, coupled with T-cell-mediated and cytokine-mediated apoptosis, result in thyroid gland injury.
“Thyroid tissue B cells are activated, leading to the secretion of antithyroid antibodies such as antithyroid peroxidase and antithyroglobulin antibodies, which, coupled with T-cell-mediated and cytokine-mediated apoptosis, result in thyroid gland injury. 38”
From Hypothyroidism: A Review (2025) · cites this paper as [38]
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[78]Grob JJ Hamid O Wolchok J Proceedings of the Joint ECCO 15–34th ESMO Multidisciplinary Congress Berlin, Germany 2009
[85]Agabegi SS Derby EA Step-up To Medicine 3 170 171 Lippincott Williams & Wilkins 2013

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Retrospective Side Effect Profiling of the Metastatic Melanoma Combination Therapy Ipilimumab-Nivolumab Using Adverse Event Data
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Authors: Byun, D. J., Wolchok, J. D., Rosenberg, L. M., & Girotra, M.
Affiliations: Memorial Sloan Kettering Cancer Center (US)
Weill Cornell Medicine (US)
Corresponding author: Wolchok, Jedd D.
Girotra, Monica
ORCID: Byun, David J.
Wolchok, Jedd D.
Rosenberg, Lynne M.
Girotra, Monica
Venue: Nature Reviews Endocrinology
Publisher: Springer Science and Business Media LLC
Published: 2017-01-20
Volume: 13
Issue: 4
Pages: 195-207
ISSN: 1759-5029 (ISSN-L)
1759-5037
DOI: 10.1038/nrendo.2016.205
PMC: PMC5629093
OpenAlex: W2577007969
Cited by: 685
References: 136
Citations by year: 2026: 36 · 2025: 46 · 2024: 65 · 2023: 62 · 2022: 78 · 2021: 99 · 2020: 95 · 2019: 89 · 2018: 77 · 2017: 38
FWCI: 8.58
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Endocrinology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (P30CA008748)
Topics: Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords: cancer immunotherapy, immune checkpoint blockade, immune-related adverse events, immune-related endocrinopathy, hypophysitis, thyroid dysfunction, CTLA-4, PD-1, co-inhibitory receptors
MeSH terms: Ipilimumab, Animals, Antibodies, Monoclonal, Endocrine System Diseases, Humans, Immunotherapy, Neoplasms, CTLA-4 Antigen, Programmed Cell Death 1 Receptor

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Cancer immunotherapy—immune checkpoint blockade and associated endocrinopathies.

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