Primary aldosteronism in patients with adrenal incidentaloma: is screening appropriate for everyone?
Open accessAbstract
Primary aldosteronism (PA) is a common form of secondary hypertension. Several guidelines recommend that patients with adrenal incidentaloma have a high probability of suffering from PA. We conducted a prospective study of 269 consecutive adults with adrenal incidentaloma to investigate the prevalence and clinical characteristics of PA. In total, 9 participants were detected with PA, suggesting a prevalence of 3.35% among the study population. PA participants had a higher blood pressure level by 14/20.8 mm Hg and a lower serum potassium level by 0.8 mmol/L (P < .05). Importantly, all patients with PA presented with concurrent indications (hypertension with or without hypokalemia) for screening of the disease, but they have not undergone relative screening by the referring physician, thus casting doubts about the appropriate implementation of current guidelines in real-life practice. Intense efforts are needed to familiarize physicians with recommendations for PA to minimize undiagnosed cases and the detrimental sequelae of this endocrine form of hypertension.
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Hyperaldosteronism in AI is relatively uncommon compared with cortisol hypersecretion or pheochromocytoma.
“The discovery of hyperaldosteronism in the context of an AI is relatively uncommon, compared with the detection of cortisol hypersecretion or pheochromocytoma (45,270).”
From Adrenal incidentaloma (2020) · cites this paper as [270]
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Cites
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Research works printed but not linked: 1
- [21]21. Stavropoulos K, Imprialos KP, Doumas M. Bypass of confirmatory tests of primary aldosteronism in leaner patients? J Clin Hypertens (Greenwich). 2017;19:798‐800. [DOI] [PMC free article] [PubMed] [Google Scholar]
Cited by
Sorted by citations
Sherlock, M., Scarsbrook, A., Abbas, A., Fraser, S., Limumpornpetch, P., Dineen, R., & Stewart, P. M. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnaa008 · Cited by 347 · see citing works
“Screening for primary aldosteronism The discovery of hyperaldosteronism in the context of an AI is relatively uncommon, compared with the detection of cortisol hypersecretion or pheochromocytoma (45,270).”
Background
- Authors
- Stavropoulos, K., Imprialos, K. P., Katsiki, N., Petidis, K., Kamparoudis, A., Petras, P., Georgopoulou, V., Finitsis, S., Papadopoulos, C., Athyros, V. G., Doumas, M., & Karagiannis, A.
- Affiliations
- Aristotle University of Thessaloniki (GR)
- Ippokrateio General Hospital of Thessaloniki (GR)
- Department of Radiology and Interventional Radiology Aristotle University Thessaloniki Greece
- George Washington University (US)
- Corresponding author
- Doumas, Michael
- ORCID
- Venue
- The Journal of Clinical Hypertension
- Publisher
- Wiley
- Published
- 2018-05
- Volume
- 20
- Issue
- 5
- Pages
- 942-948
- ISSN
- 1524-6175 (ISSN-L)
- 1751-7176
- PMC
- PMC8031295
- OpenAlex
- W2802096921
- Cited by
- 23
- References
- 39
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2020: 2 · 2019: 2 · 2018: 1
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Hypertension (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
- Health Sciences › Medicine › Surgery › Adrenal and Paraganglionic Tumors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- primary aldosteronism, adrenal incidentaloma, secondary hypertension, hypokalemia, screening appropriateness, prevalence, guideline adherence, undiagnosed cases, serum potassium
- MeSH terms
- Adrenal Gland Neoplasms, Aged, Aldosterone, Female, Humans, Hyperaldosteronism, Hypertension, Hypokalemia, Male, Mass Screening, Middle Aged, Prospective Studies, Renin, Prevalence, Practice Guidelines as Topic
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