Primary aldosteronism: renaissance of a syndrome

Young, William F.

doi:10.1111/j.1365-2265.2007.02775.x

Cited by 680Hormonal Regulation and HypertensionRenin-Angiotensin System StudiesPotassium and Related Disorders

Primary aldosteronism: renaissance of a syndrome

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Young, William F.·2007·Clinical Endocrinology

DOI 10.1111/j.1365-2265.2007.02775.x

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Abstract

Great strides have been made in our understanding of the pathophysiology of primary aldosteronism syndrome since Conn's description of the clinical presentation of a patient with an aldosterone-producing adenoma (APA) more than 50 years ago. It is now recognized that the APA is just one of the seven subtypes of primary aldosteronism. APA and bilateral idiopathic hyperaldosteronism (IHA) are the most common subtypes of primary aldosteronism. Although most clinicians had thought primary aldosteronism to be a rare form of hypertension for more than three decades, it is now recognized to be the most common form of secondary hypertension. Using the plasma aldosterone to plasma renin activity ratio as a case-finding test, followed by aldosterone suppression confirmatory testing, has resulted in much higher prevalence estimates of 5-13% of all patients with hypertension. In addition, there has been a new recognition of the aldosterone-specific cardiovascular morbidity and mortality associated with aldosterone excess. Although thought to be daunting and complex in the past, the diagnostic approach to primary aldosteronism is straightforward and can be considered in three phases: case-finding tests, confirmatory tests and subtype evaluation tests. Patients with hypertension and hypokalaemia (regardless of presumed cause), treatment-resistant hypertension (three antihypertensive drugs and poor control), severe hypertension (>or= 160 mmHg systolic or >or= 100 mmHg diastolic), hypertension and an incidental adrenal mass, onset of hypertension at a young age or patients being evaluated for other forms of secondary hypertension should undergo screening for primary aldosteronism. In patients with suspected primary aldosteronism, screening can be accomplished by measuring a morning (preferably between 0800 and 1000 h) ambulatory paired random plasma aldosterone concentration (PAC) and plasma renin activity (PRA). An increased PAC:PRA ratio is not diagnostic by itself, and primary aldosteronism must be confirmed by demonstrating inappropriate aldosterone secretion. Aldosterone suppression testing can be performed with orally administered sodium chloride and measurement of urinary aldosterone or with intravenous sodium chloride loading and measurement of PAC. Unilateral adrenalectomy in patients with APA or unilateral adrenal hyperplasia results in normalization of hypokalaemia in all these patients; hypertension is improved in all and is cured in approximately 30-60% of them. In bilateral adrenal forms of primary aldosteronism, unilateral or bilateral adrenalectomy seldom corrects the hypertension and they should be treated medically with a mineralocorticoid receptor antagonist.

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PA is associated with low plasma renin activity because aldosterone-induced hypervolemia suppresses renin release.
“PA is associated with low plasma renin activity (or concentration) because aldosterone-induced hypervolemia results in suppression of renin release (275).”
From Adrenal incidentaloma (2020) · cites this paper as [275]

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Authors: Young, W. F.
Affiliations: Mayo Clinic (US)
Corresponding author: Young, William F.
ORCID: Young, William F.
Venue: Clinical Endocrinology
Publisher: Wiley
Published: 2007-02-13
Volume: 66
Issue: 5
Pages: 607-618
ISSN: 0300-0664 (ISSN-L)
1365-2265
DOI: 10.1111/j.1365-2265.2007.02775.x
OpenAlex: W2024885055
Cited by: 680
References: 94
Citations by year: 2026: 19 · 2025: 24 · 2024: 29 · 2023: 26 · 2022: 32 · 2021: 29 · 2020: 41 · 2019: 44 · 2018: 29 · 2017: 38 · 2016: 46 · 2015: 53 · 2014: 35 · 2013: 29 · 2012: 44
FWCI: 5.50
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Clinical Endocrinology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Potassium and Related Disorders
Keywords: primary aldosteronism, aldosterone-producing adenoma, secondary hypertension, hypokalemia, treatment-resistant hypertension, adrenalectomy, mineralocorticoid receptor antagonists, cardiovascular morbidity, unilateral adrenal hyperplasia
MeSH terms: Adrenal Cortex Neoplasms, Adrenalectomy, Mineralocorticoid Receptor Antagonists, Diagnosis, Differential, Humans, Hyperaldosteronism, Hypertension, Hypokalemia, Adrenocortical Adenoma

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Primary aldosteronism: renaissance of a syndrome

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