Keeping it off: the challenge of weight loss maintenance

Management of obesity

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Long term maintenance of weight loss with non-surgical interventions in obese adults: Systematic review and meta-analyses of randomised controlled trials

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Physiological adaptations to weight loss and factors favouring weight regain

Greenway, F. L. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.59 · Cited by 431 · see citing works

Effects of anti-obesity drugs, diet, and exercise on weight-loss maintenance after a very-low-calorie diet or low-calorie diet: a systematic review and meta-analysis of randomized controlled trials

Johansson, K., Neovius, M., & Hemmingsson, E. (2014) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.070052 · Cited by 243 · see citing works

Understanding the challenge of weight loss maintenance: a systematic review and synthesis of qualitative research on weight loss maintenance

Greaves, C. J., Poltawski, L., Garside, R., & Briscoe, S. (2017) · Health Psychology Review · doi:10.1080/17437199.2017.1299583 · Cited by 182 · see citing works

Lessons from obesity management programmes: greater initial weight loss improves long‐term maintenance

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Weighing the Evidence of Common Beliefs in Obesity Research

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Interest, views and perceived barriers to bariatric surgery in patients with morbid obesity

Wharton, S., Serodio, K., Kuk, J. L., Sivapalan, N., Craik, A., & Aarts, M.-A. W. (2016) · Clinical Obesity · doi:10.1111/cob.12131 · Cited by 78 · see citing works

Comparison of a low‐energy diet and a very low‐energy diet in sedentary obese individuals: a pragmatic randomized controlled trial

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Scientific Opinion on the essential composition of total diet replacements for weight control

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Weight Loss and Weight Regain—5-Year Follow-Up for Circular- vs. Linear-Stapled Gastrojejunostomy in Laparoscopic Roux-en-Y Gastric Bypass

Langer, F. B., Prager, G., Poglitsch, M., Kefurt, R., Shakeri‐Leidenmühler, S., Ludvik, B. H., Schindler, K., & Bohdjalian, A. (2013) · Obesity Surgery · doi:10.1007/s11695-013-0892-4 · Cited by 31 · see citing works

Comparison among criteria to define successful weight-loss maintainers and regainers in the Action for Health in Diabetes (Look AHEAD) and Diabetes Prevention Program trials

Berger, S. E., Huggins, G. S., McCaffery, J. M., & Lichtenstein, A. H. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.157446 · Cited by 24 · see citing works

Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial

Lean, M. E. J., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Peters, C., Zhyzhneuskaya, S., Al-Mrabeh, A., Hollingsworth, K. G., et al. (2019) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(19)30068-3 · Cited by 981 · see citing works

Evidence-based European recommendations for the dietary management of diabetes

The Diabetes and Nutrition Study Group (DNSG) of the European Association for the Study of Diabetes (EASD), Aas, A.-M., Axelsen, M., Churuangsuk, C., Hermansen, K., Kendall, C. W. C., Kahleova, H., Khan, T., Lean, M. E. J., Mann, J. I., et al. (2023) · Diabetologia · doi:10.1007/s00125-023-05894-8 · Cited by 262 · see citing works

Persuasive System Design Principles and Behavior Change Techniques to Stimulate Motivation and Adherence in Electronic Health Interventions to Support Weight Loss Maintenance: Scoping Review

Asbjørnsen, R. A., Smedsrød, M. L., Solberg Nes, L., Wentzel, J., Varsi, C., Hjelmesæth, J., & van Gemert-Pijnen, J. E. (2019) · Journal of Medical Internet Research · doi:10.2196/14265 · Cited by 150 · see citing works

DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial

Keller, M., Meir, A. Y., Bernhart, S. H., Gepner, Y., Shelef, I., Schwarzfuchs, D., Tsaban, G., Zelicha, H., Hopp, L., Müller, L., et al. (2020) · Genome Medicine · doi:10.1186/s13073-020-00794-7 · Cited by 78 · see citing works

Association between characteristics of behavioural weight loss programmes and weight change after programme end: systematic review and meta-analysis

Hartmann-Boyce, J., Theodoulou, A., Oke, J. L., Butler, A. R., Scarborough, P., Bastounis, A., Dunnigan, A., Byadya, R., Hobbs, F. D. R., Sniehotta, F. F., et al. (2021) · BMJ · doi:10.1136/bmj.n1840 · Cited by 55 · see citing works

Filling the intervention gap: service evaluation of an intensive nonsurgical weight management programme for severe and complex obesity

McCombie, L., Brosnahan, N., Ross, H., Bell‐Higgs, A., Govan, L., & Lean, M. E. J. (2019) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12611 · Cited by 40 · see citing works

Low-calorie diets in the management of type 2 diabetes mellitus

Lean, M. E. J. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0186-6 · Cited by 29 · see citing works

The Long-Term Dietitian and Psychological Support of Obese Patients Who Have Reduced Their Weight Allows Them to Maintain the Effects

Iłowiecka, K., Glibowski, P., Skrzypek, M., & Styk, W. (2021) · Nutrients · doi:10.3390/nu13062020 · Cited by 26 · see citing works

Maintaining the Outcomes of a Successful Weight Gain Prevention Intervention in Mid-Age Women: Two Year Results from the 40-Something Randomized Control Trial

Williams, L. T., Collins, C. E., Morgan, P. J., & Hollis, J. (2019) · Nutrients · doi:10.3390/nu11051100 · Cited by 16 · see citing works

Protection against overfeeding-induced weight gain is preserved in obesity but does not require FGF21 or MC4R

Lund, C., Ranea‐Robles, P., Falk, S., Rausch, D. M., Skovbjerg, G., Vibe-Petersen, V. K., Krauth, N., Skytte, J. L., Vana, V., Roostalu, U., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45223-0 · Cited by 13 · see citing works

Brief formula low-energy-diet for relapse management during weight loss maintenance in the Diabetes Remission Clinical Trial (DiRECT)

Brosnahan, N., Leslie, W., McCombie, L., Barnes, A., Thom, G., McConnachie, A., Messow, C. M., Sattar, N., Taylor, R., & Lean, M. E. J. (2021) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12839 · Cited by 12 · see citing works

Effectiveness to promote weight loss maintenance and healthy lifestyle habits of a group educational intervention program in adults with obesity: IGOBE program

Porca, C., Rodríguez-Carnero, G., Pérez, C. T., Andújar-Plata, P., Casanueva, F. F., Crujeiras, A. B., & Bellido, D. (2021) · Obesity Research & Clinical Practice · doi:10.1016/j.orcp.2021.10.003 · Cited by 12 · see citing works

Sharing digital self-monitoring data with others to enhance long-term weight loss: A randomized controlled trial

Miller, N. A., Ehmann, M. M., Hagerman, C. J., Forman, E. M., Arigo, D., Spring, B. J., LaFata, E. M., Zhang, F., Milliron, B., & Butryn, M. L. (2023) · Contemporary Clinical Trials · doi:10.1016/j.cct.2023.107201 · Cited by 12 · see citing works

‘I have been all in, I have been all out and I have been everything in‐between’: A 2‐year longitudinal qualitative study of weight loss maintenance

Thom, G., Lean, M. E. J., Brosnahan, N., Algindan, Y., Malkova, D., & Dombrowski, S. U. (2020) · Journal of Human Nutrition and Dietetics · doi:10.1111/jhn.12826 · Cited by 10 · see citing works

Social comparisons between group members during behavioural weight loss treatment: comparison direction, scale, and associations with weight loss maintenance

Arigo, D., Roberts, S. R., & Butryn, M. L. (2021) · Psychology and Health · doi:10.1080/08870446.2021.1967953 · Cited by 8 · see citing works

An Experientially Derived Model of Flexible and Intentional Actions for Weight Loss Maintenance After Severe Obesity

Natvik, E., Råheim, M., Andersen, J. R., & Moltu, C. (2019) · Frontiers in Psychology · doi:10.3389/fpsyg.2019.02503 · Cited by 8 · see citing works

“I’m Still on Track”: A Qualitative Exploration of Participant Experiences of a Weight Loss Maintenance Program

McGill, B., O'Hara, B. J., Phongsavan, P., Bauman, A. E., Lawler, L., & Grunseit, A. C. (2020) · Healthcare · doi:10.3390/healthcare8010021 · Cited by 8 · see citing works

Effect of hypoglycemic agents with weight loss effect plus a high protein diet and moderate exercise on diabetes remission in adults with obesity and type 2 diabetes: a randomized controlled trial

Zhang, S., Wang, Y., Wang, X., Leng, M., Liu, R., Li, Z., Li, J., Xiao, J., Hou, D., Gao, X., et al. (2025) · BMC Medicine · doi:10.1186/s12916-025-04072-4 · Cited by 7 · see citing works

Pharmaceutical interventions for weight-loss maintenance: no effect from cabergoline

Manning, P. J., Grattan, D. R., Merriman, T. R., Manning, T., Williams, S., & Sutherland, W. H. F. (2018) · International Journal of Obesity · doi:10.1038/s41366-018-0165-3 · Cited by 7 · see citing works

Dissociation Between Long-term Weight Loss Intervention and Blood Pressure: an 18-month Randomized Controlled Trial

Gepner, Y., Goldstein, N., Shelef, I., Schwarzfuchs, D., Zelicha, H., Meir, A. Y., Tsaban, G., & Grossman, E. (2021) · Journal of General Internal Medicine · doi:10.1007/s11606-021-06655-2 · Cited by 9 · see citing works

Striving for early effective glycaemic and weight management in type 2 diabetes: A narrative review

CHENG, A. Y. Y., Heine, R. J., Prato, S. D., Green, J. B., Thieu, V. T., & Zeytinoglu, M. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16206 · Cited by 6 · see citing works

Current Treatments on Obesity

Lee, C. J., Kim, M.-J., & An, S. J. (2019) · Daehan imsang geon-gang jeungjin hakoeji/Daehan imsang geon'gang jeungjin haghoeji · doi:10.15384/kjhp.2019.19.4.171 · Cited by 5 · see citing works

Management of obesity and overweight

Lean, M. E. J. (2019) · Medicine · doi:10.1016/j.mpmed.2018.12.008 · Cited by 5 · see citing works

VLCD for weight loss and remission of type 2 diabetes? – Authors' reply

Taylor, R., Adamson, A., Sattar, N. A., Lean, M. E. J., & Mathers, J. C. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31892-0 · Cited by 5 · see citing works

Effectiveness of a community health worker-led low-sodium salt intervention to reduce blood pressure in rural Bangladesh: protocol for a cluster randomized controlled trial

Chang, A. Y., Rahman, M., Talukder, A., Shah, H., Mridha, M. K., Hasan, M., Sarker, M., & Geldsetzer, P. (2023) · Trials · doi:10.1186/s13063-023-07518-3 · Cited by 5 · see citing works

Calorie-restricted diet mitigates weight gain and metabolic abnormalities in obese women with schizophrenia: a randomized controlled trial

Zhang, L., Zhu, M., Liu, X., Zhao, Z., Han, P., Lv, L., Yang, C., & Han, Y. K. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1038070 · Cited by 3 · see citing works

Type 2 Diabetes, sarcopenic obesity and Mediterranean food pattern: Considerations about the therapeutic effect and the problem of maintaining weight loss and healthy habits. The outpatient experience of two clinical cases

Andreoli, B., Mantovani, A., & Andreoli, C. (2020) · Journal of Clinical and Translational Endocrinology Case Reports · doi:10.1016/j.jecr.2020.100061 · Cited by 3 · see citing works

Weight Loss Maintenance and Weight Cycling

Hankey, C. (2022) · Wiley eBooks · doi:10.1002/9781119695257.ch23 · Cited by 3 · see citing works

Exploring the Needs and Perspectives of Patients with Obesity to Inform Health Care Practice: A Focus Group Study

Marchesi, G., Rapelli, G., Roselli, G., Spina, G., Semonella, M., Castelnuovo, G., & Pietrabissa, G. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15083147 · Cited by 1 · see citing works

Sociodemographic and health risk profile associated with participation in a private health insurance weight loss maintenance and chronic disease management program

McGill, B., O'Hara, B. J., Grunseit, A. C., Bauman, A. E., Lawler, L., & Phongsavan, P. (2020) · Australian Health Review · doi:10.1071/ah19046 · Cited by 1 · see citing works

Zweijahresergebnisse der DiRECT-Studie (Diabetes Remission Clinical Trial)

Jecht, M. (2019) · Der Diabetologe · doi:10.1007/s11428-019-0494-4

Dietary Interventions for Weight Loss

(2024) · The Singapore Family Physician · doi:10.33591/sfp.49.9.u3

Additional file 2 of DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial

Keller, M., Meir, A. Y., Bernhart, S. H., Gepner, Y., Shelef, I., Schwarzfuchs, D., Tsaban, G., Zelicha, H., Hopp, L., Müller, L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13245863

Additional file 1 of DNA methylation signature in blood mirrors successful weight-loss during lifestyle interventions: the CENTRAL trial

Keller, M., Meir, A. Y., Bernhart, S. H., Gepner, Y., Shelef, I., Schwarzfuchs, D., Tsaban, G., Zelicha, H., Hopp, L., Müller, L., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13245860

Additional file 2 of Effectiveness of a community health worker-led low-sodium salt intervention to reduce blood pressure in rural Bangladesh: protocol for a cluster randomized controlled trial

Chang, A. Y., Rahman, M., Talukder, A., Shah, H., Mridha, M. K., Hasan, M., Sarker, M., & Geldsetzer, P. (2023) · Figshare · doi:10.6084/m9.figshare.23797250

Additional file 3 of Effectiveness of a community health worker-led low-sodium salt intervention to reduce blood pressure in rural Bangladesh: protocol for a cluster randomized controlled trial

Chang, A. Y., Rahman, M., Talukder, A., Shah, H., Mridha, M. K., Hasan, M., Sarker, M., & Geldsetzer, P. (2023) · Figshare · doi:10.6084/m9.figshare.23797253

Additional file 5 of Effectiveness of a community health worker-led low-sodium salt intervention to reduce blood pressure in rural Bangladesh: protocol for a cluster randomized controlled trial

Chang, A. Y., Rahman, M., Talukder, A., Shah, H., Mridha, M. K., Hasan, M., Sarker, M., & Geldsetzer, P. (2023) · Figshare · doi:10.6084/m9.figshare.23797259

Additional file 4 of Effectiveness of a community health worker-led low-sodium salt intervention to reduce blood pressure in rural Bangladesh: protocol for a cluster randomized controlled trial

Chang, A. Y., Rahman, M., Talukder, A., Shah, H., Mridha, M. K., Hasan, M., Sarker, M., & Geldsetzer, P. (2023) · Figshare · doi:10.6084/m9.figshare.23797256

Additional file 1 of Effectiveness of a community health worker-led low-sodium salt intervention to reduce blood pressure in rural Bangladesh: protocol for a cluster randomized controlled trial

Chang, A. Y., Rahman, M., Talukder, A., Shah, H., Mridha, M. K., Hasan, M., Sarker, M., & Geldsetzer, P. (2023) · Figshare · doi:10.6084/m9.figshare.23797247

Obesity treatment: factors involved in weight-loss maintenance and regain

Khaodhiar, L., & Blackburn, G. L. (2002) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-200210000-00002 · Cited by 9 · see citing works

Physiological adaptations to weight loss and factors favouring weight regain

Greenway, F. L. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.59 · Cited by 431 · see citing works

Long-Term Weight Loss Maintenance

Fischer, M., Oberänder, N., & Weimann, A. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.92103 · Cited by 4 · see citing works

Weight regaining: From statistics and behaviors to physiology and metabolism

Anastasiou, C. A., Karfopoulou, E., & Yannakoulia, M. (2015) · Metabolism · doi:10.1016/j.metabol.2015.08.006 · Cited by 108 · see citing works

Biology of obesity and weight regain

Rogge, M. M., & Gautam, B. (2017) · Journal of the American Association of Nurse Practitioners · doi:10.1002/2327-6924.12504 · Cited by 25 · see citing works