Reconceptualising treatment‐resistant depression as difficult‐to‐treat depression
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The related but separate notion of difficult-to-treat depression seems more aligned with the realities of the clinical ecosystem and with patient experience of depression and sequential non-response to treatments.
“The related, but separate, notion of DTD seems more aligned with the realities of the clinical ecosystem, and with patient experi ence of depression and sequential non- re sponse to treatments 94,286 .”
From Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions (2023) · cites this paper as [94]
The discussion (p. 1) presents difficult-to-treat depression as a practical, holistic model in which clinicians collaborate with patients when treatment success remains low. It also describes the model as useful when patients and clinicians both perceive management as difficult. These passages support the claim’s clinical and patient-centred framing, but do not specifically discuss patients’ experience of sequential non-response to treatments. (LLM, conf=0.78)
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Cites
McAllister-Williams, R. H., Arango, C., Blier, P., Demyttenaere, K., Falkai, P., Gorwood, P., Hopwood, M., Javed, A., Kasper, S., Malhi, G. S., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.02.023 · Cited by 278 · see citing works
Self-citationBrown, S., Rittenbach, K., Cheung, S., McKean, G., MacMaster, F. P., & Clement, F. (2019) · The Canadian Journal of Psychiatry · doi:10.1177/0706743719828965 · Cited by 151 · see citing works
Difficult-to-treat depression: A clinical and research roadmap for when remission is elusive
Rush, A. J., Aaronson, S. T., & Demyttenaere, K. (2019) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867418808585 · Cited by 120 · see citing works
Self-citationMultiple-therapy-resistant major depressive disorder: a clinically important concept
McAllister-Williams, R. H., Christmas, D. M. B., Cleare, A. J., Currie, A., Gledhill, J., Insole, L., Malizia, A. L., McGeever, M., Morriss, R., Robinson, L. J., et al. (2018) · British Journal of Psychiatry · doi:10.1192/bjp.2017.33 · Cited by 40 · see citing works
Self-citationReconceptualising treatment-resistant depression as difficult-to-treat depression
Cosgrove, L., Naudet, F., Högberg, G., Shaughnessy, A. F., & Cristea, I. A. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(20)30416-8 · Cited by 22 · see citing works
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McIntyre, R. S., Alsuwaidan, M., Baune, B. T., Berk, M., Demyttenaere, K., Goldberg, J. F., Gorwood, P., Ho, R., Kasper, S., Kennedy, S. H., et al. (2023) · World Psychiatry · doi:10.1002/wps.21120 · Cited by 836 · see citing works
Self-citationSforzini, L., Worrell, C., Kose, M., Anderson, I. M., Aouizerate, B., Arolt, V., Bauer, M., Baune, B. T., Blier, P., Cleare, A. J., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01381-x · Cited by 214 · see citing works
Self-citationCosta, T., Menzat, B., Engelthaler, T., Fell, B., Franarin, T., Roque, G., Wei, Y., Zhang, X., & McAllister-Williams, R. H. (2022) · Journal of Psychopharmacology · doi:10.1177/02698811221090628 · Cited by 22 · see citing works
- Authors
- McAllister-Williams, R. H., Arango, C., Blier, P., Demyttenaere, K., Falkai, P., Gorwood, P., Hopwood, M., Javed, A., Kasper, S., Malhi, G. S., Soares, J. C., Vieta, E., Young, A. H., Papadopoulos, A., & Rush, A. J.
- Affiliations
- Universidad Complutense de Madrid (ES)
- University of Ottawa (CA)
- KU Leuven (BE)
- Ludwig-Maximilians-Universität München (DE)
- Inserm (FR)
- The University of Melbourne (AU)
- University of Warwick (GB)
- Medical University of Vienna (AT)
- The University of Sydney (AU)
- The University of Texas Health Science Center at Houston (US)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- King's College London (GB)
- National University of Singapore (SG)
- ORCID
- Venue
- The Lancet Psychiatry
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 8
- Issue
- 1
- Pages
- 14-15
- ISSN
- 2215-0366 (ISSN-L)
- OpenAlex
- W3111067988
- Cited by
- 30
- References
- 5
- Citations by year
- 2026: 5 · 2025: 2 · 2024: 8 · 2023: 4 · 2022: 5 · 2021: 5 · 2020: 1
- FWCI
- 2.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Lancet Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, cc-by-nc-nd)
- Lirias (submittedVersion, other-oa)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Funders
- Cilag
- Australian Rotary Health
- National Institute of Mental Health
- Canadian Institutes of Health Research
- Otsuka Pharmaceutical
- Brain and Behavior Research Foundation
- Western Economic Diversification Canada
- European College of Neuropsychopharmacology
- American Foundation for Suicide Prevention
- Michael Smith Foundation for Health Research
- King's College London
- Sage Therapeutics
- National Health and Medical Research Council
- Janssen Biotech
- British Medical Association
- H. Lundbeck A/S
- Stanley Medical Research Institute
- Royal College of Physicians
- Ramsay Health Care
- Pfizer UK
- British Association for Psychopharmacology
- Wellcome Trust
- NSW Health
- Medical Research Council
- Servier
- Johnson and Johnson
- National Institute for Health Research
- National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology
- AstraZeneca
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- treatment-resistant depression, difficult-to-treat depression, conceptual definitions, models of care, remission, psychotherapy, neurostimulation, treatment selection, clinical guidelines
- MeSH terms
- Depression, Humans, Depressive Disorder, Treatment-Resistant
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