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Nutrition state of science and dementia prevention: recommendations of the Nutrition for Dementia Prevention Working Group
Open accessAbstract
Observational studies suggest that nutritional factors have a potential cognitive benefit. However, systematic reviews of randomised trials of dietary and nutritional supplements have reported largely null effects on cognitive outcomes and have highlighted study inconsistencies and other limitations. In this Personal View, the Nutrition for Dementia Prevention Working Group presents what we consider to be limitations in the existing nutrition clinical trials for dementia prevention. On the basis of this evidence, we propose recommendations for incorporating dietary patterns and the use of genetic, and nutrition assessment tools, biomarkers, and novel clinical trial designs to guide future trial developments. Nutrition-based research has unique challenges that could require testing both more personalised interventions in targeted risk subgroups, identified by nutritional and other biomarkers, and large-scale and pragmatic study designs for more generalisable public health interventions across diverse populations.
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“Designing dietary interventions is difficult as the right doses, forms, timing in life and duration remain unclear.(322)”
From Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission (2024) · cites this paper as [322]
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“A diet encompasses multiple healthy and unhealthy food and drinks and is often part of a way of life, so observed effects may be related to lifestyle or be independent of them.(322)”
From Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission (2024) · cites this paper as [322]
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2 retracted
Dementia prevention, intervention, and care: 2020 report of the Lancet Commission
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Vyas, C. M., Ostaszewski, B. L., Anderson, A. K., Cook, N. R., Kang, J. H., Mischoulon, D., Reynolds, C. F., Chang, G., Gatchel, J. R., Manson, J. E., et al. (2026) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.70312
Metadata
- Authors
- Yassine, H. N., Samieri, C., Livingston, G., Glass, K., Wagner, M., Tangney, C., Plassman, B. L., Ikram, M. A., Voigt, R. M., Gu, Y., O'Bryant, S., Minihane, A. M., Craft, S., Fink, H. A., Judd, S., Andrieu, S., Bowman, G. L., Richard, E., Albensi, B., Meyers, E., Khosravian, S., Solis, M., Carrillo, M., Snyder, H., Grodstein, F., Scarmeas, N., & Schneider, L. S.
- Affiliations
- University of Southern California (US)
- University of East Anglia (GB)
- Corresponding author
- Yassine, Hussein N
- ORCID
- Yassine, Hussein N
- Samieri, Cécilia
- Livingston, Gill
- Glass, Kimberly
- Wagner, Maude
- Tangney, Christy
- Plassman, Brenda L
- Ikram, M Arfan
- Voigt, Robin M
- Gu, Yian
- Minihane, Anne Marie
- Craft, Suzanne
- Fink, Howard A
- Judd, Suzanne
- Andrieu, Sandrine
- Bowman, Gene L
- Richard, Edo
- Albensi, Benedict
- Meyers, Emily
- Snyder, Heather
- Grodstein, Francine
- Scarmeas, Nikolaos
- Schneider, Lon S
- Venue
- The Lancet Healthy Longevity
- Publisher
- Elsevier BV
- Published
- 2022-07
- Volume
- 3
- Issue
- 7
- Pages
- e501-e512
- ISSN
- 2666-7568 (ISSN-L)
- PMC
- PMC9273104
- OpenAlex
- W4283818777
- Cited by
- 116
- References
- 76
- Citations by year
- 2026: 24 · 2025: 32 · 2024: 35 · 2023: 17 · 2022: 8
- FWCI
- 14.99
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- The Lancet Healthy Longevity (publishedVersion, cc-by)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (publishedVersion, cc-by)
- UEA Digital Repository (University of East Anglia) (acceptedVersion)
- PubMed Central (acceptedVersion, cc-by)
- HAL (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- Oskar-Bordeaux (Universite de Bordeaux) (submittedVersion, cc-by)
- Pure Amsterdam UMC (submittedVersion, cc-by)
- Radboud Repository (Radboud University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion, other-oa)
- Funders
- Novo Nordisk
- Nestec (R01AG055122)
- American Chemical Society (PCT/EP2017/065340, PCT/EP2017/082148, PCT/EP2018/058701, PCT/EP2018/064813, R01 AG043398)
- Biogen
- Alzheimer's Association
- Eli Lilly and Company
- Novartis
- National Institutes of Health
- National Institute on Aging (R01AG054434, R01AG055770, R01AG067063, R13AG069386)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- dementia prevention, nutrition, dietary habits, dietary supplements, cognitive function, clinical trial design, biomarkers, genetic risk factors, nutrition assessment tools, personalized interventions, public health interventions
- MeSH terms
- Dementia, Diet, Humans, Nutritional Status, Biomarkers, Dietary Supplements
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