Reductions in bone turnover, mineral, and structure associated with mechanical properties of lumbar vertebra and femur in glucocorticoid-treated growing minipigs.

Ikeda, Satoshi; Morishita, Yoshiomi; Tsutsumi, Hideki; Ito, Masako; Shiraishi, Ayako; Arita, Shinobu; Akahoshi, Shojiro; Narusawa, Ken'ichiro; Nakamura, Toshitaka

doi:10.1016/s8756-3282(03)00263-1

Cited by 53Bone health and osteoporosis researchBone Metabolism and DiseasesEstrogen and related hormone effects

Reductions in bone turnover, mineral, and structure associated with mechanical properties of lumbar vertebra and femur in glucocorticoid-treated growing minipigs.

Ikeda, Satoshi, Morishita, Yoshiomi, Tsutsumi, Hideki, Ito, Masako, Shiraishi, Ayako, Arita, Shinobu, Akahoshi, Shojiro, Narusawa, Ken'ichiro +1 more·2003·Bone

DOI 10.1016/s8756-3282(03)00263-1

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Abstract

The present study was designed to determine the effects of glucocorticoid (GC) on bone turnover, minerals, structure, and bone mechanical properties in minipigs. Six 8-month-old Göttingen minipigs were subcutaneously injected with prednisolone (PN, 0.5 mg/kg body wt (BW)/day, 5 days/week for 26 weeks (Group GC)), 6 were treated with vehicle alone (Group VC), and 4 were sacrificed at start of the study for baseline controls (Group BC). The increase in BW was similar in all groups. PN significantly reduced serum osteocalcin and urinary type-1 collagen N-telopeptide levels at 13 weeks and thereafter, compared with baseline and control, and also reduced serum bone specific alkaline phosphatase levels relative to baseline. At 26 weeks, the longitudinal axis of the lumbar bone and length of femur were smaller in Group GC than Group VC. The total cross-sectional area of femur, but not the lumbar bone, in Group GC was significantly different from Group VC. BMD of the femur, but not L2, measured by DXA, was lower in Group GC than in Groups BC and VC. The cortical shell structure measured by 2D-micro-CT deteriorated and age-dependent increases in trabecular bone structure 3D micro-CT were reduced by PN. PN also caused deterioration of the cortical structure of the mid-femur. In L2 and femur, PN significantly reduced the ultimate load and maximum absorption energy of the femur and L2 compared with Group VC. The structural modulus in Group GC was lower than in Group BC. Regression analyses revealed that bone minerals, bone structure, and chemical markers correlated with mechanical properties of L2 and mid-femur. Our results indicate that PN reduced systemic bone formation and resorption and suppressed the age-dependent increases in bone minerals, structure, and mechanical properties of L2 and mid-femur. Reduced bone turnover seemed to be associated with a reduction in mechanical properties. The growing minipig could be a suitable model of GCs-induced osteoporosis in humans.

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In minipigs, prednisolone decreases biochemical parameters of bone resorption and formation while decreasing bone growth and strength.
“In minipigs, prednisolone decreased biochemical parameters of bone resorption and bone formation while decreasing bone growth and bone strength (264).”
From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [264]

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Authors: Ikeda, S., Morishita, Y., Tsutsumi, H., Ito, M., Shiraishi, A., Arita, S., Akahoshi, S., Narusawa, K., & Nakamura, T.
Affiliations: University of Occupational and Environmental Health Japan (JP)
Chugai Pharmaceutical Co., Ltd. (Japan) (JP)
Chugai Research Institute For Medical Science, Inc. (Japan) (JP)
Nagasaki University (JP)
Corresponding author: Ikeda, Satoshi
ORCID: Ikeda, Satoshi
Nakamura, Toshitaka
Venue: Bone
Publisher: Elsevier BV
Published: 2003-11
Volume: 33
Issue: 5
Pages: 779-787
ISSN: 1873-2763 (ISSN-L)
8756-3282
DOI: 10.1016/s8756-3282(03)00263-1
OpenAlex: W2038201345
Cited by: 53
References: 44
Citations by year: 2024: 3 · 2023: 1 · 2020: 1 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 3 · 2013: 2 · 2012: 3
FWCI: 2.28
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Bone (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords: glucocorticoid-induced osteoporosis, prednisolone, bone turnover, bone mineral density, bone structure, bone mechanical properties, lumbar vertebrae, femur, cortical bone, trabecular bone, bone formation and resorption, osteocalcin, bone-specific alkaline phosphatase, ultimate load, energy absorption
MeSH terms: Animals, Biomechanical Phenomena, Female, Femur, Glucocorticoids, Lumbar Vertebrae, Prednisolone, Swine, Swine, Miniature, Bone Density, Bone Remodeling

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Reductions in bone turnover, mineral, and structure associated with mechanical properties of lumbar vertebra and femur in glucocorticoid-treated growing minipigs.

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