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Cited by 309Bone health and osteoporosis researchBone Metabolism and DiseasesEstrogen and related hormone effects

Comparison of trabecular bone microarchitecture and remodeling in glucocorticoid-induced and postmenopausal osteoporosis.

Carbonare, L. Dalle, Arlot, M. E., Chavassieux, P. M., Roux, J. P., Portero, N. R., Meunier, P. J.·2001·Journal of Bone and Mineral Research
DOI 10.1359/jbmr.2001.16.1.97
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Abstract

Long-term treatment with glucocorticoids (GCs) leads to a rapid bone loss and to a greater risk of fractures. To evaluate the specific effects of this treatment on cancellous bone remodeling, structure, and microarchitecture, we compared 22 transiliac biopsy specimens taken in postmenopausal women (65 ± 6 years) receiving GCs (≥7.5 mg/day, for at least 6 months) and 22 biopsy specimens taken in age-matched women with postmenopausal osteoporosis (PMOP), all untreated and having either at least one vertebral fracture or a T score < −2.5 SD. On these biopsy specimens, we measured static and dynamic parameters reflecting trabecular bone formation and resorption. Also, we performed the strut analysis and evaluated the trabecular bone pattern factor (TBPf), Euler number/tissue volume (E/TV), interconnectivity index (ICI), and marrow star volume (MaSV). Glucocorticoid-induced osteoporosis (GIOP), when compared with PMOP, was characterized by lower bone volume (BV/TV), trabecular thickness (Tb.Th), wall thickness (W.Th), osteoid thickness (O.Th), bone formation rate/bone surface (BFR/BS), adjusted mineral apposition rate/bone surface (Aj.AR/BS), and higher ICI and resorption parameters. After adjustment for BV/TV, the W.Th remained significantly lower in GIOP (p < 0.0001). The active formation period [FP(a+)] was not different. Patients with GIOP were divided into two groups: high cumulative dose GCs (HGCs; 23.7 ± 9.7 g) and low cumulative dose GCs (LGCs; 2.7 ± 1.2 g). HGC when compared with LGC was characterized by lower W.Th (p < 0.05), BV/TV (p < 0.001), Tb.Th (p < 0.05), trabecular number (Tb.N; p < 0.05), FP(a+) (p < 0.05), and nodes (p < 0.05), and higher E/TV (p < 0.05), ICI (p < 0.005), and TBPf (p < 0.05). When HGC was compared with PMOP, the results were similar except for the MaSV, which was significantly higher (p < 0.005). In summary, GIOP was characterized by lower formation and higher resorption than in PMOP, already present after LGC. With HGCs, these changes were associated with a more dramatic bone loss caused by a major loss of trabecular connectivity.

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  • The skeletal response to prednisolone in these rats shared similarities to humans, including decreased BMD, histological evidence of increased bone resorption, and biochemical evidence of suppressed bone formation.

    “the skeletal response to prednisolone in these rats shared several similarities to changes observed in humans, including significantly decreased BMD (243), histological evidence of increased bone resorption (194), and biochemical evidence of suppressed bone formation (244, 267, 268).”

    From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [194]

  • The prednisolone-related increase in bone volume in rats is not consistent with histological data from patients with glucocorticoid-induced osteoporosis and is a recognized limitation of the model.

    “The prednisolonerelated increase in bone volume in rats, confirmed in a study described immediately below (262), is not consistent with histological data from patients with glucocorticoid-induced osteoporosis (194) and is a recognized limitation of the model (251).”

    From Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease (2008) · cites this paper as [194]

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Authors
Carbonare, L. D., Arlot, M. E., Chavassieux, P. M., Roux, J. P., Portero, N. R., & Meunier, P. J.
Affiliations
  • Inserm (FR)
  • Institut National de la Santé et de la Recherche Médicale Unit 403 and Laboratoire d'Histodynamique Osseuse, Lyon, France
Corresponding author
Carbonare, L. Dalle
ORCID
Venue
Journal of Bone and Mineral Research
Publisher
Oxford University Press (OUP)
Published
2001-01-01
Volume
16
Issue
1
Pages
97-103
ISSN
  • 0884-0431 (ISSN-L)
  • 1523-4681
DOI
10.1359/jbmr.2001.16.1.97
OpenAlex
W1972567404
Cited by
309
References
40
Citations by year
2026: 3 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 10 · 2021: 9 · 2020: 13 · 2019: 11 · 2018: 14 · 2017: 7 · 2016: 5 · 2015: 12 · 2014: 12 · 2013: 12 · 2012: 16
FWCI
20.64
Type
journal article
Language
en
Open access
closed
Licence
academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
Locations
  • Journal of Bone and Mineral Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Keywords
glucocorticoid-induced osteoporosis, postmenopausal osteoporosis, trabecular bone microarchitecture, bone remodeling, trabecular bone, bone formation rate, bone resorption, cumulative glucocorticoid dose, bone loss, trabecular thickness, wall thickness, Euler characteristic
MeSH terms
Aged, Biopsy, Bone and Bones, Female, Glucocorticoids, Histocytochemistry, Humans, Ilium, Middle Aged, Osteoporosis, Osteoporosis, Postmenopausal, Bone Remodeling, Postmenopause

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