Therelationship of adverse childhood experiences to adult medical disease, psychiatric disorders and sexual behavior: implications for healthcare
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The resulting chronic elevation of stress hormones can disrupt the maturation of children's developing brain architecture and physiological systems, with major implications for later life health, learning, and wellbeing.
“The resulting chronic elevation of stress hormones can disrupt the maturation of children's developing brain architecture and physiological systems, with major implications for later life health, learning, and wellbeing (Center on the Developing Child, 2016;Felitti & Anda, 2010).”
From Malleability, plasticity, and individuality: How children learn and develop in context<sup>1</sup> (2019) · cites this paper as Felitti & Anda, 2010
The relationship between adverse life experiences and substance use is well documented and has been explained through the self-medication model, which posits that persons experiencing PTSD attempt to cope with their distress by taking substances such as alcohol or drugs.
“The relationship between adverse life experiences and substance use is well documented and has been explained through the self-medication model, which posits that persons experiencing PTSD attempt to cope with their distress by taking substances such as alcohol or drugs [55,59–61].”
Non-stigmatising screening for adverse childhood experiences was associated with fewer emergency department visits the following year.
“Felitti and colleagues found that non-stigmatising screening for ACEs was associated with fewer ED visits the following year [55].”
Cites
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Self-citationThe interrelatedness of multiple forms of childhood abuse, neglect, and household dysfunction
Dong, M., Anda, R. F., Felitti, V. J., Dube, S. R., Williamson, D. F., Thompson, T. J., Loo, C. M., & Giles, W. H. (2004) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2004.01.008 · Cited by 1,679 · see citing works
Self-citationAllostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging
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Adverse childhood experiences and the risk of premature mortality
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Self-citationInsights Into Causal Pathways for Ischemic Heart Disease: Adverse Childhood Experiences Study
Dong, M., Giles, W. H., Felitti, V. J., Dube, S. R., Williams, J. E., Chapman, D. P., & Anda, R. F. (2004) · Circulation · doi:10.1161/01.cir.0000143074.54995.7f · Cited by 1,027 · see citing works
Self-citationDube, S. R., Miller, J. W., Brown, D. W., Giles, W. H., Felitti, V. J., Dong, M., & Anda, R. F. (2006) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2005.06.006 · Cited by 698 · see citing works
Self-citationHillis, S. D., Anda, R. F., Dube, S. R., Felitti, V. J., Marchbanks, P. A., & Marks, J. S. (2004) · Pediatrics · doi:10.1542/peds.113.2.320 · Cited by 671 · see citing works
Self-citationAdverse childhood experiences and prescribed psychotropic medications in adults
Anda, R. F., Brown, D. W., Felitti, V. J., Bremner, J. D., Dube, S. R., & Giles, W. H. (2007) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2007.01.005 · Cited by 323 · see citing works
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Herzog, J. I., & Schmahl, C. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00420 · Cited by 583 · see citing works
Social Structure, Adversity, Toxic Stress, and Intergenerational Poverty: An Early Childhood Model
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Adverse childhood experiences: towards a clear conceptual meaning
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Malleability, plasticity, and individuality: How children learn and develop in context<sup>1</sup>
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“The resulting chronic elevation of stress hormones can disrupt the maturation of children’s developing brain architecture and physiological systems, with major implications for later life health, learning, and wellbeing (Center on the Developing Child, 2016; Felitti & Anda, 2010).”
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Early childhood adversity and pregnancy outcomes
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Adverse Childhood Experiences and Trauma-Informed Care
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“with fewer ED visits the following year [55].”
BackgroundLetourneau, N., Anis, L., Cui, C., Graham, I. D., Ross, K., Nixon, K., Reimer, J., Pilipchuk, M., Wang, E., Lalonde, S., et al. (2025) · BMC Pediatrics · doi:10.1186/s12887-024-05232-w · Cited by 2 · see citing works
- Authors
- Felitti, V. J., & Anda, R. F.
- Venue
- The Impact of Early Life Trauma on Health and Disease
- Publisher
- Cambridge University Press
- Published
- 2010-08-05
- Pages
- 77-87
- OpenAlex
- W198191071
- Cited by
- 566
- References
- 9
- Citations by year
- 2026: 11 · 2025: 17 · 2024: 29 · 2023: 24 · 2022: 37 · 2021: 82 · 2020: 80 · 2019: 41 · 2018: 54 · 2017: 36 · 2016: 46 · 2015: 33 · 2014: 25 · 2013: 28 · 2012: 13
- FWCI
- 99.35
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Cambridge University Press eBooks (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Safety Research › Child Welfare and Adoption
- Social Sciences › Sociology and Political Science › Military, Security, and Education Studies
- Keywords
- adverse childhood experiences, mental illness, sexual behavior
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