Improvements in LDL particle size and distribution by short-term alternate day modified fasting in obese adults
Open accessAbstract
Alternate day modified fasting (ADMF) beneficially modulates several indicators of CHD risk, but its effects on LDL particle size have never been tested. Accordingly, we examined the effects of ADMF on LDL particle size and distribution in obese adults. Sixteen obese subjects participated in a 10-week trial with three consecutive phases: (1) 2-week control phase; (2) 4-week ADMF controlled feeding phase; (3) 4-week ADMF self-selected feeding phase. After 8 weeks of diet, body weight and waist circumference were reduced (P < 0·05) by 5·6 (sem 0·9) kg and 4·0 (sem 0·9) cm, respectively. LDL-cholesterol and TAG concentrations decreased (P < 0·05) by 25 (sem 10) % and 32 (sem 6) %, respectively. Peak LDL particle size increased (P < 0·05) from 266 (sem 1) to 268 (sem 1) Å. Additionally, the proportion of small LDL particles decreased (P < 0·05) from 13 (sem 2) % to 9 (sem 3) %, while the proportion of large LDL particles increased (P < 0·05) from 68 (sem 4) % to 76 (sem 4) % post-treatment. These findings suggest that ADMF is an effective diet strategy for increasing LDL particle size and decreasing the proportion of small, dense LDL particles in obese adults.
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In an 8-week trial, LDL cholesterol, LDL particle size, and triglyceride levels improved significantly.
“Low-density lipoprotein (LDL) cholesterol, LDL particle size, and triglyceride levels also improved significantly in this 8-week trial (7,9).”
From Alternate day fasting and endurance exercise combine to reduce body weight and favorably alter plasma lipids in obese humans (2013) · cites this paper as [9]
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- Authors
- Varady, K. A., Bhutani, S., Klempel, M. C., & Lamarche, B.
- Affiliations
- University of Illinois Chicago (US)
- Corresponding author
- Varady, Krista A.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2010-09-30
- Volume
- 105
- Issue
- 4
- Pages
- 580-583
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2144550198
- Cited by
- 39
- References
- 17
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 7 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 3 · 2014: 3 · 2013: 5 · 2012: 2
- FWCI
- 1.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- University of Illinois at Urbana-Champaign
- Topics
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- LDL particle size, small dense LDL, obesity, weight loss, LDL cholesterol, triglycerides, cardiovascular risk
- MeSH terms
- Adult, Aged, Body Weight, Fasting, Female, Humans, Cholesterol, LDL, Male, Middle Aged, Obesity, Particle Size, Patient Compliance, Triglycerides, Weight Loss
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