Metabolic impacts of altering meal frequency and timing - Does when we eat matter
Abstract
Obesity prevalence continues to rise throughout the developed world, as a result of positive energy balance and reduced physical activity. At present, there is still a perception within the general community, and amongst some nutritionists, that eating multiple small meals spaced throughout the day is beneficial for weight control and metabolic health. However, intervention trials do not generally support the epidemiological evidence, and data is emerging to suggest that increasing the fasting period between meals may beneficially impact body weight and metabolic health. To date, this evidence is of short term duration, and it is becoming increasingly apparent that meal timing must also be considered if we are to ensure optimal health benefits in response to this dietary pattern. The purpose of this review is to summate the existing human literature on modifying meal frequency and timing on body weight control, appetite regulation, energy expenditure, and metabolic health under conditions of energy balance, restriction and surplus.
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Popular concepts such as increasing or decreasing meal frequency lack concrete scientific evidence supporting their efficacy.
“Popular concepts such as increasing or decreasing meal frequency, however, lack concrete scientific evidence supporting their efficacy (238).”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [238]
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- Authors
- Hutchison, A. T., & Heilbronn, L. K.
- Affiliations
- South Australian Health and Medical Research Institute (AU)
- Corresponding author
- Heilbronn, Leonie K.
- Venue
- Biochimie
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 124
- Pages
- 187-197
- ISSN
- 0037-9042 (ISSN-L)
- 0300-9084
- OpenAlex
- W934641992
- Cited by
- 91
- References
- 142
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 13 · 2023: 7 · 2022: 6 · 2021: 10 · 2020: 10 · 2019: 10 · 2018: 8 · 2017: 7 · 2016: 9 · 2015: 1
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimie (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- Australian Research Council (FT120100027)
- Topics
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- meal frequency, meal timing, time-restricted feeding, alternate-day fasting, obesity, weight management, appetite regulation, energy expenditure, energy balance, caloric restriction, circadian rhythm, metabolic health
- MeSH terms
- Appetite, Eating, Energy Metabolism, Fasting, Humans
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