Cited by 217Probiotics and Fermented FoodsImmune responses and vaccinationsMicrobial Metabolites in Food Biotechnology

The DOI matches its Crossref record, with a small difference in title or year; 38 of the 38 references it cites were found in a registry or an index.

Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double-blind, placebo-controlled study

Open access

Rizzardini, Giuliano, Eskesen, Dorte, Calder, Philip C., Capetti, Amedeo, Jespersen, Lillian, Clerici, Mario·2012·British Journal Of Nutrition

DOI 10.1017/s000711451100420x

Open this paper in CoChat — free account Open PDF

Abstract

The present study investigated the ability of Bifidobacterium animalis ssp. lactis (BB-12®) and Lactobacillus paracasei ssp. paracasei (L. casei 431®) to modulate the immune system using a vaccination model in healthy subjects. A randomised, double-blind, placebo-controlled, parallel-group study was conducted in 211 subjects (56 % females, mean age 33·2 (sd 13·1) years). Subjects consumed a minimum of 10⁹ colony-forming units of BB-12® (capsule) or L. casei 431® (dairy drink) or a matching placebo once daily for 6 weeks. After 2 weeks, a seasonal influenza vaccination was given. Plasma and saliva samples were collected at baseline and after 6 weeks for the analysis of antibodies, cytokines and innate immune parameters. Changes from baseline in vaccine-specific plasma IgG, IgG1 and IgG3 were significantly greater in both probiotic groups v. the corresponding placebo group (L. casei 431®, P = 0·01 for IgG; P < 0·001 for remaining comparisons). The number of subjects obtaining a substantial increase in specific IgG (defined as ≥ 2-fold above baseline) was significantly greater in both probiotic groups v. placebo (BB-12®, P < 0·001 for IgG, IgG1 and IgG3; L. casei 431®, P < 0·001 for IgG1 and IgG3). Significantly greater mean fold increases for vaccine-specific secretory IgA in saliva were observed in both probiotic groups v. placebo (BB-12®, P = 0·017; L. casei 431®, P = 0·035). Similar results were observed for total antibody concentrations. No differences were found for plasma cytokines or innate immune parameters. Data herein show that supplementation with BB-12® or L. casei 431® may be an effective means to improve immune function by augmenting systemic and mucosal immune responses to challenge.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1017/s000711451100420x

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A Simple Sequentially Rejective Multiple Test Procedure
(1979) · Scandinavian Journal of Statistics · doi:10.2307/4615733 · Cited by 21,526
Effect of long term consumption of probiotic milk on infections in children attending day care centres: double blind, randomised trial
Hatakka, K., Savilahti, E., Pönkä, A., Meurman, J. H., Poussa, T., Näse, L., Saxelin, M., & Korpela, R. (2001) · BMJ · doi:10.1136/bmj.322.7298.1327 · Cited by 645
Influenza Virus: Immunity and Vaccination Strategies. Comparison of the Immune Response to Inactivated and Live, Attenuated Influenza Vaccines
Cox, R. J., Brokstad, K. A., & Ogra, P. L. O. (2004) · Scandinavian Journal of Immunology · doi:10.1111/j.0300-9475.2004.01382.x · Cited by 564
Immunomodulation of Human Blood Cells Following the Ingestion of Lactic Acid Bacteria
Schiffrin, E. J., Rochat, F., Link‐Amster, H., Aeschlimann, J., & Donnet‐Hughes, A. (1995) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(95)76659-0 · Cited by 553
Probiotics-host communication
Thomas, C. M., & Versalovic, J. A. (2010) · Gut Microbes · doi:10.4161/gmic.1.3.11712 · Cited by 470
Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children
Fukushima, Y., Kawata, Y., Hiroyoshi, H. A. R. A., Terada, A., & MITSUOKA, T. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(98)00056-7 · Cited by 333
PASSCLAIM1?Gut health and immunity
Cummings, J. H., Antoine, J.-M., Azpiroz, F., Bourdet-Sicard, R., Brandtzaeg, P., Calder, P. C., Gibson, G. R., Guarner, F., Isolauri, E., Pannemans, D., et al. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-1205-4 · Cited by 324
Self-citation
Salivary IgA as a Risk Factor for Upper Respiratory Infections in Elite Professional Athletes
Neville, V., Gleeson, M., & Folland, J. P. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31816be9c3 · Cited by 313
Probiotic Effects on Cold and Influenza-Like Symptom Incidence and Duration in Children
Leyer, G. J., Li, S., Mubasher, M., Reifer, C. J., & Ouwehand, A. C. (2009) · PEDIATRICS · doi:10.1542/peds.2008-2666 · Cited by 305
Markers to measure immunomodulation in human nutrition intervention studies
Albers, R., Antoine, J., Bourdet‐Sicard, R., Calder, P. C., Gleeson, M., Lesourd, B., Samartı́n, S., Sanderson, I. R., Loo, J. V., Dias, F. W. V., et al. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051469 · Cited by 284
Self-citation

Show all 38 references

Research works printed but not linked: 2

2002, Guidelines for the Evaluation of Probiotics in Food. Report of a Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food
2 World Health Organization (1948) WHO Definition of Health. Preamble to the Constitution of the World Health Organization as Adopted by the International Health Conference, New York, 19–22 June, 1946; Signed on 22 July 1946 by the Representatives of 61 States (Official Records of the World Health Organization, no. 2, p. 100) and Entered into Force on 7 April 1948. http://who.int/about/definition/en/print.html.

Sorted by citations

Items 101–200 of 215

Nutraceuticals Prepared with Specific Strains of Probiotics for Supplementing Gut Microbiota in Hosts Allergic to Certain Foods or Their Additives
Dahiya, D., & Nigam, P. S. N. (2023) · Nutrients · doi:10.3390/nu15132979 · Cited by 19
Intestinal Microbiota and Its Effect on Vaccine-Induced Immune Amplification and Tolerance
Liu, Y., Zhou, J., Yang, Y., Chen, X., Chen, L., & Wu, Y. (2024) · Vaccines · doi:10.3390/vaccines12080868 · Cited by 19
Use of a probiotic mixture containing Bifidobacterium animalis subsp. lactis BB12 and Enterococcus faecium L3 in atopic children
Pierro, F. D., Basile, I., Danza, M., Venturelli, L., Contini, R., RISSO, P., & Colombo, M. (2018) · Minerva Pediatrics · doi:10.23736/s0026-4946.18.05203-9 · Cited by 19
Lactobacillus plantarum GUANKE modulate anti-viral function of dendritic cells in mice
Lu, S., He, S., Yue, K., Mi, J., Huang, Y., Song, L., Yang, T., Ren, Z., Ren, L., & Xu, J. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112169 · Cited by 18
In the Age of Viral Pandemic, Can Ingredients Inspired by Human Milk and Infant Nutrition Be Repurposed to Support the Immune System?
Brink, L., Chichlowski, M., Pastor, N., Athmaram, T. N., & Shah, N. (2021) · Nutrients · doi:10.3390/nu13030870 · Cited by 18
Selection of Probiotics in the Prevention of Respiratory Tract Infections and Their Impact on Occupational Health: Scoping Review
Picó-Monllor, J. A., Ruzafa-Costas, B., Núñez-Delegido, E., Sánchez-Pellicer, P., Peris-Berraco, J., & Navarro‐López, V. (2021) · Nutrients · doi:10.3390/nu13124419 · Cited by 18
Pharmacological Efficacy of Probiotics in Respiratory Viral Infections: A Comprehensive Review
Wahab, S., Almaghaslah, D., Mahmood, S. E., Ahmad, M. F., Alsayegh, A. A., Haddash, Y. M. A., Rahman, M. A., Ahamd, I., Ahmad, W., Khalid, M., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12081292 · Cited by 18
Vaccines, Microbiota and Immunonutrition: Food for Thought
Renzo, L. D., Franza, L., Monsignore, D., Esposito, E., Rio, P., Gasbarrini, A., Gambassi, G., Cianci, R., & LORENZO, A. D. (2022) · Vaccines · doi:10.3390/vaccines10020294 · Cited by 17
Probiotic supplement consumption alters cytokine production from peripheral blood mononuclear cells: a preliminary study using healthy individuals
Hepburn, N. J., Garaiová, I., Williams, E. A., Michael, D. R., & Plummer, S. (2013) · Beneficial Microbes · doi:10.3920/bm2013.0012 · Cited by 17
Molecular monitoring of fecal microbiota in healthy adults following probiotic yogurt intake
Filteau, M., Matamoros, S., Savard, P., & Roy, D. (2013) · PharmaNutrition · doi:10.1016/j.phanu.2013.05.002 · Cited by 18
Prebiotics, Probiotics, and Synbiotics
Chen, L. A., & Sears, C. L. (2015) · Elsevier eBooks · doi:10.1016/b978-1-4557-4801-3.00003-5 · Cited by 18
The Influence of Probiotic Lactobacilli on COVID-19 and the Microbiota
Taufer, C. R., da Silva, J., & Rampelotto, P. H. (2024) · Nutrients · doi:10.3390/nu16091350 · Cited by 15
Fructans with Varying Degree of Polymerization Enhance the Selective Growth of Bifidobacterium animalis subsp. lactis BB-12 in the Human Gut Microbiome In Vitro
den Abbeele, P. V., Duysburgh, C., Ghyselinck, J., Goltz, S. R., Berezhnaya, Y., Boileau, T. W.-M., Blaiser, A. D., & Marzorati, M. (2021) · Applied Sciences · doi:10.3390/app11020598 · Cited by 15
Preventive and Tumor-Suppressive Effects of Lactobacillus Paracasei X12 in Rat Model of Colorectal Cancer.
Jam, S. A. M., Morshedi, M., Khosroushahi, A. Y., Eftekharsadat, A., Alipour, M., & Alipour, B. (2020) · PubMed · doi:10.22037/ijpr.2019.112135.13547 · Cited by 15
Consumption of yogurt fermented with Lactobacillus delbrueckii ssp. bulgaricus OLL1073R-1 augments serum antibody titers against seasonal influenza vaccine in healthy adults
Hemmi, J., Makino, S., Yokoo, T., Kano, H., Asami, Y., Takeda, K., SUZUKI, Y., Kawai, S., Nagaoka, I., Sawaki, K., et al. (2022) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.2022-037 · Cited by 14
Probiotics-Loaded Microspheres for Cosmetic Applications
Łętocha, A., Michalczyk, A., Ostrowska, P., Miastkowska, M., & Sikora, E. (2024) · Applied Sciences · doi:10.3390/app14031183 · Cited by 14
Probiotic Potential and Enhanced Adhesion of Fermented Foods-Isolated Lactic Acid Bacteria to Intestinal Epithelial Caco-2 and HT-29 Cells
Sim, E. A., Kim, S., Kim, S., & Mun, E. (2024) · Microorganisms · doi:10.3390/microorganisms13010032 · Cited by 16
Immunomodulation by the Commensal Microbiome During Immune-Targeted Interventions: Focus on Cancer Immune Checkpoint Inhibitor Therapy and Vaccination
Reens, A. L., Cabral, D. J., Liang, X., Norton, J. E., Therien, A. G., Hazuda, D. J., & Swaminathan, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.643255 · Cited by 14
Fermented food/beverage and health: current perspectives
Durazzo, A., Carocho, M., Heleno, S. A., Pedrosa, M. C., Ueda, J. M., Barros, L., Souto, E. B., Santini, A., & Lucarini, M. (2022) · RENDICONTI LINCEI · doi:10.1007/s12210-022-01093-6 · Cited by 13
Dietary intervention with functional foods modulating gut microbiota for improving the efficacy of COVID-19 vaccines
Oh, S.-Y., & Seo, H. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15668 · Cited by 13
Bifidobacterium animalis spp. lactis
Quigley, E. M. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804024-9.00013-6 · Cited by 13
Positive clinical outcomes derived from using a proprietary mixture of selected strains during pregnancy.
Pierro, F. D., Parolari, A. M., Brundu, B., & Nigro, R. (2016) · Acta bio-medica dell'Ateneo parmense/Acta biomedica · Cited by 13
The emerging role of the gut microbiota in vaccination responses
Decker, V., Qureshi, K., Roberts, L., Powell, N., Marchesi, J. R., Mullish, B. H., & Alexander, J. L. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2549585 · Cited by 14
The Prevention of Viral Infections: The Role of Intestinal Microbiota and Nutritional Factors
Altomare, A., Giovanetti, M., Baldaro, F., Ciccozzi, M., Cicala, M., & Guarino, M. P. L. (2024) · Nutrients · doi:10.3390/nu16152445 · Cited by 12
Influence of biotic interventions on the immune response to vaccines in young and older adults
Spacova, I., Patusco, R., Lebeer, S., & Jensen, M. G. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.01.001 · Cited by 13
Effects of Glucosinolate-Enriched Red Radish (Raphanus sativus) on In Vitro Models of Intestinal Microbiota and Metabolic Syndrome-Related Functionalities
Rosés, C., García-Ibáñez, P., Agudelo, A., Viadel, B., Tomás‐Cobos, L., Gallego, E., Carvajal, M., Milagro, F. I., & Barceló, A. (2023) · ACS Omega · doi:10.1021/acsomega.2c08128 · Cited by 12
Antidiarrheal Effect of Food Fermented by Various Strains of Lactobacillus
Shafi, A., Farooq, U., Akram, K., Jaskani, M., Siddique, F., & Tanveer, A. (2014) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12056 · Cited by 12
Selective method for identification and quantification ofBifidobacterium animalissubspecieslactisBB-12 (BB-12) from the gastrointestinal tract of healthy volunteers ingesting a combination probiotic of BB-12 andLactobacillus rhamnosusGG
Poutsiaka, D. D., Mahoney, I., McDermott, L. A., Stern, L. L., Thorpe, C. M., Kane, A. V., Baez-Giangreco, C., McKinney, J., Davidson, L. E., Leyva, R., et al. (2017) · Journal of Applied Microbiology · doi:10.1111/jam.13436 · Cited by 12
Bifidobacterium animalis subsp. lactis modulates early‐life immune response and gut metabolism
Du, H., Cai, Y., Shen, L., Zheng, Y., Zhao, L., Hu, R., Jiang, S., Yuan, J., Hu, C., Deng, Q., et al. (2025) · Animal Models and Experimental Medicine · doi:10.1002/ame2.70034 · Cited by 11
Immunomodulatory Activity of Probiotics in Models of Bacterial Infections
Dias, T. G., Rodrigues, L. D. S., Farias, J. R., Pereira, A. L. F., Ferreira, A. G. N., Neto, M. S., Dutra, R. P., Reis, A. S., Guerra, R. N. M., Monteiro‐Neto, V., et al. (2023) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10090-6 · Cited by 10
Drinking fermented milk containing Lactobacillus paracasei 431 (IMULUS™) improves immune response against H1N1 and cross-reactive H3N2 viruses after influenza vaccination: A pilot randomized triple-blinded placebo controlled trial
Trachootham, D., Chupeerach, C., Tuntipopipat, S., Pathomyok, L., Boonnak, K., Praengam, K., Promkam, C., & Santivarangkna, C. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.03.016 · Cited by 10
Commercial Strains of Lactic Acid Bacteria with Health Benefits
Tang, X., & Zhao, J. (2019) · Springer eBooks · doi:10.1007/978-981-13-7832-4_10 · Cited by 10
Understanding Immunomodulatory Effects of Probiotics
Pot, B., Foligné, B., Daniel, C., & Grangette, C. (2013) · Nestlé Nutrition Institute Workshop series · doi:10.1159/000351388 · Cited by 12
Obesidad, inmunidad y vacunación
Guerrero, F. F., & Lopez-Gigosos, R. M. (2021) · Vacunas · doi:10.1016/j.vacun.2021.07.001 · Cited by 9
Comparative effects of non-fermented and Lacticaseibacillus paracasei-fermented pomelo juice on gut microbiota composition and short-chain fatty acid production: An in vitro colonic model
Balmori, V., Marnpae, M., Kamonsuwan, K., Chusak, C., Nungarlee, U., Sivapornnukul, P., Chanchaem, P., Payungporn, S., Charoensiddhi, S., Suantawee, T., et al. (2024) · Food Chemistry X · doi:10.1016/j.fochx.2024.102041 · Cited by 9
Subphenotypes of Long COVID and the clinical applications of probiotics
Lim, H. X., Khalid, K., Abdullah, A., Lee, L., & Ali, R. A. R. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.117855 · Cited by 9
Can probiotics enhance vaccine-specific immunity in children and adults?
Kwak, J., & Lamousé-Smith, E. S. N. (2017) · Beneficial Microbes · doi:10.3920/bm2016.0147 · Cited by 9
Effects of non-pharmacological interventions as vaccine adjuvants in humans: a systematic review and network meta-analysis
Vedhara, K., Royal, S., Sunger, K., Caldwell, D. M., Halliday, V., Taylor, C. M., Fairclough, L. C., Avery, A. J., & Welton, N. J. (2020) · Health Psychology Review · doi:10.1080/17437199.2020.1854050 · Cited by 9
Beer for live microbe delivery
Ramanan, M., Fox, G. P., & Marco, M. L. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105987 · Cited by 9
Staying alive: growth and survival of Bifidobacterium animalis subsp. animalis under in vitro and in vivo conditions
Egan, M., Bottacini, F., Motherway, M. O., Casey, P. G., Morrissey, R., Melgar, S., Faurie, J., Chervaux, C., Smokvina, T., & van Sinderen, D. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9413-7 · Cited by 8
Development of a novel multi-epitope oral DNA vaccine for rabies based on a food-borne microbial vector
Ding, Y., Gao, Y., Chen, S., Zhang, Z., Li, Q., Jia, T., Zhang, T., Xu, R., Shi, W., Chen, L., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128085 · Cited by 7
Diet, microbiome, and probiotics establish a crucial link in vaccine efficacy
Dutta, S., Chatterjee, N., Gallina, N. L. F., Kar, S., Koley, H., Nanda, P. K., Biswas, O., Das, A. K., Biswas, S., Bhunia, A. K., et al. (2025) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2025.2480230 · Cited by 7
Regulation divergences of Lactobacillus fermentum PCC and Lactobacillus paracasei 431 on penicillin-induced upper respiratory tract microbial dysbiosis in BALB/c mice
Gao, F., Fang, Z., & Lu, W. (2021) · Food & Function · doi:10.1039/d0fo02981e · Cited by 7
Factors that Influence the Immunological Adjuvant Effect of Lactobacillus fermentum PC1 on Specific Immune Responses in Mice to Orally Administered Antigens
Esvaran, M., & Conway, P. L. (2016) · Vaccines · doi:10.3390/vaccines4030024 · Cited by 7
Role of Acacia catechu and Scutellaria baicalensis in Enhancing Immune Function Following Influenza Vaccination of Healthy Adults: A Randomized, Triple-Blind, Placebo-Controlled Clinical Trial
Lewis, E. D., Crowley, D. C., Guthrie, N., & Evans, M. (2022) · Journal of the American Nutrition Association · doi:10.1080/27697061.2022.2145525 · Cited by 7
Collateral damage during antibiotic treatment ofC. difficileinfection in the aged host: Insights into why recurrent disease happens
Shin, J. H., & Warren, C. A. (2017) · Gut Microbes · doi:10.1080/19490976.2017.1323616 · Cited by 7
Probiotics: An adjuvant treatment strategy for chronic respiratory diseases
Verma, B., Kumar, N., Ashique, S., Debnath, B., Garg, A., Mishra, N., Mojgani, N., Kaurav, M., Gupta, M., Bhowmick, M., et al. (2025) · Respiratory Medicine · doi:10.1016/j.rmed.2025.108268 · Cited by 7
Probiotics and Vaccination in Children
del Giudice, M. M. (2014) · Journal of Vaccines & Vaccination · doi:10.4172/2157-7560.1000226 · Cited by 6
Structure-Function Correlations of Commercial Fucoidan Extracts: Antioxidant, Antiviral, Antifungal, Antibacterial and Prebiotic Activities
Chadwick, M., Lancerin, M. S. R., Hazelton, P., Vidalis, K., Petit, E., Lukova, P., Delattre, C., Chen, X., Schneiders, T., Makrantoni, V., et al. (2026) · Molecules · doi:10.3390/molecules31101618 · Cited by 5
Fermented Milks and Cancer
Utz, V. E. M., Perdigón, G., & de LeBlanc, A. D. M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809868-4.00026-1 · Cited by 5
Healthy adults supplemented with a nutraceutical formulation containing Aloe vera gel, rosemary and Poria cocos enhances the effect of influenza vaccination in a randomized, triple-blind, placebo-controlled trial
Lewis, E. D., Crowley, D. C., Guthrie, N., & Evans, M. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1116634 · Cited by 5
Dairy products in the nutrition of young children: the evolution from tradition to functionality
Fayzullina, R. A., Анатольевна, С. Е., & Fedotova, O. B. (2019) · Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) · doi:10.21508/1027-4065-2019-64-4-133-140 · Cited by 5
Updated Genome Sequence for the Probiotic Bacterium Bifidobacterium animalis subsp. lactis BB-12
Jensen, K. L., Al-Nakeeb, K., Koza, A., & Zeidan, A. A. (2021) · Microbiology Resource Announcements · doi:10.1128/mra.00078-21 · Cited by 5
Oligosaccharide equine feed supplement, Immulix, has minor impact on vaccine responses in mice
Henriksen, I. W., Castro-Mejía, J. L., Mentzel, C. M. J., Lindenberg, F., & Hansen, A. K. (2022) · Scientific Reports · doi:10.1038/s41598-021-04132-8 · Cited by 5
Prebiotics, Probiotics, and Synbiotics: A Bifidobacterial View
Morelli, L., Callegari, M. L., & Patrone, V. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805060-6.00017-x · Cited by 6
Probiotics and virus infections : The effects of Lactobacillus rhamnosus GG on respiratory and gastrointestinal virus infections
Lehtoranta, L. (2012) · Työväentutkimus Vuosikirja · Cited by 5
Comparative effectiveness of oral nutritional supplements in preventing respiratory tract infections among adults: a systematic review and network meta-analysis
Zhu, Z., Zhu, X., Chu, Y., Zhang, B., & Chen, Y. (2025) · EClinicalMedicine · doi:10.1016/j.eclinm.2025.103479 · Cited by 4
Tapioca-resistant maltodextrin enhances probiotic survival more effectively than commercial prebiotics under simulated gastrointestinal conditions
Namkieat, P., Borompichaichartkul, C., Ayuni, D., Sapwarobol, S., & Phumsombat, P. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107358 · Cited by 4
Cloning and expression of enterovirus 71 capsid protein 1 in a probioticBifidobacterium pseudocatenulatum
Thinbanmai, T., Lulitanond, V., Mayo, B., Lulitanond, A., & Panya, M. (2018) · Letters in Applied Microbiology · doi:10.1111/lam.13089 · Cited by 4
The intestinal microbiota: determinants of resiliency?
Voigt, R. M., & Bishehsari, F. (2021) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(20)30048-9 · Cited by 4
Modes of Action of Probiotics
Nguyen, T. L., Thi, H. H. P., Lee, Y., Lee, J., & Kim, D. (2022) · Springer eBooks · doi:10.1007/978-3-030-98621-6_12 · Cited by 4
Antiobesity Effects of Lactobacillus paracasei Subsp. paracasei , L. casei 431 on High-Fat Diet-Induced Obese Rats
Shin, Y. J., Bae, J.-M., Cho, H.-R., Mahoro, P., Kim, H. H., Kim, S. H., Kim, T. H., & Bae, M. (2023) · Journal of Medicinal Food · doi:10.1089/jmf.2022.k.0144 · Cited by 5
The resident gut microbiome modulates the effect of synbiotics on the immunogenicity after SARS-COV-2 vaccination in elderly and diabetes patients
Zhang, L., Wang, S., Wong, M. C. S., Mok, C. K. P., Ching, J. Y., Mak, J. W. Y., Chen, C., Huo, B., Yan, S., Cheung, C. P., et al. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00804-9 · Cited by 3
Lactobacilli in COVID-19: A Systematic Review Based on Next-Generation Sequencing Studies
Taufer, C. R., & Rampelotto, P. H. (2024) · Microorganisms · doi:10.3390/microorganisms12020284 · Cited by 3
Study protocol for a randomised controlled trial evaluating the efficacy of dietary modulation of probiotics on nutritional status and antibody response to SARS-CoV-2 in Indonesian adolescents: gut-lung axis (DIVINE)
Agustina, R., Ekawidyani, K. R., Mutiyani, M., Prafiantini, E., Nindya, T. S., Damayanti, W., Rejeki, P. S., Djuari, L., Huriyati, E., Bines, J. E., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-087934 · Cited by 3
Impact of probiotics on the immune response to influenza vaccination is strongly influenced by ageing
Yaqoob, P. (2017) · Nutrition Bulletin · doi:10.1111/nbu.12253 · Cited by 3
Probiotics in Pediatrics: How to Choose Effective and Safety Specimen for a Child
Drozdov, V. N., Vorobieva, O. A., Алексеевич, А. А., & Ших, Е. В. (2019) · Вопросы современной педиатрии · doi:10.15690/vsp.v18i4.2045 · Cited by 3
Pediococcus pentosaceus MIANGUAN Enhances the Immune Response to Vaccination in Mice
Chen, Y., Cao, Z., Lu, S., Wang, Z., Ma, C., Zhang, G., Chen, M.-S., Yang, J., Ren, Z.-H., & Xu, J.-G. (2024) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-023-10205-z · Cited by 3
PROBIOTICS AND BACTERIAL IMMUNOMODULATORS FOR PREVENTION OF RESPIRATORY INFECTIONS
Викторовна, Х. Н. (2014) · Вопросы современной педиатрии · doi:10.15690/vsp.v13i4.1092 · Cited by 3
Efectos del Bifidobacterium animalis y dos cepas de Lactococcus lactis en el queso costeño
Arteaga-Márquez, M., Mendoza-Corvis, F. A., Montes-Guzmán, M., & Ruiz-Sánchez, O. (2016) · Ciencia y Tecnología Agropecuaria · doi:10.21930/rcta.vol17_num3_art:515 · Cited by 3
Sustainable probiotic production via AI: medium optimization and metabolic mechanisms in Bifidobacterium animalis ssp. lactis BB-12 using agricultural waste
Zhang, H., Feng, R., Ding, N., Huang, T., Hong, H., Luo, Y., Chang, S. K. C., Zhang, Y., & Tan, Y. (2025) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2025.2577224 · Cited by 2
The Immune-Boosting Potential of Lacticaseibacillus paracasei HY7017 in Adults with Suboptimal Immune Function: A Double-Blind, Randomized, Placebo-Controlled, Clinical Trial
Jeon, S., Lee, H., Hong, D.-K., Park, S.-D., Choi, I.-D., Shim, J.-J., Hong, S.-S., & Lee, J.-H. (2026) · Journal of Medicinal Food · doi:10.1177/1096620x251384553 · Cited by 2
The Effects of Bifidobacterium animalis Subsp. Lactis and Vitamin D on Immunological Response Following Vaccination in Puppies
Saridag, G., ERDOĞAN, S., Özalp, T., Ural, K., & Erdoğan, H. (2023) · Macedonian Veterinary Review · doi:10.2478/macvetrev-2023-0025 · Cited by 2
Lactobacillus paracasei: probiotic properties and clinical efficacy
Новикова, В. П., & Кравцова, К. А. (2024) · Russian Medical Inquiry · doi:10.32364/2587-6821-2024-8-5-4 · Cited by 2
Exploring the associations between gut microbiota composition and SARS-CoV-2 inactivated vaccine response in mice with type 2 diabetes mellitus
Liu, L., He, X., Wang, J., Li, M., Wei, X., Yang, J., Cheng, G., Du, W., Liu, Z., & Xiao, X. (2024) · mSphere · doi:10.1128/msphere.00380-24 · Cited by 2
Lactobacillus helveticus GCL1815 induces salivary IgA production and alleviates common cold-like symptoms: A randomized, double-blind, placebo-controlled, parallel-group comparative study
Kikuchi, K. M., Wada, H., Saito, Y., Uesugi, T., Takahashi, K., Azuma, N., Mawatari, T., Nishimura, K., & Iwama, Y. (2025) · Journal of Functional Foods · doi:10.1016/j.jff.2025.106815 · Cited by 2
Encapsulation of Aqueous Components in Solid Fat Beads: Studies of a Model Dye and a Probiotic Culture
Wolfe, L. A., Roberts, R., & Coupland, J. N. (2014) · Journal of the American Oil Chemists Society · doi:10.1007/s11746-014-2567-2 · Cited by 2
The in vitro antiviral activity of Lacticaseibacillus casei MCJ protein-based metabolites on bovine viral diarrhea virus
Bhuyan, A. A., Bhuiyan, A. A., Memon, A. M., Zhang, B., Alam, J., & He, Q. (2021) · Animal Biotechnology · doi:10.1080/10495398.2021.1967964 · Cited by 2
Impact of oral administration of single strain Lactococcus lactis spp. cremoris on immune responses to keyhole limpet hemocyanin immunization and gut microbiota: A randomized placebo-controlled trial in healthy volunteers
Saghari, M., Gal, P., Grievink, H. W., Klaassen, E. S., Itano, A. A., McHale, D., & Moerland, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1009304 · Cited by 2
Obesity, immunity and vaccination
Guerrero, F. F., & Lopez-Gigosos, R. M. (2021) · Vacunas (English Edition) · doi:10.1016/j.vacune.2021.10.005 · Cited by 2
Effect of probiotic administration to breastfeeding mothers with very low birthweight neonates on some neonatal and maternal outcomes: study protocol for a randomised, double-blind, placebo-controlled trial
Alikamali, M., Mohammad‐Alizadeh‐Charandabi, S., Mirghafourvand‬‬‬‬‬‬‬‬‬‬‬‬‬‬, M., Gharehbaghi, M. M., Rad, A. H., Fardiazar, Z., & Shahnazi, M. (2024) · BMJ Open · doi:10.1136/bmjopen-2023-079526 · Cited by 1
Ascertaining the claims and reality of probiotic usage as an adjuvant therapy against virus-induced respiratory tract infections
Banerjee, A., Pal, S., Das, A. K., & Dhar, P. (2025) · Food and Humanity · doi:10.1016/j.foohum.2025.100725 · Cited by 1
Heat-Killed Enterococcus faecalis EF-2001 Promotes Systemic Th1-Skewed Immune Activation Without Detectable Reduction of Influenza Viral Load in Mice
Ohashi, T., Hagihara, M., Asai, N., Yamagishi, Y., & Mikamo, H. (2026) · Microorganisms · doi:10.3390/microorganisms14020316 · Cited by 1
Health benefits of Bifidobacterium animalis subsp. lactis BB-12 in infants and children: a mini-review
Acosta-Rodríguez-Bueno, C. P., Domínguez, A. M. C., Guyonnet, D., & Pouteau, E. B. (2026) · Frontiers in Microbiology · doi:10.3389/fmicb.2026.1773473 · Cited by 1
Role of Synbiotics in Inflammatory Lung Diseases
Ashique, S., Kumar, S., Upadhyay, A., Garg, A., Mishra, N., Kumar, P., Dua, K., Farid, A., & Hussain, A. (2024) · Springer eBooks · doi:10.1007/978-981-99-5575-6_3 · Cited by 1
Efficacy of Probiotics and Postbiotics in Treating Dengue Fever – A Potential Strategy to Reduce Antibody-dependent Enhancement
Mahooti, M., Ahmad, S., Ahmadbeigi, G., Abdolalipour, E., Safaei, F., Mahooti, K., Eslami, M., Yaghmayee, S., Sanami, S., & Pajand, O. (2026) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-026-11075-x · Cited by 1
easles Vaccine Failure in 9-month-old Infants
Yalçın, S. S., Karasimav, D., & Yurdakök, K. (2015) · Çocuk Enfeksiyon Dergisi/Journal of Pediatric Infection · doi:10.5152/ced.2015.2195 · Cited by 1
Probiotics and human gut microbiota modulation
Sinisterra-Loaiza, L., Lamas, A., Miranda, J. M., Cepeda, A., & Cardelle‐Cobas, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-89908-6.00024-8 · Cited by 1
Immunomodulatory Role of Milk on Gut Microbiota: Implications for Enhancing Oral Vaccine Efficacy
Asri, N. A. M., Bushra, S. M. R., Asri, A. A. M., Suppıan, R., & Norazmi, M. N. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10785-y · Cited by 1
Probiotics and Prebiotics in Immune System Protection
Nova, E., Abad, C., Gómez-Martínez, S., Pozo-Rubio, T., & Marcos, A. (2013) · CRC Press eBooks · doi:10.1201/b15561-14 · Cited by 3
Clinical Significance of Bifidobacteria
Riedel, C. U. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-805060-6.00013-2 · Cited by 3
Probiotics: Past, Present and Future Challenges
AL-Taha, B. M., Wadi, J., & Shehabi, A. A. (2018) · The International Arabic Journal of Antimicrobial Agents · doi:10.3823/816 · Cited by 1
Perspectives of treatment with probiotics in acute respiratory infections
Ivashkin, V. T., Zolnikova, O. Y., Potskhverashvili, N. D., Kokina, N. I., Леонидовна, Б. Е., Sedova, A., & Трухманов, А. С. (2019) · PULMONOLOGIYA · doi:10.18093/0869-0189-2019-29-5-612-619 · Cited by 1
Probiotic Bacteria as a Functional Delivery Vehicle for the Development of Live Oral Vaccines
Dadar, M., Shahali, Y., & Mojgani, N. (2021) · Microorganisms for sustainability · doi:10.1007/978-981-16-0223-8_13 · Cited by 1
Probiotics in Respiratory Infections
Bruzzese, E., Vecchio, A. L., & Ruberto, E. (2013) · World review of nutrition and dietetics · doi:10.1159/000345743
Evaluación de la viabilidad de Lactobacillus casei libre y encapsulado en alginato sódico como probiótico en jugo de guayaba
M., A. V. D. L. C., & R., A. R. T. (2013)
Probiotics and Anti-inflammatory Processes in HIV Infection
Reale, M., & Falasca, K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805417-8.00024-x
Efeitos clínicos, microbiológicos e imunológicos do probiótico Bifidobacterium animalis subsp. lactis com terapia adjuvante no tratamento não cirúrgico da periodontite crônica: estudo clínico controlado e aleatorizado
Invernici, M. D. M. (2019) · doi:10.11606/t.58.2019.tde-29082018-131312
Aşılar ve Mikrobiyota
Çelik, M., & Yalçın, S. S. (2019) · Turkish Journal of Pediatric Disease · doi:10.12956/tchd.509182
Microbiota, Cancer and Immune Therapy
Cabezón‐Gutiérrez, L., Palka-Kotlowska, M., Custodio‐Cabello, S., Villamayor-Delgado, M. L., Franco‐Moreno, A., & Khosravi‐Shahi, P. (2023) · Advances in Medicine and Engineering Interdisciplinary Research · doi:10.32629/ameir.v1i4.1629

Authors: Rizzardini, G., Eskesen, D., Calder, P. C., Capetti, A., Jespersen, L., & Clerici, M.
Affiliations: Luigi Sacco Hospital (IT)
Chr. Hansen (Denmark) (DK)
Southampton General Hospital (GB)
University of Milan (IT)
Corresponding author: Jespersen, Lillian
ORCID: Rizzardini, Giuliano
Calder, Philip C.
Capetti, Amedeo
Clerici, Mario
Venue: British Journal Of Nutrition
Publisher: Cambridge University Press (CUP)
Published: 2011-09-07
Volume: 107
Issue: 6
Pages: 876-884
ISSN: 0007-1145 (ISSN-L)
1475-2662
DOI: 10.1017/s000711451100420x
OpenAlex: W2168275695
Cited by: 217
References: 38
Citations by year: 2026: 12 · 2025: 17 · 2024: 18 · 2023: 17 · 2022: 23 · 2021: 23 · 2020: 11 · 2019: 13 · 2018: 9 · 2017: 21 · 2016: 11 · 2015: 10 · 2014: 11 · 2013: 14 · 2012: 7
FWCI: 14.96
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified)
Locations: British Journal Of Nutrition (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: probiotics, Bifidobacterium animalis subsp. lactis BB-12, seasonal influenza vaccination, IgG subclasses, secretory IgA, mucosal immunity, systemic immunity, cytokines, innate immunity, immunomodulation
MeSH terms: Adult, Antibody Specificity, Bifidobacterium, Double-Blind Method, Female, Humans, Immunoglobulin G, Influenza, Human, Influenza Vaccines, Italy, Lactobacillus, Male, Middle Aged, Patient Compliance, Patient Dropouts, Saliva, Incidence, Probiotics, Young Adult, Immunity, Humoral

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double-blind, placebo-controlled study

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks