The DOI matches its Crossref record, with a small difference in title or year; 38 of the 38 references it cites were found in a registry or an index.
Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double-blind, placebo-controlled study
Open accessAbstract
The present study investigated the ability of Bifidobacterium animalis ssp. lactis (BB-12®) and Lactobacillus paracasei ssp. paracasei (L. casei 431®) to modulate the immune system using a vaccination model in healthy subjects. A randomised, double-blind, placebo-controlled, parallel-group study was conducted in 211 subjects (56 % females, mean age 33·2 (sd 13·1) years). Subjects consumed a minimum of 10⁹ colony-forming units of BB-12® (capsule) or L. casei 431® (dairy drink) or a matching placebo once daily for 6 weeks. After 2 weeks, a seasonal influenza vaccination was given. Plasma and saliva samples were collected at baseline and after 6 weeks for the analysis of antibodies, cytokines and innate immune parameters. Changes from baseline in vaccine-specific plasma IgG, IgG1 and IgG3 were significantly greater in both probiotic groups v. the corresponding placebo group (L. casei 431®, P = 0·01 for IgG; P < 0·001 for remaining comparisons). The number of subjects obtaining a substantial increase in specific IgG (defined as ≥ 2-fold above baseline) was significantly greater in both probiotic groups v. placebo (BB-12®, P < 0·001 for IgG, IgG1 and IgG3; L. casei 431®, P < 0·001 for IgG1 and IgG3). Significantly greater mean fold increases for vaccine-specific secretory IgA in saliva were observed in both probiotic groups v. placebo (BB-12®, P = 0·017; L. casei 431®, P = 0·035). Similar results were observed for total antibody concentrations. No differences were found for plasma cytokines or innate immune parameters. Data herein show that supplementation with BB-12® or L. casei 431® may be an effective means to improve immune function by augmenting systemic and mucosal immune responses to challenge.
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“Along these lines there has been interest in utilizing probiotics (live microorganisms having beneficial effects on human hosts) to enhance response to vaccinations, based on substantial pre-clinical evidence identifying their immune-modulating properties (Rizzardini et al., 2012).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Rizzardini et al., 2012
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A Simple Sequentially Rejective Multiple Test Procedure
(1979) · Scandinavian Journal of Statistics · doi:10.2307/4615733 · Cited by 21,526
Hatakka, K., Savilahti, E., Pönkä, A., Meurman, J. H., Poussa, T., Näse, L., Saxelin, M., & Korpela, R. (2001) · BMJ · doi:10.1136/bmj.322.7298.1327 · Cited by 645
Cox, R. J., Brokstad, K. A., & Ogra, P. L. O. (2004) · Scandinavian Journal of Immunology · doi:10.1111/j.0300-9475.2004.01382.x · Cited by 564
Immunomodulation of Human Blood Cells Following the Ingestion of Lactic Acid Bacteria
Schiffrin, E. J., Rochat, F., Link‐Amster, H., Aeschlimann, J., & Donnet‐Hughes, A. (1995) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(95)76659-0 · Cited by 553
Thomas, C. M., & Versalovic, J. A. (2010) · Gut Microbes · doi:10.4161/gmic.1.3.11712 · Cited by 470
Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children
Fukushima, Y., Kawata, Y., Hiroyoshi, H. A. R. A., Terada, A., & MITSUOKA, T. (1998) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(98)00056-7 · Cited by 333
PASSCLAIM1?Gut health and immunity
Cummings, J. H., Antoine, J.-M., Azpiroz, F., Bourdet-Sicard, R., Brandtzaeg, P., Calder, P. C., Gibson, G. R., Guarner, F., Isolauri, E., Pannemans, D., et al. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-1205-4 · Cited by 324
Self-citationSalivary IgA as a Risk Factor for Upper Respiratory Infections in Elite Professional Athletes
Neville, V., Gleeson, M., & Folland, J. P. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31816be9c3 · Cited by 313
Probiotic Effects on Cold and Influenza-Like Symptom Incidence and Duration in Children
Leyer, G. J., Li, S., Mubasher, M., Reifer, C. J., & Ouwehand, A. C. (2009) · PEDIATRICS · doi:10.1542/peds.2008-2666 · Cited by 305
Markers to measure immunomodulation in human nutrition intervention studies
Albers, R., Antoine, J., Bourdet‐Sicard, R., Calder, P. C., Gleeson, M., Lesourd, B., Samartı́n, S., Sanderson, I. R., Loo, J. V., Dias, F. W. V., et al. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051469 · Cited by 284
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Research works printed but not linked: 2
- 2002, Guidelines for the Evaluation of Probiotics in Food. Report of a Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food
- 2 World Health Organization (1948) WHO Definition of Health. Preamble to the Constitution of the World Health Organization as Adopted by the International Health Conference, New York, 19–22 June, 1946; Signed on 22 July 1946 by the Representatives of 61 States (Official Records of the World Health Organization, no. 2, p. 100) and Entered into Force on 7 April 1948. http://who.int/about/definition/en/print.html.
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Suh, M., Mitchell, M., Hooda, N., Bylsma, L. C., & Cohen, S. S. (2024) · International Journal Of Nutrition · doi:10.14302/issn.2379-7835.ijn-24-4938
kohan, A., & Keshtmand, Z. (2024) · Comparative Clinical Pathology · doi:10.1007/s00580-024-03583-5 · Cited by 1
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Paul, P., & Balaji, S. (2025) · Springer eBooks · doi:10.1007/978-3-031-77911-4_3
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Modi, K., Gohil, S., Khan, T. A., Jobby, R., & Jha, P. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-40483-2.00042-x
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Metadata
- Authors
- Rizzardini, G., Eskesen, D., Calder, P. C., Capetti, A., Jespersen, L., & Clerici, M.
- Affiliations
- Luigi Sacco Hospital (IT)
- Chr. Hansen (Denmark) (DK)
- Southampton General Hospital (GB)
- University of Milan (IT)
- Corresponding author
- Jespersen, Lillian
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2011-09-07
- Volume
- 107
- Issue
- 6
- Pages
- 876-884
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2168275695
- Cited by
- 217
- References
- 38
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 18 · 2023: 17 · 2022: 23 · 2021: 23 · 2020: 11 · 2019: 13 · 2018: 9 · 2017: 21 · 2016: 11 · 2015: 10 · 2014: 11 · 2013: 14 · 2012: 7
- FWCI
- 14.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- probiotics, Bifidobacterium animalis subsp. lactis BB-12, seasonal influenza vaccination, IgG subclasses, secretory IgA, mucosal immunity, systemic immunity, cytokines, innate immunity, immunomodulation
- MeSH terms
- Adult, Antibody Specificity, Bifidobacterium, Double-Blind Method, Female, Humans, Immunoglobulin G, Influenza, Human, Influenza Vaccines, Italy, Lactobacillus, Male, Middle Aged, Patient Compliance, Patient Dropouts, Saliva, Incidence, Probiotics, Young Adult, Immunity, Humoral
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