The DOI matches its Crossref record, with a small difference in title or year; 38 of the 38 references it cites were found in a registry or an index.
Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double-blind, placebo-controlled study
Open accessAbstract
The present study investigated the ability of Bifidobacterium animalis ssp. lactis (BB-12®) and Lactobacillus paracasei ssp. paracasei (L. casei 431®) to modulate the immune system using a vaccination model in healthy subjects. A randomised, double-blind, placebo-controlled, parallel-group study was conducted in 211 subjects (56 % females, mean age 33·2 (sd 13·1) years). Subjects consumed a minimum of 10⁹ colony-forming units of BB-12® (capsule) or L. casei 431® (dairy drink) or a matching placebo once daily for 6 weeks. After 2 weeks, a seasonal influenza vaccination was given. Plasma and saliva samples were collected at baseline and after 6 weeks for the analysis of antibodies, cytokines and innate immune parameters. Changes from baseline in vaccine-specific plasma IgG, IgG1 and IgG3 were significantly greater in both probiotic groups v. the corresponding placebo group (L. casei 431®, P = 0·01 for IgG; P < 0·001 for remaining comparisons). The number of subjects obtaining a substantial increase in specific IgG (defined as ≥ 2-fold above baseline) was significantly greater in both probiotic groups v. placebo (BB-12®, P < 0·001 for IgG, IgG1 and IgG3; L. casei 431®, P < 0·001 for IgG1 and IgG3). Significantly greater mean fold increases for vaccine-specific secretory IgA in saliva were observed in both probiotic groups v. placebo (BB-12®, P = 0·017; L. casei 431®, P = 0·035). Similar results were observed for total antibody concentrations. No differences were found for plasma cytokines or innate immune parameters. Data herein show that supplementation with BB-12® or L. casei 431® may be an effective means to improve immune function by augmenting systemic and mucosal immune responses to challenge.
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“Along these lines there has been interest in utilizing probiotics (live microorganisms having beneficial effects on human hosts) to enhance response to vaccinations, based on substantial pre-clinical evidence identifying their immune-modulating properties (Rizzardini et al., 2012).”
From Viral Infections, the Microbiome, and Probiotics (2021) · cites this paper as Rizzardini et al., 2012
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Metadata
- Authors
- Rizzardini, G., Eskesen, D., Calder, P. C., Capetti, A., Jespersen, L., & Clerici, M.
- Affiliations
- Luigi Sacco Hospital (IT)
- Chr. Hansen (Denmark) (DK)
- Southampton General Hospital (GB)
- University of Milan (IT)
- Corresponding author
- Jespersen, Lillian
- Venue
- British Journal Of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2011-09-07
- Volume
- 107
- Issue
- 6
- Pages
- 876-884
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2168275695
- Cited by
- 217
- References
- 38
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 18 · 2023: 17 · 2022: 23 · 2021: 23 · 2020: 11 · 2019: 13 · 2018: 9 · 2017: 21 · 2016: 11 · 2015: 10 · 2014: 11 · 2013: 14 · 2012: 7
- FWCI
- 14.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- probiotics, Bifidobacterium animalis subsp. lactis BB-12, seasonal influenza vaccination, IgG subclasses, secretory IgA, mucosal immunity, systemic immunity, cytokines, innate immunity, immunomodulation
- MeSH terms
- Adult, Antibody Specificity, Bifidobacterium, Double-Blind Method, Female, Humans, Immunoglobulin G, Influenza, Human, Influenza Vaccines, Italy, Lactobacillus, Male, Middle Aged, Patient Compliance, Patient Dropouts, Saliva, Incidence, Probiotics, Young Adult, Immunity, Humoral
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