Cited by 217Probiotics and Fermented FoodsImmune responses and vaccinationsMicrobial Metabolites in Food Biotechnology

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Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double-blind, placebo-controlled study

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Rizzardini, Giuliano, Eskesen, Dorte, Calder, Philip C., Capetti, Amedeo, Jespersen, Lillian, Clerici, Mario·2012·British Journal Of Nutrition

DOI 10.1017/s000711451100420x

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Abstract

The present study investigated the ability of Bifidobacterium animalis ssp. lactis (BB-12®) and Lactobacillus paracasei ssp. paracasei (L. casei 431®) to modulate the immune system using a vaccination model in healthy subjects. A randomised, double-blind, placebo-controlled, parallel-group study was conducted in 211 subjects (56 % females, mean age 33·2 (sd 13·1) years). Subjects consumed a minimum of 10⁹ colony-forming units of BB-12® (capsule) or L. casei 431® (dairy drink) or a matching placebo once daily for 6 weeks. After 2 weeks, a seasonal influenza vaccination was given. Plasma and saliva samples were collected at baseline and after 6 weeks for the analysis of antibodies, cytokines and innate immune parameters. Changes from baseline in vaccine-specific plasma IgG, IgG1 and IgG3 were significantly greater in both probiotic groups v. the corresponding placebo group (L. casei 431®, P = 0·01 for IgG; P < 0·001 for remaining comparisons). The number of subjects obtaining a substantial increase in specific IgG (defined as ≥ 2-fold above baseline) was significantly greater in both probiotic groups v. placebo (BB-12®, P < 0·001 for IgG, IgG1 and IgG3; L. casei 431®, P < 0·001 for IgG1 and IgG3). Significantly greater mean fold increases for vaccine-specific secretory IgA in saliva were observed in both probiotic groups v. placebo (BB-12®, P = 0·017; L. casei 431®, P = 0·035). Similar results were observed for total antibody concentrations. No differences were found for plasma cytokines or innate immune parameters. Data herein show that supplementation with BB-12® or L. casei 431® may be an effective means to improve immune function by augmenting systemic and mucosal immune responses to challenge.

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Authors: Rizzardini, G., Eskesen, D., Calder, P. C., Capetti, A., Jespersen, L., & Clerici, M.
Affiliations: Luigi Sacco Hospital (IT)
Chr. Hansen (Denmark) (DK)
Southampton General Hospital (GB)
University of Milan (IT)
Corresponding author: Jespersen, Lillian
ORCID: Rizzardini, Giuliano
Calder, Philip C.
Capetti, Amedeo
Clerici, Mario
Venue: British Journal Of Nutrition
Publisher: Cambridge University Press (CUP)
Published: 2011-09-07
Volume: 107
Issue: 6
Pages: 876-884
ISSN: 0007-1145 (ISSN-L)
1475-2662
DOI: 10.1017/s000711451100420x
OpenAlex: W2168275695
Cited by: 217
References: 38
Citations by year: 2026: 12 · 2025: 17 · 2024: 18 · 2023: 17 · 2022: 23 · 2021: 23 · 2020: 11 · 2019: 13 · 2018: 9 · 2017: 21 · 2016: 11 · 2015: 10 · 2014: 11 · 2013: 14 · 2012: 7
FWCI: 14.96
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.cambridge.org/core/terms (unspecified)
Locations: British Journal Of Nutrition (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
INFM-OAR (INFN Catania) (submittedVersion, other-oa)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords: probiotics, Bifidobacterium animalis subsp. lactis BB-12, seasonal influenza vaccination, IgG subclasses, secretory IgA, mucosal immunity, systemic immunity, cytokines, innate immunity, immunomodulation
MeSH terms: Adult, Antibody Specificity, Bifidobacterium, Double-Blind Method, Female, Humans, Immunoglobulin G, Influenza, Human, Influenza Vaccines, Italy, Lactobacillus, Male, Middle Aged, Patient Compliance, Patient Dropouts, Saliva, Incidence, Probiotics, Young Adult, Immunity, Humoral

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Evaluation of the immune benefits of two probiotic strains Bifidobacterium animalis ssp. lactis, BB-12® and Lactobacillus paracasei ssp. paracasei, L. casei 431® in an influenza vaccination model: a randomised, double-blind, placebo-controlled study

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