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LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised controlled studies
Open accessAbstract
Phytosterols (PS, comprising plant sterols and plant stanols) have been proven to lower LDL-cholesterol concentrations. The dose–response relationship for this effect has been evaluated in several meta-analyses by calculating averages for different dose ranges or by applying continuous dose–response functions. Both approaches have advantages and disadvantages. So far, the calculation of averages for different dose ranges has not been done for plant sterols and stanols separately. The objective of the present meta-analysis was to investigate the combined and separate effects of plant sterols and stanols when classified into different dose ranges. Studies were searched and selected based on predefined criteria. Relevant data were extracted. Average LDL-cholesterol effects were calculated when studies were categorised by dose, according to random-effects models while using the variance as weighing factor. This was done for plant sterols and stanols combined and separately. In total, 124 studies (201 strata) were included. Plant sterols and stanols were administered in 129 and fifty-nine strata, respectively; the remaining used a mix of both. The average PS dose was 2·1 (range 0·2–9·0) g/d. PS intakes of 0·6–3·3 g/d were found to gradually reduce LDL-cholesterol concentrations by, on average, 6–12 %. When plant sterols and stanols were analysed separately, clear and comparable dose–response relationships were observed. Studies carried out with PS doses exceeding 4 g/d were not pooled, as these were scarce and scattered across a wide range of doses. In conclusion, the LDL-cholesterol-lowering effect of both plant sterols and stanols continues to increase up to intakes of approximately 3 g/d to an average effect of 12 %.
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In the citing paper
“The expected reductions of the intended combination of a Portfolio dietary pattern and NCEP Step II diet of ~27% (32% in efficacy and 15% in effectiveness trials) are similar to those seen with the starting doses of low intensity statins (18 to 28%) 67 or 10 mg of ezetimibe (15-20%).69”
From Portfolio Dietary Pattern and Cardiovascular Disease: A Systematic Review and Meta-analysis of Controlled Trials (2018) · cites this paper as [67]
Experimental — accuracy not yet measuredIn the citing paper
“their LDL cholesterol-lowering effect continues to increase up to intakes of approximately 3 g/day with an average LDL-C reduction of 12% [12].”
From Nutraceuticals in the Management of Dyslipidemia: Which, When, and for Whom? Could Nutraceuticals Help Low-Risk Individuals with Non-optimal Lipid Levels? (2021) · cites this paper as [12]
In the citing paper
“A large meta-analysis of 124 studies (201 strata) concluded that the PS are safe and that their LDL cholesterol-lowering effect continues to increase up to intakes of approximately 3 g/day with an average LDL-C reduction of 12% [12].”
From Nutraceuticals in the Management of Dyslipidemia: Which, When, and for Whom? Could Nutraceuticals Help Low-Risk Individuals with Non-optimal Lipid Levels? (2021) · cites this paper as [12]
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Citations
Cites
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Lichtenstein, A. H., Appel, L. J., Brands, M., Carnethon, M., Daniels, S., Franch, H. A., Franklin, B., Kris-Etherton, P., Harris, W. S., Howard, B., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.176158 · Cited by 2,705
Efficacy and Safety of Plant Stanols and Sterols in the Management of Blood Cholesterol Levels
Katan, M., Grundy, S. M., Jones, P. J. H., Law, M., Miettinen, T. A., & Paoletti, R. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.8.965 · Cited by 1,078
Plant sterol and stanol margarines and health
Law, M. (2000) · BMJ · doi:10.1136/bmj.320.7238.861 · Cited by 729 · cited 3×
“The meta-analyses carried out by Law(9), Katan et al.(6) and Abumweis et al.(10) described a dose–response relationship based on the calculation of average LDL-cholesterol-lowering effects for different categories of PS doses.”
MethodGylling, H., Plat, J., Turley, S., Ginsberg, H. N., Ellegård, L., Jessup, W., Jones, P. J., Lütjohann, D., Maerz, W., Masana, L., et al. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.11.043 · Cited by 529
Continuous Dose-Response Relationship of the LDL-Cholesterol–Lowering Effect of Phytosterol Intake
Demonty, I., Ras, R. T., van der Knaap, H. C. M., Duchateau, G. S. M. J. E., Meijer, L., Zock, P. L., Geleijnse, J. M., & Trautwein, E. A. (2008) · Journal of Nutrition · doi:10.3945/jn.108.095125 · Cited by 516
Self-citationHendriks, H., Weststrate, J., van Vliet, T., & Meijer, G. W. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600728 · Cited by 399
Abumweis, S., Barake, R., & Jones, P. (2008) · Food & Nutrition Research · doi:10.3402/fnr.v52i0.1811 · Cited by 369
Grundy, S. M. (2013) · Journal of clinical lipidology · doi:10.1016/j.jacl.2013.10.001 · Cited by 353
Assmann, G., Cullen, P., Erbey, J. R., Ramey, D. R., Kannenberg, F., & Schulte, H. (2005) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2005.04.001 · Cited by 255
Research works printed but not linked: 3
- 10.1016/S0025-6196(11)63144-3 · DOI
- 2008, Food Nutr Res, 52
- 2005, Am J Cardiol, 96, 23D
Cited by
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Stellaard, F., & Lütjohann, D. (2025) · Nutrients · doi:10.3390/nu17040654 · Cited by 16
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Do, D. N., Fleming, A., Schenkel, F. S., Miglior, F., Zhao, X., & Ibeagha-Awemu, E. M. (2018) · Canadian Journal of Animal Science · doi:10.1139/cjas-2018-0010 · Cited by 13
Huang, Y., He, W., Zhao, M., McClements, D. J., Xu, Y., Li, L., Dong, W., Hu, X., & Li, C. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.105274 · Cited by 13
Case Studies in Pediatric Lipid Disorders and Their Management
Ashraf, A. P., Sunil, B., Bamba, V., Breidbart, E., Brar, P. C., Chung, S. T., Gupta, A., Khokhar, A., Kumar, S., Lightbourne, M., et al. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab568 · Cited by 12
Gao, P., Liu, R., Jin, Q., & Wang, X. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101436 · Cited by 13
Mitry, P., Wawro, N., Sharma, S., Kriebel, J., Artati, A., Adamski, J., Heier, M., Meisinger, C., Thorand, B., Grallert, H., et al. (2019) · British Journal Of Nutrition · doi:10.1017/s000711451900103x · Cited by 12
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Jones, J. L., Sabaté, J., Heskey, C. E., Oda, K., Miles, F. L., & Rajaram, S. (2023) · Journal of Nutritional Science · doi:10.1017/jns.2023.39 · Cited by 11
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Wang, Y., Liu, B., Hu, Y., Sampson, L., Manson, J. E., Rimm, E. B., & Sun, Q. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2023.11.020 · Cited by 11
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Ge, Q., Yue, Y., Luo, Y., Teng, T., Cao, C., Zhao, D., Zhang, J., Li, C., Chen, W., Yang, B., et al. (2024) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2024.2342301 · Cited by 12
Qiao, W., Feng, H., Zhang, Y.-F., Zhang, Z., Yang, J., Wu, M., Xie, J., Huang, J., Zhou, T., & Zhang, Y. (2025) · Food & Function · doi:10.1039/d4fo05439c · Cited by 11
Prevention and Treatment of Atherosclerosis: The Use of Nutraceuticals and Functional Foods
Visioli, F., & Poli, A. (2019) · Handbook of experimental pharmacology · doi:10.1007/164_2019_341 · Cited by 11
Jacobs, D. M., Mihaleva, V. V., van Schalkwijk, D. B., de Graaf, A. A., Vervoort, J. J. M., van Dorsten, F. A., Ras, R. T., Demonty, I., Trautwein, E. A., & van Duynhoven, J. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500152 · Cited by 11
Self-citationProtic, O., Bonfigli, A. R., & Antonicelli, R. (2021) · Nutrients · doi:10.3390/nu13093128 · Cited by 11
Mohammed, S. G. A. A., & Qoronfleh, M. W. (2020) · Advances in neurobiology · doi:10.1007/978-3-030-30402-7_9 · Cited by 13
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Liu, J., Zhang, J., Zeng, M., Li, M., Xie, S., Zheng, X., & Feng, W. (2022) · Molecules · doi:10.3390/molecules27154870 · Cited by 12
Hwang, K., Hwang, Y.-J., & Song, J. (2017) · Journal of the Chinese Medical Association · doi:10.1016/j.jcma.2017.06.007 · Cited by 11
Do, D. N., Schenkel, F. S., Miglior, F., Zhao, X., & Ibeagha-Awemu, E. M. (2020) · Animal Genetics · doi:10.1111/age.12901 · Cited by 11
Jefrei, E., Xu, M., Moore, J. B., & Thorne, J. L. (2023) · British Journal Of Nutrition · doi:10.1017/s0007114523002532 · Cited by 10
Kaçar, Ö. F., Kose, T., & Kaçar, H. K. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1669375 · Cited by 12
Nutraceutical Approaches to Dyslipidaemia: The Main Formulative Issues Preventing Efficacy
Colletti, A., Fratter, A., Pellizzato, M., & Cravotto, G. (2022) · Nutrients · doi:10.3390/nu14224769 · Cited by 10
Role of Functional Foods in Human Health and Disease Prevention
Sharma, L., & Yadav, A. (2022) · Springer eBooks · doi:10.1007/978-981-19-2366-1_14 · Cited by 19
Lin, Y., Koppenol, W. P., Knol, D., Vermeer, M. A., Hiemstra, H., Friedrichs, S., Lütjohann, D., & Trautwein, E. A. (2019) · Nutrients · doi:10.3390/nu11102319 · Cited by 10
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Shin, J., Song, M., Yu, J.-W., Ko, E. Y., Shang, X., Oh, J., Keum, Y., & Saini, R. K. (2021) · Antioxidants · doi:10.3390/antiox10101629 · Cited by 10
Integrated Biorefinery for Valorization of Engineered Bioenergy Crops—A Review
Singh, R. D., & Singh, V. (2021) · Industrial Biotechnology · doi:10.1089/ind.2021.0020 · Cited by 10
Yang, S., Zhang, X., Saleh, A. S. M., Wang, L., Duan, Y., & Xiao, Z. (2024) · LWT · doi:10.1016/j.lwt.2024.116775 · Cited by 9
Yang, Y., Xia, J., Yu, T., Wan, S., Zhou, Y., & Sun, G. (2024) · Phytotherapy Research · doi:10.1002/ptr.8308 · Cited by 9
Eurasian clinical practice guidelines for dietary management of cardiovascular diseases (2024)
Starodubova, A. V., Chazova, I. E., Tutelyan, V. A., Nikityuk, D. B., Pavlovskaya, E. V., Кislyak, O. A., Blinova, N. V., Brumberg, A. A. B., Bubnova, M. G., Varaeva, Y. R., et al. (2024) · Eurasian heart journal · doi:10.38109/2225-1685-2024-4-6-66 · Cited by 10
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Salsinha, A. S., Machado, M., Rodríguez-Alcalá, L. M., Gomes, A., & Pintado, M. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-824043-4.00014-2 · Cited by 12
Authorised EU health claims for phytosterols
Shortt, C. (2015) · Elsevier eBooks · doi:10.1016/b978-1-78242-382-9.00002-5 · Cited by 9
Daels, E., Goderis, B., Matton, V., & Foubert, I. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b05049 · Cited by 9
Novidiyanto, Asrullah, M., Lestari, L. A., Helmyati, S., & Farmawati, A. (2019) · KnE Life Sciences · doi:10.18502/kls.v4i11.3850 · Cited by 9
Kaewduangdee, S., Chaveerach, A., Tanee, T., Siripiyasing, P., & Sudmoon, R. (2020) · ScienceAsia · doi:10.2306/scienceasia1513-1874.2020.053 · Cited by 9
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Mirzai, S., & Laffin, L. J. (2023) · Current Cardiology Reports · doi:10.1007/s11886-023-01903-9 · Cited by 9
Laitinen, K., Gylling, H., Kaipiainen, L., Nissinen, M. J., & Simonen, P. P. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2017.01.012 · Cited by 9
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Chen, S., Bi, Y., Sun, S., & Chen, J. (2017) · Journal of the American Oil Chemists Society · doi:10.1007/s11746-017-2952-8 · Cited by 9
Deng, D., Xie, Y., Wang, Y., Wang, S., Li, Z., Mo, T., & Guo, H. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.110147 · Cited by 8
Palmeiro-Silva, Y. K., Aravena, R. I., Ossio, L., & Fluxá, J. P. (2020) · Nutrients · doi:10.3390/nu12082392 · Cited by 8
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Frumuzachi, O., Babotă, M., Miere, D., Mocan, A., & Crișan, G. (2024) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2286475 · Cited by 8
Spinedi, M., Clark, C., Zullo, L., Kerksiek, A., Pistis, G., Castelao, E., von Gunten, A., Preisig, M., Lütjohann, D., & Popp, J. (2024) · iScience · doi:10.1016/j.isci.2024.109013 · Cited by 8
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Cicero, A. F. G., & Colletti, A. (2015) · Springer eBooks · doi:10.1007/978-3-319-20433-8_11 · Cited by 8
Daels, E., Goderis, B., Steen, L., & Foubert, I. (2018) · Food Structure · doi:10.1016/j.foostr.2018.04.001 · Cited by 8
Development of new food products based on phytonutrients
Bule, M. H., Issa, I. A., Khan, F., Shah, M. A., & Niaz, K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815354-3.00008-3 · Cited by 8
Lopez, C., David-Briand, E., Lollier, V., Mériadec, C., Bizien, T., Pérez, J., & Artzner, F. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112496 · Cited by 8
Xu, Y., Mo, G., Yao, Y., & Li, C. (2023) · European Journal of Clinical Nutrition · doi:10.1038/s41430-023-01283-x · Cited by 10
Noikotr, K., Chaveerach, A., Sudmoon, R., Tanee, T., & Patarapadungkit, N. (2018) · ScienceAsia · doi:10.2306/scienceasia1513-1874.2018.44.170 · Cited by 8
Baumgartner, S., Ras, R. T., Trautwein, E. A., Konings, M. C. J. M., Mensink, R. P., & Plat, J. (2019) · Journal of Lipid Research · doi:10.1194/jlr.ra119000274 · Cited by 8
Self-citationKopeć, A., Zawistowski, J., & Kitts, D. D. (2020) · Molecules · doi:10.3390/molecules25225363 · Cited by 8
Kopčeková, J., Lenártová, P., Mrázová, J., Gažarová, M., Habánová, M., & Jančichová, K. (2021) · Roczniki Państwowego Zakładu Higieny · doi:10.32394/rpzh.2021.0159 · Cited by 8
Betageri, O., Al-Turk, B., Freeman, A. M., & Aggarwal, M. (2021) · Current Cardiology Reports · doi:10.1007/s11886-021-01577-1 · Cited by 9
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Salo, P., & Kuusisto, P. (2016) · Cholesterol · doi:10.1155/2016/5349389 · Cited by 8
Pappe, C. L., Lutzenberger, S., Goebler, K., Meier, S., Jeitler, M., Michalsen, A., & Dommisch, H. (2024) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.14066 · Cited by 7
Matas, R. F., Popović, M., Čagalj, M., & Šimat, V. (2023) · Frontiers in Marine Science · doi:10.3389/fmars.2023.1221417 · Cited by 7
Tavares, A. K. M. M., Ribas, S. A., Paravidino, V. B., Sgambato, M. R., Rodrigues, R. D. R. M., da Rocha, C. M. M., Sichieri, R., & Cunha, D. B. (2020) · Nutrition · doi:10.1016/j.nut.2020.111051 · Cited by 7
IRIS MILKY-WHITE (IRIS LACTEA PALL.) – A PROMISING SOURCE OF BIOLOGICALLY ACTIVE SUBSTANCES
Luzhanin, V. G., Whaley, A. K., Ponkratova, A. O., Zhokhova, E. V., Zingalyuk, M. A., & Pryaknina, N. I. (2021) · chemistry of plant raw material · doi:10.14258/jcprm.2021038890 · Cited by 7
Non-Cholesterol Sterols in Breast Milk and Risk of Allergic Outcomes in the First Two Years of Life
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Thaipitakwong, T., & Aramwit, P. (2016) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-016-0191-2 · Cited by 7
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Fuster, V. P. (2017) · Nutrición Hospitalaria · doi:10.20960/nh.1574 · Cited by 7
Gandola, A., Dainelli, L., Zimmermann, D., Dahlui, M., & Detzel, P. (2019) · Nutrients · doi:10.3390/nu11061235 · Cited by 7
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Gylling, H., & Simonen, P. P. (2016) · Expert Review of Cardiovascular Therapy · doi:10.1586/14779072.2016.1166956 · Cited by 7
Lôbo, I. M. D. B., Bordallo, C. D. O. S., Sacramento, J. M., Leite, L. D. O., & Santana, P. D. S. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.08.022 · Cited by 6
Should We Be Screening for Ischaemic Heart Disease Earlier in Childhood?
Bassareo, P. P., O'Brien, S. T., Dunne, E., Duignan, S. M., Martino, E., Martino, F., & McMahon, C. J. (2022) · Children · doi:10.3390/children9070982 · Cited by 7
Fabrication and structural properties of water-dispersible phytosterol using hot melt extrusion
Li, Y., Ruan, Q., Wang, J., & Yang, X. (2021) · Journal of Food Science and Technology · doi:10.1007/s13197-020-04956-8 · Cited by 6
Makran, M., Barberá, R., & Cilla, A. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104751 · Cited by 6
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Berni, P. R. D. A., Rodrigues, D. B., Zandoná, L. R., Morzelle, M. C., Geraldi, M. V., & Maróstica, M. R. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21873-6.00010-5 · Cited by 5
Gao, Y., Pan, D., Xia, J., Xia, H., Wang, S., Liao, W., Yang, L., & Sun, G. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70248 · Cited by 5
Yogurt With Plant Sterols and Stanols
Büyüktuncer, Z. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-805134-4.00008-0 · Cited by 5
Integrative Therapies and Cardiovascular Disease in the Breast Cancer Population: A Review, Part 2.
Lucius, K., & Trukova, K. (2015) · PubMed Central · Cited by 5
Natural Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors: A Review
Singh, S. K., Sharma, H., Ramankutty, R., Ramaswamy, S., & Agrawal, N. (2023) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207326666230627122630 · Cited by 6
Synthesis and characterization of antioxidant-enriched Moringa oil-based edible oleogel
Yaqoob, N., Rehman, S., Shafiq, N., Mohsin, M. J., Akbar, A., Ibenmoussa, S., Wondmie, G. F., Jardan, Y. A. B., & Bourhia, M. (2024) · Open Chemistry · doi:10.1515/chem-2024-0038 · Cited by 5
Scholz, B., Weiherer, R., & Engel, K. (2017) · Steroids · doi:10.1016/j.steroids.2017.06.012 · Cited by 4
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López, J. F. M., Fuster, V. P., & Solà, R. (2016) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2016.04.001 · Cited by 4
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Dąbrowska, J., Wójcik, M., Borowik, J., Kuśmierczuk, K., & Piecewicz‐Szczęsna, H. (2020) · Journal of Education Health and Sport · doi:10.12775/jehs.2020.10.05.015 · Cited by 4
Shamloo, M., Granger, M. J., Trautwein, E. A., House, J. D., & MacKay, D. (2020) · Trials · doi:10.1186/s13063-020-04364-5 · Cited by 4
Self-citationДолженко, М. М., Barnett, O., Grassos, C. A., Dragomiretska, N. V., Goloborodko, B., Ілащук, Т. О., Зуєв, К. О., Карпенко, О. В., Kolesnikova, O. V., Колесник, Т. В., et al. (2020) · Advances in Therapy · doi:10.1007/s12325-020-01490-z · Cited by 4
Pereira, T., Fonseca, F. A. H., Fonseca, M. I. H., Martins, C. M., Fonseca, H. A. R., Fonzar, W. T., Goulart, A. C., Benseñor, I. M., Lotufo, P. A., & Izar, M. C. D. O. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.02.031 · Cited by 4
Zeitz, J. O., Ehbrecht, T., Fleischmann, A., Most, E., Geßner, D. K., Friedrichs, S., Sparenberg, M., Failing, K., Whelan, R., Lütjohann, D., et al. (2020) · Animals · doi:10.3390/ani10112050 · Cited by 4
Alzuwaid, N. T., Laddomada, B., Fellows, C. M., Egan, N., & Sissons, M. J. (2021) · Cereal Chemistry · doi:10.1002/cche.10408 · Cited by 4
Dawson, J., Rangan, A., & Rangan, G. K. (2025) · Journal of Nephrology · doi:10.1007/s40620-025-02378-3 · Cited by 3
Zurbau, A., Haintz, L., Chen, V., Glenn, A. J., Kavanagh, M. E., Oguntala, J. O., Mejía, S. B., Khan, T. A., Leiter, L., Kendall, C., et al. (2026) · Clinical Nutrition · doi:10.1016/j.clnu.2026.106698 · Cited by 3
Plant sterols and stanols that lower low-density lipoprotein cholesterol
Fedotova, V. V. (2022) · Человек и его здоровье · doi:10.21626/vestnik/2022-2/10 · Cited by 3
Некрасов, П. О., Berezka, T., Некрасов, О. П., Гудзь, О. М., Руднєва, С. І., & Molchenko, S. (2022) · Journal of Chemistry and Technologies · doi:10.15421/jchemtech.v30i3.265174 · Cited by 3
van den Belt, M., van der Haar, S., Oosterink, E., van Loenhout, T., Ishiguro, T., & Esser, D. (2022) · Nutrients · doi:10.3390/nu15010049 · Cited by 3
Xenosterolemia in clinical practice: what is in a name?
Loh, W. J., & Watts, G. F. (2022) · Current Opinion in Endocrinology Diabetes and Obesity · doi:10.1097/med.0000000000000795 · Cited by 3
Drug nutraceutical interactions
Godad, A. P., Ansari, A. Z., Bhatia, N. Y., Ali, A., Zine, S. P., & Doshi, G. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-824312-1.00020-0 · Cited by 3
Ambika, H. D., & U, H. V. P. (2025) · Grand challenges in biology and biotechnology · doi:10.1007/978-3-031-84282-5_8 · Cited by 3
Chemical composition of fermented green olives
Montaño, A., & Sánchez, A.-H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819528-4.00052-3 · Cited by 3
Phytostérols : un point sur les recommandations de l’ANSES
Fumeron, F., Bard, J., Vergès, B. L., Paillard, F., & Lecerf, J. (2015) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2015.02.004 · Cited by 3
Devries, S. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35868-2.00026-8 · Cited by 3
Jaramillo-Madrid, A. C., Abbriano, R. M., Ashworth, J., Fabris, M., & Ralph, P. J. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.30.228171 · Cited by 3
Girma, T., Genet, S., Feyisa, T. O., & Abdissa, T. (2021) · Research Square · doi:10.21203/rs.3.rs-198182/v1 · Cited by 3
Blood Phytosterol Concentration and Genetic Variant Associations in a Sample Population
Garrido-Sanchez, L., Badosa, E. L., Talaverón, J. M. L., Pintó, X., Lozano-Andreu, T., Corbella, E., Alía‐Ramos, P., Arias, L., Ramon-Torrel, J. M., & Tahull, M. B. (2024) · Nutrients · doi:10.3390/nu16071067 · Cited by 3
The Role of Functional Ingredients in the Management of Dyslipidemia
Arachchige, G. K. J., Truong, T., Chandrapala, J., Danaher, J., & Newman, L. P. (2025) · Food Reviews International · doi:10.1080/87559129.2025.2544171 · Cited by 2
Musto, L., Alegrı́a, A., & García‐Llatas, G. (2026) · Lipids in Health and Disease · doi:10.1186/s12944-026-02869-7 · Cited by 2
Silva-Santos, T., Morais, C., Cosme, F., Abreu, S., & Gonçalves, C. (2026) · Applied Sciences · doi:10.3390/app16147361 · Cited by 2
Metadata
- Authors
- Ras, R. T., Geleijnse, J. M., & Trautwein, E. A.
- Affiliations
- Unilever Research and Development Vlaardingen (NL)
- Wageningen University & Research (NL)
- Corresponding author
- Ras, Rouyanne T.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2014-04-30
- Volume
- 112
- Issue
- 2
- Pages
- 214-219
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- PMC
- PMC4071994
- OpenAlex
- W2145483967
- Cited by
- 379
- References
- 31
- Citations by year
- 2026: 22 · 2025: 17 · 2024: 20 · 2023: 36 · 2022: 31 · 2021: 42 · 2020: 43 · 2019: 41 · 2018: 34 · 2017: 32 · 2016: 31 · 2015: 26 · 2014: 2
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
- Keywords
- phytosterols, plant stanols, LDL cholesterol, dose-response relationship, cholesterol-lowering effect, dietary supplementation, hypercholesterolemia, dose range
- MeSH terms
- Adult, Anticholesteremic Agents, Humans, Hypercholesterolemia, Cholesterol, LDL, Phytosterols, Randomized Controlled Trials as Topic, Evidence-Based Medicine, Dietary Supplements, Functional Food
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