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LDL-cholesterol-lowering effect of plant sterols and stanols across different dose ranges: a meta-analysis of randomised controlled studies
Open accessAbstract
Phytosterols (PS, comprising plant sterols and plant stanols) have been proven to lower LDL-cholesterol concentrations. The dose–response relationship for this effect has been evaluated in several meta-analyses by calculating averages for different dose ranges or by applying continuous dose–response functions. Both approaches have advantages and disadvantages. So far, the calculation of averages for different dose ranges has not been done for plant sterols and stanols separately. The objective of the present meta-analysis was to investigate the combined and separate effects of plant sterols and stanols when classified into different dose ranges. Studies were searched and selected based on predefined criteria. Relevant data were extracted. Average LDL-cholesterol effects were calculated when studies were categorised by dose, according to random-effects models while using the variance as weighing factor. This was done for plant sterols and stanols combined and separately. In total, 124 studies (201 strata) were included. Plant sterols and stanols were administered in 129 and fifty-nine strata, respectively; the remaining used a mix of both. The average PS dose was 2·1 (range 0·2–9·0) g/d. PS intakes of 0·6–3·3 g/d were found to gradually reduce LDL-cholesterol concentrations by, on average, 6–12 %. When plant sterols and stanols were analysed separately, clear and comparable dose–response relationships were observed. Studies carried out with PS doses exceeding 4 g/d were not pooled, as these were scarce and scattered across a wide range of doses. In conclusion, the LDL-cholesterol-lowering effect of both plant sterols and stanols continues to increase up to intakes of approximately 3 g/d to an average effect of 12 %.
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In the citing paper
“The expected reductions of the intended combination of a Portfolio dietary pattern and NCEP Step II diet of ~27% (32% in efficacy and 15% in effectiveness trials) are similar to those seen with the starting doses of low intensity statins (18 to 28%) 67 or 10 mg of ezetimibe (15-20%).69”
From Portfolio Dietary Pattern and Cardiovascular Disease: A Systematic Review and Meta-analysis of Controlled Trials (2018) · cites this paper as [67]
Experimental — accuracy not yet measuredIn the citing paper
“their LDL cholesterol-lowering effect continues to increase up to intakes of approximately 3 g/day with an average LDL-C reduction of 12% [12].”
From Nutraceuticals in the Management of Dyslipidemia: Which, When, and for Whom? Could Nutraceuticals Help Low-Risk Individuals with Non-optimal Lipid Levels? (2021) · cites this paper as [12]
In the citing paper
“A large meta-analysis of 124 studies (201 strata) concluded that the PS are safe and that their LDL cholesterol-lowering effect continues to increase up to intakes of approximately 3 g/day with an average LDL-C reduction of 12% [12].”
From Nutraceuticals in the Management of Dyslipidemia: Which, When, and for Whom? Could Nutraceuticals Help Low-Risk Individuals with Non-optimal Lipid Levels? (2021) · cites this paper as [12]
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Citations
Cites
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Lichtenstein, A. H., Appel, L. J., Brands, M., Carnethon, M., Daniels, S., Franch, H. A., Franklin, B., Kris-Etherton, P., Harris, W. S., Howard, B., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.176158 · Cited by 2,705
Efficacy and Safety of Plant Stanols and Sterols in the Management of Blood Cholesterol Levels
Katan, M., Grundy, S. M., Jones, P. J. H., Law, M., Miettinen, T. A., & Paoletti, R. (2003) · Mayo Clinic Proceedings · doi:10.4065/78.8.965 · Cited by 1,078
Plant sterol and stanol margarines and health
Law, M. (2000) · BMJ · doi:10.1136/bmj.320.7238.861 · Cited by 729 · cited 3×
“The meta-analyses carried out by Law(9), Katan et al.(6) and Abumweis et al.(10) described a dose–response relationship based on the calculation of average LDL-cholesterol-lowering effects for different categories of PS doses.”
MethodGylling, H., Plat, J., Turley, S., Ginsberg, H. N., Ellegård, L., Jessup, W., Jones, P. J., Lütjohann, D., Maerz, W., Masana, L., et al. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2013.11.043 · Cited by 529
Continuous Dose-Response Relationship of the LDL-Cholesterol–Lowering Effect of Phytosterol Intake
Demonty, I., Ras, R. T., van der Knaap, H. C. M., Duchateau, G. S. M. J. E., Meijer, L., Zock, P. L., Geleijnse, J. M., & Trautwein, E. A. (2008) · Journal of Nutrition · doi:10.3945/jn.108.095125 · Cited by 516
Self-citationHendriks, H., Weststrate, J., van Vliet, T., & Meijer, G. W. (1999) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1600728 · Cited by 399
Abumweis, S., Barake, R., & Jones, P. (2008) · Food & Nutrition Research · doi:10.3402/fnr.v52i0.1811 · Cited by 369
Grundy, S. M. (2013) · Journal of clinical lipidology · doi:10.1016/j.jacl.2013.10.001 · Cited by 353
Assmann, G., Cullen, P., Erbey, J. R., Ramey, D. R., Kannenberg, F., & Schulte, H. (2005) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2005.04.001 · Cited by 255
Research works printed but not linked: 3
- 10.1016/S0025-6196(11)63144-3 · DOI
- 2008, Food Nutr Res, 52
- 2005, Am J Cardiol, 96, 23D
Cited by
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2016 European Guidelines on cardiovascular disease prevention in clinical practice
Piepoli, M. F., Hoes, A. W., Agewall, S., Albus, C., Brotons, C., Catapano, A. L., Cooney, M.-T., Corrà, U., Cosyns, B., Deaton, C., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw106 · Cited by 6,457
2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Benetos, A., Biffi, A., Boavida, J.-M., Capodanno, D., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab484 · Cited by 6,485
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Authors/Task Force Members, Piepoli, M. F., Hoes, A. W., Agewall, S., Albus, C., Brotons, C., Catapano, A. L., Cooney, M. T., Corrà, U., Cosyns, B., et al. (2016) · European Journal of Preventive Cardiology · doi:10.1177/2047487316653709 · Cited by 1,435
2021 ESC Guidelines on cardiovascular disease prevention in clinical practice
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Bénétos, A., Biffi, A., Boavida, J.-M., Capodanno, D., et al. (2021) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwab154 · Cited by 586
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Piepoli, M. F., Hoes, A. W., Agewall, S., Albus, C., Brotons, C., Catapano, A. L., Cooney, M. T., Corrà, U., Cosyns, B., Deaton, C., et al. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.05.037 · Cited by 502
Moreau, R. A., Nyström, L., Whitaker, B. D., Winkler‐Moser, J. K., Baer, D. J., Gebauer, S. K., & Hicks, K. B. (2018) · Progress in Lipid Research · doi:10.1016/j.plipres.2018.04.001 · Cited by 451
Moringa oleifera Seeds and Oil: Characteristics and Uses for Human Health
Leone, A., Spada, A., Battezzati, A., Schiraldi, A., Aristil, J., & Bertoli, S. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122141 · Cited by 406
Fabris, M., Abbriano, R. M., Pernice, M., Sutherland, D. L., Commault, A. S., Hall, C. C., Labeeuw, L., McCauley, J. I., Kuzhiuparambil, U., Ray, P., et al. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.00279 · Cited by 382
Jin, D., Dai, K., Xie, Z., & Chen, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-60172-6 · Cited by 348
Nutrition and Cardiovascular Health
Casas, R. M., Castro‐Barquero, S., Estruch, R., & Sacanella, E. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19123988 · Cited by 370
2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Dyslipidemia
Blumenthal, R. S., Morris, P. B., Gaudino, M., Johnson, H. M., Anderson, T. S., Bittner, V. A., Blankstein, R., Brewer, L. C., Cho, L., de Ferranti, S. D., et al. (2026) · JACC · doi:10.1016/j.jacc.2025.11.016 · Cited by 304
Trautwein, E. A., & McKay, S. (2020) · Nutrients · doi:10.3390/nu12092671 · Cited by 257
Self-citationChiavaroli, L., Nishi, S. K., Khan, T. A., Braunstein, C. R., Glenn, A. J., Mejia, S. B., Rahelić, D., Kahleová, H., Salas-Salvadó, J., Jenkins, D. J. A., et al. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.05.004 · Cited by 226
Sievenpiper, J. L., Chan, C. B., Dworatzek, P. D., Freeze, C., & Williams, S. L. (2018) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2017.10.009 · Cited by 200
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Poli, A., Marangoni, F., Corsini, A., Manzato, E., Marrocco, W., Martini, D., Medea, G., & Visioli, F. (2021) · Nutrients · doi:10.3390/nu13082810 · Cited by 201
Lipid-modifying effects of nutraceuticals: An evidence-based approach
Sahebkar, A., Șerban, M.-C., Gluba-Brzózka, A., Mikhailidis, D. P., Cicero, A. F. G., Rysz, J., & Banach, M. (2016) · Nutrition · doi:10.1016/j.nut.2016.04.007 · Cited by 188
Phytosterols in the Treatment of Hypercholesterolemia and Prevention of Cardiovascular Diseases
Cabral, C. E. L., & Klein, M. R. S. T. (2017) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20170158 · Cited by 190
He, W., Zhu, H., & Chen, Z. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b00059 · Cited by 177
F. Piepoli, M. (2017) · International Journal of Behavioral Medicine · doi:10.1007/s12529-016-9583-6 · Cited by 162
Kim, Y., Keogh, J. B., & Clifton, P. M. (2017) · Nutrients · doi:10.3390/nu9111271 · Cited by 161
Evening Primrose (Oenothera biennis) Biological Activity Dependent on Chemical Composition
Timoszuk, M., Bielawska, K., & Skrzydlewska, E. (2018) · Antioxidants · doi:10.3390/antiox7080108 · Cited by 152
Food Ingredients That Inhibit Cholesterol Absorption.
Jesch, E. D., & Carr, T. P. (2017) · PubMed Central · doi:10.3746/pnf.2017.22.2.67 · Cited by 151
Rico, R. F., Bulló, M., & Salas‐Salvadó, J. (2015) · Food Science & Nutrition · doi:10.1002/fsn3.294 · Cited by 156
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Piepoli, M. F., Hoes, A. W., Agewall, S., Albus, C., Brotons, C., Catapano, A. L., Cooney, M. T., Corrà, U., Cosyns, B., Deaton, C., et al. (2016) · Kardiologia Polska · doi:10.5603/kp.2016.0120 · Cited by 152
Poli, A., Barbagallo, C. M., Cicero, A. F. G., Corsini, A., Manzato, E., Trimarco, B., Bernini, F., Visioli, F., Bianchi, A., Canzone, G., et al. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.05.015 · Cited by 134
Plat, J., Baumgartner, S., Vanmierlo, T., Lütjohann, D., Calkins, K. L., Burrin, D. G., Guthrie, G. J., Thijs, C. T., Velde, A. A. T., Vreugdenhil, A. C. E., et al. (2019) · Progress in Lipid Research · doi:10.1016/j.plipres.2019.02.003 · Cited by 138
Self-citationWriting Committee Members, Blumenthal, R. S., Morris, P. B., Gaudino, M., Johnson, H. M., Anderson, T. S., Bittner, V. A., Blankstein, R., Brewer, L. C., Cho, L., et al. (2026) · Circulation · doi:10.1161/cir.0000000000001423 · Cited by 122
Nutraceuticals in hypercholesterolaemia: an overview
Santini, A., & Novellino, E. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13636 · Cited by 120
Kirkpatrick, C. F., Sikand, G., Petersen, K. S., Anderson, C. A. M., Aspry, K. E., Bolick, J. P., Kris‐Etherton, P. M., & Maki, K. C. (2023) · Journal of clinical lipidology · doi:10.1016/j.jacl.2023.05.099 · Cited by 137
Najjar, R. S., Moore, C. E., & Montgomery, B. D. (2018) · Clinical Cardiology · doi:10.1002/clc.22863 · Cited by 117
The role of nutraceuticals in the prevention of cardiovascular disease
Sosnowska, B., Penson, P. E., & Banach, M. (2017) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt.2017.03.20 · Cited by 117
Cicero, A. F. G., Fogacci, F., Stoian, A. P., Vrablik, M., Al Rasadi, K., Banach, M., Toth, P. P., & Rizzo, M. (2021) · Current Atherosclerosis Reports · doi:10.1007/s11883-021-00955-y · Cited by 110
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Rocha, V. Z., Ras, R. T., Gagliardi, A. C. M., Mangili, L. C., Trautwein, E. A., & Santos, R. D. (2016) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2016.01.035 · Cited by 106
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Pirro, M., Vetrani, C., Bianchi, C., Mannarino, M. R., Bernini, F., & Rivellese, A. A. (2017) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2016.11.122 · Cited by 99
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Self-citationPatel, S. V. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.02.010 · Cited by 98
Yang, C., Shang, K., Lin, C., Wang, C., Shi, X., Wang, H., & Li, H. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.09.011 · Cited by 93
Belardo, D., Michos, E. D., Blankstein, R., Blumenthal, R. S., Ferdinand, K. C., Hall, K., Klatt, K., Natajaran, P., Ostfeld, R. J., Reddy, K., et al. (2022) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2022.100323 · Cited by 90
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Adorni, M. P., Zimetti, F., Lupo, M. G., Ruscica, M., & Ferri, N. (2020) · Nutrients · doi:10.3390/nu12051440 · Cited by 92
Song, L., Qu, D. C., Zhang, Q., Jiang, J., Zhou, H., Jiang, R., Li, Y., Zhang, Y., & Yan, H. (2017) · Scientific Reports · doi:10.1038/srep41604 · Cited by 91
Truong, T., Prakash, S., & Bhandari, B. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.01.134 · Cited by 84
Progress and perspectives in plant sterol and plant stanol research
Jones, P. J. H., Shamloo, M., MacKay, D., Rideout, T. C., Myrie, S. B., Plat, J., Roullet, J., Baer, D. J., Calkins, K. L., Davis, H. R., et al. (2018) · Nutrition Reviews · doi:10.1093/nutrit/nuy032 · Cited by 86
Self-citationSpecialty seeds: Nutrients, bioactives, bioavailability, and health benefits: A comprehensive review
Alasalvar, C., Chang, S. K., Bolling, B. W., Oh, W. Y., & Shahidi, F. (2021) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12730 · Cited by 90
Guía ESC 2021 sobre la prevención de la enfermedad cardiovascular en la práctica clínica
Visseren, F. L. J., Mach, F., Smulders, Y. M., Carballo, D., Koskinas, K. C., Bäck, M., Bénétos, A., Biffi, A., Boavida, J. M., Capodanno, D., et al. (2022) · Revista Española de Cardiología · doi:10.1016/j.recesp.2021.10.016 · Cited by 89
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Barkas, F., Bathrellou, E., Nomikos, T., Panagiotakos, D. B., Liberopoulos, E. N., & Kontogianni, M. D. (2023) · Nutrients · doi:10.3390/nu15132845 · Cited by 77
Ferguson, J. J. A., Stojanovski, E., MacDonald‐Wicks, L. K., & Garg, M. L. (2016) · Progress in Lipid Research · doi:10.1016/j.plipres.2016.08.002 · Cited by 68
Ras, R. T., van der Schouw, Y. T., Trautwein, E. A., Sioen, I., Dalmeijer, G. W., Zock, P. L., & Beulens, J. W. J. (2014) · European Journal of Preventive Cardiology · doi:10.1177/2047487314554864 · Cited by 65
Self-citationLin, Y., Knol, D., & Trautwein, E. A. (2015) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.201500368 · Cited by 64
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Han, S., Jiao, J., Xu, J., Zimmermann, D., Actis-Goretta, L., Guan, L., Zhao, Y., & Qin, L. (2016) · Scientific Reports · doi:10.1038/srep31337 · Cited by 63
The Lipid-Lowering Effects and Associated Mechanisms of Dietary Phytosterol Supplementation
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Diet, exercise and weight loss and dyslipidaemia
Clifton, P. M. (2018) · Pathology · doi:10.1016/j.pathol.2018.10.013 · Cited by 66
Barkas, F., Nomikos, T., Liberopoulos, E. N., & Panagiotakos, D. B. (2020) · Nutrients · doi:10.3390/nu12082436 · Cited by 66
Jin, D., Henry, P., Shan, J. J., & Chen, J. (2021) · Frontiers in Plant Science · doi:10.3389/fpls.2021.699530 · Cited by 63
Ras, R. T., Fuchs, D., Koppenol, W. P., Garczarek, U., Greyling, A., Keicher, C., Verhoeven, C., Bouzamondo, H., Wagner, F. D., & Trautwein, E. A. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.102053 · Cited by 62
Self-citationUbeyitogullari, A., & Ciftci, O. N. (2019) · Food Research International · doi:10.1016/j.foodres.2019.04.014 · Cited by 61
Rusu, M. E., Fizeșan, I., Pop, A., Gheldiu, A.-M., Mocan, A., Crișan, G., Vlase, L., Loghin, F., Popa, D., & Tomuță, I. (2019) · Antioxidants · doi:10.3390/antiox8100460 · Cited by 61
Rusu, M. E., Gheldiu, A.-M., Mocan, A., Vlase, L., & Popa, D. (2018) · Food & Function · doi:10.1039/c7fo01967j · Cited by 59
Torri, L., Bondioli, P., Folegatti, L., Rovellini, P., Piochi, M., & Morini, G. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.02.063 · Cited by 58
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Ghobadi, S., Hassanzadeh-Rostami, Z., Mohammadian, F., Zare, M., & Faghih, S. (2018) · Journal of the American College of Nutrition · doi:10.1080/07315724.2018.1475270 · Cited by 54
Baumgartner, S., Bruckert, É., Gallo, A., & Plat, J. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.07.019 · Cited by 57
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Kopylov, A. T., Malsagova, K. A., Stepanov, A. A., & Kaysheva, A. L. (2021) · Nutrients · doi:10.3390/nu13051623 · Cited by 53
Guo, S., Ma, C., Hu, Y., Bai, G., Song, Z.-J., & Cao, X.-Q. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.133412 · Cited by 50
Jie, F., Yang, X., Wu, L., Wang, M., & Lu, B. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1867819 · Cited by 50
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Zhang, Q., Zhang, L., Chen, C., Li, P., & Lu, B. (2022) · Progress in Lipid Research · doi:10.1016/j.plipres.2022.101209 · Cited by 50
Trautwein, E. A., Koppenol, W. P., de Jong, A., Hiemstra, H., Vermeer, M. A., Noakes, M., & Luscombe‐Marsh, N. D. (2018) · Nutrition and Diabetes · doi:10.1038/s41387-018-0039-8 · Cited by 51
Self-citationEvtyugin, D. D., Evtuguin, D. V., Casal, S. I. P., & Domingues, M. R. (2023) · Molecules · doi:10.3390/molecules28186526 · Cited by 52
Drapkina, O. M., Karamnova, N. S., Васильевна, К. А., Gornyi, B., Дадаева, В. А., Drozdova, L. Y., Yeganyan, R. A., Олеговна, Е. С., Izmailova, O. V., Lavrenova, Е. A., et al. (2021) · CARDIOVASCULAR THERAPY AND PREVENTION · doi:10.15829/1728-8800-2021-2952 · Cited by 62
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Masana, L., Ros, E., Sudano, I., Angoulvant, D., Ibarretxe, D., Eizagaechevarría, N. M., Arrarte, V., Quintana, A. G., Zamora, A., Silva, A. M. E., et al. (2017) · Atherosclerosis Supplements · doi:10.1016/s1567-5688(17)30020-x · Cited by 47
Nakano, T., Inoue, I., & Murakoshi, T. (2019) · Nutrients · doi:10.3390/nu11020310 · Cited by 48
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Effects of phytosterols supplementation on blood pressure: A systematic review and meta-analysis.
Ghaedi, E., Foshati, S., Ziaei, R., Beigrezaei, S., Kord-Varkaneh, H., Ghavami, A., & Miraghajani, M. (2019) · Clinical Nutrition · doi:10.1016/j.clnu.2019.12.020 · Cited by 39
Baumgartner, S., Ras, R. T., Trautwein, E. A., Mensink, R. P., & Plat, J. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1289-7 · Cited by 45
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Self-citation
Metadata
- Authors
- Ras, R. T., Geleijnse, J. M., & Trautwein, E. A.
- Affiliations
- Unilever Research and Development Vlaardingen (NL)
- Wageningen University & Research (NL)
- Corresponding author
- Ras, Rouyanne T.
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2014-04-30
- Volume
- 112
- Issue
- 2
- Pages
- 214-219
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- PMC
- PMC4071994
- OpenAlex
- W2145483967
- Cited by
- 379
- References
- 31
- Citations by year
- 2026: 22 · 2025: 17 · 2024: 20 · 2023: 36 · 2022: 31 · 2021: 42 · 2020: 43 · 2019: 41 · 2018: 34 · 2017: 32 · 2016: 31 · 2015: 26 · 2014: 2
- FWCI
- 5.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion, cc-by)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Natural Products and Biological Research
- Keywords
- phytosterols, plant stanols, LDL cholesterol, dose-response relationship, cholesterol-lowering effect, dietary supplementation, hypercholesterolemia, dose range
- MeSH terms
- Adult, Anticholesteremic Agents, Humans, Hypercholesterolemia, Cholesterol, LDL, Phytosterols, Randomized Controlled Trials as Topic, Evidence-Based Medicine, Dietary Supplements, Functional Food
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