Cited by 477Animal Nutrition and PhysiologyFood Nutrient Composition and Product DevelopmentMuscle metabolism and nutrition

The DOI matches its Crossref record; 26 of the 27 references it cites were found in a registry or an index; 1 of the 54 sources its claims cite were checked for support.

Values for digestible indispensable amino acid scores (DIAAS) for some dairy and plant proteins may better describe protein quality than values calculated using the concept for protein digestibility-corrected amino acid scores (PDCAAS)

Open access
Mathai, John K., Liu, Yanhong, Stein, Hans H.·2017·British Journal of Nutrition

Abstract

An experiment was conducted to compare values for digestible indispensable amino acid scores (DIAAS) for four animal proteins and four plant proteins with values calculated as recommended for protein digestibility-corrected amino acid scores (PDCAAS), but determined in pigs instead of in rats. Values for standardised total tract digestibility (STTD) of crude protein (CP) and standardised ileal digestibility (SID) of amino acids (AA) were calculated for whey protein isolate (WPI), whey protein concentrate (WPC), milk protein concentrate (MPC), skimmed milk powder (SMP), pea protein concentrate (PPC), soya protein isolate (SPI), soya flour and whole-grain wheat. The PDCAAS-like values were calculated using the STTD of CP to estimate AA digestibility and values for DIAAS were calculated from values for SID of AA. Results indicated that values for SID of most indispensable AA in WPI, WPC and MPC were greater (P<0·05) than for SMP, PPC, SPI, soya flour and wheat. With the exception of arginine and tryptophan, the SID of all indispensable AA in SPI was greater (P<0·05) than in soya flour, and with the exception of threonine, the SID of all indispensable AA in wheat was less (P<0·05) than in all other ingredients. If the same scoring pattern for children between 6 and 36 months was used to calculate PDCAAS-like values and DIAAS, PDCAAS-like values were greater (P<0·05) than DIAAS values for SMP, PPC, SPI, soya flour and wheat indicating that PDCAAS-like values estimated in pigs may overestimate the quality of these proteins.

Overview

Integrity signals

Registry

Crossref · 10.1017/s0007114517000125

Cites

26 of 26 references verified0 citation errors · 0 not checkable

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Nothing to recompute.

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Claims the paper makes

41 Own result · 40 Not checked yet · 18 Own interpretation · 9 No basis given · 4 Own method · accuracy not yet measured

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Show all 77 claims

  • Probably not a substantial claim. 14
  • It may state two separate claims as one. 25
35 of 35
  • The paper relies on this without support.

    No published DIAAS values for these proteins had been determined in pigs, and it was unknown how DIAAS values determined in pigs compare with PDCAAS-like values determined in pigs.

    “To our knowledge, there are no published values for DIAAS for these proteins that have been determined in pigs and it is not known how values for DIAAS determined in pigs compare with PDCAAS-like values determined in pigs.”
  • The authors state this as an assumption.

    Amino acid digestibility in growing castrated male pigs is representative of values obtained in both male and female humans of all ages.

    “Other limitations of the experiment include the assumption that AA digestibility in growing castrated male pigs are representative of values obtained in both male and female humans of all ages.”
  • The paper relies on this without support.

    Mucin protein is resistant to protease digestion and is included in the endogenous protein fraction that reaches the distal ileum in pigs without being hydrolysed.

    “Mucin protein is resistant to protease digestion, and therefore is included in the endogenous protein fraction that reaches the distal end of the ileum in pigs without being hydrolysed.”
  • The paper relies on this without support.

    N exchange in the hindgut does not contribute to the amino acid balance in humans and monogastric animals, and amino acids are absorbed only in the small intestine.

    “because N exchange in the hindgut does not contribute to the AA balance in humans and monogastric animals and because AA are absorbed only in the small intestine”
  • The paper relies on this without support.

    PPC and wheat are not expected to be used to a great extent in the feeding of infants.

    “these proteins are not expected to be used to a great extent in the feeding of infants.”
  • The paper relies on this without support.

    Endogenous losses are really lost from the body.

    “because endogenous losses are really lost from the body”
  • The paper relies on this without support.

    Diet-specific endogenous losses may occur in addition to basal endogenous losses.

    “In addition to the basal endogenous losses, diet-specific endogenous losses may also occur”
  • The paper relies on this without support.

    The major protein in SMP is casein, which has a low concentration of cysteine.

    “The major protein in SMP is casein, which has a low concentration of cysteine”
  • The paper relies on this without support.

    For proteins that are not heat damaged, threonine usually has a lower SID value than lysine.

    “which is usually the case for proteins that are not heat damaged.”
9 of 9

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Percentages, sums and reported differences re-computed from the paper’s own numbers.

Each contradiction between two passages listed here was confirmed by an independent check.

2 of 2

Citations

Cites

Show all 27 references

Research works printed but not linked: 2

  1. 2007, Official Methods of Analysis of AOAC International
  2. 2012, Nutrient Requirements of Swine

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Metadata

Authors
Mathai, J. K., Liu, Y., & Stein, H. H.
Affiliations
University of Illinois Urbana-Champaign (US)
Corresponding author
Stein, Hans H.
Venue
British Journal of Nutrition
Published
2017-02-28
Volume
117
Issue
4
Pages
490-499
ISSN
  • 0007-1145 (ISSN-L)
  • 1475-2662
OpenAlex
W2604266670
Cited by
432
References
27
Citations by year
2026: 57 · 2025: 59 · 2024: 69 · 2023: 59 · 2022: 45 · 2021: 61 · 2020: 38 · 2019: 28 · 2018: 15 · 2017: 1
FWCI
24.89
Type
journal article
Language
en
Open access
Locations
  • British Journal Of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Food Nutrient Composition and Product Development
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords
DIAAS, PDCAAS, protein quality, whey protein isolate, whey protein concentrate, milk protein concentrate, skim milk powder, pea protein concentrate, soy protein isolate, soybean flour, whole wheat, plant proteins, milk protein, pigs, children aged 6 to 36 months
MeSH terms
Vegetable Products, Whey Proteins, Amino Acids, Essential, Animals, Child, Preschool, Diet, Dietary Proteins, Digestion, Humans, Ileum, Infant, Male, Milk Proteins, Plant Proteins, Plants, Edible, Seeds, Glycine max, Swine, Triticum, Pisum sativum, Soybean Proteins, Gastrointestinal Tract

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