Protein Digestibility-Corrected Amino Acid Scores and Digestible Indispensable Amino Acid Scores Differentially Describe Protein Quality in Growing Male Rats
Open accessAbstract
Background The FAO has recommended replacing the protein digestibility-corrected amino acid score (PDCAAS) with the digestible indispensable amino acid score (DIAAS).Objective The objective of this study was to compare aspects underlying the calculation of the DIAAS and PDCAAS, including 1) fecal digestibility vs. ileal digestibility, 2) using a single nitrogen digestibility value for all amino acids, and 3) the effect of truncation. Truncated PDCAAS and untruncated DIAAS values calculated as formally defined were also compared and DIAAS data presented for 14 dietary protein sources.Methods Semisynthetic wheat starch-based diets were formulated to contain the test protein (as consumed by humans) source (whey- and soy-protein isolates, milk-, whey-, rice- and pea- protein concentrates, cooked kidney beans, roasted peanuts, cooked peas, corn-based breakfast cereal, cooked rice, cooked rolled oats, and wheat bran) as the sole nitrogen source and with an indigestible marker (titanium dioxide). Growing male rats (∼250 g bodyweight) were given a basal casein-based diet from day 1 to day 7 and then allocated (n = 6) to the test diets for day 8 to day 14 before ileal digesta were collected after the rats were killed. Total feces were collected from day 11 to day 14.Results True fecal nitrogen digestibility was different (P < 0.05; 10% difference on average) from true ileal nitrogen digestibility for 11 of the 14 protein sources. True ileal nitrogen digestibility was different (P < 0.05) from true ileal amino acid digestibility for almost half of the indispensable and conditionally indispensable amino acids (differences ranged from 0.9% to 400%). DIAAS values ranged from 0.01 for a corn-based cereal to 1.18 for milk protein concentrate.Conclusion Untruncated PDCAAS values were generally higher than a DIAAS values, especially for the poorer quality proteins; therefore, the reported differences in the scores are of potential practical importance for populations in which dietary protein intake may be marginal.
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Mucin in humans may also have a high concentration of threonine.
“which indicates that mucin in humans also may have a high concentration of threonine (9,10)”
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Cites
Determination of titanium dioxide added as an inert marker in chicken digestibility studies
Short, F., Gorton, P., Wiseman, J., & Boorman, K. N. (1996) · Animal Feed Science and Technology · doi:10.1016/0377-8401(95)00916-7 · Cited by 1,143 · see citing works
The Protein Digestibility–Corrected Amino Acid Score
Schaafsma, G. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.7.1865s · Cited by 537 · cited 2× · see citing works
“Second, protein digestibility values (based on the digestibility of nitrogen) are less accurate than amino acid digestibility values (based on the digestibility of individual amino acids) for describing protein quality because they do not reflect the digestibility of amino acids individually (4, 5).”
BackgroundMethodRowan, A. M., Moughan, P. J., Wilson, M. N., Maher, K., & Tasman-Jones, C. (1994) · British Journal of Nutrition · doi:10.1079/bjn19940108 · Cited by 189 · see citing works
Self-citationSchaafsma, G. (2005) · Journal of AOAC International · doi:10.1093/jaoac/88.3.988 · Cited by 166 · see citing works
Young, V. R., & Borgonha, S. (2000) · Journal of Nutrition · doi:10.1093/jn/130.7.1841s · Cited by 156 · see citing works
Gaudichon, C., Bos, C., Morens, C., Petzke, K. J., Mariotti, F., Everwand, J., Benamouzig, R., Daré, S., Tomé, D., & Metges, C. C. (2002) · Gastroenterology · doi:10.1053/gast.2002.34233 · Cited by 148 · see citing works
A New Method for Determining Digestible Reactive Lysine in Foods
Moughan, P. J., & Rutherfurd, S. M. (1996) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf950032j · Cited by 146 · see citing works
Self-citationGilani, G. S., & Sepehr, E. (2003) · The Journal of Nutrition · doi:10.1093/jn/133.1.220 · Cited by 135 · see citing works
Amino acid availability: aspects of chemical analysis and bioassay methodology
Moughan, P. J. (2003) · Nutrition Research Reviews · doi:10.1079/nrr200365 · Cited by 132 · see citing works
Self-citationQuantifying the Digestibility of Dietary Protein
Hodgkinson, S. M., & Darragh, A. J. (2000) · Journal of Nutrition · doi:10.1093/jn/130.7.1850s · Cited by 108 · see citing works
Bacterial activity in the hind‐gut of pigs
Mason, V. C., Just, A., & Bech-Andersen, S. (1975) · Zeitschrift für Tierphysiologie Tierernährung und Futtermittelkunde · doi:10.1111/j.1439-0396.1975.tb01150.x · Cited by 90 · see citing works
The Digestible Amino Acid Composition of Several Milk Proteins: Application of a New Bioassay
Rutherfurd, S. M., & Moughan, P. J. (1998) · Journal of Dairy Science · doi:10.3168/jds.s0022-0302(98)75650-4 · Cited by 89 · see citing works
Self-citationAvailable lysine and digestible amino acid contents of proteinaceous foods of India
Rutherfurd, S. M., Bains, K., & Moughan, P. J. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512002280 · Cited by 73 · see citing works
Self-citationAvailable versus digestible dietary amino acids
Rutherfurd, S. M., & Moughan, P. J. (2012) · British Journal Of Nutrition · doi:10.1017/s0007114512002528 · Cited by 67 · see citing works
Self-citationHuman Amino Acid and Protein Requirements: Current Dilemmas and Uncertainties
Millward, D. J., Jackson, A. A., Price, G., & Rivers, J. P. W. (1989) · Nutrition Research Reviews · doi:10.1079/nrr19890010 · Cited by 62 · see citing works
Dietary peptides increase endogenous amino acid losses from the gut in adults
Moughan, P. J., Butts, C. A., Rowan, A., & Deglaire, A. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.6.1359 · Cited by 57 · see citing works
Self-citationGilani, G. S., Xiao, C.-W., & Lee, N. (2008) · Journal of AOAC International · doi:10.1093/jaoac/91.4.894 · Cited by 48 · see citing works
Determination of Sulfur Amino Acids in Foods as Related to Bioavailability
Rutherfurd, S. M., & Moughan, P. J. (2008) · Journal of AOAC International · doi:10.1093/jaoac/91.4.907 · Cited by 31 · see citing works
Self-citationHendriks, W. H., Sritharan, K., & Hodgkinson, S. M. (2002) · Journal of Animal Physiology and Animal Nutrition · doi:10.1046/j.1439-0396.2002.00391.x · Cited by 26 · see citing works
Rutherfurd, S. M., Cui, J. H., Goroncy, A. K., & Moughan, P. J. (2014) · Journal of Nutrition · doi:10.3945/jn.114.198283 · Cited by 22 · see citing works
Self-citationButts, C. A., Moughan, P. J., & Smith, W. C. (1992) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.2740590304 · Cited by 20 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 4
- Fenwick RM, Knighton DR, Moughan PJ. Protein quality measurement by the PDCAAS technique. Int Dairy Fed Nutr Newslett. 1995;4:40-3.
- Mason VC, Just A, Bech-Anderson S. Bacterial activity in the hindgut of piglets. 2. Its influence on apparent digestibility of nitrogen and amino acids. Z Tierphysiol Tierernahr Futtermittelkd 1976;36:310-24.
- NRC Nutrient requirement of the laboratory rat. In: Nutrient require- ments of laboratory animals. 4 th ed. Washington (DC): National Academies Press; 1995.
- Moughan PJ, Butts CA, Rowan AM, Deglaire A. Dietary peptides increase gut endogenous amino acid losses in adult humans. Am J Clin Nutr 2005;81:1359-65.
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Wells, M. L., Potin, P., Craigie, J. S., Raven, J. A., Merchant, S. S., Helliwell, K. E., Smith, A. G., Camire, M. E., & Brawley, S. H. (2017) · Journal of Applied Phycology · doi:10.1007/s10811-016-0974-5 · Cited by 1,562 · see citing works
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Day, L., Cakebread, J. A., & Loveday, S. M. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.12.020 · Cited by 681 · see citing works
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Hertzler, S. R., Lieblein-Boff, J. C., Weiler, M., & Allgeier, C. (2020) · Nutrients · doi:10.3390/nu12123704 · Cited by 594 · see citing works
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Messina, M. (2016) · Nutrients · doi:10.3390/nu8120754 · Cited by 537 · see citing works
Berrazaga, I., Micard, V., Gueugneau, M., & Walrand, S. (2019) · Nutrients · doi:10.3390/nu11081825 · Cited by 477 · see citing works
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Chalupa-Krebzdak, S., Long, C. J., & Bohrer, B. M. (2018) · International Dairy Journal · doi:10.1016/j.idairyj.2018.07.018 · Cited by 430 · see citing works
Mathai, J. K., Liu, Y., & Stein, H. H. (2017) · British Journal of Nutrition · doi:10.1017/s0007114517000125 · Cited by 432 · see citing works
Pulses and food security: Dietary protein, digestibility, bioactive and functional properties
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Roy, D., Ye, A., Moughan, P. J., & Singh, H. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.577759 · Cited by 362 · see citing works
Self-citationMicroalgae as Sources of High-Quality Protein for Human Food and Protein Supplements
Wang, Y., Tibbetts, S. M., & McGinn, P. J. (2021) · Foods · doi:10.3390/foods10123002 · Cited by 342 · see citing works
Pea protein ingredients: A mainstream ingredient to (re)formulate innovative foods and beverages.
Boukid, F., Rosell, C. M., & Castellari, M. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.02.040 · Cited by 334 · see citing works
Loveday, S. M. (2019) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-032818-121128 · Cited by 303 · see citing works
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Walther, B., Guggisberg, D., Badertscher, R., Egger, L., Portmann, R., Dubois, S., Haldimann, M., Kopf-Bolanz, K. A., Rhyn, P., Zoller, O., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.988707 · Cited by 245 · see citing works
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Singhal, S., Baker, R. D., & Baker, S. S. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001380 · Cited by 240 · see citing works
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Ahnen, R. T., Jonnalagadda, S. S., & Slavin, J. L. (2019) · Nutrition Reviews · doi:10.1093/nutrit/nuz028 · Cited by 242 · see citing works
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Marinangeli, C., & House, J. (2017) · Nutrition reviews · doi:10.1093/nutrit/nux025 · Cited by 159 · see citing works
Measuring Protein Content in Food: An Overview of Methods
Hayes, M. (2020) · Foods · doi:10.3390/foods9101340 · Cited by 204 · see citing works
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Sousa, R., Portmann, R., Dubois, S., Recio, I., & Egger, L. (2020) · Food Research International · doi:10.1016/j.foodres.2020.108996 · Cited by 196 · see citing works
Sousa, R., Recio, I., Heimo, D., Dubois, S., Moughan, P., Hodgkinson, S., Portmann, R., & Egger, L. (2022) · Food Chemistry · doi:10.1016/j.foodchem.2022.134720 · Cited by 176 · see citing works
Self-citationInvited review: Whey proteins as antioxidants and promoters of cellular antioxidant pathways
Corrochano, A. R., Buckin, V. A., Kelly, P. M., & Giblin, L. M. (2018) · Journal of Dairy Science · doi:10.3168/jds.2017-13618 · Cited by 182 · see citing works
Kaur, L., Mao, B., Beniwal, A. S., Abhilasha, A., Kaur, R., Chian, F. M., & Singh, J. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.02.021 · Cited by 180 · see citing works
Wolfe, R. R., Rutherfurd, S. M., Kim, I., & Moughan, P. J. (2016) · Nutrition Reviews · doi:10.1093/nutrit/nuw022 · Cited by 168 · see citing works
Self-citationErtl, P., Knaus, W., & Zollitsch, W. J. (2016) · animal · doi:10.1017/s1751731116000902 · Cited by 160 · see citing works
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Nosworthy, M. G., Franczyk, A. J., Medina, G., Neufeld, J., Appah, P., Utioh, A., Frohlich, P., & House, J. D. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b03597 · Cited by 99 · see citing works
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Spaen, J., & Silva, J. V. C. (2021) · LWT · doi:10.1016/j.lwt.2021.111478 · Cited by 80 · see citing works
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Vangsoe, M. T., Thøgersen, R., Bertram, H. C., Heckmann, L., & Hansen, M. (2018) · Nutrients · doi:10.3390/nu10101357 · Cited by 77 · see citing works
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Craddock, J. C., Genoni, A., Strutt, E. F., & Goldman, D. (2021) · Current Nutrition Reports · doi:10.1007/s13668-020-00348-8 · Cited by 77 · see citing works
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Messina, M. J., Duncan, A. M., Messina, V., Lynch, H. M., Kiel, J., & Erdman, J. W. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.970364 · Cited by 77 · see citing works
Plant Protein, Animal Protein, and Protein Quality
Mariotti, F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803968-7.00035-6 · Cited by 74 · see citing works
Pea protein globulins: Does their relative ratio matter?
Husband, H., Ferreira, S., Bu, F., Feyzi, S., & Ismail, B. (2023) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2023.109429 · Cited by 71 · see citing works
Stobaugh, H. C., Ryan, K. N., Kennedy, J., Grise, J. B., Crocker, A. H., Thakwalakwa, C. M., Litkowski, P., Maleta, K. M., MANARY, M. J., & Trehan, I. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.124636 · Cited by 69 · see citing works
Yang, F., Huang, X., Zhang, C., Mei, Z., Huang, C., & Yang, H. (2018) · RSC Advances · doi:10.1039/c7ra13007d · Cited by 67 · see citing works
Dave, L. A., Hayes, M., Montoya, C. A., Rutherfurd, S. M., & Moughan, P. J. (2015) · Peptides · doi:10.1016/j.peptides.2015.11.003 · Cited by 64 · see citing works
Self-citationOptimizing Adult Protein Intake During Catabolic Health Conditions
Phillips, S. M., Paddon-Jones, D., & Layman, D. K. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa047 · Cited by 65 · see citing works
Determination of Dietary Amino Acid Digestibility in Humans.
Moughan, P., & Wolfe, R. (2019) · Journal of NutriLife · doi:10.1093/jn/nxz211 · Cited by 52 · see citing works
Self-citationWang, Y., Tibbetts, S. M., Berrue, F., McGinn, P. J., MacQuarrie, S. P., Puttaswamy, A., Patelakis, S., Schmidt, D., Melanson, R., & MacKenzie, S. E. (2020) · Foods · doi:10.3390/foods9111531 · Cited by 62 · see citing works
Asen, N. D., Aluko, R. E., Martynenko, A. I., Utioh, A. C., & Bhowmik, P. (2023) · Foods · doi:10.3390/foods12213978 · Cited by 63 · see citing works
Regulation of Intestinal Inflammation by Soybean and Soy-Derived Compounds
Basson, A. R., Ahmed, S. U. M., Almutairi, R., Seo, B., & Cominelli, F. (2021) · Foods · doi:10.3390/foods10040774 · Cited by 60 · see citing works
Khalesi, M., & Fitzgerald, R. J. (2021) · Catalysts · doi:10.3390/catal11070787 · Cited by 60 · see citing works
Digestible indispensable amino acid score (DIAAS): 10 years on
Moughan, P., & Lim, W. X. J. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1389719 · Cited by 63 · see citing works
Self-citationMilk proteins: Processing, gastric coagulation, amino acid availability and muscle protein synthesis
Horstman, A. M. H., & Huppertz, T. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2078782 · Cited by 59 · see citing works
Peruzzolo, M., Ceni, G. C., Junges, A., Zeni, J., Cansian, R. L., & Backes, G. T. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.106253 · Cited by 56 · see citing works
The why and how of amino acid analytics in cancer diagnostics and therapy
Manig, F., Kuhne, K., von Neubeck, C., Schwarzenbolz, U., Yu, Z., Kessler, B. M., Pietzsch, J., & Kunz‐Schughart, L. A. (2016) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2016.12.001 · Cited by 55 · see citing works
Abelilla, J. J., Liu, Y., & Stein, H. H. (2017) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8457 · Cited by 56 · see citing works
Strauch, R. C., & Lila, M. A. (2021) · Food Science & Nutrition · doi:10.1002/fsn3.2335 · Cited by 55 · see citing works
Malla, N., Nørgaard, J. V., Lærke, H. N., Heckmann, L., & Roos, N. (2022) · Journal of Nutrition · doi:10.1093/jn/nxac019 · Cited by 55 · see citing works
Bailey, H. M., Mathai, J. K., Berg, E. P., & Stein, H. H. (2020) · British Journal Of Nutrition · doi:10.1017/s0007114520000641 · Cited by 56 · see citing works
Fanelli, N. S., Bailey, H. M., Thompson, T. W., Delmore, R. J., Nair, M. N., & Stein, H. H. (2021) · European Journal of Nutrition · doi:10.1007/s00394-021-02658-1 · Cited by 54 · see citing works
Davies, R. W., & Jakeman, P. M. (2020) · Nutrients · doi:10.3390/nu12082410 · Cited by 53 · see citing works
Calvez, J., Benoit, S., Piedcoq, J., Khodorova, N., Azzout‐Marniche, D., Tomé, D., Benamouzig, R., Airinei, G., & Gaudichon, C. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa274 · Cited by 53 · see citing works
Protein quality of cereals: Digestibility determination and processing impacts
Sá, A. G. A., & House, J. D. (2024) · Journal of Cereal Science · doi:10.1016/j.jcs.2024.103892 · Cited by 52 · see citing works
The nutritional limitations of plant-based beverages in infancy and childhood
Vitoria, I. (2017) · Nutrición Hospitalaria · doi:10.20960/nh.931 · Cited by 52 · see citing works
Balandrán‐Quintana, R. R., Wilson, A. M. M., Montfort, G. R.-C., & Huerta‐Ocampo, J. Á. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816695-6.00004-0 · Cited by 52 · see citing works
- Authors
- Rutherfurd, S. M., Fanning, A. C., Miller, B. J., & Moughan, P. J.
- Affiliations
- Riddet Institute (NZ)
- Fonterra (New Zealand) (NZ)
- Corresponding author
- Rutherfurd, Shane M
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 145
- Issue
- 2
- Pages
- 372-379
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W2171412593
- Cited by
- 433
- References
- 21
- Citations by year
- 2026: 47 · 2025: 37 · 2024: 51 · 2023: 38 · 2022: 47 · 2021: 59 · 2020: 40 · 2019: 45 · 2018: 21 · 2017: 27 · 2016: 18 · 2015: 3
- FWCI
- 22.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- New Zealand Government
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Food and Agricultural Sciences
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- protein quality, PDCAAS, DIAAS, amino acid digestibility, truncation, dietary protein source, whey protein isolate, soy protein isolate, milk protein concentrate, pea protein concentrate, rice protein concentrate, casein, growing rats
- MeSH terms
- Amino Acids, Amino Acids, Essential, Animals, Edible Grain, Zea mays, Cross-Sectional Studies, Dietary Proteins, Digestion, Feces, Food Analysis, Ileum, Fabaceae, Male, Milk, Nitrogen, Oryza, Triticum, Rats, Sprague-Dawley, Rats
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