Effect of time-restricted feeding on metabolic risk and circadian rhythm associated with gut microbiome in healthy males
Open accessAbstract
Time-restricted feeding (TRF) confers protection against nutritional challenges that predispose obesity and metabolic risks through involvement of circadian locomotor output cycles protein kaput genes and gut microbiome, but the underlying mechanism is not clearly understood. Therefore, the present study examined the effects of TRF on metabolic markers and circadian rhythm associated with gut microbiota in healthy males. Two groups (TRF, n 56; non-TRF, n 24) of male adults were enrolled. The TRF group provided blood at pre-TRF and post-TRF, while non-TRF one time after 25 d of trial. Serum lipid and liver profiles were determined. Real time-PCR was applied for circadian and inflammatory gene expression. The 16S rRNA genes were sequenced on the Illumina Miseq v3 platform to comprehensively catalogue the composition and abundance of bacteria in stool. We showed that TRF ameliorated the serum lipid and liver profiles of the individuals. In the TRF group, gut microbial richness was significantly enhanced, with enrichment of Prevotellaceae and Bacteroideaceae. TRF enhanced circadian gene expression probably by activation of sirtuin-1, which is positively associated with gut microbiome richness. TRF could be a safe remedy for the prevention of metabolic diseases related to dyslipidaemia, as it regulates circadian rhythm associated with gut microbiome modulation.
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Recent human trials on TRE have highlighted numerous beneficial metabolic effects of TRE, e.g., improved mean daily glucose levels, fasting glucose levels, insulin resistance or insulin sensitivity, triglyceride levels, total cholesterol, and LDL cholesterol levels.
“Recent human trials on TRE have highlighted numerous beneficial metabolic effects of TRE, e.g., improved mean daily glucose levels (107, 108), fasting glucose levels (108–110), insulin resistance (108, 110, 111) or insulin sensitivity (112, 113), triglyceride levels (107, 109, 114, 115), total cholesterol (115, 116), and LDL cholesterol levels (116).”
From Meal timing and its role in obesity and associated diseases (2024) · cites this paper as [115]
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FLASH: fast length adjustment of short reads to improve genome assemblies
Magoč, T., & Salzberg, S. L. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr507 · Cited by 15,366 · see citing works
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662 · see citing works
Inflammatory Mechanisms in Obesity
Gregor, M. F., & Hotamisligil, G. S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101322 · Cited by 3,754 · see citing works
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk
Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,402 · see citing works
Central and Peripheral Circadian Clocks in Mammals
Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265 · see citing works
Diet–microbiota interactions as moderators of human metabolism
Sonnenburg, J. L., & Bäckhed, F. (2016) · Nature · doi:10.1038/nature18846 · Cited by 2,257 · see citing works
Analysing controlled trials with baseline and follow up measurements
Vickers, A. J., & Altman, D. G. (2001) · BMJ · doi:10.1136/bmj.323.7321.1123 · Cited by 2,116 · see citing works
Diet Drives Convergence in Gut Microbiome Functions Across Mammalian Phylogeny and Within Humans
Muegge, B. D., Kuczynski, J., Knights, D., Clemente, J. C., González, A., Fontana, L., Henrissat, B., Knight, R., & Gordon, J. I. (2011) · Science · doi:10.1126/science.1198719 · Cited by 1,988 · see citing works
Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986 · see citing works
Harvie, M. N., Pegington, M., Mattson, M. P., Frystyk, J., Dillon, B., Evans, G., Cuzick, J., Jebb, S. A., Martin, B., Cutler, R. G., et al. (2011) · International Journal of Obesity · doi:10.1038/ijo.2010.171 · Cited by 804 · see citing works
Griffin, N. W., Ahern, P. P., Cheng, J., Heath, A. C., Ilkayeva, O., Newgard, C. B., Fontana, L., & Gordon, J. I. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2016.12.006 · Cited by 164 · see citing works
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Xie, Z., Sun, Y., Ye, Y., Hu, D., Zhang, H., He, Z., Zhao, H., Yang, H., & Mao, Y. (2022) · Nature Communications · doi:10.1038/s41467-022-28662-5 · Cited by 276 · see citing works
Moon, S., Kang, J., Kim, S. H., Chung, H. S., Kim, Y. J., Yu, J. M., Cho, S. T., Oh, C.-M., & Kim, T. (2020) · Nutrients · doi:10.3390/nu12051267 · Cited by 231 · see citing works
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Pureza, I. R. D. O. M., Macena, M. D. L., da Silva Junior, A. E., Praxedes, D. R. S., Vasconcelos, L. G. L., & Bueno, N. B. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.10.031 · Cited by 89 · see citing works
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Peters, B., Vahlhaus, J., & Pivovarova-Ramich, O. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1359772 · Cited by 72 · see citing works
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He, Z., Xu, H., Li, C., Yang, H., & Mao, Y. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1048230 · Cited by 28 · see citing works
Peters, B., Koppold-Liebscher, D. A., Schuppelius, B., Steckhan, N., Pfeiffer, A. F. H., Kramer, A., Michalsen, A., & Pivovarova-Ramich, O. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.765543 · Cited by 20 · see citing works
- Authors
- Zeb, F., Wu, X., Chen, L., Fatima, S., Haq, I.-U., Chen, A., Majeed, F., Feng, Q., & Li, M.
- Affiliations
- Nanjing Medical University (CN)
- Khyber Medical University (PK)
- Corresponding author
- Feng, Qing
- Li, Min
- Venue
- British Journal of Nutrition
- Publisher
- Cambridge University Press (CUP)
- Published
- 2020-01-06
- Volume
- 123
- Issue
- 11
- Pages
- 1216-1226
- ISSN
- 0007-1145 (ISSN-L)
- 1475-2662
- OpenAlex
- W2999037967
- Cited by
- 202
- References
- 11
- Citations by year
- 2026: 24 · 2025: 43 · 2024: 41 · 2023: 32 · 2022: 28 · 2021: 27 · 2020: 7
- FWCI
- 14.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- British Journal Of Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Funders
- China Scholarship Council
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Topics
- Health Sciences › Medicine › Physiology › Dietary Effects on Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
- Keywords
- time-restricted feeding, circadian rhythm, gut microbiota, metabolic risk, serum lipids, liver function, circadian gene expression, SIRT1, Prevotellaceae, Bacteroidaceae, dyslipidemia, obesity prevention, healthy men
- MeSH terms
- Gastrointestinal Microbiome, Cardiometabolic Risk Factors, Adult, Bacterial Proteins, Circadian Rhythm, Fasting, Humans, Lipids, Liver, Male, Metabolic Diseases, RNA, Ribosomal, 16S, Biomarkers, Genetic Predisposition to Disease, Young Adult, Healthy Volunteers
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