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Cited by 46Lipoproteins and Cardiovascular HealthCholesterol and Lipid MetabolismNatural Products and Biological Research

Double-blind study of the addition of high-protein soya milk v. cows' milk to the diet of patients with severe hypercholesterolaemia and resistance to or intolerance of statins

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Sirtori, C. R., Pazzucconi, F., Colombo, L., Battistin, P., Bondioli, A., Descheemaeker, K.·1999·British Journal Of Nutrition
DOI 10.1017/s0007114599001233
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Abstract

Total substitution of soyabean protein for animal protein in the diet has been repeatedly shown to lower plasma cholesterol levels in hypercholesterolaemic individuals. A new, highly palatable, high-protein soya drink may allow replacement of a significant percentage of animal protein in the diet. The soya drink was given, within a crossover design v. a cows' milk preparation of similar composition and taste, to twenty-one severely hypercholesterolaemic patients (mean baseline plasma cholesterol 8.74 mmol/l) with a history of resistance to or intolerance of statin treatment. Each dietary supplement was given for 4 weeks, with a 4-week interval between treatments, Plasma lipid levels were monitored every 2 weeks during each dietary sequence. The concomitant dietary treatment, which had been followed for a long time by all patients, was carefully monitored throughout the study. The soya supplementation reduced plasma total cholesterol level by 6.5%, when given first, and by 7.4% when given after cows' milk. When given first, cows' milk resulted in a small, non-significant reduction of plasma cholesterol level (-3.9%), and when given after soya, it changed total plasma cholesterol to a minimal extent (-1.6%). Changes in total and LDL-cholesterol levels after 2 and 4 weeks of soya v. cows' milk treatment were, thus, respectively -6.1, -7.0 and -6.2, -7.8% (both P < 0.05). These first data from a double-blind study confirm a significant cholesterol-lowering effect of soyabean protein, even when only partly replacing animal protein in the diet, in individuals with extreme plasma cholesterol elevations.

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  • In a crossover trial of 21 hypercholesterolemic patients with statin resistance or intolerance, a soya drink lowered total cholesterol by 6.5% before and 7.4% after cow's milk supplementation.

    “The soya supplementation reduced plasma TC levels by 6.5% before cow's milk supplementation and by 7.4% after cow's milk supplementation.”

    From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [136]

  • In that trial, soya versus cow's milk changed total and LDL cholesterol by -6.1% and -7.0% at 2 weeks and -6.2% and -7.8% at 4 weeks, both significant.

    “Changes in total and LDL-C levels after soya versus cow's milk treatment were À6.1% and À7.0% after 2 weeks and À6.2% and À7.8% after 4 weeks, respectively (both p < 0.05) (136) (Table 9).”

    From The Role of Nutraceuticals in Statin Intolerant Patients (2018) · cites this paper as [136]

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Authors
Sirtori, C. R., Pazzucconi, F., Colombo, L., Battistin, P., Bondioli, A., & Descheemaeker, K.
Affiliations
  • University of Milan (IT)
  • Ospedale San Paolo (IT)
Corresponding author
Sirtori, C. R.
ORCID
Venue
British Journal Of Nutrition
Publisher
Cambridge University Press (CUP)
Published
1999-08
Volume
82
Issue
2
Pages
91-96
ISSN
  • 0007-1145 (ISSN-L)
  • 1475-2662
DOI
10.1017/s0007114599001233
OpenAlex
W2216324968
Cited by
46
References
36
Citations by year
2026: 2 · 2024: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2014: 2
FWCI
4.91
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 2777 d)
Locations
  • British Journal Of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Funders
Consiglio Nazionale delle Ricerche
Topics
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
  • Health Sciences › Medicine › Surgery › Natural Products and Biological Research
Keywords
soy milk, cow's milk, hypercholesterolemia, statin intolerance, statin resistance, dietary protein substitution, serum cholesterol, LDL cholesterol, dietary supplementation, hypolipidemic effect
MeSH terms
Contraindications, Adult, Aged, Analysis of Variance, Animals, Cholesterol, Double-Blind Method, Female, Humans, Hypercholesterolemia, Cholesterol, LDL, Male, Middle Aged, Milk, Cross-Over Studies, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Dietary Supplements, Soybean Proteins

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