Cited by 122Obsessive-Compulsive Spectrum DisordersPsychoanalysis and Psychopathology ResearchAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

Genetic and environmental influences on obsessional traits and symptoms

Clifford, C. A., Murray, R. M., Fulker, D. W.·1984·Psychological Medicine

Abstract

Synopsis: A biometrical genetic analysis was carried out on the response of 419 pairs of twins to the 42-item version of the Leyton Obsessional Inventory. Just under half the variation in both the Obsessional Trait and Symptom Scales was due to heredity. Multivariate analysis revealed a genetic effect on the development of obsessional personality and also the transmission of a general tendency predisposing to neurotic breakdown. Although the influence of heredity was outweighed by that of the environment, the latter effect showed an absence of general factors and, in particular, of any noticeable effect from the common home environment.

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Crossref · 10.1017/s0033291700019760

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33 of 33 references verified0 citation errors · 0 not checkable

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  • The common single nucleotide polymorphism heritability of OCD is estimated at 28% in meta-analyses, while overall heritability is reported at 40% to 50%.

    “The common single nucleotide polymorphism heritability of OCD has been estimated to be 28% in meta-analyses (18), whereas the overall heritability is reported to be 40% to 50% (19–24).”

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Authors
Clifford, C. A., Murray, R. M., & Fulker, D. W.
Corresponding author
Murray, R. M.
Venue
Psychological Medicine
Published
1984-11
Volume
14
Issue
4
Pages
791-800
ISSN
  • 0033-2917 (ISSN-L)
  • 1469-8978
OpenAlex
W2146471748
Cited by
122
References
33
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2023: 3 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 6 · 2013: 2 · 2012: 6
FWCI
0.61
Type
journal article
Language
en
Open access
closed
Locations
  • Psychological Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
obsessive-compulsive symptoms, heritability, twin studies, genetic factors, environmental influences, family environment, shared environment
MeSH terms
Diseases in Twins, Humans, Neurotic Disorders, Obsessive-Compulsive Disorder, Psychological Tests, Psychometrics, Social Environment

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