The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Impaired divided attention predicts delayed response and risk to relapse in subjects with depressive disorders
Abstract
Background. This study addresses the complex relationship between cognitive function and the course of depression. Method. A sample of patients (n=73) in a depressive episode (major depression or bipolar disorder) was tested with a comprehensive battery of attention and executive tasks at both admission and discharge. In addition, response to pharmacological treatment and remission was assessed with standardized rating scales. Nineteen patients, recovered from depression, were re-investigated 6 months after discharge to determine whether specific cognitive parameters were related to subsequent relapse. Results. On admission, patients were impaired in almost all cognitive tasks. At discharge, we found a significant reduction in psychopathology, but only marginal cognitive improvements. Non-responders after 4 weeks of antidepressive medication and subjects who did not achieve remission prior to discharge were specifically impaired in divided attention on admission (p<0·05). In addition, a trend was found for the association between impaired divided attention at discharge and an elevated risk to relapse (p<0·10). Conclusions. We observed generalized cognitive impairment in most cognitive domains in acute depression. Cognitive impairments were still within abnormal ranges at discharge but less distinct. Divided attention performance predicted response to treatment, remission of symptoms, and risk to relapse. Impaired divided attention capacity can be explained either by reduced attentional resources or impaired activation and/or top-down control of attentional resources by the central executive.
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In the citing paper
“Attention impairments in particular are known to negatively impact daily function3,4 and are associated with poorer clinical outcome5.”
From Paying attention to attention in depression (2019) · cites this paper as [5]
In the citing paper
“while poorer divided attention is associated with delayed response and increased risk of relapse5 as well as higher suicidality37.”
From Paying attention to attention in depression (2019) · cites this paper as [5]
In the citing paper
“Many studies, albeit largely observational or with a mix of medications used, show no change in sustained attention25,99, selective attention100, or divided attention5,101, despite improvements in mood symptoms.”
From Paying attention to attention in depression (2019) · cites this paper as [5]
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Metadata
- Authors
- MAJER, M., ISING, M., KÜNZEL, H., BINDER, E. B., HOLSBOER, F., MODELL, S., & ZIHL, J.
- Affiliations
- Max Planck Institute of Psychiatry (DE)
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2004-11
- Volume
- 34
- Issue
- 8
- Pages
- 1453-1463
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W1981847343
- Cited by
- 180
- References
- 29
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 8 · 2023: 4 · 2022: 15 · 2021: 11 · 2020: 13 · 2019: 16 · 2018: 16 · 2017: 6 · 2016: 8 · 2015: 14 · 2014: 10 · 2013: 5 · 2012: 8
- FWCI
- 1.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- divided attention, cognitive impairment, depression, bipolar disorder, major depressive disorder, relapse risk, treatment response, remission, executive function, central executive, top-down control, attentional resources, antidepressants
- MeSH terms
- Acute Disease, Adolescent, Adult, Aged, Attention, Bipolar Disorder, Cognition Disorders, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Prognosis, Psychiatric Status Rating Scales, Recurrence, Risk Factors, Cohort Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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