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Adolescent alcohol use is a risk factor for adult alcohol and drug dependence: evidence from a twin design
Open accessAbstract
Background. Early alcohol use is associated with abuse and dependence of licit and illicit substances later in life. The role of genetic and environmental factors in this association is not conclusive. Method. In 1992, data on substance use, abuse/dependence and psychiatric disorders were collected from 8169 male twin members of the Vietnam Era Twin Registry. The interview obtained age of onset of regular drinking (one drink/month for 6 or more months). Regression analyses of twin pairs discordant for early alcohol use tested whether the association between early drinking (before age 17) and adult substance use and abuse/dependence remained after controlling for genetic factors, family environment and covariates. Twin models tested for common genetic and/or environmental influences on early drinking and adult alcohol dependence and ever use and abuse/dependence on marijuana and other drugs. Results. Co-twin analyses suggested the association between early regular alcohol use and adult alcohol dependence, marijuana and other drug use, and marijuana and other drug abuse/dependence could not be entirely explained by common genetic and shared family environmental factors. Genetic contributions to early regular drinking were significantly correlated with those on use of marijuana (rA=0·59), use of other drugs (rA=0·64), alcohol dependence (rA=0·54) and abuse/dependence of marijuana and other drugs (rA=0·63 and 0·66). Small but significant unique environmental correlations (rE range 0·11–0·22) indicated that familial factors could not entirely explain the association between early alcohol use and later substance use, abuse and dependence. Conclusions. Early regular drinking is associated with later alcohol dependence and use, abuse/dependence on drugs. The association is not entirely explained by genetic or shared family environmental factors. This suggests unique environmental factors contribute to transitions from early regular alcohol drinking to use, abuse and dependence on alcohol and other substances.
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“There is a robust association between age of onset and risk for subsequent alcohol and drug problems”
From Addiction, adolescence, and the integration of control and motivation (2011) · cites this paper as Grant et al., 2006
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Cites
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Jang, J. B., Schuler, M. S., Evans‐Polce, R. J., & Patrick, M. E. (2018) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2018.79.567 · Cited by 33
“These findings are consistent with previous research showing longterm effects of adolescent and young adult substance use on later outcomes (Grant et al., 2006; Patrick et al., 2011).”
ResultTrajectories of Substance Use Disorders in Youth: Identifying and Predicting Group Memberships
Lee, C.-Y. S., Winters, K. C., & Wall, M. M. (2010) · Journal of Child & Adolescent Substance Abuse · doi:10.1080/10678281003634975 · Cited by 32
“…use is a risk factor for later heavy drinking (Barnes & Welte, 1988; Barnes, Welte, & Dintcheff, 1992) and alcohol abuse or dependence (DeWit et al., 2000; Grant & Dawson, 1997; Grant et al., 2005; McGue, Lacono, Legrand, Malone, & Elkins, 2001; Prescott & Kendler, 1999; Winters & Lee, 2008).”
Early alcohol experiences and adolescent mental health: A population-based study in Taiwan
Chen, C., Storr, C. L., Tang, G.-M., Huang, S.-L., Hsiao, C. K., & Chen, W. J. (2008) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2008.01.018 · Cited by 32
“Most individuals with alcohol problems initiate drinking during adolescence, a period when not only the body is changing dramatically, but behavioral, cognitive, emotional, and attitudinal changes also take place (Dawson, 2000; Grant et al., 2006; Maggs and Schulenberg, 2005; Semlitz and Gold, 1986).”
BackgroundGenetic and Environmental Influences on the Rate of Progression to Alcohol Dependence in Young Women
Sartor, C. E., Arpana Agrawal, A., Lynskey, M. T., Bucholz, K. K., & Heath, A. C. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00621.x · Cited by 32
“In contrast, an investigation of common vulnerability to early onset of regular drinking and AD development in an all-male twin sample, which also revealed genetic and shared environmental sources of risk, concluded that the association could not be fully explained by familial factors common to the 2 alcohol outcomes…”
BackgroundInfluentialSelf-citationPatrick, M. E., Evans‐Polce, R. J., Parks, M. J., & Terry‐McElrath, Y. M. (2021) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2021.82.362 · Cited by 32
Prevalence and predictors of illicit drug use among school-going adolescents in Harare, Zimbabwe
Rudatsikira, E., Maposa, D., Mukandavire, Z., Muula, A. S., & Siziya, S. (2009) · Annals of African Medicine · doi:10.4103/1596-3519.59574 · Cited by 30
Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence
Meng, W., Sjöholm, L. K., Kononenko, O., Tay, N., Zhang, D., Sarkisyan, D., Geske, J. R., Ing, A., Qiu, W., Watanabe, H., et al. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0588-9 · Cited by 30
Koskinen, S. M., Ahveninen, J., Kujala, T., Kaprio, J. A., O’Donnell, B. F., Osipova, D. V., Viken, R. J., Näätänen, R., & Rose, R. J. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01470.x · Cited by 28
“…as frontal areas) in memory and learning, we suggest that these subtle brain changes could interfere with academic performance and lead to experiencing failures that foster increased adolescent alcohol use (Bergen et al., 2005)—a high-risk pathway to later alcohol dependence (Grant et al., 2006).”
Teen Alcohol Use and Social Networks: The Contributions of Friend Influence and Friendship Selection
Cheadle, J. E., & Goosby, W. B. J. (2015) · Journal of Alcoholism and Drug Dependence · doi:10.4172/2329-6488.1000224 · Cited by 29
Weybright, E. H., Caldwell, L. L., Ram, N., Smith, E. A., & Wegner, L. (2016) · Journal of Adolescence · doi:10.1016/j.adolescence.2016.03.012 · Cited by 28
“Adolescent substance use is associated with short- and long-term negative outcomes including risky sexual behavior (Palen, Smith, Flisher, Caldwell, & Mpofu, 2006), school dropout (Townsend, Flisher, & King, 2007), future substance use/abuse (Grant et al., 2006), and injury, violence, and suicide (Bauman & Phongsavan,…”
BackgroundLa Edad de Inicio en el Consumo de Drogas, un Indicador de Consumo Problemático
López, T. H., & Fernández, J. R. (2009) · Psychosocial Intervention · doi:10.5093/in2009v18n3a2 · Cited by 26
“…visto asociado con consumo de alcohol más intensivo, con más frecuencia de borracheras, con consumos más prevalentes de otras drogas (Vieira, Ribeiro y Laranjeira, 2007) y también con trastornos de abuso/dependencia del alcohol en la edad adulta (Grant et al., 2006; Warner, White y Johnson, 2007).”
BackgroundFreichel, R., Pfirrmann, J., Cousijn, J., de Jong, P. J., Franken, I. H. A., Banaschewski, T., Bokde, A. L. W., Desrivières, S., Flor, H., Grigis, A., et al. (2023) · Addiction · doi:10.1111/add.16231 · Cited by 28
Colour Vision Impairment in Young Alcohol Consumers
Brasil, A., Castro, A. J. O., Martins, I. C. V. S., Lacerda, E. M. D. C. B., Souza, G. D. S., Herculano, A. M., Rosa, A. A. M., Rodrigues, A. R., & Silveira, L. C. L. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140169 · Cited by 27
Heavy episodic drinking and alcohol-related injuries: An open cohort study among college students
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Charles, N. E., Mathias, C. W., Acheson, A., & Dougherty, D. M. (2017) · Addictive Behaviors · doi:10.1016/j.addbeh.2017.01.005 · Cited by 26
“Previous research has demonstrated that youth who begin using alcohol and illicit drugs at earlier ages, and those who engage in more frequent use during adolescence have a greater risk of experiencing negative outcomes such as poor psychological development, psychiatric disorders, substance use disorders, disease, ac…”
BackgroundResponse Inhibition and Binge Drinking During Transition to University: An fMRI Study
Suárez‐Suárez, S., Doallo, S., García, J. M. P., Corral, M., Holguı́n, S. R., & Cadaveira, F. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00535 · Cited by 29
Structural differences in adolescent brains can predict alcohol misuse
Rane, R. P., de Man, E. F., Kim, J., Görgen, K., Tschorn, M., Rapp, M. A., Banaschewski, T., Bokde, A. L. W., Desrivières, S., Flor, H., et al. (2022) · eLife · doi:10.7554/elife.77545 · Cited by 26
Crews, F. T., Coleman, L. G., Macht, V. A., & Vetreno, R. P. (2022) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000710 · Cited by 27
Substance dependence: Decades apart in a teaching hospital
Suresh, S. D., & Venkatesan, J. (2008) · Indian Journal of Psychiatry · doi:10.4103/0019-5545.42396 · Cited by 25
“In our study there is rise in number of persons taking to substances earlier in their life in the present decade and this correlates with the worldwide trend.[2,17-22] Recent trends in substance abuse in China shows a re-emergence of substance abuse (increasing trend in substances abuse) and also abuse of new substanc…”
BackgroundKalungi, H., Kamacooko, O., Lunkuse, J. F., Namutebi, J., Naluwooza, R., Price, M. A., Ruzagira, E., & Mayanja, Y. (2024) · BMC Public Health · doi:10.1186/s12889-024-19250-x · Cited by 24
“This study confirms earlier findings that demonstrate a high correlation between drug and alcohol use [17, 25, 33].”
BackgroundResultTesting the nicotine dependence measure mFTQ for adolescent smokers: A multinational investigation
Prokhorov, A. V., Khalil, G. E., Foster, D. W., Marani, S. K., Guindani, M., Espada, J. P., Gonzálvez, M. T., Idrisov, B. T., Galimov, A., Arora, M., et al. (2017) · American Journal on Addictions · doi:10.1111/ajad.12583 · Cited by 24
“Research shows common genetic vulnerability for nicotine, marijuana, and alcohol dependence,(23) and associations are found between marijuana or alcohol use and nicotine dependence among adolescents.(24) Finally, previous research has shown an association between extensiveness of smoking (measured by the number of cig…”
BackgroundGuerin, A., & Kim, J. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182212259 · Cited by 22
“an association not explained by genetic or shared environmental factors [13].”
Differential predictors for alcohol use in adolescents as a function of familial risk
Tschorn, M., Lorenz, R. C., O’Reilly, P. F., Reichenberg, A., Banaschewski, T., Bokde, A. L. W., Quinlan, E. B., Desrivières, S., Flor, H., Grigis, A., et al. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01260-7 · Cited by 24
Strandheim, A., Bratberg, G. H., Holmen, T. L., Coombes, L., & Bentzen, N. (2011) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/1753-2000-5-17 · Cited by 22
“That early alcohol début affects later health and addictive behaviour is well documented [16-19].”
BackgroundDubé, S., Lavoie, F., Blais, M., & Hébert, M. (2017) · Archives of Sexual Behavior · doi:10.1007/s10508-016-0914-0 · Cited by 23
“, weekly, consumption is regarded as risky for developing into a substance dependence disorder (Grant et al., 2006).”
BackgroundRamage, A. E., Lin, A., Olvera, R. L., Fox, P. T., & Williamson, D. E. (2015) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2015.01.012 · Cited by 21
“INTRODUCTION Adolescence is a period of developmental change marked by significant brain maturation and vulnerability of the brain to influences of environmental factors and exposure to substances (Grant et al., 2005).”
BackgroundTully, E. C., & Iacono, W. G. (2014) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780199381708.013.20 · Cited by 21
“…environmental risk exposure and age-related expression of genes that are specific to certain externalizing attributes (Agrawal, Neale, Prescott, & Kendler, 2004b; Grant et al., 2006; Hicks et al., 2004; Kendler, Prescott et al., 2003; Krueger et al., 2002; McGue et al., 2006; Young et al., 2000).”
Intergenerational Transmission of Drinking Motives and How They Relate to Young Adults' Alcohol Use
Mares, S. H. W., Lichtwarck‐Aschoff, A., & Engels, R. C. M. E. (2013) · Alcohol and Alcoholism · doi:10.1093/alcalc/agt025 · Cited by 20
“Alcohol use, especially among adolescents and young adults, is widely recognized as being risky behavior, since it is associated with various negative outcomes such as aggression, risky sexual behavior, cognitive impairments and alcohol disorders later in life (DeBellis et al., 2000; Exum, 2006; Grant et al., 2006; Od…”
BackgroundProblemas associados ao binge drinking entre estudantes das capitais brasileiras
Gomes, K. M. D. S., Amato, T. D. C., Bedendo, A., dos Santos, E. L., & Noto, A. R. (2019) · Ciência & Saúde Coletiva · doi:10.1590/1413-81232018242.35452016 · Cited by 20
Underage Alcohol Sales—It Only Takes a Minute: A New Approach to Underage Alcohol Availability
van Hoof, J. J., & Gosselt, J. F. (2013) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2013.74.423 · Cited by 20
Deutsch, A. R., Slutske, W. S., Richmond‐Rakerd, L. S., Chernyavskiy, P., Heath, A. C., & Martin, N. G. (2013) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2013.74.703 · Cited by 20
Earlier alcohol use onset prospectively predicts changes in functional connectivity
Nguyen‐Louie, T. T., Simmons, A. N., Squeglia, L. M., Infante, M. A., Schacht, J. P., & Tapert, S. F. (2018) · Psychopharmacology · doi:10.1007/s00213-017-4821-4 · Cited by 25
Borges, A. M., Lejuez, C. W., & Felton, J. W. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.02.029 · Cited by 20
Spillane, N. S., Schick, M. R., Kirk-Provencher, K. T., Hill, D. C., Wyatt, J., & Jackson, K. M. (2020) · Substance Use & Misuse · doi:10.1080/10826084.2020.1762652 · Cited by 26
“, 2007), future substance use/problems (Grant et al., 2006; Green et al., 2016), and injury, violence, and suicide (Bauman & Phongsavan, 1999; Hall et al.”
BackgroundPeer‐led interventions to reduce alcohol consumption in college students: A scoping review
Lavilla-Gracia, M., Pueyo-Garrigues, M., Pueyo-Garrigues, S., Pardavila-Belio, M., Canga-Armayor, A., Esandi, N., Alfaro-Díaz, C., & Canga-Armayor, N. (2022) · Health and Social Care in the community · doi:10.1111/hsc.13990 · Cited by 15
“Drinking has acute and immediate effects on young people, in addition to increasing the risk of alcohol- related problems in adulthood (Grant et al., 2006).”
BackgroundPatterns of Alcohol Consumption in Spanish University Alumni: Nine Years of Follow-Up
Salgado, P. G., Moure-Rodríguez, L., López‐Caneda, E., Boubeta, A. R., Cadaveira, F., & Caamaño‐Isorna, F. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00756 · Cited by 19
“At this point, it is of utmost importance to note that the main prevention efforts should be set in the adolescence period, because the codes of behavior acquired at that time tend to be maintained in adulthood (Grant et al., 2005).”
BackgroundJankowski, M. K., Rosenberg, H. J., Sengupta, A., Rosenberg, S. D., & Wolford, G. (2006) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2006.09.016 · Cited by 19
“linked to later life substance abuse, and associated with two leading causes of adult death (cardiovascular disease and cancer) [1,4,5].”
BackgroundSUBSTANCE USE AND KNOWLEDGE AMONG ITALIAN HIGH SCHOOL STUDENTS
Spacilova, L., Klusoňová, H., Petrelli, F., Signorelli, C., Visńovský, P., & Grappasonni, I. (2009) · Biomedical Papers · doi:10.5507/bp.2009.028 · Cited by 18
Associations Between ADH Gene Variants and Alcohol Phenotypes in Dutch Adults
van Beek, J. H. D. A., Willemsen, G. A. H. M., de Moor, M. H. M., Hottenga, J., & Boomsma, D. I. (2010) · Twin Research and Human Genetics · doi:10.1375/twin.13.1.30 · Cited by 18
Newton, N. C., Conrod, P., Rodríguez, D., & Teesson, M. (2014) · BMJ Open · doi:10.1136/bmjopen-2013-004750 · Cited by 19
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Meisel, S. N., Colder, C. R., Bowker, J. C., & Hussong, A. M. (2018) · Developmental Psychology · doi:10.1037/dev0000569 · Cited by 20
“Alcohol use is typically initiated and escalates during adolescence, and it is a major health concern because it is associated with a number of maladaptive outcomes such as illicit drugs use (Hill, White, Chung, Hawkins, & Catalano, 2000) and the development of Alcohol Use Disorder (Grant et al., 2006).”
InfluentialEarly-Life Sleep Deprivation Enhanced Alcohol Consumption in Adolescent Rats
Atrooz, F., Alrousan, G., Hassan, A., & Salim, S. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.856120 · Cited by 18
“Alcohol is one of the most commonly used substances among adolescents, followed by marijuana (Gray and Squeglia, 2018).”
BackgroundDeutsch, A. R., Slutske, W. S., Lynskey, M. T., Bucholz, K. K., Madden, P. A. F., Heath, A. C., & Martin, N. G. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000523 · Cited by 17
“Behavioral genetics research has indicated this link to be mostly noncausal (Grant et al., 2006; Prescott & Kendler, 1999).”
BackgroundSelf-citationSchelleman‐Offermans, K., Roodbeen, R. T. J., & Lemmens, P. H. H. M. (2017) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2017.07.016 · Cited by 17
Chung, Y.-R., Hong, J.-W., Kim, B.-B., Kim, J.-S., Noh, I. S., Wee, J. H., Kim, N. H., Bae, S., & Lim, M. H. (2020) · Medicine · doi:10.1097/md.0000000000019423 · Cited by 17
Dampened psychobiological responses to stress and substance use in adolescence
Rahal, D., Shirtcliff, E. A., Fuligni, A. J., Kogut, K. R., Gonzales, N. A., Johnson, M. M., Eskenazi, B., & Deardorff, J. (2022) · Development and Psychopathology · doi:10.1017/s0954579422000244 · Cited by 16
“…ages 14 and 16 specifically are related to poorer adjustment and higher use later in adolescence and adulthood (e.g., Colell et al., 2014; DeWit et al., 2000; Duke, 2018; Grant & Dawson, 1997; Grant et al., 2006; Hingson et al., 2006; Strunin et al., 2017; Swift et al., 2008; Wagner et al., 2005).”
BackgroundMethodAdolescent Substance Misuse: Neurobiology and Evidence-Based Interventions
Newton, N. C., O’Leary-Barrett, M., & Conrod, P. (2011) · Current topics in behavioral neurosciences · doi:10.1007/978-3-642-28720-6_164 · Cited by 15
Teesson, M., Farrugia, P. L., Mills, K. L., Hall, W., & Baillie, A. (2012) · Substance Use & Misuse · doi:10.3109/10826084.2012.663283 · Cited by 17
“The syndrome of delinquency, alcohol and drug abuse, precocious sexual activity, and poor school performance may, for example, be manifestations of a shared genetic predisposition and family circumstances that increase the chances of developing alcohol and drug dependence disorders (Grant et al., 2006; Jessor & Jessor…”
BackgroundDrogas, violência e aspectos emocionais em apenados
Pereira, G. C., Scheffer, M., & de Almeida, R. M. M. (2012) · Psicologia Reflexão e Crítica · doi:10.1590/s0102-79722012000100011 · Cited by 16
Sartor, C. E., Nelson, E. C., Lynskey, M. T., Madden, P. A. F., Heath, A. C., & Bucholz, K. K. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12185 · Cited by 16
“…and Kendler’s (1999) investigation of initiation of alcohol use and AD revealed that the association could be accounted for entirely by familial influences, nearly all genetic, but others have concluded that the association is not attributable in full to familial risk factors (Grant et al., 2006).”
Self-citationDynamic associations among alcohol use and anxiety symptoms in early adolescence.
Pardee, C. S., Colder, C. R., & Bowker, J. C. (2014) · Psychology of Addictive Behaviors · doi:10.1037/a0038372 · Cited by 16
Development of working memory in the male adolescent rat
Kirschmann, E. K., Pollock, M. W., Nagarajan, V., & Torregrossa, M. M. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2018.11.003 · Cited by 17
“…only assessed behavior at a few discrete time points or used tasks that rely on short-term memory or other innate behaviors (e.g. object recognition and delayed alternation) that do not mimic the types of working memory assessments used in humans (Castner et al., 2004; Green and Stanton, 1989).”
Bulimic Behaviors and Early Substance Use: Findings from a Cotwin‐Control Study
Munn‐Chernoff, M. A., Grant, J. D., Bucholz, K. K., Arpana Agrawal, A., Lynskey, M. T., Madden, P. A. F., Heath, A. C., & Duncan, A. E. (2015) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12829 · Cited by 15
“…while an early study by Prescott and Kendler (1999) reported that this association was entirely attributable to shared familial liabilities, others (Grant et al. 2006) found that relative to their non-early regular drinker cotwins, twins who drank alcohol regularly before age 17 were significantly…”
BackgroundSelf-citationThe usefulness of ‘age at first drink’ as a concept in alcohol research and prevention
Hingson, R., Zha, W., & White, A. M. (2016) · Addiction · doi:10.1111/add.13218 · Cited by 15
“Rather than being a fatal weakness, the replication of those relations using a variety of terms suggests a robust association, which has been found in cross-sectional surveys [4–6], in some [7–11] but not all [12] longitudinal studies and studies that control for genetics [13], such as studies of identical twins [14].”
ResultDastgerdi, Z. F., Eslami, A. A., Ghofranipour, F. F., Mostafavi, F., & Ebrahimi, A. A. (2015) · Journal of Substance Use · doi:10.3109/14659891.2015.1018973 · Cited by 15
Kelly, S. M., O’Grady, K. E., Gryczynski, J., Mitchell, S. G., Kirk, A. S., & Schwartz, R. P. (2017) · Substance Abuse · doi:10.1080/08897077.2017.1351413 · Cited by 16
“cence is associated with increased risk of developing a SUD in adulthood.(8,9) These factors emphasize the importance of”
BackgroundÁlcool e violência em homens e mulheres
de Almeida, R. M. M., Pasa, G. G., & Scheffer, M. (2009) · Psicologia Reflexão e Crítica · doi:10.1590/s0102-79722009000200012 · Cited by 15
Statewide Administration of the CRAFFT Screening Tool: Highlighting the Spectrum of Substance Use
Agley, J. D., Gassman, R. A., Jun, M. C., Nowicke, C. E., & Samuel, S. M. (2015) · Substance Use & Misuse · doi:10.3109/10826084.2015.1027930 · Cited by 14
“It is especially important to identify and address problem use among adolescents because this is the period when alcohol and drugs are commonly first used (Kandel & Logan, 1984; McArdle, 2008; O’Connell, Boat, & Warner, 2009), and regular alcohol use during adolescence may present a risk factor for alcohol and drug us…”
BackgroundRoodbeen, R. T. J., Schelleman‐Offermans, K., & Lemmens, P. H. H. M. (2016) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2016.03.005 · Cited by 14
The Speed of Progression to Tobacco and Alcohol Dependence: A Twin Study
Huggett, S. B., Hatoum, A. S., Hewitt, J. K., & Stallings, M. C. (2018) · Behavior Genetics · doi:10.1007/s10519-018-9888-0 · Cited by 14
“Whether early use causes future substance use related problems or is attributed to a common liability remains controversial due to mixed findings in the literature (Prescott and Kendler 1999a; Grant et al. 2006; Kendler et al. 2013; Ystrom et al. 2014).”
Adolescents and Young Adult Health
Ozer, E. M., & Irwin, C. E. (2009) · Wiley eBooks · doi:10.1002/9780470479193.adlpsy001019 · Cited by 14
Interventions for adolescent alcohol use
Chun, T. H., & Linakis, J. G. (2012) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e32834faa83 · Cited by 13
Rada, C., & Ispas, A. T. (2016) · Substance Abuse Treatment Prevention and Policy · doi:10.1186/s13011-016-0080-3 · Cited by 13
“to other studies, we noted that pressure from peers/ friends and curiosity may be predisposing factors for AC [52].”
BackgroundSeemiller, L. R., Logue, S. F., & Gould, T. J. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173429 · Cited by 13
Amadio, D. M., Adam, T., & Buletza, K. (2008) · Sexual and Gender Diversity in Social Services · doi:10.1080/10538720802310717 · Cited by 13
“There is some evidence from human and animal studies that excessive and/or early alcohol consumption increases one’s chances of developing alcohol-related problems (Barr, Schwandt, Newman, & Higley, 2004; Grant et al., 2006; Nishiyori et al., 2005); lesbian adults not only drink more often compared with heterosexual w…”
BackgroundSchick, M. R., Nalven, T., & Spillane, N. S. (2020) · American Journal of Orthopsychiatry · doi:10.1037/ort0000504 · Cited by 14
“…alcohol use presents a significant public health concern, as exposure to alcohol during the adolescent years is associated with increased risk for a variety of negative alcohol-related consequences and poor outcomes in adulthood (i.e., future substance use problems; (Grant et al., 2006).”
BackgroundAutomatic Cognitive Processes and Youth Substance Use: Risks and Prevention
Krank, M. D., & Robinson, J. M. (2017) · Current Addiction Reports · doi:10.1007/s40429-017-0168-5 · Cited by 13
Does polygenic risk for substance‐related traits predict ages of onset and progression of symptoms?
Kranzler, H. R., Feinn, R., Xu, H., Ho, B. L., Saini, D., Nicastro, O. R., Jacoby, A., Toikumo, S., Gelernter, J. E., Hartwell, E. E., et al. (2023) · Addiction · doi:10.1111/add.16210 · Cited by 14
Gebru, N. M., Gonçalves, P., Cruz, R. A., Thompson, W. K., Allegair, N., Potter, A., Garavan, H., Dumas, J. A., Leeman, R. F., & Johnson, M. E. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1213894 · Cited by 11
Alcohol gains access to appetitive learning through adolescent heavy drinking.
DiLeo, A., Wright, K. M., Mangone, E., & McDannald, M. A. (2015) · Behavioral Neuroscience · doi:10.1037/bne0000075 · Cited by 12
Li, H., Lv, J., Yu, C., Guo, Y., Bian, Z., Fan, J., Yang, L., Chen, Y., Du, H., Long, H., et al. (2020) · American Journal of Epidemiology · doi:10.1093/aje/kwaa119 · Cited by 12
“Some previous studies showed that early age at initiation of alcohol consumption, defined as age at alcohol initiation (AAI) less than 18 years, and long duration of alcohol drinking increased the risk of alcohol-use disorders, heavy drinking, and alcohol dependence (9, 10).”
BackgroundResultKandemır, H., Aydemır, Ö., Ekinci, S., Selek, S., Kandemir, S. B., & Bayazıt, H. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s82232 · Cited by 12
“Alcohol and drug use typically begins during adolescence and it is associated with increased risk of addictive disorders in later life.(6,7) It is also significantly associated with lower levels of quality of life among adolescents.”
A National Swedish Longitudinal Twin‐Sibling Study of alcohol use disorders among males
Long, E. C., Lönn, S. L., Sundquist, J., Sundquist, K., & Kendler, K. S. (2017) · Addiction · doi:10.1111/add.13833 · Cited by 12
Genetic and environmental influences on developmental trajectories of adolescent alcohol use
Zheng, Y., Brendgen, M. R., Dionne, G., Boivin, M., & Vitaro, F. (2019) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-019-01284-x · Cited by 12
Yeung, E. W., Spychala, K. M., Miller, A. P., Otto, J. M., Deak, J. D., Kim, H., Gilder, D. A., Ehlers, C. L., Wilhelmsen, K. C., & Gizer, I. R. (2021) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2021.109117 · Cited by 11
Mattioni, J., Vansteene, C., Poupon, D., Gorwood, P. A. P. M., & Ramoz, N. (2023) · Addiction Biology · doi:10.1111/adb.13269 · Cited by 11
Galbo, L. K., Davenport, A. T., Epperly, P. M., & Czoty, P. W. (2023) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.15163 · Cited by 11
A Co-Twin Control Study of the Relationship Between Adolescent Drinking and Adult Outcomes
Waldron, J. S., Malone, S. M., McGue, M. K., & Iacono, W. G. (2018) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2018.79.635 · Cited by 11
“Several studies have used the co-twin control design to investigate the impact of adolescent drinking (Grant et al., 2006, 2012; Malone et al., 2014; Prescott & Kendler, 1999); however, only two prospective longitudinal investigations implemented the co-twin control method to assess the longterm…”
BackgroundTraube, D. E., Yarnell, L. M., & Schrager, S. M. (2015) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2015.11.020 · Cited by 11
“Age 15 is a recognized cutoff point for early substance use that as particularly negative consequences (Grant & Dawson, 1997; Grant et al., 2006; Grant, Stinson, & Harford, 2001).”
BackgroundTang, S., & Patrick, M. E. (2019) · Human Behavior and Emerging Technologies · doi:10.1002/hbe2.154 · Cited by 11
Monshouwer, K. (2008) · Utrecht University Repository (Utrecht University) · Cited by 11
Mancha, B. E., Rojas, V. C., & Latimer, W. W. (2012) · Alcohol · doi:10.1016/j.alcohol.2012.06.002 · Cited by 10
“…about variations in adolescent alcohol experimentation may be instrumental in gauging the degree to which youths may also be engaging in a range of behaviors that place them at risk for more severe risk behaviors and a progression to more serious forms of alcohol and drug use (Grant et al., 2006).”
BackgroundDavis, C. N., Natta, S. S., & Slutske, W. S. (2017) · Behavior Genetics · doi:10.1007/s10519-017-9867-x · Cited by 11
“Some prior findings suggest unique environmental factors may help explain the association between early alcohol use and later substance abuse and dependence (Grant et al. 2005).”
BackgroundRyzin, M. J. V., Lee, J. Y. H., & Biglan, A. (2019) · Journal of Child & Adolescent Substance Abuse · doi:10.1080/1067828x.2018.1544525 · Cited by 10
The Legal Drinking Age and Underage Drinking in the United States
Hingson, R. (2009) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpediatrics.2009.66 · Cited by 10
Making sense of alcohol experiences
van Hoof, J. J., den Boom, S. G. M. V., & de Jong, M. D. T. (2011) · Addictive Behaviors · doi:10.1016/j.addbeh.2011.03.017 · Cited by 9
Aspects épidémiologiques de l’alcoolodépendance
Laqueille, X., Lacombe, M., & Dervaux, A. (2018) · La Presse Médicale · doi:10.1016/j.lpm.2018.04.009 · Cited by 9
School-based Alcohol and Other Drug Prevention
Newton, N. C., Conrod, P., Teesson, M., & Faggiano, F. (2012) · Springer eBooks · doi:10.1007/978-1-4614-3375-0_46 · Cited by 9
Davis, C. N., Slutske, W. S., Piasecki, T. M., Martin, N. G., & Lynskey, M. T. (2019) · Journal of Abnormal Psychology · doi:10.1037/abn0000474 · Cited by 9
Self-citationThe effects of multiple early life stressors on adolescent alcohol consumption
Thompson, S. M., Simmons, A. N., & McMurray, M. S. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.112449 · Cited by 8
Dampened autonomic nervous system responses to stress and substance use in adolescence
Rahal, D., Alkon, A., Shirtcliff, E. A., Gonzales, N. A., Fuligni, A. J., Eskenazi, B., & Deardorff, J. (2022) · Stress and Health · doi:10.1002/smi.3173 · Cited by 11
Shared genetic contributions to early-onset drinking and drinking to cope motives
Young‐Wolff, K. C., Kendler, K. S., & Prescott, C. A. (2012) · Addictive Behaviors · doi:10.1016/j.addbeh.2012.05.009 · Cited by 8
“Moreover, given evidence that both early-onset drinking (Grant et al., 2006; Prescott & Kendler, 1999) andDTC (Prescott et al., 2004; Young-Wolff et al., 2009) share genetic liability with alcohol use disorders, the current results point to the possibility that the well-known correlation between…”
BackgroundInfluentialHernáez, Á. M., Marí‐Klose, M., Julià, A., Escapa, S., & Marí‐Klose, P. (2012) · Revista Española de Salud Pública · doi:10.1590/s1135-57272012000100009 · Cited by 8
Lee, B., Choi, M., & Choi, M. (2020) · Applied Research in Quality of Life · doi:10.1007/s11482-019-09808-y · Cited by 8
May, A. C., Aguinaldo, L. D., Tan, R., Courtney, K. E., & Jacobus, J. (2021) · Substance Use & Misuse · doi:10.1080/10826084.2021.1899231 · Cited by 10
“Despite these variations in definition, multiple quantitative studies have found early onset of regular alcohol use to be a risk factor for future use problems (Grant et al., 2006; Guttmannova et al., 2011).”
BackgroundShin, S. H., Bouchard, L. M., & Montemayor, B. N. (2021) · Prevention Science · doi:10.1007/s11121-021-01300-0 · Cited by 9
Abdala, N., Hansen, N. B., Toussova, O., Krasnoselskikh, Т. V., Kozlov, A. P., & Heimer, R. (2011) · AIDS and Behavior · doi:10.1007/s10461-011-0013-0 · Cited by 8
“Furthermore, early drinking onset may be associated with later substance use problems [17, 18].”
BackgroundUsing biological samples for youth ATOD survey validation
Gassman, R. A., Agley, J. D., Fly, A. D., Beckmeyer, J. J., He, K., Sayegh, M. A., & Tidd, D. (2015) · Addiction Research & Theory · doi:10.3109/16066359.2015.1094061 · Cited by 8
“illicit substance abuse later in life (Grant et al., 2006).”
BackgroundDid the 18 Drinking Age Promote High School Dropout? Implications for Current Policy
Plunk, A. D., Arpana Agrawal, A., Tate, W. F., Cavazos‐Rehg, P. A., Bierut, L. J., & Grucza, R. A. (2015) · Journal of Studies on Alcohol and Drugs · doi:10.15288/jsad.2015.76.680 · Cited by 7
“EARLY ONSET OF REGULAR ALCOHOL USE has been linked to subsequent alcohol dependence, heavy drinking patterns, misuse of other substances, and even lower educational attainment, both contemporaneously and later in life (Agrawal et al., 2006, 2009; Grant et al., 2006, 2012; Hingson et al., 2006).”
Background
Metadata
- Authors
- GRANT, J. D., SCHERRER, J. F., LYNSKEY, M. T., LYONS, M. J., EISEN, S. A., TSUANG, M. T., TRUE, W. R., & BUCHOLZ, K. K.
- Affiliations
- Washington University in St. Louis (US)
- Boston University (US)
- Harvard University (US)
- Saint Louis University (US)
- ORCID
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2005-09-29
- Volume
- 36
- Issue
- 1
- Pages
- 109-118
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2122953373
- Cited by
- 321
- References
- 32
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 8 · 2023: 6 · 2022: 23 · 2021: 19 · 2020: 12 · 2019: 14 · 2018: 14 · 2017: 17 · 2016: 16 · 2015: 25 · 2014: 23 · 2013: 17 · 2012: 23
- FWCI
- 7.17
- Type
- journal article
- Language
- en
- Open access
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Digital Commons@Becker (Washington University School of Medicine) (submittedVersion)
- Funders
- U.S. Department of Defense
- U.S. Department of Veterans Affairs
- Health Services Research and Development
- Temple University
- National Institutes of Health (AA11998)
- National Institute on Alcohol Abuse and Alcoholism (AA11998, AA 12640, R01AA012640)
- National Institute on Drug Abuse (DA-14363, R01DA014632, DA 14632, R01DA014363)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- adolescent alcohol use, alcoholism, cannabis use, drug addiction, substance abuse, genetic factors, family environment, unique environmental factors, twin discordance, Vietnam Era Twin Registry, age of onset of drinking
- MeSH terms
- Adolescent, Adult, Age Factors, Alcohol Drinking, Alcoholism, Female, Humans, Male, Registries, Risk Factors, Social Environment, Illicit Drugs, Twins, Disease Progression, Substance-Related Disorders
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