Modelling complex pathways between late-life depression and disability: evidence for mediating and moderating factors
Open accessAbstract
Previous research has consistently shown an association between depression and disability in the elderly but little is known about the mechanisms linking the two. Recent longitudinal population studies have shown considerable inconsistency in the criteria used to establish causality and terms such as mediation and effect modification have been frequently applied incorrectly in terms of the inferences drawn. We underline the necessity to adopt more stringent theoretical criteria for the establishment of intermediary effects in the relationship between depression and disability to better identify cross-validated potential intervention points for reducing the risk of disablement and depression.
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Functional decline may lead to depression by limiting participation in social, leisure, and physical activities, thereby increasing chronic stress and social isolation.
“functional decline may lead to depression by limiting participation in social, leisure, and physical activities, thereby increasing chronic stress and social isolation. (Carriere, Villebrun, Peres, Stewart, Ritchie, and Ancelin 2009;James, Wilson, Barnes, and Bennett 2011)”
From Successful aging: Advancing the science of physical independence in older adults (2015) · cites this paper as Carriere et al. 2009
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Successful aging: Advancing the science of physical independence in older adults
Anton, S. D., Woods, A. J., Ashizawa, T., Barb, D., Buford, T. W., Carter, C. S., Clark, D. J., Cohen, R. A., Corbett, D. B., Cruz-Almeida, Y., et al. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.09.005 · Cited by 292 · see citing works
- Authors
- Carrière, I., Villebrun, D., Pérès, K., Stewart, R., Ritchie, K., & Ancelin, M. L.
- Affiliations
- Inserm (FR)
- King's College London (GB)
- Corresponding author
- Carrière, I.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-02-26
- Volume
- 39
- Issue
- 10
- Pages
- 1587-1590
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- PMC
- PMC2691412
- OpenAlex
- W2097674086
- Cited by
- 19
- References
- 14
- Citations by year
- 2023: 3 · 2020: 1 · 2018: 1 · 2016: 1 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 3
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion, other-oa)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Institut pour la Recherche en Santé Publique
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Social Sciences › Health › Health disparities and outcomes
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- geriatric depression, disability, older adults, mediation, effect modification, causal inference, disability risk, intervention targets
- MeSH terms
- Activities of Daily Living, Aged, Depressive Disorder, Persons with Disabilities, Disabled Persons, Humans, Longitudinal Studies, Models, Psychological, Risk Factors
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