The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The genetic and environmental relationship between major depression and the five-factor model of personality
Abstract
Background: Certain personality traits have long been suspected to reflect an enduring vulnerability to major depression (MD) in part because of shared genetic risk factors. Although many have agreed that normative personality is well captured by the ‘Big-Five’ personality traits of Openness (O), Conscientiousness (C), Extraversion (E), Agreeableness (A) and Neuroticism (N), to date genetically informative studies have only examined the relationship between MD and N and E. Method: Questionnaires were completed on a website, yielding a sample of 44 112 subjects including both members of 542 same-sex twin pairs. Personality was measured by the Big Five Inventory. Structural modeling was performed by Mx. Results: Three of the big-five personality traits – O, E and A – had small phenotypic associations with risk for MD and small genetic correlations. Two traits – N and C – had stronger phenotypic associations (positive for N and negative for C) with the following estimates of the genetic correlation with MD: +0.43 for N and −0.36 for C. N and C were moderately negatively correlated. Controlling for N reduced the genetic correlation between C and MD more than controlling for C reduced the genetic correlation between N and MD. Conclusions: A large proportion of the genetic risk for MD that is expressed via personality is captured by N, with a modest amount due to C, and small amounts from O, E and A.
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Cites
Akaike, H. (1987) · Psychometrika · doi:10.1007/bf02294359 · Cited by 5,264
Akaike, H. (1987) · Springer Series in Statistics · doi:10.1007/978-1-4612-1694-0_29 · Cited by 4,027
Genetic Epidemiology of Major Depression: Review and Meta-Analysis
Sullivan, P. F., Neale, M. C., & Kendler, K. S. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.10.1552 · Cited by 3,431
Self-citationGosling, S. D., Vazire, S., Srivastava, S., & John, O. P. (2004) · American Psychologist · doi:10.1037/0003-066x.59.2.93 · Cited by 2,932 · cited 2×
“However, a recent review of the psychological literature suggests that fears about the unrepresentativeness of web-based samples are exaggerated (Gosling et al. 2004).”
BackgroundResultA Swedish National Twin Study of Lifetime Major Depression
Kendler, K. S., Gatz, M., Gardner, C. O., & Pedersen, N. L. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.1.109 · Cited by 794
Self-citationPersonality and Major Depression: A Swedish Longitudinal, Population-Based Twin Study
Kendler, K. S., Gatz, M., Gardner, C. O., & Pedersen, N. L. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.10.1113 · Cited by 663
Self-citationPersonality Dimensions and Depression: Review and Commentary
Enns, M. W., & Cox, B. J. (1997) · The Canadian Journal of Psychiatry · doi:10.1177/070674379704200305 · Cited by 241 · cited 1×
“A long tradition of research has examined the interrelationship between personality and major depression (MD) with a leading hypothesis being that certain personality traits reflect an enduring vulnerability to MD (Kendler et al. 1993a ; Klein et al. 1993 ; Bagby et al. 1995; Enns & Cox, 1997).”
BackgroundWELLS, J. E., & HORWOOD, L. J. (2004) · Psychological Medicine · doi:10.1017/s0033291703001843 · Cited by 199
Cited by
Study, L. C., Okbay, A., Baselmans, B. M. L., De Neve, J.-E., Turley, P., Nivard, M. G., Fontana, M. A., Meddens, S. F. W., Linnér, R. K., Rietveld, C. A., et al. (2016) · Nature Genetics · doi:10.1038/ng.3552 · Cited by 1,013
23andMe Research Team, Nagel, M., Jansen, P. R., Stringer, S., Watanabe, K., de Leeuw, C. A., Bryois, J., Savage, J. E., Hammerschlag, A. R., Skene, N. G., et al. (2018) · Nature Genetics · doi:10.1038/s41588-018-0151-7 · Cited by 799
Neuroticism and common mental disorders: meaning and utility of a complex relationship.
Ormel, J., Jeronimus, B. F., Kotov, R., Riese, H., Bos, E. H., Hankin, B., Rosmalen, J. G. M., & Oldehinkel, A. J. (2013) · Clinical Psychology Review · doi:10.1016/j.cpr.2013.04.003 · Cited by 703
What is conscientiousness and how can it be assessed?
Roberts, B. W., Lejuez, C., Krueger, R. F., Richards, J. M., & Hill, P. L. (2014) · Developmental Psychology · doi:10.1037/a0031109 · Cited by 599
Cramer, A. O. J., Van Der Sluis, S., Noordhof, A., Wichers, M., Geschwind, N., Aggen, S. H., Kendler, K. S., & Borsboom, D. (2012) · European Journal of Personality · doi:10.1002/per.1866 · Cited by 477
Self-citation
Metadata
- Authors
- Kendler, K. S., & Myers, J.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2009-09-07
- Volume
- 40
- Issue
- 5
- Pages
- 801-806
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2110293539
- Cited by
- 250
- References
- 8
- FWCI
- 12.83
- Type
- journal article
- Language
- en
- Open access
- closed
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