Time to diagnosis in young-onset dementia as compared with late-onset dementia
Abstract
Background The extent to which specific factors influence diagnostic delays in dementia is unclear. Therefore, the aim of the present study was to compare duration from symptom onset to diagnosis for young-onset dementia (YOD) and late-onset dementia (LOD) and to assess the effect of age at onset, type of dementia, gender, living situation, education and family history of dementia on this duration. Method Data on 235 YOD and 167 LOD patients collected from caregivers from two prospective cohort studies were used. Multiple linear regression analysis was performed. Results The duration between symptom onset and the diagnosis of YOD exceeded that of LOD by an average of 1.6 years (2.8 v. 4.4 years). Young age and being diagnosed with frontotemporal dementia were related to increases in the time to diagnosis. Subjects with vascular dementia experienced shorter time to diagnosis. Conclusions There is a need to raise special awareness of YOD to facilitate a timely diagnosis.
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Average diagnostic delay from symptom onset in bvFTD is up to 5-6 years.
“average diagnostic delay is up to 5-6 years from symptom onset (Woolley et al. , 2011; van Vliet et al. , 2013; Ducharme et al. , 2017).”
From Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders (2020) · cites this paper as van Vliet et al., 2013
Around 50% of patients with bvFTD receive a prior psychiatric diagnosis.
“Around 50% of patients with bvFTD receive a prior psychiatric diagnosis”
From Recommendations to distinguish behavioural variant frontotemporal dementia from psychiatric disorders (2020) · cites this paper as van Vliet et al., 2013
Cites
Mackenzie, C. S., Gekoski, W. L., & Knox, V. J. (2006) · Aging & Mental Health · doi:10.1080/13607860600641200 · Cited by 878 · cited 2× · see citing works
“Higher education levels and female gender were hypothesized to facilitate earlier recognition and help-seeking behaviour (Tijhuis et al. 1990 ; Mackenzie et al. 2006 ; Tedstone Doherty & Kartalova-O’Doherty, 2010).”
BackgroundDoherty, D. T., & Kartalova‐O'Doherty, Y. (2010) · British Journal of Health Psychology · doi:10.1348/135910709x457423 · Cited by 221 · see citing works
Early onset dementia: clinical and social aspects
Werner, P., Stein-Shvachman, I., & Korczyn, A. D. (2009) · International Psychogeriatrics · doi:10.1017/s1041610209009223 · Cited by 122 · see citing works
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Global Prevalence of Young-Onset Dementia: A Systematic Review and Meta-analysis
Hendriks, S., Peetoom, K., Bakker, C., van der Flier, W. M., Papma, J. M., Koopmans, R., Verhey, F. R. J., de Vugt, M., Köhler, S., Young-Onset Dementia Epidemiology Study Group, et al. (2021) · JAMA Neurology · doi:10.1001/jamaneurol.2021.2161 · Cited by 409 · see citing works
Self-citationDucharme, S., Dols, A., Laforce, R., Devenney, E., Kumfor, F., van den Stock, J., Dallaire-Théroux, C., Seelaar, H., Gossink, F., Vijverberg, E., et al. (2020) · Brain · doi:10.1093/brain/awaa018 · Cited by 320 · see citing works
Self-citationGruters, A. A. A., Christie, H. L., Ramakers, I. H. G. B., Verhey, F. R. J., Kessels, R. P. C., & de Vugt, M. E. (2021) · The Clinical Neuropsychologist · doi:10.1080/13854046.2020.1749936 · Cited by 33 · see citing works
Self-citationHill, J. D., Schmucker, A. M., Siman, N., Goldfeld, K. S., Cuthel, A. M., Chodosh, J., Bouillon‐Minois, J., & Grudzen, C. R. (2022) · Journal of the American Geriatrics Society · doi:10.1111/jgs.17833 · Cited by 28 · see citing works
Diagnostic Instability Over Time in the Late-Onset Frontal Lobe Syndrome: When Can We Say it's FTD?
de Boer, S. C. M., Gossink, F., Krudop, W., Vijverberg, E., Schouws, S., Reus, L. M., Pijnenburg, Y. A. L., & Dols, A. (2023) · The American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2023.02.006 · Cited by 15 · see citing works
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- Authors
- van Vliet, D., de Vugt, M. E., Bakker, C., Pijnenburg, Y. A. L., Vernooij-Dassen, M. J. F. J., Koopmans, R. T. C. M., & Verhey, F. R. J.
- Affiliations
- Radboud University Nijmegen (NL)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Maastricht University Medical Centre (NL)
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-05-28
- Volume
- 43
- Issue
- 2
- Pages
- 423-432
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2007389916
- Cited by
- 309
- References
- 3
- Citations by year
- 2026: 28 · 2025: 45 · 2024: 40 · 2023: 33 · 2022: 30 · 2021: 34 · 2020: 23 · 2019: 18 · 2018: 10 · 2017: 11 · 2016: 9 · 2015: 14 · 2014: 6 · 2013: 5 · 2012: 2
- FWCI
- 6.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Alzheimer Society
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- early-onset dementia, late-onset dementia, time to diagnosis, delayed diagnosis, frontotemporal dementia, vascular dementia, age of onset, family history of dementia, living situation, gender differences
- MeSH terms
- Age Factors, Aged, Attitude to Health, Dementia, Family Health, Female, Humans, Male, Middle Aged, Netherlands, Prospective Studies, Regression Analysis, Severity of Illness Index, Caregivers, Age of Onset, Genetic Predisposition to Disease, Delayed Diagnosis
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