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Update on the treatment of anorexia nervosa: review of clinical trials, practice guidelines and emerging interventions

Watson, H. J., Bulik, C. M.·2013·Psychological Medicine

DOI 10.1017/s0033291712002620

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Abstract

Background Anorexia nervosa is a potentially deadly psychiatric illness that develops predominantly in females around puberty but is increasingly being recognized as also affecting boys and men and women across the lifespan. The aim of this environmental scan is to provide an overview of best practices in anorexia nervosa treatment across the age spectrum. Method A triangulation approach was used. First, a detailed review of randomized controlled trials (RCTs) for anorexia nervosa published between 1980 and 2011 was conducted; second, clinical practice guidelines were consulted and reviewed; third, information about RCTs currently underway was sourced. This approach facilitated a comprehensive overview, which addressed the extant evidence base, recent advances in evidence and improvements in treatment, and future directions. Results The evidence base for the treatment of anorexia nervosa is advancing, albeit unevenly. Evidence points to the benefit of family-based treatment for youth. For adults no specific approach has shown superiority and, presently, a combination of renourishment and psychotherapy such as specialist supportive clinical management, cognitive behavioral therapy, or interpersonal psychotherapy is recommended. RCTs have neither sufficiently addressed the more complex treatment approaches seen in routine practice settings, such as multidisciplinary treatment or level of care, nor specifically investigated treatment in ethnically diverse populations. Methodolog…

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Authors: Watson, H. J., & Bulik, C. M.
Affiliations: The University of Western Australia (AU)
University of North Carolina at Chapel Hill (US)
Corresponding author: Bulik, C. M.
ORCID: Watson, H. J.
Bulik, C. M.
Venue: Psychological Medicine
Publisher: Cambridge University Press (CUP)
Published: 2012-12-10
Volume: 43
Issue: 12
Pages: 2477-2500
ISSN: 0033-2917 (ISSN-L)
1469-8978
DOI: 10.1017/s0033291712002620
OpenAlex: W2090670445
Cited by: 339
References: 101
Citations by year: 2026: 5 · 2025: 16 · 2024: 14 · 2023: 21 · 2022: 23 · 2021: 25 · 2020: 31 · 2019: 31 · 2018: 35 · 2017: 39 · 2016: 33 · 2015: 33 · 2014: 23 · 2013: 9
FWCI: 2.99
Type: journal article
Language: en
Open access: closed
Licence: www.cambridge.org/core/terms (unspecified)
Locations: Psychological Medicine (publishedVersion)
PubMed (publishedVersion)
UWA Profiles and Research Repository (UWA) (submittedVersion)
Topics: Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Health Sciences › Nursing › Nutrition and Dietetics › Nutrition, Health and Food Behavior
Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords: anorexia nervosa, treatment of anorexia nervosa, family-based treatment, cognitive behavioral therapy, interpersonal psychotherapy, multidisciplinary treatment, randomized controlled trials, evidence base, eating disorders in adults
MeSH terms: Anorexia Nervosa, Humans, Psychotherapy, Practice Guidelines as Topic, Evidence-Based Practice

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Update on the treatment of anorexia nervosa: review of clinical trials, practice guidelines and emerging interventions

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