CoChat
Sign Up
Cited by 129Obsessive-Compulsive Spectrum DisordersDeep Brain Stimulation and Movement DisordersAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Cognitive-behavioural therapy augments the effects of deep brain stimulation in obsessive-compulsive disorder

Mantione, M., Nieman, D. H., Figee, M., Denys, D.·2014·Psychological Medicine
DOI 10.1017/s0033291714000956
Open this paper in CoChat — free account

Abstract

BACKGROUND: Deep brain stimulation (DBS) is a promising new treatment for patients with treatment-refractory obsessive-compulsive disorder (OCD). However, since most DBS patients only show a partial response, the treatment still needs to be improved. In this study we hypothesized that cognitive-behavioural therapy (CBT) could optimize the post-operative management in DBS and we evaluated the efficacy of CBT as augmentation to DBS targeted at the nucleus accumbens. METHOD: A total of 16 patients with treatment-refractory OCD were treated with DBS targeted at the nucleus accumbens. After stabilization of decline in OCD symptoms, a standardized 24-week CBT treatment programme was added to DBS in an open-phase trial of 8 months. Changes in obsessive-compulsive, anxiety and depressive symptoms were evaluated using the Yale-Brown Obsessive Compulsive Scale, Hamilton Anxiety Scale and Hamilton Rating Scale for Depression. RESULTS: Following the addition of CBT to DBS, a significant decrease in obsessive-compulsive symptoms was observed, but not in anxiety and depressive symptoms. In a subsequent double-blind phase, in which stimulation was discontinued, OCD symptoms returned to baseline (relapse) and anxiety and depressive symptoms worsened (rebound) compared with baseline. CONCLUSIONS: The results of this explorative study suggest that a combined treatment of accumbens DBS and CBT may be optimal for improving obsessive-compulsive symptoms in treatment-refractory OCD. However, a subsequent randomized controlled trial is necessary to draw firm conclusions. It seems that DBS results in affective changes that may be required to enable response prevention in CBT. This may indicate that DBS and CBT act as two complementary treatments.

Overview

Integrity signals

Registry

Crossref · 10.1017/s0033291714000956

Cites

33 of 33 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 33 references

Research works printed but not linked: 2

  1. March, 1997, The expert consensus guideline series: treatment of obsessive–compulsive disorder, Journal of Clinical Psychiatry, 58, 5
  2. Kozak, 1997, Mastery of Obsessive Compulsive Disorder: A Cognitive Behavioural Approach

Cited by

Sorted by citations

Items 101–129 of 129

Related

See all

Metadata

Authors
Mantione, M., Nieman, D. H., Figee, M., & Denys, D.
Affiliations
  • Amsterdam UMC Location University of Amsterdam (NL)
  • Netherlands Institute for Neuroscience (NL)
Corresponding author
  • Mantione, M.
  • Denys, D.
ORCID
Venue
Psychological Medicine
Publisher
Cambridge University Press (CUP)
Published
2014-04-25
Volume
44
Issue
16
Pages
3515-3522
ISSN
  • 0033-2917 (ISSN-L)
  • 1469-8978
DOI
10.1017/s0033291714000956
OpenAlex
W2105399857
Cited by
129
References
33
Citations by year
2026: 6 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 20 · 2019: 15 · 2018: 23 · 2017: 6 · 2016: 6 · 2015: 10
FWCI
8.65
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified)
Locations
  • Psychological Medicine (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
Funders
Nederlandse Organisatie voor Wetenschappelijk Onderzoek
Topics
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
obsessive-compulsive disorder, deep brain stimulation, cognitive behavioral therapy, treatment-refractory OCD, nucleus accumbens, augmentation therapy, response prevention, symptom recurrence, anxiety and depressive symptoms
MeSH terms
Adult, Combined Modality Therapy, Double-Blind Method, Female, Humans, Male, Middle Aged, Netherlands, Obsessive-Compulsive Disorder, Psychiatric Status Rating Scales, Severity of Illness Index, Cognitive Behavioral Therapy, Treatment Outcome, Cross-Over Studies, Deep Brain Stimulation

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review