The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Cognitive-behavioural therapy augments the effects of deep brain stimulation in obsessive-compulsive disorder
Abstract
BACKGROUND: Deep brain stimulation (DBS) is a promising new treatment for patients with treatment-refractory obsessive-compulsive disorder (OCD). However, since most DBS patients only show a partial response, the treatment still needs to be improved. In this study we hypothesized that cognitive-behavioural therapy (CBT) could optimize the post-operative management in DBS and we evaluated the efficacy of CBT as augmentation to DBS targeted at the nucleus accumbens. METHOD: A total of 16 patients with treatment-refractory OCD were treated with DBS targeted at the nucleus accumbens. After stabilization of decline in OCD symptoms, a standardized 24-week CBT treatment programme was added to DBS in an open-phase trial of 8 months. Changes in obsessive-compulsive, anxiety and depressive symptoms were evaluated using the Yale-Brown Obsessive Compulsive Scale, Hamilton Anxiety Scale and Hamilton Rating Scale for Depression. RESULTS: Following the addition of CBT to DBS, a significant decrease in obsessive-compulsive symptoms was observed, but not in anxiety and depressive symptoms. In a subsequent double-blind phase, in which stimulation was discontinued, OCD symptoms returned to baseline (relapse) and anxiety and depressive symptoms worsened (rebound) compared with baseline. CONCLUSIONS: The results of this explorative study suggest that a combined treatment of accumbens DBS and CBT may be optimal for improving obsessive-compulsive symptoms in treatment-refractory OCD. However, a subsequent randomized controlled trial is necessary to draw firm conclusions. It seems that DBS results in affective changes that may be required to enable response prevention in CBT. This may indicate that DBS and CBT act as two complementary treatments.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“a recent study demonstrated that combining DBS with CBT (which included ERP) resulted in a reduction of OCD symptoms in a treatment-refractory sample.[70]”
From Exposure and response prevention for obsessive-compulsive disorder: A review and new directions (2019) · cites this paper as [70]
In the citing paper
“Rehabilitation and behavioral therapy have been shown to have an additive effect for patients receiving DBS for OCD [113].”
From Deep brain stimulation for depression. (2022) · cites this paper as [113]
Citations
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
The assessment of anxiety states by rating
HAMILTON, M. (1959) · British Journal of Medical Psychology · doi:10.1111/j.2044-8341.1959.tb00467.x · Cited by 11,455
The Yale-Brown Obsessive Compulsive Scale: I. Development, Use, and Reliability
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110048007 · Cited by 7,712
The Yale-Brown Obsessive Compulsive Scale: II. Validity
Goodman, W. K. (1989) · Archives of General Psychiatry · doi:10.1001/archpsyc.1989.01810110054008 · Cited by 2,799
Optimizing inhibitory learning during exposure therapy
Craske, M. G., Kircanski, K., Zelikowsky, M., Mystkowski, J., Chowdhury, N., & Baker, A. (2008) · Behaviour Research and Therapy · doi:10.1016/j.brat.2007.10.003 · Cited by 1,607
Foa, E. B., Liebowitz, M. R., Kozak, M. J., Davies, S., Campeas, R., Franklin, M. E., Huppert, J. D., Kjernisted, K., Rowan, V., Schmidt, A. B., et al. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.1.151 · Cited by 1,048
Subthalamic nucleus stimulation in severe obsessive-compulsive disorder
Mallet, L., Polosan, M., Jaafari, N., Baup, N., Welter, M.-L., Fontaine, D., Montcel, S. T. D., Yelnik, J., Chéreau, I., Arbus, C., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0708514 · Cited by 965
Bewernick, B. H., Hurlemann, R., Matusch, A., Kayser, S., Grubert, C., Hadrysiewicz, B., Axmacher, N., Lemke, M., Cooper-Mahkorn, D., Cohen, M. X., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.09.013 · Cited by 865
Denys, D., Mantione, M., Figee, M., van den Munckhof, P., Koerselman, F., Westenberg, H., Bosch, A., & Schuurman, R. (2010) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2010.122 · Cited by 763
Deep brain stimulation for refractory obsessive-compulsive disorder
Abelson, J. L., Curtis, G. C., Sagher, O., Albucher, R. C., Harrigan, M., Taylor, S. F., Martis, B., & Giordani, B. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.042 · Cited by 522
Long-term Electrical Capsular Stimulation in Patients with Obsessive-Compulsive Disorder
Nuttin, B., Gabriëls, L. A., Cosyns, P. R., Meyerson, B. A., Andréewitch, S., Sunaert, S. G., Maes, A., Dupont, P. J., Gybels, J., Gielen, F. L. H., et al. (2003) · Neurosurgery · doi:10.1227/01.neu.0000064565.49299.9a · Cited by 482
Eddy, K. T., Dutra, L., Bradley, R., & Westen, D. (2004) · Clinical Psychology Review · doi:10.1016/j.cpr.2004.08.004 · Cited by 475
Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder
Figee, M., Luigjes, J., Smolders, R., Valencia-Alfonso, C.-E., van Wingen, G., de Kwaasteniet, B., Mantione, M., Ooms, P., de Koning, P., Vulink, N., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3344 · Cited by 466
Enhanced avoidance habits in obsessive-compulsive disorder
Gillan, C. M., Morein-Zamir, S., Urcelay, G. P., Sule, A., Voon, V., Apergis-Schoute, A. M., Fineberg, N. A., Sahakian, B. J., & Robbins, T. W. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.02.002 · Cited by 399 · cited 2×
“Recent research indicates that compulsivity in OCD may arise from excessive stimulus–response habit formation (Gillan et al. 2014).”
BackgroundFranklin, M. E., Abramowitz, J. S., Kozak, M. J., Levitt, J. T., & Foa, E. B. (2000) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.68.4.594 · Cited by 387 · cited 2×
“In addition, medication can have significant side effects and the exposure and response prevention in CBT often provokes intense anxiety, resulting in a 25% drop-out of patients (Franklin et al. 2000).”
BackgroundThe psychological treatment of obsessive-compulsive disorder
Abramowitz, J. S. (2006) · The Canadian Journal of Psychiatry · doi:10.1177/070674370605100702 · Cited by 371
Goodman, W. K., Foote, K. D., Greenberg, B. D., Ricciuti, N., Bauer, R., Ward, H., Shapira, N. A., Wu, S. S., Hill, C. L., Rasmussen, S. A., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.028 · Cited by 362
Simpson, H. B., Foa, E. B., Liebowitz, M. R., Ledley, D. R., Huppert, J. D., Cahill, S., Vermes, D., Schmidt, A. B., Hembree, E., Franklin, M., et al. (2008) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07091440 · Cited by 316
Huff, W., Lenartz, D., Schormann, M., Lee, S.-H., Kuhn, J., Koulousakis, A., Mai, J., Daumann, J., Maarouf, M., Klosterkötter, J., et al. (2010) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2009.11.006 · Cited by 315
Nakao, T., Nakagawa, A., Yoshiura, T., Nakatani, E., Nabeyama, M., Yoshizato, C., Kudoh, A., Tada, K., Yoshioka, K., Kawamoto, M., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.12.039 · Cited by 307
Trauma: prevalence, impairment, service use, and cost.
Solomon, S. D., & Davidson, J. R. T. (1997) · PubMed · Cited by 289
Brody, A. L., Saxena, S., Schwartz, J. M., Stoessel, P. W., Maidment, K., Phelps, M. E., & Baxter, L. R. (1998) · Psychiatry Research: Neuroimaging · doi:10.1016/s0925-4927(98)00041-9 · Cited by 285
Response versus remission in obsessive-compulsive disorder
Simpson, H. B., Huppert, J. D., Petkova, E., Foa, E. B., & Liebowitz, M. R. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n0214 · Cited by 241
Pharmacotherapy of Obsessive-compulsive Disorder and Obsessive-Compulsive Spectrum Disorders
Denys, D. (2006) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2006.02.013 · Cited by 213
Self-citationde Koning, P. P., Figee, M., van den Munckhof, P., Schuurman, P. R., & Denys, D. (2011) · Current Psychiatry Reports · doi:10.1007/s11920-011-0200-8 · Cited by 202
Post-treatment effects of exposure therapy and clomipramine in obsessive–compulsive disorder
Simpson, H. B., Liebowitz, M. R., Foa, E. B., Kozak, M. J., Schmidt, A. B., Rowan, V., Petkova, E., Kjernisted, K., Huppert, J. D., Franklin, M. E., et al. (2004) · Depression and Anxiety · doi:10.1002/da.20003 · Cited by 161
Deep brain stimulation of the ventral striatum enhances extinction of conditioned fear
Rodríguez-Romaguera, J., Monte, F. H. D., & Quirk, G. J. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200782109 · Cited by 146
Freyer, T., Klöppel, S., Tüscher, O., Kordon, A., Zurowski, B., Kuelz, A.-K., Speck, O., Glauche, V., & Voderholzer, U. (2011) · Psychological Medicine · doi:10.1017/s0033291710000309 · Cited by 105
Cognitive behaviour therapy and medication in the treatment of obsessive–compulsive disorder
O’Connor, K. P., Aardema, F., Robillard, S., Guay, S., Pélissier, M., Todorov, C., Borgeat, F., Leblanc, V., Grenier, S., & Doucet, P. (2006) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2006.00767.x · Cited by 77
Protocollaire behandelingen in de ambulante geestelijke gezondheidszorg I
Keijsers, G. P. J., Minnen, A., & Hoogduin, C. A. L. (2004) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-7117-4 · Cited by 36
Pence, S. L., Sulkowski, M. L., Jordan, C., & Storch, E. A. (2010) · American Journal of Psychotherapy · doi:10.1176/appi.psychotherapy.2010.64.1.39 · Cited by 30
Protocollaire behandeling van patiënten met een obsessieve-compulsieve stoornis:
Verbraak, M. J. P. M., Hoogduin, C. A. L., Methorst, G., Arts, W., Hansen, A., & Keijsers, G. P. J. (2004) · Bohn Stafleu van Loghum eBooks · doi:10.1007/978-90-313-7117-4_3 · Cited by 6
Targets for Deep Brain Stimulation in Obsessive-Compulsive Disorder
Figee, M., Mantione, M. H. M., van den Munckhof, P., Schuurman, R., & Denys, D. A. J. P. (2010) · Psychiatric Annals · doi:10.3928/00485713-20100924-06 · Cited by 6
Research works printed but not linked: 2
- March, 1997, The expert consensus guideline series: treatment of obsessive–compulsive disorder, Journal of Clinical Psychiatry, 58, 5
- Kozak, 1997, Mastery of Obsessive Compulsive Disorder: A Cognitive Behavioural Approach
Cited by
Sorted by citations
Val‐Laillet, D., Aarts, E., Weber, B., Ferrari, M., Quaresima, V., Stoeckel, L. E., Alonso‐Alonso, M., Audette, M. A., Malbert, C., & Stice, E. M. (2015) · NeuroImage Clinical · doi:10.1016/j.nicl.2015.03.016 · Cited by 466
“Even though it has never been tested in our knowledge, the ef fi cacy of targeting speci fi c nuclei for DBS might be validated through its ability to improve real-time brain and cognitive processes related to self-control over highly palatable food stimuli (Mantione et al., 2014).”
Brain circuitry of compulsivity
van den Heuvel, O. A., van Wingen, G., Soriano-Mas, C., Alonso, P., Chamberlain, S. R., Nakamae, T., Denys, D., Goudriaan, A. E., & Veltman, D. J. (2016) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.12.005 · Cited by 374
“Also for DBS rules that optimal treatment effects are achieved in case of adjuvant CBT (Mantione et al. 2014).”
Self-citationBergfeld, I. O., Mantione, M., Hoogendoorn, M. L. C., Ruhé, H. G., Notten, P., van Laarhoven, J., Visser, I., Figee, M., de Kwaasteniet, B. P., Horst, F., et al. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2016.0152 · Cited by 336
Tyagi, H., Apergis-Schoute, A. M., Akram, H., Foltynie, T., Limousin, P., Drummond, L. M., Fineberg, N. A., Matthews, K., Jahanshahi, M., Robbins, T. W., et al. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.01.017 · Cited by 227
Deep brain stimulation for depression.
Figee, M., Riva-Posse, P., Choi, K. S., Bederson, L., Mayberg, H. S., & Kopell, B. H. (2022) · Neurotherapeutics · doi:10.1007/s13311-022-01270-3 · Cited by 175
Metadata
- Authors
- Mantione, M., Nieman, D. H., Figee, M., & Denys, D.
- Affiliations
- Amsterdam UMC Location University of Amsterdam (NL)
- Netherlands Institute for Neuroscience (NL)
- Corresponding author
- Mantione, M.
- Denys, D.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2014-04-25
- Volume
- 44
- Issue
- 16
- Pages
- 3515-3522
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2105399857
- Cited by
- 129
- References
- 33
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 11 · 2020: 20 · 2019: 15 · 2018: 23 · 2017: 6 · 2016: 6 · 2015: 10
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- obsessive-compulsive disorder, deep brain stimulation, cognitive behavioral therapy, treatment-refractory OCD, nucleus accumbens, augmentation therapy, response prevention, symptom recurrence, anxiety and depressive symptoms
- MeSH terms
- Adult, Combined Modality Therapy, Double-Blind Method, Female, Humans, Male, Middle Aged, Netherlands, Obsessive-Compulsive Disorder, Psychiatric Status Rating Scales, Severity of Illness Index, Cognitive Behavioral Therapy, Treatment Outcome, Cross-Over Studies, Deep Brain Stimulation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
