Cognitive–behavioural therapy for patients with schizophrenia: a multicentre randomized controlled trial in Beijing, China
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Background: Meta-analyses support the efficacy of cognitive–behavioural therapy (CBT) for schizophrenia in western cultures. This study aimed to compare the efficacy of CBT and supportive therapy (ST) for patients with schizophrenia in China. Method: A multicentre randomized controlled, single-blinded, parallel-group trial enrolled a sample of 192 patients with schizophrenia. All patients were offered 15 sessions of either CBT or ST over 24 weeks and followed up for an additional 60 weeks. All measures used were standardized instruments with good reliability and validity. The Positive and Negative Syndrome Scale (PANSS) was used to assess symptoms of schizophrenia. The Schedule for Assessing Insight (SAI) was used to assess patients’ insight and the Personal and Social Performance Scale (PSP) was used to assess their social functioning. Results: Effect-size analysis showed that patients made rapid improvements in all symptoms, insight and social functioning as measured by the PANSS, SAI and PSP at 12 and 24 weeks and maintained these improvements over the course of the study to 84 weeks. Patients in the CBT group showed significantly greater and more durable improvement in PANSS total score (p = 0.045, between-group d = 0.48), positive symptoms (p = 0.018, between-group d = 0.42) and social functioning (p = 0.037, between-group d = 0.64), with significant differences emerging after completion of therapy. Conclusions: Both CBT and ST combined with medication had benefits on psychopathology, insight and social functioning of patients with schizophrenia. CBT was significantly more effective than ST on overall, positive symptoms and social functioning of patients with schizophrenia in the long term.
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Cognitive behavior therapy for psychosis is linked with improvements in insight relative to treatment as usual in two separate trials.
“Cognitive behavior therapy for psychosis (CBT-p) has been linked with improvements relative to treatment as usual in two separate trials 160,161 .”
From Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments (2018) · cites this paper as [161]
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- Authors
- Li, Z.-J., Guo, Z.-H., Wang, N., Xu, Z.-Y., Qu, Y., Wang, X.-Q., Sun, J., Yan, L.-Q., Ng, R. M. K., Turkington, D., & Kingdon, D.
- Affiliations
- Capital Medical University (CN)
- Beijing HuiLongGuan Hospital (CN)
- Peking University (CN)
- Griffith University (AU)
- Kowloon Hospital (CN)
- Newcastle University (GB)
- University of Southampton (GB)
- Corresponding author
- Li, Z.-J.
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2014-12-23
- Volume
- 45
- Issue
- 9
- Pages
- 1893-1905
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2097718574
- Cited by
- 49
- References
- 39
- Citations by year
- 2025: 5 · 2024: 2 · 2023: 3 · 2022: 9 · 2021: 1 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 7 · 2016: 5 · 2015: 1
- FWCI
- 3.31
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Griffith Research Online (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Clinical Psychology › Counseling, Therapy, and Family Dynamics
- Keywords
- cognitive behavioral therapy, schizophrenia, supportive therapy, treatment efficacy, insight, social functioning, positive symptoms, long-term outcomes
- MeSH terms
- Beijing, Adult, Combined Modality Therapy, Female, Humans, Male, Schizophrenia, Social Adjustment, Antipsychotic Agents, Cognitive Behavioral Therapy, Single-Blind Method, Treatment Outcome, Young Adult
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