Prevalence of current anxiety disorders in people with bipolar disorder during euthymia: a meta-analysis
Abstract
Background: Anxiety disorders are highly prevalent in people with bipolar disorder, but it is not clear how many have anxiety disorders even at times when they are free of major mood episodes. We aimed to establish what proportion of euthymic individuals with bipolar disorder meet diagnostic criteria for anxiety disorders. Method: We performed a random-effects meta-analysis of prevalence rates of current DSM-III- and DSM-IV-defined anxiety disorders (panic disorder, agoraphobia, social anxiety disorder, generalized anxiety disorder, specific phobia, obsessive–compulsive disorder, post-traumatic stress disorder, and anxiety disorder not otherwise specified) in euthymic adults with bipolar disorder in studies published by 31 December 2015. Results: Across 10 samples with 2120 individuals with bipolar disorder, 34.7% met diagnostic criteria for one or more anxiety disorders during euthymia [95% confidence interval (CI) 23.9–45.5%]. Direct comparison of 189 euthymic individuals with bipolar disorder and 17 109 population controls across three studies showed a 4.6-fold increase (risk ratio 4.60, 95% CI 2.37–8.92, p < 0.001) in prevalence of anxiety disorders in those with bipolar disorder. Conclusions: These findings suggest that anxiety disorders are common in people with bipolar disorder even when their mood is adequately controlled. Euthymic people with bipolar disorder should be routinely assessed for anxiety disorders and anxiety-focused treatment should be initiated if indicated.
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10% of people with bipolar disorder still meet diagnostic criteria for social anxiety disorder when they are euthymic.
“10% of people with bipolar disorder still meet diagnostic criteria for social anxiety disorder when they are euthymic (Pavlova et al. 2017).”
From Cognitive behavioural therapy for social anxiety disorder in people with bipolar disorder: a case series (2024) · cites this paper as Pavlova et al. 2017
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- Authors
- Pavlova, B., Perlis, R. H., Mantere, O., Sellgren, C. M., Isometsä, E., Mitchell, P. B., Alda, M., & Uher, R.
- Affiliations
- Harvard University (US)
- Douglas Mental Health University Institute (CA)
- Broad Institute (US)
- University of Helsinki (FI)
- Black Dog Institute (AU)
- Dalhousie University (CA)
- Venue
- Psychological Medicine
- Publisher
- Cambridge University Press (CUP)
- Published
- 2016-12-20
- Volume
- 47
- Issue
- 6
- Pages
- 1107-1115
- ISSN
- 0033-2917 (ISSN-L)
- 1469-8978
- OpenAlex
- W2566434738
- Cited by
- 55
- References
- 51
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 6 · 2023: 4 · 2022: 7 · 2021: 8 · 2020: 12 · 2019: 7 · 2018: 3
- FWCI
- 0.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- bipolar disorder, anxiety disorders, euthymia, prevalence, comorbidities, panic disorder, agoraphobia, social anxiety disorder, generalized anxiety disorder, specific phobia, obsessive-compulsive disorder, post-traumatic stress disorder
- MeSH terms
- Anxiety Disorders, Bipolar Disorder, Humans, Comorbidity, Prevalence
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