The DOI matches its Crossref record; 283 of the 283 references it cites were found in a registry or an index.
Structure and function of SNARE and SNARE-interacting proteins
Abstract
This review focuses on the so-called SNARE (soluble N-ethyl maleimide sensitive factor attachment protein receptor) proteins that are involved in exocytosis at the pre-synpatic plasma membrane. SNAREs play a role in docking and fusion of synaptic vesicles to the active zone, as well as in the Ca 2+-triggering step itself, most likely in combination with the Ca 2+ sensor synaptotagmin. Different SNARE domains are involved in different processes, such as regulation, docking, and fusion. SNAREs exhibit multiple configurational, conformational, and oliogomeric states. These different states allow SNAREs to interact with their matching SNARE partners, auxiliary proteins, or with other SNARE domains, often in a mutually exclusive fashion. SNARE core domains undergo progressive disorder to order transitions upon interactions with other proteins, culminating with the fully folded post-fusion (cis) SNARE complex. Physiological concentrations of neuronal SNAREs can juxtapose membranes, and promote fusion in vitro under certain conditions. However, significantly more work will be required to reconstitute an in vitro system that faithfully mimics the Ca 2+-triggered fusion of a synaptic vesicle at the active zone.
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Cites
1 retracted
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Cited by
SNAREs — engines for membrane fusion
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Metadata
- Authors
- Brunger, A. T.
- Venue
- Quarterly Reviews of Biophysics
- Publisher
- Cambridge University Press (CUP)
- Published
- 2005-02
- Volume
- 38
- Issue
- 1
- Pages
- 1-47
- ISSN
- 0033-5835 (ISSN-L)
- 1469-8994
- OpenAlex
- W2127061791
- Cited by
- 309
- References
- 283
- FWCI
- 9.89
- Type
- journal article
- Language
- en
- Open access
- closed
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