CoChat
Sign Up
Cited by 67Antimicrobial Resistance in StaphylococcusNeuroscience of respiration and sleepNeonatal and Maternal Infections

Factors enhancing adherence of toxigenic Staphylococcus aureus to epithelial cells and their possible role in sudden infant death syndrome

Open access
Saadi, A. T., Blackwell, C. C., Raza, M. W., James, V. S., Stewart, J., Elton, R. A., Weir, D. M.·1993·Epidemiology and Infection
DOI 10.1017/s0950268800050937PMC PMC2272294
Open this paper in CoChat — free accountOpen PDF

Abstract

SUMMARY: Toxigenic strains of Staphylococcus aureus have been suggested to play a role in sudden infant death syndrome (SIDS). In this study we examined two factors that might enhance binding of toxigenic staphylococci to epithelial cells of infants in the age range in which cot deaths are prevalent: expression of the Lewis a antigen and infection with respiratory syncytial virus (RSV). By flow cytometry we demonstrated that binding of three toxigenic strains of S. aureus to cells from non-secretors was significantly greater than to cells of secretors. Pre-treatment of epithelial cells with monoclonal anti-Lewis a or anti-type-1 precursor significantly reduced bacterial binding (P< 0·01); however, attachment of the bacteria correlated only with the amount of Lewis a antigen detected on the cells (P< 0·01). HEp-2 cells infected with RSV bound significantly more bacteria than uninfected cells. These findings are discussed in context of factors previously associated with SIDS (mother's smoking, bottle feeding and the prone sleeping position) and a hypothesis proposed to explain some cases of SIDS.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1017/s0950268800050937

Cites

44 of 44 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 13

  1. Froggat P. Lynas MA. Mackenzie G. Epidemiology of sudden unexpected death in infants in X." Ireland. Br J Paediatr Soc Med 1971; 25: 199-34.
  2. Yaldes-Dapena MA. A review of the world literature 1954-1966. Paediatrics 1967: 39: 123-38.
  3. Bonham GS, Wilson PW. Childrens health in families with cigarette smokers. Am J Public Health 1981; 71: 290-3.
  4. Williams AL, Uren EC, Bretherton L. RSV and SIDS. BMJ 1984; 288: 1491-3.
  5. Arnon SS, Damus K, Chin J. Infant botulism: epidemiology and relation to SIDS. Epidemiol Rev 1981; 3: 45-66.
  6. Morris JA. Hypothesis: common bacterial toxins are a possible cause of SIDS. Medical Hypothesis 1987; 22: 211-22.
  7. Telford DR, Morris JA, Hughes P, Conway AR, Lee S, Barton AJ, Drucker DB. The nasopharyngeal bacterial flora in the SIDS. J Infect 1989; 18: 125-30.
  8. May SJ, Blackwell CC, Weir DM. Lewis a blood group antigen of non-secretors: a receptor for Candida blastospores. FEMS Microbiol Immunol 1989; 47: 407-10.
  9. Ramfrez-Ronda CH, Fuxench-Lopez A, Nevarez M. Increased bacterial colonisation during viral illness. Arch Intern Med 1981; 141: 1599-603.
  10. Xewbold MJ. Malam J. Mclllmurray JM, Morris JA, Telford DR, Barson AJ. Immunobiological localisation of staphylococcal toxic shock S.T.I antigen in SIDS. J Clin Pathol 1989; 42: 935-9.
  11. Kremastinou J, Blackwell CC, Tzanakaki G et al. Parental smoking and carriage of Neisseri meningitidis among school children. Eighth International Pathogenic Neisseria Conference, 1992: 123.
  12. Ponsonby AL, Dwyer T, Gibbons LE, Cochrane JA, Jones ME, McCall MJ. Thermal environment and SIDS: case-control study. BMJ 1992; 304: 277-82.
  13. Fleming PJ, Gilbert R, Azaz Y, Berry PJ, Rudd PJ, Stewart A, Hall E. Interaction between bedding and sleeping position in the SIDS: a population based case-control study. BMJ 1990; 301: 85-9.

Cited by

Sorted by citations

Related

Authors
Saadi, A. T., Blackwell, C. C., Raza, M. W., James, V. S., Stewart, J., Elton, R. A., & Weir, D. M.
Affiliations
University of Edinburgh (GB)
ORCID
Venue
Epidemiology and Infection
Publisher
Cambridge University Press (CUP)
Published
1993-06
Volume
110
Issue
3
Pages
507-517
ISSN
  • 0950-2688 (ISSN-L)
  • 1469-4409
DOI
10.1017/s0950268800050937
PMC
PMC2272294
OpenAlex
W2107945609
Cited by
67
References
44
Citations by year
2026: 1 · 2022: 1 · 2018: 2 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 2
FWCI
5.43
Type
journal article
Language
en
Open access
Licence
www.cambridge.org/core/terms (unspecified, 5827 d)
Locations
  • Epidemiology and Infection (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Neonatal and Maternal Infections
Keywords
Staphylococcus aureus, sudden infant death syndrome, bacterial adhesion, Lewis a antigen, secretor status, respiratory syncytial virus, epithelial cells, HEp-2 cells
MeSH terms
Antibodies, Monoclonal, Bacterial Adhesion, Cells, Cultured, Epithelial Cells, Epithelium, Humans, Infant, Isoantigens, Lewis Blood Group Antigens, Respiratory Syncytial Viruses, Staphylococcus aureus, Sudden Infant Death

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review