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Cited by 306Respiratory viral infections researchMicrobial infections and disease researchPneumonia and Respiratory Infections

The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.

Respiratory viral infection predisposing for bacterial disease: a concise review.

Open access
Hament, Jeanne-Marie, Kimpen, Jan L.L, Fleer, Andre, Wolfs, Tom F.W·1999·FEMS Immunology & Medical Microbiology
DOI 10.1111/j.1574-695x.1999.tb01389.x
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Abstract

Although bacterial superinfection in viral respiratory disease is a clinically well documented phenomenon, the pathogenic mechanisms are still poorly understood. Recent studies have revealed some of the mechanisms involved. Physical damage to respiratory cells as a result of viral infection may lead to opportunistic adherence of bacteria. Enhanced bacterial adherence by specific mechanisms has been documented for respiratory cells infected with influenza A virus, respiratory syncytial virus and adenovirus in both in vitro and in vivo models. To date, results of various experimental studies indicate that different mechanisms for increased bacterial adherence induced by viruses are operating for specific viral-bacterial combinations. In the present review, a number of key findings obtained during the past two decades is presented and discussed.

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Registry

Crossref · 10.1111/j.1574-695x.1999.tb01389.x

Cites

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  • Bacterial infection may be concurrent with influenza viral infection.

    “Bacterial infection may be concurrent with influenza viral infection, and the resulting co‐infection can lead to an enhanced pneumonic illness or may occur shortly after influenza virus has been largely cleared from the lungs”

    From Bacterial and viral infections associated with influenza (2013) · cites this paper as [2]

  • Influenza-associated bacterial co-infection can lead to an enhanced pneumonic illness.

    “the resulting co‐infection can lead to an enhanced pneumonic illness”

    From Bacterial and viral infections associated with influenza (2013) · cites this paper as [2]

  • Bacterial infection may occur shortly after influenza virus has been largely cleared from the lungs, when the host appears more susceptible.

    “may occur shortly after influenza virus has been largely cleared from the lungs, when the host appears to be more susceptible to bacterial infection”

    From Bacterial and viral infections associated with influenza (2013) · cites this paper as [2]

  • Mucus hypersecretion plays a central role in the pathogenesis of severe airway obstruction in virus-induced exacerbations of asthma, cystic fibrosis, and COPD.

    “Mucus hypersecretion plays a central role in the pathogenesis of severe airway obstruction in virus-induced exacerbations of asthma, cystic fibrosis, and COPD (15, 99, 235, 236).”

    From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [99]

  • Influenza, as well as other upper respiratory tract viral infections, leads to a greater risk of infection from bacterial pathobionts and an increased likelihood of colonization with bacteria such as S. pneumoniae, H. influenzae, and S. aureus.

    “It has become clear that influenza, as well as other upper respiratory tract viral infections, leads not only to a greater risk of infection from bacterial pathobionts but also an increased likelihood that an individual may become colonized with bacteria such as S. pneumoniae, H. influenzae and S. aureus (Hament et al., 1999; Hilleman, 2002).”

    From Secondary bacterial infections associated with influenza pandemics (2017) · cites this paper as Hament et al., 1999

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Citations

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Research works printed but not linked: 2

  1. [29] Wilson, J., Braunwald, E., Isselbacher, K., Petersdorf, R., Martin, J., Fauci, A. and Root, R. (1991) Bronchiectasis and broncholithiasis. In: Principles of Internal Medicine (Harrison, T.R., Ed.), pp. 1069–1071. McGraw-Hill, New York.
  2. Sanford, 1978, Bacterial adherence to virus-infected cells: a cell culture model of bacterial superinfection, J. Infect. Dis., 137, 176, 10.1093/infdis/137.2.176 · DOI · Paper page

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Metadata

Authors
Hament, J.-M., Kimpen, J. L. L., Fleer, A., & Wolfs, T. F. W.
Affiliations
University Medical Center Utrecht (NL)
Corresponding author
Kimpen, Jan L.L
ORCID
Wolfs, Tom F.W
Venue
FEMS Immunology & Medical Microbiology
Publisher
Oxford University Press (OUP)
Published
1999-12
Volume
26
Issue
3-4
Pages
189-195
ISSN
  • 0928-8244 (ISSN-L)
  • 1574-695X
DOI
10.1111/j.1574-695x.1999.tb01389.x
OpenAlex
W2137313784
Cited by
306
References
44
Citations by year
2026: 3 · 2025: 6 · 2024: 7 · 2023: 4 · 2022: 10 · 2021: 15 · 2020: 18 · 2019: 7 · 2018: 12 · 2017: 18 · 2016: 8 · 2015: 14 · 2014: 14 · 2013: 15 · 2012: 18
FWCI
4.64
Type
journal article
Language
en
Open access
Locations
  • FEMS Immunology & Medical Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
  • Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
  • Health Sciences › Medicine › Epidemiology › Pneumonia and Respiratory Infections
Keywords
respiratory viral infections, secondary bacterial infection, viral-bacterial coinfection, bacterial adhesion, airway epithelial cells, influenza A virus, respiratory syncytial virus, adenovirus, host cell damage, pathophysiological mechanisms
MeSH terms
Animals, Bacterial Infections, Humans, Respiratory Tract Infections, Virus Diseases, Causality

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