Ethnic difference in the relationship between acute inflammation and serum ferritin in US adult males
Open accessAbstract
This study examined the ethnic difference in the association between increased serum ferritin (SF) (>300 microg/l) and acute inflammation (AI) (C-reactive protein > or = 1.0 mg/dl) between black and white males aged > or = 20 years. Using data from the third National Health and Nutrition Examination Survey (NHANES III), we determined the risk for having elevated SF in black males (n=164) and white males (n=325) with AI present as well as black males (n=1731) and white males (n=2877) with AI absent. Black subjects with AI present were 1.71 times (95% CI 1.18-2.49), and 1.87 times (95% CI 1.46-2.40) more likely to have increased SF than AI absent blacks and AI present whites, respectively. Furthermore, with AI present, every increment of C-reactive protein, white blood cell count, serum albumin, lymphocyte count and platelet count was associated with higher odds of having elevations in SF in blacks than whites. Regardless of AI status, blacks were more likely to have elevations in SF than whites, and the prevalence of elevated SF was significantly higher in blacks than whites. This finding suggested that black males may respond to inflammation with a more aggressive rise in SF compared to white males. Future research is needed to investigate the underlying mechanisms.
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Multicollinearity was assessed by VIF and no variable had VIF greater than 4.
“Multicollinearity was assessed by checking variance inflation factors (VIF). A value of 4 has been considered as a maximum level of VIF [19] and no variable with VIF greater than 4 was found.”
From Barriers to access improved water and sanitation in poor peri-urban settlements of Abidjan, Côte d'Ivoire (2018) · cites this paper as [19]
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“Multicollinearity was assessed by checking variance inflation factors (VIF).”
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- Authors
- PAN, Y., & JACKSON, R. T.
- Affiliations
- University of Maryland, College Park (US)
- Corresponding author
- PAN, Y.
- Venue
- Epidemiology and Infection
- Publisher
- Cambridge University Press (CUP)
- Published
- 2007-03-22
- Volume
- 136
- Issue
- 3
- Pages
- 421-431
- ISSN
- 0950-2688 (ISSN-L)
- 1469-4409
- PMC
- PMC2870810
- OpenAlex
- W2105872934
- Cited by
- 294
- References
- 53
- Citations by year
- 2026: 6 · 2025: 9 · 2024: 18 · 2023: 13 · 2022: 22 · 2021: 25 · 2020: 14 · 2019: 28 · 2018: 35 · 2017: 41 · 2016: 32 · 2015: 21 · 2014: 14 · 2013: 8 · 2012: 2
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Epidemiology and Infection (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- serum ferritin, acute inflammation, C-reactive protein, racial differences, black-white disparities, elevated ferritin, adult male, NHANES III
- MeSH terms
- Acute-Phase Reaction, Adult, Ethnicity, Ferritins, Humans, Male, Nutrition Surveys, Surveys and Questionnaires, Risk Factors, United States, Prevalence
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