The DOI matches its Crossref record; 119 of the 123 references it cites were found in a registry or an index, and 4 are not checked yet.
An integrative theory of attention-deficit/ hyperactivity disorder based on the cognitive and affective neurosciences
Abstract
Attention-deficit/hyperactivity disorder (ADHD) is a behavioral syndrome that arises in early childhood, often co-occurs with conduct disorder and leads, developmentally, to antisocial behavior and substance abuse. Models from cognitive and affective neuroscience have been invoked in an effort to understand the development of ADHD, leading to a broad array of interrelated theories and hypothesized mechanisms. In this paper, we highlight core mechanisms that may cut across several theories and constructs, and thus provide some leverage for further study and conceptualization from a neuroscience perspective. We emphasize the joint operations of frontostriatal and frontocerebellar neural loops in detecting and predicting what and when important events in the environment will occur and their interaction with frontoamygdala loops in assigning emotional significance to these events. We note that weaknesses in the development of these basic operations could lead to decrement in the development of cognitive and affective control and other mental operations mediated by prefrontal cortex during development. In turn, such decrement could lead to many of the phenotypic cognitive and neuropsychological features seen in children with ADHD. This work was supported by National Institute of Mental Health Grants R01-MH59105 and R01-MH63146 to J.T.N. and NIMH R01 MH63255 and NIDA R21 DA15882 to B.J.C.
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“The etiological heterogeneity in terms of the biological and environmental factors is likely reflected in variation in neural correlates (Nigg and Casey, 2005; Mackie et al., 2007; Fair et al., 2012; Costa Dias et al., 2013, 2015; Karalunas et al., 2014), and results in the diverse cognitive and behavioral profiles and developmental trajectories of the disorder (Halperin and Schulz, 2006; Rajendr”
From A Review of Heterogeneity in Attention Deficit/Hyperactivity Disorder (ADHD) (2019) · cites this paper as Nigg and Casey, 2005
In the citing paper
“abnormalities in DA and NE signalling have been reported in both MDD and ADHD, suggesting a potentially shared underlying pathophysiology, at least in some individuals [56][57][58][59].”
From Adult ADHD and comorbid disorders: clinical implications of a dimensional approach (2017) · cites this paper as [58]
In the citing paper
“It is well established that people with ADHD encounter various severe cognitive control difficulties [57], but cognitive flexibility does not seem to be a key deficit [4,12,26,57,67].”
From The paradox of cognitive flexibility in autism (2009) · cites this paper as [57]
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Inhibition and impulsivity: behavioral and neural basis of response control
Bari, A., & Robbins, T. W. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.005 · Cited by 1,921
Emotion Dysregulation in Attention Deficit Hyperactivity Disorder
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Self-citationToward systems neuroscience of ADHD: a meta-analysis of 55 fMRI studies
Cortese, S., Kelly, C., Chabernaud, C., Proal, E., Di Martino, A., Milham, M. P., & Castellanos, F. X. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.11101521 · Cited by 1,067
Temperament and developmental psychopathology
Nigg, J. T. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2006.01612.x · Cited by 971
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Metadata
- Authors
- NIGG, J. T., & CASEY, B. J.
- Affiliations
- Michigan State University (US)
- Cornell University (US)
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2005-09
- Volume
- 17
- Issue
- 3
- Pages
- 785-806
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- OpenAlex
- W2133071740
- Semantic Scholar
- db5357ccb3aa14505ed4437ae9473313adc26425
- Cited by
- 593
- References
- 120
- Citations by year
- 2026: 20 · 2025: 10 · 2024: 8 · 2023: 13 · 2022: 14 · 2021: 21 · 2020: 43 · 2019: 27 · 2018: 32 · 2017: 31 · 2016: 39 · 2015: 27 · 2014: 41 · 2013: 45 · 2012: 37
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Development and Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R10 MH63255, R01MH063146, R01MH059105)
- National Institute on Drug Abuse (R21DA015882)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Keywords
- attention deficit hyperactivity disorder, prefrontal cortex development, cognitive control, affective control, emotional meaning, event prediction, conduct disorder, antisocial behavior, substance abuse, neuropsychological characteristics
- MeSH terms
- Affect, Amygdala, Attention Deficit Disorder with Hyperactivity, Brain, Cognition Disorders, Frontal Lobe, Humans, Nerve Net, Neurosciences, Phenotype, Psychological Theory
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