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Ten good reasons to consider biological processes in prevention and intervention research
Open accessAbstract
Most contemporary accounts of psychopathology acknowledge the importance of both biological and environmental influences on behavior. In developmental psychopathology, multiple etiological mechanisms for psychiatric disturbance are well recognized, including those operating at genetic, neurobiological, and environmental levels of analysis. However, neuroscientific principles are rarely considered in current approaches to prevention or intervention. In this article, we explain why a deeper understanding of the genetic and neural substrates of behavior is essential for the next generation of preventive interventions, and we outline 10 specific reasons why considering biological processes can improve treatment efficacy. Among these, we discuss (a) the role of biomarkers and endophenotypes in identifying those most in need of prevention; (b) implications for treatment of genetic and neural mechanisms of homotypic comorbidity, heterotypic comorbidity, and heterotypic continuity; (c) ways in which biological vulnerabilities moderate the effects of environmental experience; (d) situations in which Biology x Environment interactions account for more variance in key outcomes than main effects; and (e) sensitivity of neural systems, via epigenesis, programming, and neural plasticity, to environmental moderation across the life span. For each of the 10 reasons outlined we present an example from current literature and discuss critical implications for prevention.
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“As interactions between biology and environment sometimes explain more variance in outcomes than do main effects (Beauchaine et al., 2008), accounting for these neural factors can clarify why some adolescents may be more primed for good or bad outcomes given their combination of neural susceptibility and social-contextual exposures.”
From Adolescent neurobiological susceptibility to social context (2016) · cites this paper as Beauchaine et al., 2008
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Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Baron, R. M., & Kenny, D. A. (1986) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.51.6.1173 · Cited by 91,532
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Multiple regression: testing and interpreting interactions
(1992) · Choice Reviews Online · doi:10.5860/choice.29-3352 · Cited by 36,647
The Structure of Scientific Revolutions
Kuhn, T. S., & Schlegel, R. (1963) · Physics Today · doi:10.1063/1.3050879 · Cited by 35,538
Cognitive Therapy for Depression
(2012) · PsycEXTRA Dataset · doi:10.1037/e675542012-001 · Cited by 9,678
The Construct of Resilience: A Critical Evaluation and Guidelines for Future Work
Luthar, S. S., Cicchetti, D., & Becker, B. (2000) · Child Development · doi:10.1111/1467-8624.00164 · Cited by 9,381
THE STRUCTURE OF SCIENTIFIC REVOLUTIONS
McGuire, J. E. (1963) · Philosophical Books · doi:10.1111/j.1468-0149.1963.tb00813.x · Cited by 8,547
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120
Research works printed but not linked: 18
- Beauchaine, 2008, Child psychopathology: Genetic, neurobiological, and environmental substrates, 58
- Perry, 2008, Child psychopathology: Genetic, neurobiological, and environmental substrates, 93
- 10.2741/a472 · DOI
- Thorndike, 1911, Animal intelligence
- 10.1037/0893-164x.14.3.243 · DOI
- Beauchaine, 2008, Child psychopathology: Genetic, neurobiological, and environmental substrates, 129
- Gatzke-Kopp, 2007, Human behavior and the developing brain: Atypical development, 239
- 10.1037/0022-006x.60.3.426 · DOI
- Klein, 2008, Child and adolescent psychopathology, 477
- Beauchaine, 2006, Developmental psychopathology, 931
- Crowell, 2008, Child psychopathology: Genetic, neurobiological, and environmental substrates, 510
- DiClemente, 2001, Project MATCH: A priori matching hypotheses, results, and mediating mechanisms, 8, 239
- Beauchaine, 2006, Some recommendations for testing mediating and moderating effects in treatment-outcome research, International Journal of Psychology Research, 1, 1
- Fryer, 2008, Child psychopathology: Genetic, neurobiological, and environmental substrates, 180
- 10.1037/0021-843x.108.3.400 · DOI
- Fowles, 2006, Handbook of psychopathy, 14
- Hinshaw, 2003, Child psychopathology, 144
- Cicchetti, 2006, Developmental psychopathology: Vol. 2. Developmental neuroscience, 1
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Andler, D. (2016) · Gallimard eBooks · doi:10.3917/gall.andle.2016.01.0411
de Ruigh, E. L. (2023) · doi:10.5463/thesis.180
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van Langen, M. J. M. (2023) · Utrecht University Repository (Utrecht University) · doi:10.33540/1965
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Metadata
- Authors
- Beauchaine, T. P., Neuhaus, E., Brenner, S. L., & Gatzke-Kopp, L.
- Affiliations
- University of Washington (US)
- Corresponding author
- Beauchaine, Theodore P.
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2008
- Volume
- 20
- Issue
- 3
- Pages
- 745-774
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- PMC
- PMC2690981
- OpenAlex
- W2172045957
- Cited by
- 215
- References
- 268
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 7 · 2023: 7 · 2022: 8 · 2021: 16 · 2020: 13 · 2019: 9 · 2018: 14 · 2017: 18 · 2016: 14 · 2015: 20 · 2014: 12 · 2013: 18 · 2012: 16
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Development and Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH063699, MH63699)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- biological processes, prevention research, intervention research, developmental psychopathology, genetic etiology, neurobiological mechanisms, biomarkers, endophenotypes, psychiatric comorbidity, heterotypic continuity, gene-environment interaction, epigenesis, neuroplasticity, biological vulnerability, treatment efficacy
- MeSH terms
- Adolescent, Attention Deficit Disorder with Hyperactivity, Mental Disorders, Brain, Child, Child, Preschool, Depressive Disorder, Female, Humans, Infant, Infant, Newborn, Neuronal Plasticity, Phenotype, Pregnancy, Prenatal Exposure Delayed Effects, Psychopathology, Risk Factors, Schizophrenia, Schizophrenic Psychology, Social Environment, Neurotransmitter Agents, Twin Studies as Topic, Conduct Disorder, Genetic Predisposition to Disease, Early Diagnosis
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