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Serotonin functioning and adolescents' alcohol use: A genetically informed study examining mechanisms of risk
Open accessAbstract
The current study used data from two longitudinal samples to test whether self-regulation, depressive symptoms, and aggression/antisociality were mediators in the relation between a polygenic score indexing serotonin (5-HT) functioning and alcohol use in adolescence. The results from an independent genome-wide association study of 5-hydroxyindoleacetic acid in the cerebrospinal fluid were used to create 5-HT polygenic risk scores. Adolescents and/or parents reported on adolescents’ self-regulation (Time 1), depressive symptoms (Time 2), aggression/antisociality (Time 2), and alcohol use (Time 3). The results showed that 5-HT polygenic risk did not predict self-regulation. However, adolescents with higher levels of 5-HT polygenic risk showed greater depression and aggression/antisociality. Adolescents’ aggression/antisociality mediated the relation between 5-HT polygenic risk and later alcohol use. Deficits in self-regulation also predicted depression and aggression/antisociality, and indirectly predicted alcohol use through aggression/antisociality. Pathways to alcohol use were especially salient for males from families with low parental education in one of the two samples. The results provide insights into the longitudinal mechanisms underlying the relation between 5-HT functioning and alcohol use (i.e., earlier aggression/antisociality). There was no evidence that genetically based variation in 5-HT functioning predisposed individuals to deficits in self-regulation. Genetically based variation in 5-HT functioning and self-regulation might be separate, transdiagnostic risk factors for several types of psychopathology.
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Metadata
- Authors
- Wang, F. L., Chassin, L., Bates, J. E., Dick, D., Lansford, J. E., Pettit, G. S., & Dodge, K. A.
- Affiliations
- Arizona State University (US)
- Indiana University Bloomington (US)
- Virginia Commonwealth University (US)
- Duke University (US)
- Auburn University (US)
- Corresponding author
- Wang, Frances L.
- Venue
- Development and Psychopathology
- Publisher
- Cambridge University Press (CUP)
- Published
- 2017-05-23
- Volume
- 30
- Issue
- 1
- Pages
- 213-233
- ISSN
- 0954-5794 (ISSN-L)
- 1469-2198
- PMC
- PMC6463296
- OpenAlex
- W2619295420
- Cited by
- 6
- References
- 262
- Citations by year
- 2025: 1 · 2024: 1 · 2019: 1 · 2018: 2 · 2017: 1
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Development and Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DukeSpace (Duke University) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (R21AA022097, P50AA011998, F31AA023128, R01AA016213)
- National Institute of Mental Health (R01MH057024, R01MH057095, R01MH056961)
- National Institute on Drug Abuse (R01DA016903)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD030572)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- serotonin, adolescent alcohol use, self-regulation, depressive symptoms, aggression, antisocial behavior, mediation, 5-hydroxyindoleacetic acid, cerebrospinal fluid, parental education, sex differences, genetic risk factors
- MeSH terms
- Underage Drinking, Adolescent, Aggression, Depression, Female, Humans, Hydroxyindoleacetic Acid, Male, Parents, Risk Factors, Serotonin, Genome-Wide Association Study
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