Cited by 51Maternal Mental Health During Pregnancy and PostpartumBirth, Development, and HealthChild and Adolescent Psychosocial and Emotional Development

Opening windows of opportunities: evidence for interventions to prevent or treat depression in pregnant women being associated with changes in offspring's developmental trajectories of psychopathology risk

Goodman, Sherryl H., Cullum, Katherine A., Dimidjian, Sona, River, Laura M., Kim, Christine Youngwon·2018·Development and Psychopathology

Abstract

Although animal models and correlational studies support a model of fetal programming as a mechanism in the transmission of risk for psychopathology from parents to children, the experimental studies that are required to empirically test the model with the human prenatal dyad are scarce. With a systematic review and meta-analysis of the literature, we critically examined the evidence regarding the neurobiological and behavioral changes in infants as a function of randomized clinical trials to prevent or reduce maternal depression during pregnancy, treating randomized clinical trials as experiments testing the fetal programming model. Based on 25 articles that met inclusion criteria, we found support for interventions designed to change maternal prenatal mood being associated with changes in offspring functioning, but with a very small effect size. Effect sizes ranged broadly, and were higher for younger children. The findings enhance understanding of putative mechanisms in the transmission of risk from women's prenatal depression to infants’ vulnerabilities to, and early signs of, the development of psychopathology. We note limitations of the literature and suggest solutions to advance understanding of how preventing or treating depression in pregnant women might disrupt the transmission of risk to the infants.

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Crossref · 10.1017/s0954579418000536

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75 of 75 references verified0 citation errors · 0 not checkable

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  • There is strong evidence that perinatal mental health conditions can be prevented and effectively treated through psychotherapy and/or pharmacotherapy.

    “Importantly, there is strong evidence that PMH conditions can be prevented52-54 and effectively treated through psychotherapy54-57 and/or pharmacotherapy.58,59”

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Authors
Goodman, S. H., Cullum, K. A., Dimidjian, S., River, L. M., & Kim, C. Y.
Affiliations
  • Emory University (US)
  • University of Colorado Boulder (US)
  • University of Denver (US)
Corresponding author
Goodman, Sherryl H.
Venue
Development and Psychopathology
Published
2018-08
Volume
30
Issue
3
Pages
1179-1196
ISSN
  • 0954-5794 (ISSN-L)
  • 1469-2198
OpenAlex
W2887933677
Cited by
51
References
75
Citations by year
2026: 2 · 2025: 1 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 17 · 2020: 10 · 2019: 1 · 2018: 2
FWCI
1.37
Type
journal article
Language
en
Open access
closed
Locations
  • Development and Psychopathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
maternal depression, pregnancy, fetal programming, infant development, intergenerational transmission of risk, randomized controlled trials
MeSH terms
Child, Child Development, Depressive Disorder, Female, Humans, Infant, Pregnancy, Pregnancy Complications, Prenatal Exposure Delayed Effects, Risk Factors

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