The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Physiological and functional consequences of caregiving for relatives with dementia
Open accessAbstract
BACKGROUND: Chronic stress negatively affects health and well-being. A growing population of informal dementia caregivers experience chronic stress associated with extraordinary demands of caring for a relative with dementia. This review summarizes physiological and functional changes due to chronic dementia caregiver stress. METHODS: A literature search for papers assessing effects of dementia caregiving was conducted focusing on publications evaluating differences between caregivers and non-caregivers in objective measures of health and cognition. RESULTS: The review identified 37 studies describing data from 4,145 participants including 749 dementia caregivers and 3,396 non-caregiver peers. Objective outcome measures affected in dementia caregivers included markers of dyscoagulation, inflammation, and cell aging as well as measures of immune function, sleep, and cognition. Though diverse in designs, samples, and study quality, the majority of the studies indicated increased vulnerability of dementia caregivers to detrimental changes in health and cognition. Demographic and personality characteristics moderating or mediating effects of chronic stress in caregivers were also reviewed. CONCLUSIONS: There is accumulating evidence that chronic dementia caregiver stress increases their vulnerability to disease and diminishes their ability to provide optimal care. Clinicians and society need to appreciate the extent of deleterious effects of chronic stress on dementia caregiver health.
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“Evidence suggests that the stress of providing dementia care increases caregivers' susceptibility to disease and health complications.505”
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“Evidence suggests that the stress of providing dementia care increases caregivers’ susceptibility to disease and health complications. 551”
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Metadata
- Authors
- Fonareva, I., & Oken, B. S.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Oken, Barry S.
- ORCID
- Oken, Barry S.
- Venue
- International Psychogeriatrics
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 26
- Issue
- 5
- Pages
- 725-747
- ISSN
- 1041-6102 (ISSN-L)
- PMC
- PMC3975665
- OpenAlex
- W2125058262
- Cited by
- 249
- References
- 50
- Citations by year
- 2026: 21 · 2025: 19 · 2024: 17 · 2023: 19 · 2022: 21 · 2021: 36 · 2020: 31 · 2019: 21 · 2018: 23 · 2017: 19 · 2016: 13 · 2015: 5 · 2014: 2
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Psychogeriatrics (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (P30AG008017)
- National Institute on Drug Abuse (T32DA007262)
- National Center for Complementary and Integrative Health (F31AT006647, T32AT002688, K24AT005121)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Nursing › Research and Theory › Nursing care and research
- Social Sciences › Psychology › Clinical Psychology › Family Caregiving in Mental Illness
- Keywords
- dementia caregiving, informal caregivers, chronic stress, caregiver health, inflammation, cellular aging, immune function, sleep, cognition, personality moderators, caregiver burden
- MeSH terms
- Aged, Dementia, Female, General Adaptation Syndrome, Humans, Male, Stress, Physiological, Stress, Psychological, Time, Caregivers, Outcome Assessment, Health Care
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