The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Physiological and functional consequences of caregiving for relatives with dementia
Open accessAbstract
BACKGROUND: Chronic stress negatively affects health and well-being. A growing population of informal dementia caregivers experience chronic stress associated with extraordinary demands of caring for a relative with dementia. This review summarizes physiological and functional changes due to chronic dementia caregiver stress. METHODS: A literature search for papers assessing effects of dementia caregiving was conducted focusing on publications evaluating differences between caregivers and non-caregivers in objective measures of health and cognition. RESULTS: The review identified 37 studies describing data from 4,145 participants including 749 dementia caregivers and 3,396 non-caregiver peers. Objective outcome measures affected in dementia caregivers included markers of dyscoagulation, inflammation, and cell aging as well as measures of immune function, sleep, and cognition. Though diverse in designs, samples, and study quality, the majority of the studies indicated increased vulnerability of dementia caregivers to detrimental changes in health and cognition. Demographic and personality characteristics moderating or mediating effects of chronic stress in caregivers were also reviewed. CONCLUSIONS: There is accumulating evidence that chronic dementia caregiver stress increases their vulnerability to disease and diminishes their ability to provide optimal care. Clinicians and society need to appreciate the extent of deleterious effects of chronic stress on dementia caregiver health.
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“Evidence suggests that the stress of providing dementia care increases caregivers' susceptibility to disease and health complications.505”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [505]
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“Evidence suggests that the stress of providing dementia care increases caregivers’ susceptibility to disease and health complications. 551”
From 2024 Alzheimer's disease facts and figures (2024) · cites this paper as [551]
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Is caregiving hazardous to one’s physical health? A meta-analysis
Vitaliano, P. P., Zhang, J., & Scanlan, J. M. (2003) · Psychological Bulletin · doi:10.1037/0033-2909.129.6.946 · Cited by 1,734 · cited 6×
“Caring for a relative with any health problem might negatively affect caregiver’s health; however, family caregivers of dementia patients are a growing population who face additional caregiving challenges associated with the chronic, debilitating, and incurable nature of the disease along with the progressive mental l…”
InfluentialChronic stress and age-related increases in the proinflammatory cytokine IL-6.
Kiecolt-Glaser, J. K., Preacher, K. J., MacCallum, R. C., Atkinson, C., Malarkey, W. B., & Glaser, R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1531903100 · Cited by 1,267
Kiecolt-Glaser, J. K., Gouin, J.-P., Weng, N.-P., Malarkey, W. B., Beversdorf, D. Q., & Glaser, R. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31820573b6 · Cited by 430
Damjanovic, A. K., Yang, Y., Glaser, R., Kiecolt‐Glaser, J. K., Nguyen, H., Laskowski, B. F., Zou, Y., Beversdorf, D. Q., & Weng, N. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.4249 · Cited by 413
Schoenmakers, B., Buntinx, F., & de Lepeleire, J. (2010) · Maturitas · doi:10.1016/j.maturitas.2010.02.009 · Cited by 328 · cited 3×
“Caucasian DCGs are especially prone to social isolation compared to African-American or Latino DCGs who traditionally rely on extended family networks (Schoenmakers et al., 2010).”
BackgroundInfluentialChronic stress, daily stressors, and circulating inflammatory markers
Gouin, J.-P., Glaser, R., Malarkey, W. B., Beversdorf, D., & Kiecolt-Glaser, J. (2012) · Health Psychology · doi:10.1037/a0025536 · Cited by 293 · cited 4×
“For example, DCGs experience more stressors within a 24-hour period than non-DCGs, and this occurrence of multiple daily stressors is linked to increased serum interleukin (IL)-6 and C-reactive protein (CRP) levels (Gouin et al., 2012).”
InfluentialDynamics of telomerase activity in response to acute psychological stress
Epel, E. S., Lin, J., Dhabhar, F. S., Wolkowitz, O. M., Puterman, E. M., Karan, L. D., & Blackburn, E. H. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.11.018 · Cited by 224
Does cellular aging relate to patterns of allostasis?
Tomiyama, A. J., O’Donovan, A., Lin, J., Puterman, E. M., Lazaro, A., Chan, J. L., Dhabhar, F. S., Wolkowitz, O. M., Kirschbaum, C., Blackburn, E. H., et al. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.11.016 · Cited by 216
Greater Risk of Dementia When Spouse Has Dementia? The Cache County Study
Norton, M. C., Smith, K. R., Østbye, T., Tschanz, J. T., Corcoran, C., Schwartz, S., Piercy, K. W., Rabins, P. V., Steffens, D. C., Skoog, I. G., et al. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02806.x · Cited by 194
Fauth, E. B., Hess, K., Piercy, K., Norton, M. C., Corcoran, C., Rabins, P. V., Lyketsos, C. G., & Tschanz, J. T. (2012) · Aging & Mental Health · doi:10.1080/13607863.2012.678482 · Cited by 189
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Sorted by citations
2016 Alzheimer's disease facts and figures
Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069
“Evidence suggests that the stress of dementia care provision increases caregivers’ susceptibility to disease and health complications [244].”
2023 Alzheimer's disease facts and figures
(2023) · Alzheimer's & Dementia · doi:10.1002/alz.13016 · Cited by 3,212
2024 Alzheimer's disease facts and figures
(2024) · Alzheimer's & Dementia · doi:10.1002/alz.13809 · Cited by 2,536
2019 Alzheimer’s disease facts and figures.
Alzheimer's Association (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2019.01.010 · Cited by 2,461
“Evidence suggests that the stress of providing dementia care increases caregivers’ susceptibility to disease and health complications [339].”
2020 Alzheimer's disease facts and figures
(2020) · Alzheimer's & Dementia · doi:10.1002/alz.12068 · Cited by 2,353
Metadata
- Authors
- Fonareva, I., & Oken, B. S.
- Affiliations
- Oregon Health & Science University (US)
- Corresponding author
- Oken, Barry S.
- ORCID
- Oken, Barry S.
- Venue
- International Psychogeriatrics
- Publisher
- Elsevier BV
- Published
- 2014-05
- Volume
- 26
- Issue
- 5
- Pages
- 725-747
- ISSN
- 1041-6102 (ISSN-L)
- PMC
- PMC3975665
- OpenAlex
- W2125058262
- Cited by
- 249
- References
- 50
- Citations by year
- 2026: 21 · 2025: 19 · 2024: 17 · 2023: 19 · 2022: 21 · 2021: 36 · 2020: 31 · 2019: 21 · 2018: 23 · 2017: 19 · 2016: 13 · 2015: 5 · 2014: 2
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Psychogeriatrics (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (P30AG008017)
- National Institute on Drug Abuse (T32DA007262)
- National Center for Complementary and Integrative Health (F31AT006647, T32AT002688, K24AT005121)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Nursing › Research and Theory › Nursing care and research
- Social Sciences › Psychology › Clinical Psychology › Family Caregiving in Mental Illness
- Keywords
- dementia caregiving, informal caregivers, chronic stress, caregiver health, inflammation, cellular aging, immune function, sleep, cognition, personality moderators, caregiver burden
- MeSH terms
- Aged, Dementia, Female, General Adaptation Syndrome, Humans, Male, Stress, Physiological, Stress, Psychological, Time, Caregivers, Outcome Assessment, Health Care
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