Diagnostic accuracy of CERAD total score in a Colombian cohort with mild cognitive impairment and Alzheimer's disease affected by E280A mutation on presenilin-1 gene
Open accessAbstract
BACKGROUND: This study aimed to determine Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychological Assessment Battery total score diagnostic accuracy in the diagnosis of mild cognitive impairment (MCI) and dementia in familial Alzheimer's disease (FAD) with E280A mutation on presenilin-1 gene (PSEN1). METHODS: A cross-sectional study was conducted in a cohort of PSEN1 E280A carriers and non-carriers assessed between January 1995 and February 2013. During the first neuropsychological assessment, 76 were having dementia, 46 had MCI, and 1,576 were asymptomatic. CERAD cut-off points were established for MCI and dementia using a Receiver Operating Characteristics (ROC) analysis, and were further analyzed according to education level in two groups: low education level (eight years or less), and high education level (over eight years). RESULTS: The area under curve-ROC CERAD total score for dementia was 0.994 (95% CI = 0.989-0.999), and that for MCI was 0.862 (95% CI = 0.816-0.908). The dementia diagnosis cut-off point for the low education group was 54, (98.4% sensitivity, 92.6% specificity), and that for the high education group was 67 (100% sensitivity, 94.1% specificity). The MCI diagnosis cut-off point for the low education group was 66 (91.2% sensitivity, 56.4% specificity), and that for the high education group was 72 (91.7% sensitivity, 76.3% specificity). CONCLUSIONS: The CERAD total score is a useful screening tool for dementia and MCI in a population at risk of FAD.
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The neuropsychological battery had been adapted and validated to detect Alzheimer's disease-related cognitive impairment in this kindred.
“Neuropsychological assessments were conducted in Spanish with the use of a battery that has been adapted and validated for the detection of Alzheimer’s disease–related cognitive impairment in this kindred”
From <i>APOE3</i> Christchurch Heterozygosity and Autosomal Dominant Alzheimer’s Disease (2024) · cites this paper as [11]
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- Authors
- Aguirre-Acevedo, D. C., Jaimes-Barragán, F., Henao, E., Tirado, V., Muñoz, C., Reiman, E. M., Tariot, P. N., Langbaum, J. B., & Lopera, F.
- Affiliations
- Universidad de Antioquia (CO)
- Banner Alzheimer’s Institute (US)
- ORCID
- Venue
- International Psychogeriatrics
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 28
- Issue
- 3
- Pages
- 503-510
- ISSN
- 1041-6102 (ISSN-L)
- OpenAlex
- W1794166075
- Cited by
- 25
- References
- 26
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 1
- FWCI
- 1.08
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Psychogeriatrics (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Institutional Repository University of Antioquia (University of Antioquia) (submittedVersion, cc-by-nc-nd)
- Funders
- National Institute on Aging (R01AG055444)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Clinical Psychology › Historical and Modern Theater Studies
- Keywords
- mild cognitive impairment, dementia, familial Alzheimer's disease, PSEN1 E280A mutation, presenilin 1, diagnostic accuracy, neuropsychological assessment, educational attainment, dementia screening
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Amnesia, Colombia, Cross-Sectional Studies, Female, Genetic Markers, Humans, Male, Middle Aged, Mutation, Neuropsychological Tests, Sensitivity and Specificity, Severity of Illness Index, Reproducibility of Results, Area Under Curve, Genetic Predisposition to Disease, Recognition, Psychology, Presenilin-1, Cognitive Dysfunction
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