Psychotropic drug prescriptions in western European nursing homes
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BACKGROUND: Despite the numerous warnings of European and national drug agencies as well as clinical guidelines since the year 2004, psychotropic drugs are still frequently used in dementia. A systematic review comparing the use of psychotropic drugs in nursing homes from different European countries is lacking. OBJECTIVE: The aim of this study was to examine prescription rates of psychotropic drug use in nursing home patients between different Western European countries since the first warnings were published. METHODS: A literature review was performed and the various psychotropic prescribing rates in European nursing homes were investigated. The prescription rates of antipsychotic and antidepressants were pooled per country. Other classes of psychotropic drugs could not be pooled because of the limited number of studies found. RESULTS: Thirty-seven studies on antipsychotic drug use and 27 studies on antidepressant drug use conducted in 12 different European countries. The antipsychotic use in nursing homes ranged from 12% to 59% and antidepressant use from 19% to 68%. The highest rates of antipsychotic drug prescription were found in Austria, Ireland, and Belgium while for antidepressants in Belgium, Sweden, and France. CONCLUSIONS: Despite warnings about the side effects and recommendation to focus on non-pharmacological interventions, antipsychotics and antidepressants are commonly used drugs in nursing homes. The data suggest that Norway does best with regards having a low antipsychotic drug usage. Studies are needed to explain the differences between Norway and other European countries.
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Rates of psychotropic prescribing are particularly high across care homes in Western Europe, where up to 63% of residents are prescribed at least one psychotropic drug.
“Rates of prescribing are particularly high across care homes, where studies in the Western Europe have shown that up to 63% of residents are prescribed at least one psychotropic drug [5–8].”
From Stakeholders' views on the use of psychotropic medication in older people: a systematic review (2022) · cites this paper as [8]
Previous research has also shown that country of residence is more important than clinical factors in determining psychotropic use and this also suggests that prescribing habits, social, cultural, behavioural and regulatory factors play an important role.
“Previous research has also shown that country of residence is more important than clinical factors in determining psychotropic use and this also suggests that prescribing habits, social, cultural, behavioural and regulatory factors play an important role [8, 87].”
From Stakeholders' views on the use of psychotropic medication in older people: a systematic review (2022) · cites this paper as [8]
Cites
Barendregt, J. J., Doi, S. A., Lee, Y. Y., Norman, R. E., & Vos, T. (2013) · Journal of Epidemiology and Community Health · doi:10.1136/jech-2013-203104 · Cited by 2,169 · see citing works
Pharmacological Treatment of Neuropsychiatric Symptoms of Dementia: A Review of the Evidence
Sink, K. M., Holden, K. F., & Yaffe, K. (2005) · JAMA · doi:10.1001/jama.293.5.596 · Cited by 910 · see citing works
Point and 5‐year period prevalence of neuropsychiatric symptoms in dementia: the Cache County Study
Steinberg, M., Shao, H., Zandi, P. P., Lyketsos, C. G., Welsh-Bohmer, K. A., Norton, M. C., Breitner, J. C. S., Steffens, D. C., & Tschanz, J. T. (2007) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1858 · Cited by 743 · see citing works
Potentially Inappropriate Medication Use Among Elderly Home Care Patients in Europe
Fialová, D. (2005) · JAMA · doi:10.1001/jama.293.11.1348 · Cited by 709 · see citing works
Husebo, B. S., Ballard, C., Sandvik, R., Nilsen, O. B., & Aarsland, D. (2011) · BMJ · doi:10.1136/bmj.d4065 · Cited by 571 · see citing works
Meta-Analysis of Nonpharmacological Interventions for Neuropsychiatric Symptoms of Dementia
Brodaty, H., & Arasaratnam, C. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.11101529 · Cited by 479 · see citing works
Management of behavioral problems in Alzheimer's disease
Gauthier, S., Cummings, J., Ballard, C., Brodaty, H., Grossberg, G., Robert, P., & Lyketsos, C. (2010) · International Psychogeriatrics · doi:10.1017/s1041610209991505 · Cited by 369 · see citing works
the SHELTER project, Onder, G., Carpenter, I., Finne‐Soveri, H., Gindin, J., Frijters, D. H. M., Henrard, J. C., Nikolaus, T., Topinková, E., Tosato, M., et al. (2012) · BMC Health Services Research · doi:10.1186/1472-6963-12-5 · Cited by 320 · see citing works
Place of Death of Older Persons with Dementia. A Study in Five European Countries
Houttekier, D., Cohen, J., Bilsen, J. J. R., Addington-Hall, J. M., Onwuteaka-Philipsen, B. D., & Deliëns, L. (2010) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2010.02771.x · Cited by 267 · see citing works
Nursing Home and Nursing Home Physician: The Dutch Experience
Schols, J. M. G. A., Crebolder, H. F. J. M., & van Weel, C. (2004) · Journal of the American Medical Directors Association · doi:10.1016/s1525-8610(04)70116-4 · Cited by 200 · see citing works
Azermai, M., Petrović, M., Elseviers, M. M., Bourgeois, J., Bortel, L. M. V., & Stichele, R. V. (2011) · Ageing Research Reviews · doi:10.1016/j.arr.2011.07.002 · Cited by 197 · see citing works
Course of Neuropsychiatric Symptoms in Residents with Dementia in Nursing Homes Over 2-Year Period
Wetzels, R. B., Zuidema, S. U., de Jonghe, J. F. M., Verhey, F. R. J., & Koopmans, R. T. C. M. (2010) · American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e3181f60fa1 · Cited by 158 · see citing works
Prevalence of dementia in nursing home and community-dwelling older adults in Germany
Hoffmann, F., Kaduszkiewicz, H., Glaeske, G., van den Bussche, H., & Koller, D. (2014) · Aging Clinical and Experimental Research · doi:10.1007/s40520-014-0210-6 · Cited by 147 · see citing works
Zwijsen, S. A., Kabboord, A., Eefsting, J. A., Hertogh, C. M. P. M., Pot, A. M., Gerritsen, D. L., & Smalbrugge, M. (2013) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4014 · Cited by 145 · see citing works
Ballard, C. G., Creese, B., Corbett, A., & Aarsland, D. (2010) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2010.506711 · Cited by 139 · see citing works
Richter, T., Mann, E., Meyer, G., Haastert, B., & Köpke, S. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.03.007 · Cited by 127 · see citing works
Ballard, C. G., Corbett, A., Chitramohan, R., & Aarsland, D. (2009) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32833111f9 · Cited by 113 · see citing works
Kuske, B., Luck, T., Hanns, S., Matschinger, H., Angermeyer, M. C., Behrens, J., & Riedel-Heller, S. G. (2009) · International Psychogeriatrics · doi:10.1017/s1041610208008387 · Cited by 113 · see citing works
A 12 months follow-up study of depression among nursing-home patients in Norway
Barca, M. L., Engedal, K., Laks, J., & Selbaek, G. (2010) · Journal of Affective Disorders · doi:10.1016/j.jad.2009.04.028 · Cited by 104 · see citing works
Descriptive study of nursing home residents from the REHPA network
Rolland, Y., van Kan, G. A., Hermabessière, S., Gérard, S., Guyonnet, S., & Vellas, B. J. (2009) · The journal of nutrition health & aging · doi:10.1007/s12603-009-0197-4 · Cited by 94 · see citing works
Gallini, A., Andrieu, S., Donohue, J. M., Oumouhou, N., Lapeyre‐Mestre, M., & Gardette, V. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.09.003 · Cited by 94 · see citing works
Prescribing pattern of psychotropic drugs in nursing home residents with dementia
Wetzels, R. B., Zuidema, S. U., de Jonghe, J. F. M., Verhey, F. R. J., & Koopmans, R. T. C. M. (2011) · International Psychogeriatrics · doi:10.1017/s1041610211000755 · Cited by 90 · see citing works
Stewart, R. J., Hotopf, M. H., Dewey, M. E., Ballard, C. G., Bisla, J., Calem, M., Fahmy, V., Hockley, J., Kinley, J., Pearce, H., et al. (2014) · Age and Ageing · doi:10.1093/ageing/afu062 · Cited by 83 · see citing works
Benzodiazepine use in Belgian nursing homes: a closer look into indications and dosages
Bourgeois, J., Elseviers, M. M., Azermai, M., Bortel, L. M. V., Petrović, M., & Stichele, R. V. (2011) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-011-1188-z · Cited by 75 · see citing works
Johnell, K., & Fastbom, J. (2012) · Drugs & Aging · doi:10.1007/s40266-012-0002-7 · Cited by 74 · see citing works
Helvik, A., Engedal, K., Benth, J. Š., & Selbæk, G. (2014) · BMC Geriatrics · doi:10.1186/1471-2318-14-45 · Cited by 69 · see citing works
Gustafsson, M. V., Karlsson, S., & Lövheim, H. (2013) · BMC Pharmacology and Toxicology · doi:10.1186/2050-6511-14-10 · Cited by 68 · see citing works
Potentially Inappropriate Drug Prescribing and Associated Factors in Nursing Homes
Cool, C., Cestac, P., Laborde, C., Lebaudy, C., Rouch, L., Lepage, B., Vellas, B. J., Barreto, P. D. S., Rolland, Y., & Lapeyre‐Mestre, M. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.08.003 · Cited by 66 · see citing works
Zuidema, S. U., Johansson, A., Selbæk, G., Murray, M., Burns, A. S., Ballard, C. G., & Koopmans, R. T. C. M. (2015) · International Psychogeriatrics · doi:10.1017/s1041610215000745 · Cited by 66 · see citing works
Estimating the prevalence of dementia: cognitive screening in Glasgow nursing homes
Lithgow, S., Jackson, G. A., & Browne, D. (2011) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2784 · Cited by 63 · see citing works
The course of neuropsychiatric symptoms in patients with dementia in Norwegian nursing homes
Bergh, S., Engedal, K., Røen, I., & Selbæk, G. (2011) · International Psychogeriatrics · doi:10.1017/s1041610211001177 · Cited by 63 · see citing works
Shah, S. M., Carey, I. M., Harris, T. J., DeWilde, S., & Cook, D. G. (2010) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2557 · Cited by 60 · see citing works
Psychotropic Medications and Falls in Nursing Homes: A Cross-Sectional Study
Olazarán, J., Valle, D., Rexach, J. A. S., Cano, P., & Múñiz, R. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.10.020 · Cited by 57 · see citing works
Schulze, J., van den Bussche, H., Glaeske, G., Kaduszkiewicz, H., Wiese, B., & Hoffmann, F. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.02.001 · Cited by 55 · see citing works
Foebel, A. D., Liperoti, R., Onder, G., Finne‐Soveri, H., Henrard, J. C., Lukas, A., Denkinger, M. D., Gambassi, G., & Bernabei, R. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.07.012 · Cited by 53 · see citing works
The Pharmacotherapy of Neuropsychiatric Symptoms of Dementia
Majić, T., Pluta, J.-P., Mell, T., Aichberger, M. C., Treusch, Y., Gutzmann, H., Heinz, A., & Rapp, M. A. (2010) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2010.0320 · Cited by 50 · see citing works
Gustafsson, M. V., Sandman, P., Karlsson, S., Gustafson, Y., & Lövheim, H. (2013) · International Psychogeriatrics · doi:10.1017/s1041610213000859 · Cited by 47 · see citing works
Mjørud, M., Røsvik, J., Rokstad, A. M. M., Kirkevold, M., & Engedal, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0115248 · Cited by 46 · see citing works
Variability between nursing homes in prevalence of antipsychotic use in patients with dementia
Kleijer, B. C., van Marum, R. J., Frijters, D. H. M., Jansen, P. A. F., Ribbe, M. W., Egberts, T. C. G., & Heerdink, E. R. (2013) · International Psychogeriatrics · doi:10.1017/s1041610213002019 · Cited by 46 · see citing works
Barry, H. E., Parsons, C., Passmore, A. P., & Hughes, C. M. (2014) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4111 · Cited by 45 · see citing works
Pitkälä, K. H., Juola, A.-L., Hosia‐Randell, H., Teramura-Grönblad, M., Soini, H., Savikko, N. M., & Bell, J. S. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.06.009 · Cited by 45 · see citing works
Testad, I., Auer, S., Mittelman, M. S., Ballard, C. G., Fossey, J., Donabauer, Y., & Aarsland, D. (2009) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.2414 · Cited by 42 · see citing works
Mauléon, A. D., Sourdet, S., Guiteras, A. R., Guyonnet, S., Leino‐Kilpi, H., Karlsson, S., Bleijlevens, M. H. C., Zabalegui, A., Saks, K., Vellas, B. J., et al. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.06.015 · Cited by 38 · see citing works
Iden, K. R., Engedal, K., Hjörleifsson, S., & Ruths, S. (2013) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000355427 · Cited by 37 · see citing works
Trinh, N.-H., Hoblyn, J., Mohanty, S., & Yaffe, K. (2003) · JAMA · doi:10.1001/jama.289.2.210 · Cited by 37 · see citing works
Borza, T., Engedal, K., Bergh, S., Barca, M. L., Benth, J. Š., & Selbæk, G. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.12.053 · Cited by 36 · see citing works
Eggermont, L. H. P., de Vries, K., & Scherder, E. (2009) · International Psychogeriatrics · doi:10.1017/s1041610209008552 · Cited by 33 · see citing works
Toscani, F., Giulio, P. D., Villani, D., Giunco, F., Brunelli, C., Gentile, S., Finetti, S., Charrier, L., Monti, M., & van der Steen, J. T. (2013) · Journal of Palliative Medicine · doi:10.1089/jpm.2012.0165 · Cited by 33 · see citing works
'HE WAS LIKE A ZOMBIE': OFF-LABEL PRESCRIPTION OF ANTIPSYCHOTIC DRUGS IN DEMENTIA
Harding, R., & Peel, E. (2012) · Medical Law Review · doi:10.1093/medlaw/fws029 · Cited by 28 · see citing works
de Mazières, C. L., Lapeyre‐Mestre, M., Vellas, B. J., Barreto, P. D. S., & Rolland, Y. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.01.092 · Cited by 26 · see citing works
Zuidema, S. U., van Iersel, M. B., Koopmans, R. T. C. M., Verhey, F. R. J., & Rikkert, M. G. M. O. (2006) · PubMed · Cited by 25 · see citing works
Antipsychotic prescribing in nursing homes
McCleery, J. M., & Fox, R. A. (2012) · BMJ · doi:10.1136/bmj.e1093 · Cited by 22 · see citing works
Sturm, H., van Gilst, W. H., Veeger, N. J. G. M., & Haaijer‐Ruskamp, F. M. (2006) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.1216 · Cited by 21 · see citing works
A reliable and valid index was developed to measure appropriate psychotropic drug use in dementia
van der Spek, K., Gerritsen, D. L., Smalbrugge, M., Nelissen-Vrancken, M. H. J. M. G., Wetzels, R. B., Smeets, C. H. W., Zuidema, S. U., & Koopmans, R. T. C. M. (2015) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2015.03.012 · Cited by 20 · see citing works
Involvement in Activities and Wandering in Nursing Home Residents With Cognitive Impairment
Volicer, L., van der Steen, J. T., & Frijters, D. H. M. (2012) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e31826d012e · Cited by 18 · see citing works
Depression and use of antidepressants in Swedish nursing homes: a 12-month follow-up study
Midlöv, P., Andersson, M., Östgren, C. J., & Mölstad, S. (2013) · International Psychogeriatrics · doi:10.1017/s1041610213002354 · Cited by 16 · see citing works
(2015) · ASHA Leader · doi:10.1044/leader.ppl.20122015.22 · Cited by 11 · see citing works
(2015) · Comptes Rendus Chimie · doi:10.1016/j.crci.2015.09.007 · Cited by 2 · see citing works
Hundertmark, G. (2014) · Cited by 1 · see citing works
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Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia
Mühlbauer, V., Möhler, R., Dichter, M. N., Zuidema, S. U., Köpke, S., & Luijendijk, H. J. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013304.pub2 · Cited by 117 · see citing works
Antipsychotic deprescription for older adults in long-term care: the HALT study
Brodaty, H., Aerts, L., Harrison, F., Jessop, T., Cations, M., Chenoweth, L., Shell, A., Popovic, G. C., Heffernan, M., Hilmer, S., et al. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.05.002 · Cited by 104 · see citing works
Van Leeuwen, E., van Driel, M. L., Horowitz, M. A., Kendrick, T., Donald, M., De Sutter, A. I., Robertson, L., & Christiaens, T. (2021) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013495.pub2 · Cited by 90 · see citing works
The economics of patient safety Part III: Long-term care
Bienassis, K. D., Nozal, A. L., & Klazinga, N. S. (2020) · OECD health working papers · doi:10.1787/be07475c-en · Cited by 76 · see citing works
Cioltan, H., Alshehri, S. O., Howe, C. L., Lee, J. K., Fain, M. J., Eng, H. J., Schachter, K. A., & Mohler, J. M. (2017) · BMC Geriatrics · doi:10.1186/s12877-017-0428-1 · Cited by 73 · see citing works
Ngcobo, N. N. (2025) · Clinical Pharmacokinetics · doi:10.1007/s40262-024-01466-0 · Cited by 95 · see citing works
Huang, N., Li, W., Rong, X., Champ, M., Wei, L., Li, M., Mu, H., Hu, Y., Ma, Z., & Lyu, J. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190487 · Cited by 64 · see citing works
Evrard, P., Pétein, C., Beuscart, J.-B., & Spinewine, A. (2022) · Implementation Science · doi:10.1186/s13012-022-01206-7 · Cited by 62 · see citing works
Harrison, S. L., Cations, M., Jessop, T., Hilmer, S. N., Sawan, M. J., & Brodaty, H. (2018) · Drugs & Aging · doi:10.1007/s40266-018-0623-6 · Cited by 62 · see citing works
Associations between pain and depression in nursing home patients at different stages of dementia
Erdal, A., Flo, E., Selbæk, G., Aarsland, D., Bergh, S., Daltveit, D. S., & Husebo, B. S. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.04.038 · Cited by 60 · see citing works
Gedde, M. H., Husebo, B. S., Mannseth, J., Kjome, R. L. S., Naik, M., & Berge, L. I. (2020) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2020.07.004 · Cited by 56 · see citing works
Richter, C., Berg, A., Langner, H., Meyer, G., Köpke, S., Balzer, K., Wolschon, E.-M., Silies, K., Sönnichsen, A. C., Löscher, S., et al. (2019) · Age and Ageing · doi:10.1093/ageing/afz016 · Cited by 54 · see citing works
Persistent use of psychotropic drugs in nursing home residents in Norway
Helvik, A., Benth, J. Š., Wu, B., Engedal, K., & Selbæk, G. (2017) · BMC Geriatrics · doi:10.1186/s12877-017-0440-5 · Cited by 50 · see citing works
Erdal, A., Flo, E., Aarsland, D., Selbæk, G., Ballard, C. G., Daltveit, D. S., & Husebo, B. S. (2018) · Clinical Interventions in Aging · doi:10.2147/cia.s161052 · Cited by 43 · see citing works
Antipsychotics for agitation and psychosis in people with Alzheimer's disease and vascular dementia
Mühlbauer, V., Luijendijk, H. J., Dichter, M., Mohler, R. A., Zuidema, S. U., & Köpke, S. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013304 · Cited by 42 · see citing works
Roitto, H., Kautiainen, H., Aalto, U. L., Öhman, H., Laurila, J., & Pitkälä, K. H. (2019) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.12.022 · Cited by 38 · see citing works
Benzodiazepine Use and Deprescribing in Belgian Nursing Homes: Results from the COME‐ON Study
Evrard, P., Henrard, S., Foulon, V., & Spinewine, A. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16751 · Cited by 38 · see citing works
Walsh, K. A., Sinnott, C., Fleming, A., Mc Sharry, J., Byrne, S., Browne, J., & Timmons, S. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.07.004 · Cited by 37 · see citing works
Birkenhäger‐Gillesse, E. G., Kollen, B. J., Achterberg, W. P., Boersma, F., Lydia, J., & Zuidema, S. U. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.12.100 · Cited by 37 · see citing works
Erdal, A., Flo, E., Aarsland, D., Ballard, C. G., Daltveit, D. S., & Husebo, B. S. (2018) · Drugs & Aging · doi:10.1007/s40266-018-0546-2 · Cited by 35 · see citing works
Interventions to optimize medication use in nursing homes: a narrative review
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Aerts, L., Cations, M., Harrison, F., Jessop, T., Shell, A., Chenoweth, L., & Brodaty, H. (2019) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5167 · Cited by 33 · see citing works
Psychiatric consultation in the nursing home: reasons for referral and recognition of delirium
Wilson, L., Power, C., Owens, R. L., & LAWLOR, B. A. (2017) · Irish Journal of Psychological Medicine · doi:10.1017/ipm.2017.71 · Cited by 33 · see citing works
Smeets, C. H. W., Smalbrugge, M., Koopmans, R. T. C. M., Nelissen-Vrancken, M. H. J. M. G., van der Spek, K., Teerenstra, S., Gerritsen, D. L., & Zuidema, S. U. (2020) · International Psychogeriatrics · doi:10.1017/s1041610220000629 · Cited by 29 · see citing works
Stakeholders' views on the use of psychotropic medication in older people: a systematic review
Bednarczyk, E., Cook, S., Brauer, R., & Garfield, S. (2022) · Age and Ageing · doi:10.1093/ageing/afac060 · Cited by 22 · see citing works
Wiggin, D. A., Timmons, S., Rukundo, A., & Walsh, K. A. (2021) · Aging & Mental Health · doi:10.1080/13607863.2021.1922601 · Cited by 25 · see citing works
Psychotropic Drug Prescription in Nursing Homes During the COVID-19 Pandemic
Uriguen, A. F., Lucas, E. L., Sannino, C., Arrechea, I. I., Álaba, J., Echevarrı́a, E., Goikouria, J. G., & Telleria, I. B. (2022) · Drugs & Aging · doi:10.1007/s40266-022-00948-9 · Cited by 24 · see citing works
Janus, S. I. M., van Manen, J. G., IJzerman, M. J., Bisseling, M., Drossaert, C. H. C., & Zuidema, S. U. (2016) · International Psychogeriatrics · doi:10.1017/s1041610216001897 · Cited by 24 · see citing works
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Marazzi, F., Mortari, A. P., Belotti, F., Carrà, G., Cattuto, C., Kopinska, J. A., Paolotti, D., & Atella, V. (2022) · Scientific Reports · doi:10.1038/s41598-022-22085-4 · Cited by 20 · see citing works
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Fog, A. F., Mdala, I., Engedal, K., & Straand, J. (2020) · BMC Geriatrics · doi:10.1186/s12877-020-01745-y · Cited by 19 · see citing works
Psychosocial interventions for reducing antipsychotic medication in care home residents
Lühnen, J., Richter, T., Calo, S., Meyer, G., Köpke, S., & Mohler, R. A. (2023) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008634.pub3 · Cited by 18 · see citing works
Fog, A. F., Straand, J., Engedal, K., & Blix, H. S. (2019) · BMC Geriatrics · doi:10.1186/s12877-019-1064-8 · Cited by 19 · see citing works
Lexow, M., Wernecke, K., Sultzer, R., Bertsche, T., & Schiek, S. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03025-3 · Cited by 19 · see citing works
Múñiz, R., Pérez-Wehbe, A. I., Couto, F., Pérez, M. A. H., Ramírez, N., López, A., Rodriguez, J. M., Usieto, T., Lavin, L., Rigueira, A., et al. (2019) · International Psychogeriatrics · doi:10.1017/s104161021900111x · Cited by 18 · see citing works
Pharmacogenomics of Alzheimer’s Disease: Novel Strategies for Drug Utilization and Development
Cacabelos, R., Naidoo, V., Martínez-Iglesias, O. A., Corzo, L., Cacabelos, N., Pego, R., & Carril, J. C. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2573-6_13 · Cited by 19 · see citing works
Kormelinck, C. M. G., van Teunenbroek, C. F., Kollen, B. J., Reitsma, M., Gerritsen, D. L., Smalbrugge, M., & Zuidema, S. U. (2019) · BMC Psychiatry · doi:10.1186/s12888-019-2291-4 · Cited by 18 · see citing works
General practitioners’ perspectives on discontinuation of long-term antidepressants in nursing homes
Leeuwen, E. V., Anthierens, S., van Driel, M., Sutter, A. I. M. D., van den Branden, E., & Christiaens, T. (2022) · European Journal of General Practice · doi:10.1080/13814788.2022.2038131 · Cited by 16 · see citing works
Developing consensus description of group music therapy characteristics for persons with dementia
Janus, S. I. M., Vink, A. C., Ridder, H. M. O., Geretsegger, M., Stige, B., Gold, C., & Zuidema, S. U. (2020) · Nordic Journal of Music Therapy · doi:10.1080/08098131.2020.1779790 · Cited by 16 · see citing works
Palliative care for people with dementia
Timmons, S., & Fox, S. (2023) · Handbook of clinical neurology · doi:10.1016/b978-0-12-824535-4.00013-6 · Cited by 15 · see citing works
Gerritsen, D. L., de Vries, E., Smalbrugge, M., Smeets, C. H. W., van der Spek, K., Zuidema, S. U., & Koopmans, R. T. C. M. (2019) · International Psychogeriatrics · doi:10.1017/s1041610219000577 · Cited by 14 · see citing works
Walsh, K. A., Timmons, S., Byrne, S., Browne, J. P., & McSharry, J. (2020) · Translational Behavioral Medicine · doi:10.1093/tbm/ibaa053 · Cited by 14 · see citing works
Medications in Post-Acute and Long-Term Care: Challenges and Controversies
Sloane, P. D., Brandt, N., Cherubini, A., Dharmarajan, T. S., Dosa, D. M., Hanlon, J. T., Katz, P. R., Koopmans, R. T. C. M., Laird, R. D., Petrović, M., et al. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2020.11.027 · Cited by 13 · see citing works
Yoon, J. M., Trinkoff, A. M., Galik, E. M., Storr, C. L., Lerner, N. B., Brandt, N., & Zhu, S. (2022) · Journal of Nursing Scholarship · doi:10.1111/jnu.12776 · Cited by 12 · see citing works
Arzneimitteltherapiesicherheit bei Heimbewohnern
Jaehde, U., & Thürmann, P. (2018) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-018-2796-x · Cited by 12 · see citing works
Habiger, T. F., Achterberg, W. P., Flo, E., & Husebo, B. S. (2019) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5067 · Cited by 12 · see citing works
Psychotropic Medication Prescribing to Patients with Dementia Admitted to Acute Hospitals in Ireland
Timmons, S., Bracken-Scally, M., Chakraborty, S., Gallagher, P., Hamilton, V., Begley, E., & O’Shea, E. (2023) · Drugs & Aging · doi:10.1007/s40266-023-01020-w · Cited by 11 · see citing works
Intervention for sleep problems in nursing home residents with dementia: a cluster-randomized study
Dichter, M., Dörner, J., Wilfling, D., Berg, A., Klatt, T., Möhler, R., Haastert, B., Meyer, G., Halek, M., & Köpke, S. (2024) · International Psychogeriatrics · doi:10.1017/s1041610223004489 · Cited by 8 · see citing works
Pinazo‐Clapés, C., Hernandis, S. P., & Sales, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17238845 · Cited by 10 · see citing works
Lai, R., Withiel, T., Angelone, M., Redpath, C., O’Connor, D., & Plakiotis, C. (2022) · Australian Journal on Ageing · doi:10.1111/ajag.13043 · Cited by 10 · see citing works
Comparing Three Methods for Reducing Psychotropic Use in Older Demented Spanish Care Home Residents
Weeks, W. B., Mishra, M. K., Curto, D., Petersen, C. L., Cano, P., Hswen, Y., Serra, S. V., Elwyn, G. J., Godfrey, M. M., Soro, P. S., et al. (2019) · Journal of the American Geriatrics Society · doi:10.1111/jgs.15855 · Cited by 10 · see citing works
van Teunenbroek, C. F., Verhagen, K., Smalbrugge, M., Persoon, A., Zuidema, S. U., & Gerritsen, D. L. (2020) · BMC Geriatrics · doi:10.1186/s12877-020-01569-w · Cited by 10 · see citing works
Ozaki, T. J., Katsumata, Y., & Arai, A. (2018) · Psychogeriatrics · doi:10.1111/psyg.12374 · Cited by 10 · see citing works
Mulders, A., Zuidema, S. U., Leeuwis, R., Bor, H. H. J., Verhey, F. R. J., & Koopmans, R. T. C. M. (2019) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5116 · Cited by 10 · see citing works
Johannessen, A., Tevik, K., Engedal, K., & Helvik, A. (2020) · Nordic Studies on Alcohol and Drugs · doi:10.1177/1455072520961890 · Cited by 10 · see citing works
Ma, D., Zhao, Y., Wan, Z., Sun, D., Li, H., Xie, Z., & Sun, J. (2019) · Geriatric Nursing · doi:10.1016/j.gerinurse.2019.10.007 · Cited by 8 · see citing works
Hamada, S., Kojima, T., Hattori, Y., Maruoka, H., Ishii, S., Okochi, J., & Akishita, M. (2021) · BMJ Open · doi:10.1136/bmjopen-2020-045787 · Cited by 8 · see citing works
Leach, M., Sangalli, M., Breakspear, I., & Walsh, S. (2021) · Integrative Medicine Research · doi:10.1016/j.imr.2021.100747 · Cited by 7 · see citing works
Du, J., Janus, S. I. M., Voorthuis, B. J., van Manen, J. G., Achterberg, W. P., Smalbrugge, M., Zwijsen, S. A., Gerritsen, D. L., Koopmans, R. T. C. M., & Zuidema, S. U. (2022) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5697 · Cited by 7 · see citing works
Strong, J. V., Arnold, M., Schneider, L., Perschl, J., Villringer, A., & Fritz, T. H. (2022) · Brain Sciences · doi:10.3390/brainsci12091260 · Cited by 7 · see citing works
den IJssel, J. C. L. V. D., Bakker, C., Smalbrugge, M., Zwijsen, S. A., Adang, E., Appelhof, B., Zuidema, S. U., de Vugt, M. E., Verhey, F. R. J., & Koopmans, R. T. C. M. (2019) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5229 · Cited by 6 · see citing works
Discontinuation of long-term antidepressant use for depressive and anxiety disorders in adults
Leeuwen, E. V., van Driel, M., Sutter, A. I. D., Anderson, K., Robertson, L., & Christiaens, T. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013495 · Cited by 5 · see citing works
Walsh, K. A., Byrne, S., O'Riordan, A., McSharry, J., Browne, J. P., Irving, K., Hurley, E., & Timmons, S. (2022) · Exploratory Research in Clinical and Social Pharmacy · doi:10.1016/j.rcsop.2022.100190 · Cited by 5 · see citing works
The Prevalence of and Documented Indications for Antipsychotic Prescribing in Irish Nursing Homes
Kelleher, J. E., Weedle, P., & Donovan, M. D. (2021) · Pharmacy · doi:10.3390/pharmacy9040160 · Cited by 5 · see citing works
Lühnen, J., Mühlhauser, I., & Richter, T. (2017) · Dementia · doi:10.1177/1471301217746751 · Cited by 5 · see citing works
Shrestha, S., Cross, A. J., Steeper, M., Martini, A., Cenin, D. R., Smith, J., Glamorgan, F., Pond, C. D., Bell, J. S., & Caze, A. L. (2025) · Australian Journal on Ageing · doi:10.1111/ajag.70013 · Cited by 4 · see citing works
Patterns of Antipsychotic Use in Belgian Nursing Homes 2017-2022: Admission is a Decision Point
Vandenberghe, I., Kestens, W., Bruyneel, L., der Linden, L. R. V., & Tournoy, J. (2024) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2024.105222 · Cited by 4 · see citing works
Kijowska, V., Barańska, I., & Szczerbińska, K. E. (2020) · European Geriatric Medicine · doi:10.1007/s41999-020-00331-0 · Cited by 4 · see citing works
Ökonomie der Patientensicherheit, Teil III: Langzeitpflege
Bienassis, K. D., Nozal, A. L., & Klazinga, N. S. (2021) · doi:10.1787/03307512-de · Cited by 4 · see citing works
Nuutinen, M., Leskelä, R., Fialová, D., Haavisto, I., Finne‐Soveri, H., Häsä, J., Edgren, J., van Hout, H. P. J., Leme, D. E. D. C., Hirdes, J. P., et al. (2025) · BMC Medicine · doi:10.1186/s12916-025-04304-7 · Cited by 3 · see citing works
What’s behind delirium: is there a specific role for medications?
Beccacece, A., Samúelsson, Ó., Jónsdóttir, F., Fedecostante, M., Guðmundsson, A., & Cherubini, A. (2025) · European Geriatric Medicine · doi:10.1007/s41999-025-01269-x · Cited by 3 · see citing works
Abdeljalil, A.-B., Arbus, C., Montastruc, F., Barreto, P. D. S., André, L., Vellas, B. J., & Rolland, Y. (2019) · European Geriatric Medicine · doi:10.1007/s41999-019-00189-x · Cited by 3 · see citing works
(2018) · International Journal of Pharmacy Practice · doi:10.1111/ijpp.12442 · Cited by 3 · see citing works
Impact of behavioral and psychological symptoms of dementia (BPSD) in institutionalized people
Hernandis, S. P. (2019) · MOJ Gerontology & Geriatrics · doi:10.15406/mojgg.2019.04.00212 · Cited by 3 · see citing works
Gerridzen, I. J., Doejaaren, E., Veenhuizen, R. B., Hertogh, C. M. P. M., & Joling, K. J. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12093133 · Cited by 3 · see citing works
Kijowska, V., Barańska, I., & Szczerbińska, K. E. (2020) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5432 · Cited by 2 · see citing works
Petersen, N. (2025) · SSM - Mental Health · doi:10.1016/j.ssmmh.2025.100568 · Cited by 2 · see citing works
Gisladottir, S., Sigurðardóttir, Á. K., & Hjaltadóttir, I. (2021) · International Journal of Circumpolar Health · doi:10.1080/22423982.2021.1920252 · Cited by 2 · see citing works
Incidence and type of restrictive practice use in nursing homes in Ireland
Dunbar, P., McMahon, M. J., Durkan, C., Walsh, K. A., & Keyes, L. M. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03450-4 · Cited by 2 · see citing works
Treatment of Challenging Behavior in Dementia
Leontjevas, R., Klaver, M., Smalbrugge, M., & Gerritsen, D. L. (2024) · Practical issues in geriatrics · doi:10.1007/978-3-031-58488-6_4 · Cited by 2 · see citing works
Evrard, P., Chevallereau, T., Aikpitanyi, J., Pétein, C., Tubeuf, S., Henrard, S., & Spinewine, A. (2024) · BMJ Open · doi:10.1136/bmjopen-2024-085435 · Cited by 2 · see citing works
Boucaud‐Maitre, D., Jaballah, F., Letenneur, L., Rinaldo, L., Dartigues, J., Dramé, M., Amieva, H., & Tabué-Teguo, M. (2025) · PLoS ONE · doi:10.1371/journal.pone.0311823 · Cited by 2 · see citing works
Kok, J. S., Voshaar, R. C. O., & Scherder, E. (2019) · Aging & Mental Health · doi:10.1080/13607863.2019.1584784 · Cited by 2 · see citing works
Exploring the Relationship between Falls in Long Term Care and Psychoactive Prescribing
Hughes, L. D. (2022) · The Journal of Frailty & Aging · doi:10.14283/jfa.2022.53 · Cited by 2 · see citing works
Adherence to Guideline Recommendations on Psychotropic Drug Use for Challenging Behavior in Dementia
van der Griend, J., Wouters, F., Yeung, G. Y. C., Gerridzen, I. J., Joling, K. J., Zuidema, S. U., Smalbrugge, M., & Sizoo, E. M. (2025) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2024.105474 · Cited by 1 · see citing works
Biering, P., & Hjaltadóttir, I. (2020) · Læknablaðið · doi:10.17992/lbl.2021.01.615 · Cited by 1 · see citing works
Giovannini-Green, Z. E. M., Gamble, J., Barrett, B., Gao, Z., Stuckless, S. N., & Parfrey, P. S. (2021) · Canadian Pharmacists Journal / Revue des Pharmaciens du Canada · doi:10.1177/17151635211005161 · Cited by 1 · see citing works
Vredeveld, E. J., Hulshof, T. A., Zuidema, S. U., & Luijendijk, H. J. (2019) · CNS Drugs · doi:10.1007/s40263-019-00654-y · Cited by 1 · see citing works
Die hausärztliche gerontopsychiatrische Versorgung in Stadtbasler Alters- und Pflegeheimen
Kiss, N., Giezendanner, S., & Zeller, A. (2021) · Praxis · doi:10.1024/1661-8157/a003642 · Cited by 1 · see citing works
GOY, N., EPOUPA, J., Bier, J., Naeije, G., Beernaert, L., Nicolay, C., & Breucker, S. D. (2021) · Research Square · doi:10.21203/rs.3.rs-279516/v1 · Cited by 1 · see citing works
Petersen, C. L., Curto, D., Mishra, M., Cano, P., & Weeks, W. B. (2019) · Journal of General Internal Medicine · doi:10.1007/s11606-019-05517-2
Kijowska, V., Barańska, I., Stodolska, A., & Szczerbińska, K. E. (2020) · Polskie Archiwum Medycyny Wewnętrznej · doi:10.20452/pamw.15731
Aalto, U. L., Rantsi, M., Juola, A.-L., Kautiainen, H., & Pitkälä, K. H. (2022) · Scandinavian Journal of Primary Health Care · doi:10.1080/02813432.2022.2074055
Patterns of Antipsychotic Dispensation to Long-Term Care Residents
Trenaman, S. C., von Maltzahn, M., SKETRIS, I. S., Tamim, H., Wang, Y., & Stewart, S. A. (2022) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2022.09.009
Delirium in nursing homes: the continued case of B.M.
Rahman, S. (2023) · Journal of Gerontology and Geriatrics · doi:10.36150/2499-6564-n593
Public Reporting der Qualität der Leistung der Langzeitpflege
Meyer, G., & Berg, A. (2023) · Springer eBooks · doi:10.1007/978-3-662-67669-1_6
Kormelinck, C. M. G., Gerritsen, D. L., van Teunenbroek, C. F., de Boer, M. R., Smalbrugge, M., & Zuidema, S. U. (2025) · BMC Geriatrics · doi:10.1186/s12877-025-06206-y
- Authors
- Janus, S. I. M., van Manen, J. G., IJzerman, M. J., & Zuidema, S. U.
- Affiliations
- University of Twente (NL)
- University Medical Center Groningen (NL)
- Corresponding author
- Janus, Sarah I. M.
- Venue
- International Psychogeriatrics
- Publisher
- Elsevier BV
- Published
- 2016-07-29
- Volume
- 28
- Issue
- 11
- Pages
- 1775-1790
- ISSN
- 1041-6102 (ISSN-L)
- 1741-203X
- OpenAlex
- W2491277325
- Cited by
- 110
- References
- 59
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 4 · 2023: 6 · 2022: 23 · 2021: 14 · 2020: 16 · 2019: 19 · 2018: 9 · 2017: 6 · 2016: 1
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- International Psychogeriatrics (publishedVersion)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (publishedVersion, cc-by-nc-nd)
- University of Twente Research Information (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- University of Twente Research Information (submittedVersion)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Pharmaceutical Practices and Patient Outcomes
- Health Sciences › Health Professions › General Health Professions › Geriatric Care and Nursing Homes
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- psychotropic drugs, nursing homes, antipsychotic drugs, antidepressants, dementia, prescription rates, Western Europe, cross-national comparison, non-pharmacological treatment
- MeSH terms
- Potentially Inappropriate Medication List, Cross-Cultural Comparison, Dementia, Europe, Homes for the Aged, Humans, Nursing Homes, Psychotropic Drugs, Inappropriate Prescribing
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