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Long-Term Treatment of Elderly Individuals With Emotional Disturbances: An Open Study With Citalopram
Open accessAbstract
In the present open study, the long-term safety, tolerability, and efficacy of citalopram in the treatment of elderly people with emotional disturbances were studied. One hundred twenty-three elderly patients with symptoms of depression-anxiety were included. Most of the patients (76%) were demented. Fifty-two patients completed a 12-month treatment. Irritability, depressed mood, anxiety, restlessness, and fear-panic were significantly reduced. The severity of illness from baseline to Month 9 was rated as significantly improved. The side effects were infrequent and mostly mild.
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Citalopram has been suggested as an alternative to antipsychotic drugs for agitation and aggression in dementia.
“and has been suggested as an alternative to antipsychotic drugs for agitation and aggression in dementia13–16.”
From Effect of Citalopram on Agitation in Alzheimer Disease: The CitAD Randomized Clinical Trial (2014) · cites this paper as [15]
The Abstract reports reduced restlessness and irritability in a citalopram study whose patients were mostly demented; the Discussion suggests citalopram reduces restlessness. The paper includes aggressive behavior among the symptoms it set out to study, but the passages do not report a reduction in aggression or explicitly suggest citalopram as an alternative to antipsychotic drugs. (LLM, conf=0.84)
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Research works printed but not linked: 19
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Cited by
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Effect of Citalopram on Agitation in Alzheimer Disease: The CitAD Randomized Clinical Trial
Porsteinsson, A. P., Drye, L. T., Pollock, B. G., Devanand, D. P., Frangakis, C., Ismail, Z., Marano, C., Meinert, C. L., Mintzer, J. E., Munro, C. A., et al. (2014) · JAMA · doi:10.1001/jama.2014.93 · Cited by 572
Metadata
- Authors
- Ragneskog, H., Eriksson, S., Karlsson, I., & Gottfries, C.-G.
- Affiliations
- University of Gothenburg (SE)
- Umeå University (SE)
- ORCID
- Eriksson, Sture
- Venue
- International Psychogeriatrics
- Publisher
- Elsevier BV
- Published
- 1996-12
- Volume
- 8
- Issue
- 4
- Pages
- 659-668
- ISSN
- 1041-6102 (ISSN-L)
- OpenAlex
- W1975688404
- Cited by
- 22
- References
- 0
- Citations by year
- 2019: 1 · 2018: 1 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Psychogeriatrics (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- citalopram, elderly patients, depression, anxiety, long-term treatment, demented patients, adverse effects, irritability, restlessness
- MeSH terms
- Affective Symptoms, Aged, Alzheimer Disease, Antidepressive Agents, Anxiety Disorders, Dementia, Depressive Disorder, Female, Humans, Long-Term Care, Male, Sweden, Citalopram, Comorbidity, Treatment Outcome
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